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description Publicationkeyboard_double_arrow_right Article , Other literature type 2020 France EnglishPublisher:MDPI AG Funded by:UKRI | Multi-donor allogeneic hu...UKRI| Multi-donor allogeneic human retinal progenitor cell therapy (hRPC) 4sightAuthors: Achache, Sofiane; Sanchette, Frédéric;Achache, Sofiane; Sanchette, Frédéric;Ta ternary thin film metallic glasses (TFMGs) were deposited through the direct current (DC) magnetron sputtering of pure metallic targets in a dynamic mode. The effect of tantalum addition on the microstructure, mechanical properties, and thermal behavior of TFMGs were investigated. Nanoindentation measurements showed that an increase in tantalum content from 0 to 47 at % favored hardness and Young&rsquo s modulus, which rose from 5.8 to 11.23 Gpa and from 90 to 136 Gpa, respectively. XRD analysis and differential scanning calorimetry (DSC) measurements highlighted an improvement of thermal stability with the tantalum addition from 377 to 582 ° C when the tantalum content increased from 0 to 31 at %. Cu&ndash Zr&ndash
Coatings arrow_drop_down CoatingsOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/2079-6412/10/6/515/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::9e6d9ff4a541a7166d792fe60047a424&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Coatings arrow_drop_down CoatingsOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/2079-6412/10/6/515/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::9e6d9ff4a541a7166d792fe60047a424&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Italy, Ireland, France, United Kingdom EnglishPublisher:HAL CCSD Authors: Fyfe, Aileen; Squazzoni, Flaminio; Torny, Didier; Dondio, Pierpaolo;Fyfe, Aileen; Squazzoni, Flaminio; Torny, Didier; Dondio, Pierpaolo;handle: 2434/659039 , 10023/18111
This collaboration was supported by the COST Action TD1306 “New Frontiers of Peer Review” (PEERE). The historical research for this paper was supported by the UK Arts & Humanities Research Council, grant AH/K001841, “Publishing the Philosophical Transactions, 1665-2015.” This article examines the evolution of peer review and the modern editorial processes of scholarly journals by analyzing a novel dataset derived from the Royal Society’s archives and covering 1865 to 1965, i.e., the historical period in which refereeing (not yet known as peer review) became firmly established. Our analysis reveals how the Royal Society’s editorial processes coped with both an increasing reliance on refereeing and a growth in submissions, while maintaining collective responsibility and minimizing research waste. By engaging more of its fellows in editorial activity, the society was able to establish an equilibrium of number of submissions per reviewer that was relatively stable over time. Nevertheless, our analysis shows that the distribution of editorial work was significantly uneven. Our findings reveal interesting parallels with current concerns about the scale and distribution of peer-review work and suggest the strategic importance of the management of the editorial process to achieve a creative mix of community commitment and professional responsibility that is essential in contemporary journals. Publisher PDF Peer reviewed
Archivio Istituziona... arrow_drop_down St Andrews Research RepositoryArticle . 2019 . Peer-reviewedData sources: St Andrews Research RepositoryHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2019License: CC BY NCMémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NCFull-Text: https://hal.science/hal-02187277/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2434/659039&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down St Andrews Research RepositoryArticle . 