project . 2020 - 2022 . On going

UCUPA

Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 894039 Call for proposal: H2020-MSCA-IF-2019
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 212,934 EURFunder Contribution: 212,934 EUR
  • Status: On going
  • Start Date
    01 Sep 2020
    End Date
    31 Aug 2022
  • Detailed project information (CORDIS)
Description
What defines the functional specialization of a cell is its unique proteome. Proteins need to be translated and properly folded to ensure their biological function. Several protein quality control pathways have arisen during evolution, some of them specialized in monitoring protein folding in specific organelles . As a result of ageing, animals lose their ability to protect their proteome, leading to the accumulation of protein aggregates and the onset of age-related disorders. The Unfolded Protein Response (UPR) of the Endoplasmic Reticulum (ER) is a central protein quality control mechanism that declines with ageing. This project will use the nematode Caenorha...
Partners
Description
What defines the functional specialization of a cell is its unique proteome. Proteins need to be translated and properly folded to ensure their biological function. Several protein quality control pathways have arisen during evolution, some of them specialized in monitoring protein folding in specific organelles . As a result of ageing, animals lose their ability to protect their proteome, leading to the accumulation of protein aggregates and the onset of age-related disorders. The Unfolded Protein Response (UPR) of the Endoplasmic Reticulum (ER) is a central protein quality control mechanism that declines with ageing. This project will use the nematode Caenorha...
Partners
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