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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    Ten tijde van de Covid-19-pandemie hebben vierdejaars studenten Facility Management de Best Practices onderzocht bij diverse zorginstellingen in Noord-Nederland. Drie organisaties uit de eerstelijnszorg, twee verpleeghuizen en twee ziekenhuizen hebben deelgenomen aan het onderzoek. De studenten hebben medewerkers geïnterviewd en ieder individueel een rapport geschreven met als onderzoeksvraag welke veranderingen nodig zijn. Is het in de zorg “roeien met de riemen die we hebben?” zoals twee respondenten zich afvragen. Eind juni verschijnt een uitgebreide analyse in de vorm van een bachelor scriptie. Nu alvast een eerste beeld van de analyse van de interviews en rapporten.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ NARCISarrow_drop_down
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    NARCIS
    Other literature type . 2021
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ NARCISarrow_drop_down
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      Other literature type . 2021
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    Authors: Olié, Émilie; Dubois, Jonathan; Benramdane, Myriam; Guillaume, Sebastien; +1 Authors

    International audience

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    Journal of Affective Disorders
    Article . 2022 . Peer-reviewed
    License: Elsevier TDM
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Journal of Affective...arrow_drop_down
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      Journal of Affective Disorders
      Article . 2022 . Peer-reviewed
      License: Elsevier TDM
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Dequin, Pierre-François; Heming, Nicholas; Meziani, Ferhat; Plantefève, Gaëtan; +18 Authors

    International audience; Importance: Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.Objective: To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure.Design, setting, and participants: Multicenter randomized double-blind sequential trial conducted in France, with interim analyses planned every 50 patients. Patients admitted to the intensive care unit (ICU) for COVID-19-related acute respiratory failure were enrolled from March 7 to June 1, 2020, with last follow-up on June 29, 2020. The study intended to enroll 290 patients but was stopped early following the recommendation of the data and safety monitoring board.Interventions: Patients were randomized to receive low-dose hydrocortisone (n = 76) or placebo (n = 73).Main outcomes and measures: The primary outcome, treatment failure on day 21, was defined as death or persistent dependency on mechanical ventilation or high-flow oxygen therapy. Prespecified secondary outcomes included the need for tracheal intubation (among patients not intubated at baseline); cumulative incidences (until day 21) of prone position sessions, extracorporeal membrane oxygenation, and inhaled nitric oxide; Pao2:Fio2 ratio measured daily from day 1 to day 7, then on days 14 and 21; and the proportion of patients with secondary infections during their ICU stay.Results: The study was stopped after 149 patients (mean age, 62.2 years; 30.2% women; 81.2% mechanically ventilated) were enrolled. One hundred forty-eight patients (99.3%) completed the study, and there were 69 treatment failure events, including 11 deaths in the hydrocortisone group and 20 deaths in the placebo group. The primary outcome, treatment failure on day 21, occurred in 32 of 76 patients (42.1%) in the hydrocortisone group compared with 37 of 73 (50.7%) in the placebo group (difference of proportions, -8.6% [95.48% CI, -24.9% to 7.7%]; P = .29). Of the 4 prespecified secondary outcomes, none showed a significant difference. No serious adverse events were related to the study treatment.Conclusions and relevance: In this study of critically ill patients with COVID-19 and acute respiratory failure, low-dose hydrocortisone, compared with placebo, did not significantly reduce treatment failure (defined as death or persistent respiratory support) at day 21. However, the study was stopped early and likely was underpowered to find a statistically and clinically important difference in the primary outcome.Trial registration: ClinicalTrials.gov Identifier: NCT02517489.

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    Authors: Alemanno, Alberto;

    The European response to COVID-19 has revealed an inconvenient truth. Despite having integrated public health concerns across all its policies – be it agriculture, consumer protection, or security –, the Union cannot directly act to save people’s lives. Only member states can do so. Yet when they adopted unilateral measures to counter the spread of the virus, those proved not only ineffective but also disruptive on vital supply chains, by ultimately preventing the flow of essential goods and people across the Union. These fragmented efforts in tackling cross-border health threats have almost immediately prompted political calls for the urgent creation of a European Health Union. Yet this call raises more questions than answers. With the aim to offer a rigorous and timely blueprint to decision-makers and the public at large, this Special Issue of the European Journal of Risk Regulation contextualizes such a new political project within the broader constitutional and institutional framework of EU public health law and policy. By introducing the Special, this paper argues that unless the envisaged Health Union will tackle the root causes of what prevented the Union from effectively responding to COVID-19 – the divergent health capacity across the Union –, it might fall short of its declared objective of strengthening the EU’resilience for cross-border health threats.

