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Publication . Article . 1995

Effect of the delivery system on the biodistribution of Ge(IV) octabutoxy-phthalocyanines in tumour-bearing mice

Marina Soncin; Laura Polo; Elena Reddi; Giulio Jori; M. E. Kenney; Gongzhen Cheng; Michael A. J. Rodgers;
Closed Access
Published: 01 Feb 1995 Journal: Cancer Letters, volume 89, pages 101-106 (issn: 0304-3835, Copyright policy )
Publisher: Elsevier BV
Abstract

Abstract The pharmacokinetic properties of the Ge(IV)-octabutoxy-phthalocyanines (GePc) with two axially ligated triethyl-siloxy (GePcEt) or trihexyl-siloxy (GePcHex) chains were studied in BALB/C mice bearing a transplanted MS-2 fibrosarcoma. The GePcs were delivered to mice after incorporation into unilamellar liposomes of dipalmitoyl phosphatidylcholine (DPPC) or in an emulsion of Cremophor-EL. The Cremophor delivered GePcs were cleared from the blood circulation at a much slower rate than the liposome-delivered GePcs. At the same time, Cremophor induced a slower and reduced uptake of the GePcs in the liver and spleen while it greatly enhanced the uptake in the tumour as compared to liposomes. Maximum tumour uptake was observed at 24 h post-injection and was equivalent to 0.67 and 0.50 nmol/g, respectively, for the Cremophor delivered GePcHex and GePcEt. The corresponding values for the liposome-delivered drugs were approximately one fourth of that observed with Cremophor.

Subjects by Vocabulary

Microsoft Academic Graph classification: Pharmacokinetics Pharmacology Immunology Photodynamic therapy medicine.medical_treatment medicine Spleen medicine.anatomical_structure Liposome Ratón Photosensitizer Fibrosarcoma medicine.disease Chemistry Biodistribution

Subjects

Cancer Research, Oncology

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