project . 2016 - 2018 . Closed

APCINTERACTIONS

Molecular basis for securin and cyclin ubiquitylation by the anaphase-promoting complex (APC/C)
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 657725 Call for proposal: H2020-MSCA-IF-2014
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 183,455 EURFunder Contribution: 183,455 EUR
  • Status: Closed
  • Start Date
    01 Mar 2016
    End Date
    28 Feb 2018
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
This research proposal describes an ambitious effort to characterize structurally and biochemically ubiquitin chain initiation and elongation by the anaphase-promoting complex or cyclosome (APC/C) in complex with two well-characterized substrates. The APC/C is a multi-subunit cullin-RING E3 ubiquitin ligase that controls progression through the cell cycle by a temporal regulation of its activity and substrate specificity. Regulation and specificity of this E3 ligase is achieved through mutually exclusive binding of two structurally related co-activator subunits termed Cdc20 and Cdh1, as well as through APC/C inhibitors, varying substrate affinities and auto-ubiq...
Partners
Description
This research proposal describes an ambitious effort to characterize structurally and biochemically ubiquitin chain initiation and elongation by the anaphase-promoting complex or cyclosome (APC/C) in complex with two well-characterized substrates. The APC/C is a multi-subunit cullin-RING E3 ubiquitin ligase that controls progression through the cell cycle by a temporal regulation of its activity and substrate specificity. Regulation and specificity of this E3 ligase is achieved through mutually exclusive binding of two structurally related co-activator subunits termed Cdc20 and Cdh1, as well as through APC/C inhibitors, varying substrate affinities and auto-ubiq...
Partners
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