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    European Journal of Risk Regulation
    Article . 2020 . Peer-reviewed
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    SSRN Electronic Journal
    Article . 2020 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ European Journal of ...arrow_drop_down
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      European Journal of Risk Regulation
      Article . 2020 . Peer-reviewed
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      SSRN Electronic Journal
      Article . 2020 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sakkila, Laila; Tatkeu, C.; Rivenq, Atika; Zaidouni, J.; +1 Authors

    Due to the current events related to Covid-19, the conference originally planned for July 2020 has been postponed to April 7-9, 2021.The conference will be organized virtually by videoconference. ORAL; International audience; In this paper, a study of UWB receivers in terms of detection theory is presented. The UWB radar which is presented in many works previously [1]-[3] has many applications. For road UWB radar application, the receiver based on correlation is the optimum receiver [4]. In fact, it maximizes the probability of detection. We will consider, in this study, a correlator receiver based on a threshold detection method. As in narrowband [5] [6], we will describe the theoretical study that evaluates the performance of the UWB receiver based on correlation in terms of detection and false alarm probabilities. Then a study of curves showing threshold receiver operating characteristics (ROC system), based on correlation and destined to be used for a UWB radar is presented. The study is original because it is presented for the first time in a UWB radar system.

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    https://doi.org/10.1109/isivc4...
    Conference object . 2021 . Peer-reviewed
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      https://doi.org/10.1109/isivc4...
      Conference object . 2021 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Wang, Shihan; Schraagen, Marijn; Tjong Kim Sang, Erik; Dastani, Mehdi; +11 Authors

    Public sentiment (the opinion, attitude or feeling that the public expresses) is a factor of interest for government, as it directly influences the implementation of policies. Given the unprecedented nature of the COVID-19 crisis, having an up-to-date representation of public sentiment on governmental measures and announcements is crucial. In this paper, we analyse Dutch public sentiment on governmental COVID-19 measures from text data collected across three online media sources (Twitter, Reddit and Nu.nl) from February to September 2020. We apply sentiment analysis methods to analyse polarity over time, as well as to identify stance towards two specific pandemic policies regarding social distancing and wearing face masks. The presented preliminary results provide valuable insights into the narratives shown in vast social media text data, which help understand the influence of COVID-19 measures on the general public.

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    Part of book or chapter of book . 2020
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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    Part of book or chapter of book . 2020
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    https://doi.org/10.18653/v1/20...
    Conference object . 2020 . Peer-reviewed
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      Part of book or chapter of book . 2020
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Valéry Ridde; Lara Gautier; Christian Dagenais; Fanny Chabrol; +18 Authors

    AbstractBackgroundAll prevention efforts currently being implemented for COVID-19 are aimed at reducing the burden on strained health systems and human resources. There has been little research conducted to understand how SARS-CoV-2 has affected health care systems and professionals in terms of their work. Finding effective ways to share the knowledge and insight between countries, including lessons learned, is paramount to the international containment and management of the COVID-19 pandemic. The aim of this project is to compare the pandemic response to COVID-19 in Brazil, Canada, China, France, Japan, and Mali. This comparison will be used to identify strengths and weaknesses in the response, including challenges for health professionals and health systems.MethodsWe will use a multiple case study approach with multiple levels of nested analysis. We have chosen these countries as they represent different continents and different stages of the pandemic. We will focus on several major hospitals and two public health interventions (contact tracing and testing). It will employ a multidisciplinary research approach that will use qualitative data through observations, document analysis, and interviews, as well as quantitative data based on disease surveillance data and other publicly available data. Given that the methodological approaches of the project will be largely qualitative, the ethical risks are minimal. For the quantitative component, the data being used will be made publicly available.DiscussionWe will deliver lessons learned based on a rigorous process and on strong evidence to enable operational-level insight for national and international stakeholders.