2019 . Peer-reviewedData sources: St Andrews Research RepositoryHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2019License: CC BY NCMémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NCFull-Text: https://hal.science/hal-02187277/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2434/659039&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 France, Netherlands, France EnglishPublisher:Springer Funded by:EC | FLAMINGOEC| FLAMINGOSperotto, Anna; Doyen, Guillaume; Latré, Steven; Charalambides, Marinos; Famaey, Jeroen; Velan, Petr; Celeda, Pavel;International audience; This article is a report of the IFIP AIMS 2014, which was held at Masaryk University, Czech Republic from June 30 to July 3, 2014. AIMS 2014 focused on the theme “Monitoring and Securing Virtualized Networks and Services”. The focus of the 2014 edition of the AIMS conference series was re-defined in comparison with earlier editions. AIMS 2014 positions itself in the network management community as an educational venue for Ph.D. students and young researchers. The AIMS program included hands-on tutorials and labs, a keynote, technical sessions and Ph.D. Workshop sessions, but also an educational session for training young academics on transversal topics. The highlights on each of the parts of the AIMS 2014 program are summarized in this article.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::894652d002863062ebd83605ed83e903&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy EnglishPublisher:Journal of Preventive Medicine and Hygiene Publicly fundedAysha Karim, Kiani; Derek, Pheby; Gary, Henehan; Richard, Brown; Paul, Sieving; Peter, Sykora; Robert, Marks; Benedetto, Falsini; Natale, Capodicasa; Stanislav, Miertus; Lorenzo, Lorusso; Daniele, Dondossola; Gianluca Martino, Tartaglia; Mahmut Cerkez, Ergoren; Munis, Dundar; Sandro, Michelini; Daniele, Malacarne; Gabriele, Bonetti; Astrit, Dautaj; Kevin, Donato; Maria Chiara, Medori; Tommaso, Beccari; Michele, Samaja; Stephen Thaddeus, Connelly; Donald, Martin; Assunta, Morresi; Ariola, Bacu; Karen L, Herbst; Mykhaylo, Kapustin; Liborio, Stuppia; Ludovica, Lumer; Giampietro, Farronato; Matteo, Bertelli; Giampietro, Farronato;Animal experimentation is widely used around the world for the identification of the root causes of various diseases in humans and animals and for exploring treatment options. Among the several animal species, rats, mice and purpose-bred birds comprise almost 90% of the animals that are used for research purpose. However, growing awareness of the sentience of animals and their experience of pain and suffering has led to strong opposition to animal research among many scientists and the general public. In addition, the usefulness of extrapolating animal data to humans has been questioned. This has led to Ethical Committees’ adoption of the ‘four Rs’ principles (Reduction, Refinement, Replacement and Responsibility) as a guide when making decisions regarding animal experimentation. Some of the essential considerations for humane animal experimentation are presented in this review along with the requirement for investigator training. Due to the ethical issues surrounding the use of animals in experimentation, their use is declining in those research areas where alternative in vitro or in silico methods are available. However, so far it has not been possible to dispense with experimental animals completely and further research is needed to provide a road map to robust alternatives before their use can be fully discontinued. Journal of Preventive Medicine and Hygiene, Vol. 63 No. 2S3 (2022): The secret of Mediterranean food: How “omic” sciences, biochemistry and human physiology can be applied to exploit the secrets of Mediterranean foods
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.15167/2421-4248/jpmh2022.63.2s3.2768&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.15167/2421-4248/jpmh2022.63.2s3.2768&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2009 France, United Kingdom, France, France, France EnglishPublisher:CIRP - Collège International pour la Recherche en Productique van Wijk, D.; Eynard, B.; Troussier, N.; Belkadi, F.; Roucoules, L.; Ducellier, G.;handle: 10985/6736 , 1826/3765
Organised by: Cranfield University Well known challenges in Aeronautic industry, namely reducing time to market, risks and development costs, could be reached thanks to innovative design methods supported by PLM technologies. Such methods are based on integrated design or collaborative engineering enabling close exchanges and cooperation between the project partners. The paper proposes a survey on integrated design methods and PLM technologies. It presents the development of a collaborative design platform, as part of SEINE project, which aims to improve partners’ cooperation in the French aeronautics supply chain. The paper also discusses how to include multiple expertises and integrated design in this collaborative platform. Mori Seiki – The Machine Tool Company
