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Publication . Conference object . 1994

<title>Synthesis and biological evaluation of a series of new germanium phthalocyanines incorporated into liposomes--part I: chemistry</title>

Hans-Georg Capraro; Klaus Schieweck; Rolf Hilfiker; Martin Ochsner; Ute Isele; Peter van Hoogevest; R. Naef; +1 Authors
Published: 01 Mar 1994 Journal: SPIE Proceedings (issn: 0277-786X, Copyright policy )
Publisher: SPIE

Germanium-dihydroxy-phthalocyanine GePc(OH2) was synthesized and used as starting material for several new, axially disubstituted derivatives of the general formula GePc[OSi(R2)R']2. The preparation of the monosubstituted silanol side chains HOSi(R)2R' was performed either by Mitsunobu reaction starting from diphenylsilandiol Si(Ph)2(OH)2 followed by direct coupling of the side-chain with GePc(OH)2, or by synthesis from a dichlorosilyl derivative. The new compounds were fully characterized and the chemical and main photophysical properties determined. The absorption maxima of these compounds lie in the range of 675 nm. They were found to possess a high quantum efficiency of singlet-oxygen production and fluorescence. The compounds were incorporated into small, unilamellar liposomes following a technology developed by Ciba-Geigy. The dye-to-lipid ratio was 1:100. The liposomal suspensions were freeze-dried for storage. The new compounds were evaluated for their pharmacokinetic and phototherapeutic properties.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

Subjects by Vocabulary

Microsoft Academic Graph classification: Phosphorescence Polymer chemistry Liposome Organic chemistry Luminescence Absorption (chemistry) Chemistry Mitsunobu reaction Silanol chemistry.chemical_compound Fluorescence Side chain

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Conference object . 1994
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