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    https://doi.org/10.21203/rs.3....
    Preprint . 2021
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    Health Research Policy and Systems
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    Health Research Policy and Systems
    Article . 2021 . Peer-reviewed
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    Article . 2021
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      https://doi.org/10.21203/rs.3....
      Preprint . 2021
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      Health Research Policy and Systems
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      Health Research Policy and Systems
      Article . 2021 . Peer-reviewed
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    Authors: Knicker, Max Sina; Naumann-Woleske, Karl; Bouchaud, Jean-Philippe; Zamponi, Francesco;

    The economic shocks that followed the COVID-19 pandemic have brought to light the difficulty, both for academics and policy makers, of describing and predicting the dynamics of inflation. This paper offers an alternative modelling approach. We study the 2020-2023 period within the well-studied Mark-0 Agent-Based Model, in which economic agents act and react according to plausible behavioural rules. We include a mechanism through which trust of economic agents in the Central Bank can de-anchor. We investigate the influence of regulatory policies on inflationary dynamics resulting from three exogenous shocks, calibrated on those that followed the COVID-19 pandemic: a production/consumption shock due to COVID-related lockdowns, a supply-chain shock, and an energy price shock exacerbated by the Russian invasion of Ukraine. By exploring the impact of these shocks under different assumptions about monetary policy efficacy and transmission channels, we review various explanations for the resurgence of inflation in the United States, including demand-pull, cost-push, and profit-driven factors. Our main results are four-fold: (i) without appropriate fiscal policy, the shocked economy can take years to recover, or even tip over into a deep recession; {(ii) the success of monetary policy in curbing inflation is primarily due to expectation anchoring, rather than to the direct economic impact of interest rate hikes; (iii) however, strong inflation anchoring is detrimental to consumption and unemployment, leading to a narrow window of ``optimal'' policy responses due to the trade-off between inflation and unemployment;} (iv) the two most sensitive model parameters are those describing wage and price indexation. The results of our study have implications for Central Bank decision-making, and offers an easy-to-use tool that may help anticipate the consequences of different monetary and fiscal policies. 57 pages, 35 figures

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    https://doi.org/10.48550/arxiv...
    Article . 2023
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    SSRN Electronic Journal
    Article . 2023 . Peer-reviewed
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      https://doi.org/10.48550/arxiv...
      Article . 2023
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      SSRN Electronic Journal
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    Authors: Mahdi Ftouh; Nesrine Kalboussi; Nabil Abid; Souad Sfar; +2 Authors

    International audience; According to the Center for Disease Control and Prevention (CDC), the coronavirus disease 2019, a respiratory viral illness linked to significant morbidity, mortality, production loss, and severe economic depression, was the third-largest cause of death in 2020. Respiratory viruses such as influenza, respiratory syncytial virus, SARS-CoV-2, and adenovirus, are among the most common causes of respiratory illness in humans, spreading as pandemics or epidemics throughout all continents. Nanotechnologies are particles in the nanometer range made from various compositions. They can be lipid-based, polymer-based, protein-based, or inorganic in nature, but they are all bioinspired and virus-like. In this review, we aimed to present a short review of the different nanoparticles currently studied, in particular those which led to publications in the field of respiratory viruses. We evaluated those which could be beneficial for respiratory disease-based viruses; those which already have contributed, such as lipid nanoparticles in the context of COVID-19; and those which will contribute in the future either as vaccines or antiviral drug delivery systems. We present a short assessment based on a critical selection of evidence indicating nanotechnology’s promise in the prevention and treatment of respiratory infections.

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    PPAR Research
    Article . 2021 . Peer-reviewed
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    Authors: Yang, Fan; Pahlavan, Amir A.; Mendez, Simon; Abkarian, Manouk; +1 Authors

    It is now recognized that aerosol transport contributes to the transmission of the SARS-CoV-2 virus. Here we improve existing social distancing guidelines for airborne pathogens, which are typically given in terms of distance with vague statements (if any) about contact times. Also, estimates of inhalation of virus in a contaminated space usually assume a well-mixed environment, which is realistic for some, but not all, situations. In particular, we consider a local casual interaction of an infected individual and a susceptible individual, both maskless, account for the air flow and aerosol transport characteristics of speaking and breathing, and propose social distancing guidelines that involve both space and contact time, based on a conservative model of the interactions.

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    Physical Review Fluids
    Article . 2020 . Peer-reviewed
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    Physical Review Fluids
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      Physical Review Fluids
      Article . 2020 . Peer-reviewed
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    Ten tijde van de Covid-19-pandemie hebben vierdejaars studenten Facility Management de Best Practices onderzocht bij diverse zorginstellingen in Noord-Nederland. Drie organisaties uit de eerstelijnszorg, twee verpleeghuizen en twee ziekenhuizen hebben deelgenomen aan het onderzoek. De studenten hebben medewerkers geïnterviewd en ieder individueel een rapport geschreven met als onderzoeksvraag welke veranderingen nodig zijn. Is het in de zorg “roeien met de riemen die we hebben?” zoals twee respondenten zich afvragen. Eind juni verschijnt een uitgebreide analyse in de vorm van een bachelor scriptie. Nu alvast een eerste beeld van de analyse van de interviews en rapporten.