SAM : Science Arts e... arrow_drop_down Hyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotConference object . 2009add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10985/6736&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert SAM : Science Arts e... arrow_drop_down Hyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotConference object . 2009add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10985/6736&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017Embargo end date: 16 Feb 2017 Sweden, France, United Kingdom, Poland, Italy, United Kingdom, Cyprus, United Kingdom, Italy, Netherlands, United Kingdom EnglishPublisher:Elsevier BV Funded by:EC | BIORISE, WTEC| BIORISE ,WTSchmidt, A.F.; Swerdlow, D.I.; Holmes, M.V.; Patel, R.S.; Fairhurst-Hunter, Z.; Lyall, D.M.; Hartwig, F.P.; Horta, B.L.; Hypponen, E.; Power, C.; Moldovan, M.; Iperen, E. van; Hovingh, G.K.; Demuth, I.; Norman, K.; Steinhagen-Thiessen, E.; Demuth, J.; Bertram, L.; Liu, T.; Coassin, S.; Willeit, J.; Kiechl, S.; Willeit, K.; Mason, D.; Wright, J.; Morris, R.; Wanamethee, G.; Whincup, P.; Ben-Shlomo, Y.; McLachlan, S.; Price, J.F.; Kivimaki, M.; Welch, C.; Sanchez-Galvez, A.; Marques-Vidal, P.; Nicolaides, A.; Panayiotou, A.G.; Onland-Moret, N.C.; Schouw, Y.T. van der; Matullo, G.; Fiorito, G.; Guarrera, S.; Sacerdote, C.; Wareham, N.J.; Langenberg, C.; Scott, R.; Luan, J.A.; Bobak, M.; Malyutina, S.A.; Pajak, A.; Kubinova, R.; Tamosiunas, A.; Pikhart, H.; Husemoen, L.L.N.; Grarup, N.; Pedersen, O.; Hansen, T.; Linneberg, A.; Simonsen, K.S.; Cooper, J.; Humphries, S.E.; Brilliant, M.; Kitchner, T.; Hakonarson, H.; Carrell, D.S.; McCarty, C.A.; Kirchner, H.L.; Larson, E.B.; Crosslin, D.R.; Andrade, M. de; Roden, D.M.; Denny, J.C.; Carty, C.; Hancock, S.; Attia, J.; Holliday, E.; Donnell, M.O.; Yusuf, S.; Chong, M.; Pare, G.; Harst, P. van der; Said, M.A.; Eppinga, R.N.; Verweij, N.; Snieder, H.; Christen, T.; Mook-Kanamori, D.O.; Gustafsson, S.; Lind, L.; Ingelsson, E.; Pazoki, R.; Franco, O.; Hofman, A.; Uitterlinden, A.; Dehghan, A.; Teumer, A.; Baumeister, S.; Dorr, M.; Lerch, M.M.; Volker, U.; Volzke, H.; Ward, J.; Pell, J.P.; Smith, D.J.; Meade, T.; Maitland-van der Zee, A.H.; Baranova, E.V.; Young, R.; Ford, I.; Campbell, A.; Padmanabhan, S.; Bots, M.L.; Grobbee, D.E.; Froguel, P.; Thuillier, D.; Balkau, B.; Bonnefond, A.; Cariou, B.; Smart, M.; Bao, Y.; Kumari, M.; Mahajan, A.; Ridker, P.M.; Chasman, D.I.; Reiner, A.P.; Lange, L.A.; Ritchie, M.D.; Asselbergs, F.W.; Casas, J.P.; Keating, B.J.; Preiss, D.; Hingorani, A.D.; Sattar, N.; LifeLines Cohort Study Grp; UCLEB Consortium;doi: 10.17863/cam.7909
handle: 1887/111905 , 1983/b842e1d8-febc-49c9-8b9b-a3f34a94e1df , 11388/245300 , 20.500.11820/87149176-4f45-435c-9bd4-e29ac44c05fb , 11858/00-001M-0000-002C-6322-4 , 11858/00-001M-0000-002C-6324-F , 2318/1635254 , 1983/f4884543-93c4-4037-a3a4-617beb72b74c
pmc: PMC5266795
BACKGROUND:Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.METHODS:In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic variants with LDL cholesterol, fasting blood glucose, HbA1c, fasting insulin, bodyweight, waist-to-hip ratio, BMI, and risk of type 2 diabetes, using a standardised analysis plan, meta-analyses, and weighted gene-centric scores.FINDINGS:Data were available for more than 550 000 individuals and 51 623 cases of type 2 diabetes. Combined analyses of four independent PCSK9 variants (rs11583680, rs11591147, rs2479409, and rs11206510) scaled to 1 mmol/L lower LDL cholesterol showed associations with increased fasting glucose (0·09 mmol/L, 95% CI 0·02 to 0·15), bodyweight (1·03 kg, 0·24 to 1·82), waist-to-hip ratio (0·006, 0·003 to 0·010), and an odds ratio for type diabetes of 1·29 (1·11 to 1·50). Based on the collected data, we did not identify associations with HbA1c (0·03%, -0·01 to 0·08), fasting insulin (0·00%, -0·06 to 0·07), and BMI (0·11 kg/m2, -0·09 to 0·30).INTERPRETATION:PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefits of PCSK9 inhibitor treatment, as was previously done for statins.FUNDING:British Heart Foundation, and University College London Hospitals NHS Foundation Trust (UCLH) National Institute for Health Research (NIHR) Biomedical Research Centre.
