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CSIC

Spanish National Research Council
Country: Spain
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2,055 Projects, page 1 of 411
  • Funder: EC Project Code: 240497
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  • Funder: EC Project Code: 219811
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  • Funder: EC Project Code: 647900
    Overall Budget: 2,392,520 EURFunder Contribution: 2,392,520 EUR

    Understanding how organisms adapt to their environments is a long-standing problem in Biology with far-reaching implications: adaptation affects the ability of species to survive in changing environments, host-pathogen interactions, and resistance to pesticides and drugs. Despite recent progress, adaptation is to date a poorly understood process largely due to limitations of current approaches that focus (i) on a priori candidate genes, (ii) on signals of selection at the DNA level without functional validation of the identified candidates, and (iii) on small sets of adaptive mutations that do not represent the variability present in natural populations. As a result, major questions such as what is the relative importance of different types of mutations in adaptation?, and what is the importance of epigenetic changes in adaptive evolution?, remain largely unanswered. To gain a deep understanding of adaptation, we need to systematically identify adaptive mutations across space and time, pinpoint their molecular mechanisms and discover their fitness effects. To this end, Drosophila melanogaster has proven to be an ideal organism. Besides the battery of genetic tools and resources available, D. melanogaster has recently adapted to live in out of Africa environments. We and others have already shown that transposable elements (TEs) have substantially contributed to the adaptation of D. melanogaster to different environmental challenges. Here, we propose to use state-of-the-art techniques, such as Illumina TruSeq sequencing and CRISPR/Cas9 genome editing, to systematically identify and characterize in detail adaptive TE insertions in D. melanogaster natural populations. Only by moving from gathering anecdotic evidence to applying global approaches, we will be able to start constructing a quantitative and predictive theory of adaptation that will be relevant for other species as well.

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  • Funder: EC Project Code: 655162
    Overall Budget: 170,122 EURFunder Contribution: 170,122 EUR

    This project is devoted to the study of a system of partial differential equations of great relevance in modern geometry and theoretical physics. The Strominger system arises in the theory of heterotic supergravity and has been proposed by Shing-Tung Yau as one of the fundamental perspectives of complex geometry, in relation to the moduli problem for Calabi-Yau manifolds. The goal is to complete four research tasks, designed, on the one hand, to make progress on Yau's conjecture for the Strominger system and, on the other hand, to understand rigorously, in one simple example, a conjectural, fundamental, symmetry of the underlying physical theory, known as (0,2)-mirror symmetry. This will be achieved using the cutting-edge theory of generalized geometry introduced by N. Hitchin. The expertise of the supervisor L. Álvarez Cónsul and the host group at the Instituto de Ciencias Matemáticas (ICMAT, CSIC), leaders in the research line moduli spaces and geometric structures, combined with the expertise of the experienced researcher M. Garcia Fernandez, constitutes an essential backup and impulse for the achievement of the objectives of this project. The host group and ICMAT, in close relation with the Institute of Theoretical Physics (IFT) in Madrid and the Mathematical Institute in Oxford (Hitchin Laboratory), ensures an outstanding training of the applicant through the overall implementation of this research action. In addition, the ICMAT provides an exceptional atmosphere and management structure, and all the necessary infrastructures for the success of the Marie Curie action.

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