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    Authors: Olié, Émilie; Dubois, Jonathan; Benramdane, Myriam; Guillaume, Sebastien; +1 Authors

    International audience

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    Journal of Affective Disorders
    Article . 2022 . Peer-reviewed
    License: Elsevier TDM
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      Journal of Affective Disorders
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    Authors: Dequin, Pierre-François; Heming, Nicholas; Meziani, Ferhat; Plantefève, Gaëtan; +18 Authors

    International audience; Importance: Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.Objective: To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure.Design, setting, and participants: Multicenter randomized double-blind sequential trial conducted in France, with interim analyses planned every 50 patients. Patients admitted to the intensive care unit (ICU) for COVID-19-related acute respiratory failure were enrolled from March 7 to June 1, 2020, with last follow-up on June 29, 2020. The study intended to enroll 290 patients but was stopped early following the recommendation of the data and safety monitoring board.Interventions: Patients were randomized to receive low-dose hydrocortisone (n = 76) or placebo (n = 73).Main outcomes and measures: The primary outcome, treatment failure on day 21, was defined as death or persistent dependency on mechanical ventilation or high-flow oxygen therapy. Prespecified secondary outcomes included the need for tracheal intubation (among patients not intubated at baseline); cumulative incidences (until day 21) of prone position sessions, extracorporeal membrane oxygenation, and inhaled nitric oxide; Pao2:Fio2 ratio measured daily from day 1 to day 7, then on days 14 and 21; and the proportion of patients with secondary infections during their ICU stay.Results: The study was stopped after 149 patients (mean age, 62.2 years; 30.2% women; 81.2% mechanically ventilated) were enrolled. One hundred forty-eight patients (99.3%) completed the study, and there were 69 treatment failure events, including 11 deaths in the hydrocortisone group and 20 deaths in the placebo group. The primary outcome, treatment failure on day 21, occurred in 32 of 76 patients (42.1%) in the hydrocortisone group compared with 37 of 73 (50.7%) in the placebo group (difference of proportions, -8.6% [95.48% CI, -24.9% to 7.7%]; P = .29). Of the 4 prespecified secondary outcomes, none showed a significant difference. No serious adverse events were related to the study treatment.Conclusions and relevance: In this study of critically ill patients with COVID-19 and acute respiratory failure, low-dose hydrocortisone, compared with placebo, did not significantly reduce treatment failure (defined as death or persistent respiratory support) at day 21. However, the study was stopped early and likely was underpowered to find a statistically and clinically important difference in the primary outcome.Trial registration: ClinicalTrials.gov Identifier: NCT02517489.

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    Authors: Alemanno, Alberto;

    The European response to COVID-19 has revealed an inconvenient truth. Despite having integrated public health concerns across all its policies – be it agriculture, consumer protection, or security –, the Union cannot directly act to save people’s lives. Only member states can do so. Yet when they adopted unilateral measures to counter the spread of the virus, those proved not only ineffective but also disruptive on vital supply chains, by ultimately preventing the flow of essential goods and people across the Union. These fragmented efforts in tackling cross-border health threats have almost immediately prompted political calls for the urgent creation of a European Health Union. Yet this call raises more questions than answers. With the aim to offer a rigorous and timely blueprint to decision-makers and the public at large, this Special Issue of the European Journal of Risk Regulation contextualizes such a new political project within the broader constitutional and institutional framework of EU public health law and policy. By introducing the Special, this paper argues that unless the envisaged Health Union will tackle the root causes of what prevented the Union from effectively responding to COVID-19 – the divergent health capacity across the Union –, it might fall short of its declared objective of strengthening the EU’resilience for cross-border health threats.

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    Authors: Sakkila, Laila; Tatkeu, C.; Rivenq, Atika; Zaidouni, J.; +1 Authors

    Due to the current events related to Covid-19, the conference originally planned for July 2020 has been postponed to April 7-9, 2021.The conference will be organized virtually by videoconference. ORAL; International audience; In this paper, a study of UWB receivers in terms of detection theory is presented. The UWB radar which is presented in many works previously [1]-[3] has many applications. For road UWB radar application, the receiver based on correlation is the optimum receiver [4]. In fact, it maximizes the probability of detection. We will consider, in this study, a correlator receiver based on a threshold detection method. As in narrowband [5] [6], we will describe the theoretical study that evaluates the performance of the UWB receiver based on correlation in terms of detection and false alarm probabilities. Then a study of curves showing threshold receiver operating characteristics (ROC system), based on correlation and destined to be used for a UWB radar is presented. The study is original because it is presented for the first time in a UWB radar system.