Archivio Istituziona... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5266795Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.7909&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 216 citations 216 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 32visibility views 32 download downloads 390 Powered bymore_vert Archivio Istituziona... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5266795Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.7909&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 France EnglishPublisher:MDPI AG Funded by:UKRI | AI-CARE - Artificial Inte...UKRI| AI-CARE - Artificial Intelligence for CAtaract surgery Risk Estimation and reductionAuthors: Bouzid, Mariam; Masmoudi, Oussama; Yalaoui, Alice;Bouzid, Mariam; Masmoudi, Oussama; Yalaoui, Alice;International audience; This research focuses on an Order Acceptance Scheduling (OAS) problem on a single machine under time-of-use (TOU) tariffs and taxed carbon emissions periods with the objective to maximize total profit minus tardiness penalties and environmental costs. Due to the NP-hardness of the considered problem especially in presence of sequence-dependent setup-times, two fix-and-relax (FR) heuristics based on different time-indexed (TI) formulations are proposed. A metaheuristic based on the Dynamic Island Model (DIM) framework is also employed to tackle this optimization problem. These approached methods show promising results both in terms of solution quality and solving time compared to state-of-the-art exact solving approaches.
Applied Sciences arrow_drop_down Applied SciencesOther literature type . 2021License: CC BYFull-Text: http://www.mdpi.com/2076-3417/11/19/8919/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::050c1c4fad11be9c2b3166dd9043b0c0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Applied Sciences arrow_drop_down Applied SciencesOther literature type . 2021License: CC BYFull-Text: http://www.mdpi.com/2076-3417/11/19/8919/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::050c1c4fad11be9c2b3166dd9043b0c0&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2020 France EnglishPublisher:MDPI AG Funded by:UKRI | Multi-donor allogeneic hu...UKRI| Multi-donor allogeneic human retinal progenitor cell therapy (hRPC) 4sightAuthors: Achache, Sofiane; Sanchette, Frédéric;Achache, Sofiane; Sanchette, Frédéric;Ta ternary thin film metallic glasses (TFMGs) were deposited through the direct current (DC) magnetron sputtering of pure metallic targets in a dynamic mode. The effect of tantalum addition on the microstructure, mechanical properties, and thermal behavior of TFMGs were investigated. Nanoindentation measurements showed that an increase in tantalum content from 0 to 47 at % favored hardness and Young&rsquo s modulus, which rose from 5.8 to 11.23 Gpa and from 90 to 136 Gpa, respectively. XRD analysis and differential scanning calorimetry (DSC) measurements highlighted an improvement of thermal stability with the tantalum addition from 377 to 582 ° C when the tantalum content increased from 0 to 31 at %. Cu&ndash Zr&ndash
Coatings arrow_drop_down CoatingsOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/2079-6412/10/6/515/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::9e6d9ff4a541a7166d792fe60047a424&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Coatings arrow_drop_down CoatingsOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/2079-6412/10/6/515/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::9e6d9ff4a541a7166d792fe60047a424&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Italy, Ireland, France, United Kingdom EnglishPublisher:HAL CCSD Authors: Fyfe, Aileen; Squazzoni, Flaminio; Torny, Didier; Dondio, Pierpaolo;Fyfe, Aileen; Squazzoni, Flaminio; Torny, Didier; Dondio, Pierpaolo;handle: 2434/659039 , 10023/18111
This collaboration was supported by the COST Action TD1306 “New Frontiers of Peer Review” (PEERE). The historical research for this paper was supported by the UK Arts & Humanities Research Council, grant AH/K001841, “Publishing the Philosophical Transactions, 1665-2015.” This article examines the evolution of peer review and the modern editorial processes of scholarly journals by analyzing a novel dataset derived from the Royal Society’s archives and covering 1865 to 1965, i.e., the historical period in which refereeing (not yet known as peer review) became firmly established. Our analysis reveals how the Royal Society’s editorial processes coped with both an increasing reliance on refereeing and a growth in submissions, while maintaining collective responsibility and minimizing research waste. By engaging more of its fellows in editorial activity, the society was able to establish an equilibrium of number of submissions per reviewer that was relatively stable over time. Nevertheless, our analysis shows that the distribution of editorial work was significantly uneven. Our findings reveal interesting parallels with current concerns about the scale and distribution of peer-review work and suggest the strategic importance of the management of the editorial process to achieve a creative mix of community commitment and professional responsibility that is essential in contemporary journals. Publisher PDF Peer reviewed
Archivio Istituziona... arrow_drop_down St Andrews Research RepositoryArticle . 2019 . Peer-reviewedData sources: St Andrews Research RepositoryHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2019License: CC BY NCMémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NCFull-Text: https://hal.science/hal-02187277/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2434/659039&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down St Andrews Research RepositoryArticle . 2019 . Peer-reviewedData sources: St Andrews Research RepositoryHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2019License: CC BY NCMémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NCFull-Text: https://hal.science/hal-02187277/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2434/659039&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 France, Netherlands, France EnglishPublisher:Springer Funded by:EC | FLAMINGOEC| FLAMINGOSperotto, Anna; Doyen, Guillaume; Latré, Steven; Charalambides, Marinos; Famaey, Jeroen; Velan, Petr; Celeda, Pavel;International audience; This article is a report of the IFIP AIMS 2014, which was held at Masaryk University, Czech Republic from June 30 to July 3, 2014. AIMS 2014 focused on the theme “Monitoring and Securing Virtualized Networks and Services”. The focus of the 2014 edition of the AIMS conference series was re-defined in comparison with earlier editions. AIMS 2014 positions itself in the network management community as an educational venue for Ph.D. students and young researchers. The AIMS program included hands-on tutorials and labs, a keynote, technical sessions and Ph.D. Workshop sessions, but also an educational session for training young academics on transversal topics. The highlights on each of the parts of the AIMS 2014 program are summarized in this article.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::894652d002863062ebd83605ed83e903&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy EnglishPublisher:Journal of Preventive Medicine and Hygiene Publicly fundedAysha Karim, Kiani; Derek, Pheby; Gary, Henehan; Richard, Brown; Paul, Sieving; Peter, Sykora; Robert, Marks; Benedetto, Falsini; Natale, Capodicasa; Stanislav, Miertus; Lorenzo, Lorusso; Daniele, Dondossola; Gianluca Martino, Tartaglia; Mahmut Cerkez, Ergoren; Munis, Dundar; Sandro, Michelini; Daniele, Malacarne; Gabriele, Bonetti; Astrit, Dautaj; Kevin, Donato; Maria Chiara, Medori; Tommaso, Beccari; Michele, Samaja; Stephen Thaddeus, Connelly; Donald, Martin; Assunta, Morresi; Ariola, Bacu; Karen L, Herbst; Mykhaylo, Kapustin; Liborio, Stuppia; Ludovica, Lumer; Giampietro, Farronato; Matteo, Bertelli; Giampietro, Farronato;Animal experimentation is widely used around the world for the identification of the root causes of various diseases in humans and animals and for exploring treatment options. Among the several animal species, rats, mice and purpose-bred birds comprise almost 90% of the animals that are used for research purpose. However, growing awareness of the sentience of animals and their experience of pain and suffering has led to strong opposition to animal research among many scientists and the general public. In addition, the usefulness of extrapolating animal data to humans has been questioned. This has led to Ethical Committees’ adoption of the ‘four Rs’ principles (Reduction, Refinement, Replacement and Responsibility) as a guide when making decisions regarding animal experimentation. Some of the essential considerations for humane animal experimentation are presented in this review along with the requirement for investigator training. Due to the ethical issues surrounding the use of animals in experimentation, their use is declining in those research areas where alternative in vitro or in silico methods are available. However, so far it has not been possible to dispense with experimental animals completely and further research is needed to provide a road map to robust alternatives before their use can be fully discontinued. Journal of Preventive Medicine and Hygiene, Vol. 63 No. 2S3 (2022): The secret of Mediterranean food: How “omic” sciences, biochemistry and human physiology can be applied to exploit the secrets of Mediterranean foods
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.15167/2421-4248/jpmh2022.63.2s3.2768&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.15167/2421-4248/jpmh2022.63.2s3.2768&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2009 France, United Kingdom, France, France, France EnglishPublisher:CIRP - Collège International pour la Recherche en Productique van Wijk, D.; Eynard, B.; Troussier, N.; Belkadi, F.; Roucoules, L.; Ducellier, G.;handle: 10985/6736 , 1826/3765
Organised by: Cranfield University Well known challenges in Aeronautic industry, namely reducing time to market, risks and development costs, could be reached thanks to innovative design methods supported by PLM technologies. Such methods are based on integrated design or collaborative engineering enabling close exchanges and cooperation between the project partners. The paper proposes a survey on integrated design methods and PLM technologies. It presents the development of a collaborative design platform, as part of SEINE project, which aims to improve partners’ cooperation in the French aeronautics supply chain. The paper also discusses how to include multiple expertises and integrated design in this collaborative platform. Mori Seiki – The Machine Tool Company
SAM : Science Arts e... arrow_drop_down Hyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotConference object . 2009add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10985/6736&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert SAM : Science Arts e... arrow_drop_down Hyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotConference object . 2009add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10985/6736&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017Embargo end date: 16 Feb 2017 Sweden, France, United Kingdom, Poland, Italy, United Kingdom, Cyprus, United Kingdom, Italy, Netherlands, United Kingdom EnglishPublisher:Elsevier BV Funded by:EC | BIORISE, WTEC| BIORISE ,WTSchmidt, A.F.; Swerdlow, D.I.; Holmes, M.V.; Patel, R.S.; Fairhurst-Hunter, Z.; Lyall, D.M.; Hartwig, F.P.; Horta, B.L.; Hypponen, E.; Power, C.; Moldovan, M.; Iperen, E. van; Hovingh, G.K.; Demuth, I.; Norman, K.; Steinhagen-Thiessen, E.; Demuth, J.; Bertram, L.; Liu, T.; Coassin, S.; Willeit, J.; Kiechl, S.; Willeit, K.; Mason, D.; Wright, J.; Morris, R.; Wanamethee, G.; Whincup, P.; Ben-Shlomo, Y.; McLachlan, S.; Price, J.F.; Kivimaki, M.; Welch, C.; Sanchez-Galvez, A.; Marques-Vidal, P.; Nicolaides, A.; Panayiotou, A.G.; Onland-Moret, N.C.; Schouw, Y.T. van der; Matullo, G.; Fiorito, G.; Guarrera, S.; Sacerdote, C.; Wareham, N.J.; Langenberg, C.; Scott, R.; Luan, J.A.; Bobak, M.; Malyutina, S.A.; Pajak, A.; Kubinova, R.; Tamosiunas, A.; Pikhart, H.; Husemoen, L.L.N.; Grarup, N.; Pedersen, O.; Hansen, T.; Linneberg, A.; Simonsen, K.S.; Cooper, J.; Humphries, S.E.; Brilliant, M.; Kitchner, T.; Hakonarson, H.; Carrell, D.S.; McCarty, C.A.; Kirchner, H.L.; Larson, E.B.; Crosslin, D.R.; Andrade, M. de; Roden, D.M.; Denny, J.C.; Carty, C.; Hancock, S.; Attia, J.; Holliday, E.; Donnell, M.O.; Yusuf, S.; Chong, M.; Pare, G.; Harst, P. van der; Said, M.A.; Eppinga, R.N.; Verweij, N.; Snieder, H.; Christen, T.; Mook-Kanamori, D.O.; Gustafsson, S.; Lind, L.; Ingelsson, E.; Pazoki, R.; Franco, O.; Hofman, A.; Uitterlinden, A.; Dehghan, A.; Teumer, A.; Baumeister, S.; Dorr, M.; Lerch, M.M.; Volker, U.; Volzke, H.; Ward, J.; Pell, J.P.; Smith, D.J.; Meade, T.; Maitland-van der Zee, A.H.; Baranova, E.V.; Young, R.; Ford, I.; Campbell, A.; Padmanabhan, S.; Bots, M.L.; Grobbee, D.E.; Froguel, P.; Thuillier, D.; Balkau, B.; Bonnefond, A.; Cariou, B.; Smart, M.; Bao, Y.; Kumari, M.; Mahajan, A.; Ridker, P.M.; Chasman, D.I.; Reiner, A.P.; Lange, L.A.; Ritchie, M.D.; Asselbergs, F.W.; Casas, J.P.; Keating, B.J.; Preiss, D.; Hingorani, A.D.; Sattar, N.; LifeLines Cohort Study Grp; UCLEB Consortium;doi: 10.17863/cam.7909
handle: 1887/111905 , 1983/b842e1d8-febc-49c9-8b9b-a3f34a94e1df , 11388/245300 , 20.500.11820/87149176-4f45-435c-9bd4-e29ac44c05fb , 11858/00-001M-0000-002C-6322-4 , 11858/00-001M-0000-002C-6324-F , 2318/1635254 , 1983/f4884543-93c4-4037-a3a4-617beb72b74c
pmc: PMC5266795
BACKGROUND:Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.METHODS:In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic variants with LDL cholesterol, fasting blood glucose, HbA1c, fasting insulin, bodyweight, waist-to-hip ratio, BMI, and risk of type 2 diabetes, using a standardised analysis plan, meta-analyses, and weighted gene-centric scores.FINDINGS:Data were available for more than 550 000 individuals and 51 623 cases of type 2 diabetes. Combined analyses of four independent PCSK9 variants (rs11583680, rs11591147, rs2479409, and rs11206510) scaled to 1 mmol/L lower LDL cholesterol showed associations with increased fasting glucose (0·09 mmol/L, 95% CI 0·02 to 0·15), bodyweight (1·03 kg, 0·24 to 1·82), waist-to-hip ratio (0·006, 0·003 to 0·010), and an odds ratio for type diabetes of 1·29 (1·11 to 1·50). Based on the collected data, we did not identify associations with HbA1c (0·03%, -0·01 to 0·08), fasting insulin (0·00%, -0·06 to 0·07), and BMI (0·11 kg/m2, -0·09 to 0·30).INTERPRETATION:PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefits of PCSK9 inhibitor treatment, as was previously done for statins.FUNDING:British Heart Foundation, and University College London Hospitals NHS Foundation Trust (UCLH) National Institute for Health Research (NIHR) Biomedical Research Centre.
Archivio Istituziona... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5266795Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.7909&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 216 citations 216 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 32visibility views 32 download downloads 390 Powered bymore_vert Archivio Istituziona... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5266795Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.7909&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 France EnglishPublisher:MDPI AG Funded by:UKRI | AI-CARE - Artificial Inte...UKRI| AI-CARE - Artificial Intelligence for CAtaract surgery Risk Estimation and reductionAuthors: Bouzid, Mariam; Masmoudi, Oussama; Yalaoui, Alice;Bouzid, Mariam; Masmoudi, Oussama; Yalaoui, Alice;International audience; This research focuses on an Order Acceptance Scheduling (OAS) problem on a single machine under time-of-use (TOU) tariffs and taxed carbon emissions periods with the objective to maximize total profit minus tardiness penalties and environmental costs. Due to the NP-hardness of the considered problem especially in presence of sequence-dependent setup-times, two fix-and-relax (FR) heuristics based on different time-indexed (TI) formulations are proposed. A metaheuristic based on the Dynamic Island Model (DIM) framework is also employed to tackle this optimization problem. These approached methods show promising results both in terms of solution quality and solving time compared to state-of-the-art exact solving approaches.
Applied Sciences arrow_drop_down Applied SciencesOther literature type . 2021License: CC BYFull-Text: http://www.mdpi.com/2076-3417/11/19/8919/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::050c1c4fad11be9c2b3166dd9043b0c0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Applied Sciences arrow_drop_down Applied SciencesOther literature type . 2021License: CC BYFull-Text: http://www.mdpi.com/2076-3417/11/19/8919/pdfData sources: Multidisciplinary Digital Publishing InstituteAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::050c1c4fad11be9c2b3166dd9043b0c0&type=result"></script>'); --> </script>
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