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    https://doi.org/10.1109/isivc4...
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      https://doi.org/10.1109/isivc4...
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    Authors: Wang, Shihan; Schraagen, Marijn; Tjong Kim Sang, Erik; Dastani, Mehdi; +11 Authors

    Public sentiment (the opinion, attitude or feeling that the public expresses) is a factor of interest for government, as it directly influences the implementation of policies. Given the unprecedented nature of the COVID-19 crisis, having an up-to-date representation of public sentiment on governmental measures and announcements is crucial. In this paper, we analyse Dutch public sentiment on governmental COVID-19 measures from text data collected across three online media sources (Twitter, Reddit and Nu.nl) from February to September 2020. We apply sentiment analysis methods to analyse polarity over time, as well as to identify stance towards two specific pandemic policies regarding social distancing and wearing face masks. The presented preliminary results provide valuable insights into the narratives shown in vast social media text data, which help understand the influence of COVID-19 measures on the general public.

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    Authors: Valéry Ridde; Lara Gautier; Christian Dagenais; Fanny Chabrol; +18 Authors

    AbstractBackgroundAll prevention efforts currently being implemented for COVID-19 are aimed at reducing the burden on strained health systems and human resources. There has been little research conducted to understand how SARS-CoV-2 has affected health care systems and professionals in terms of their work. Finding effective ways to share the knowledge and insight between countries, including lessons learned, is paramount to the international containment and management of the COVID-19 pandemic. The aim of this project is to compare the pandemic response to COVID-19 in Brazil, Canada, China, France, Japan, and Mali. This comparison will be used to identify strengths and weaknesses in the response, including challenges for health professionals and health systems.MethodsWe will use a multiple case study approach with multiple levels of nested analysis. We have chosen these countries as they represent different continents and different stages of the pandemic. We will focus on several major hospitals and two public health interventions (contact tracing and testing). It will employ a multidisciplinary research approach that will use qualitative data through observations, document analysis, and interviews, as well as quantitative data based on disease surveillance data and other publicly available data. Given that the methodological approaches of the project will be largely qualitative, the ethical risks are minimal. For the quantitative component, the data being used will be made publicly available.DiscussionWe will deliver lessons learned based on a rigorous process and on strong evidence to enable operational-level insight for national and international stakeholders.

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    https://doi.org/10.21203/rs.3....
    Preprint . 2021
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    Health Research Policy and Systems
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    Health Research Policy and Systems
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      https://doi.org/10.21203/rs.3....
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    Authors: Knicker, Max Sina; Naumann-Woleske, Karl; Bouchaud, Jean-Philippe; Zamponi, Francesco;

    The economic shocks that followed the COVID-19 pandemic have brought to light the difficulty, both for academics and policy makers, of describing and predicting the dynamics of inflation. This paper offers an alternative modelling approach. We study the 2020-2023 period within the well-studied Mark-0 Agent-Based Model, in which economic agents act and react according to plausible behavioural rules. We include a mechanism through which trust of economic agents in the Central Bank can de-anchor. We investigate the influence of regulatory policies on inflationary dynamics resulting from three exogenous shocks, calibrated on those that followed the COVID-19 pandemic: a production/consumption shock due to COVID-related lockdowns, a supply-chain shock, and an energy price shock exacerbated by the Russian invasion of Ukraine. By exploring the impact of these shocks under different assumptions about monetary policy efficacy and transmission channels, we review various explanations for the resurgence of inflation in the United States, including demand-pull, cost-push, and profit-driven factors. Our main results are four-fold: (i) without appropriate fiscal policy, the shocked economy can take years to recover, or even tip over into a deep recession; {(ii) the success of monetary policy in curbing inflation is primarily due to expectation anchoring, rather than to the direct economic impact of interest rate hikes; (iii) however, strong inflation anchoring is detrimental to consumption and unemployment, leading to a narrow window of ``optimal'' policy responses due to the trade-off between inflation and unemployment;} (iv) the two most sensitive model parameters are those describing wage and price indexation. The results of our study have implications for Central Bank decision-making, and offers an easy-to-use tool that may help anticipate the consequences of different monetary and fiscal policies. 57 pages, 35 figures

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    https://doi.org/10.48550/arxiv...
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    Authors: Mahdi Ftouh; Nesrine Kalboussi; Nabil Abid; Souad Sfar; +2 Authors

    International audience; According to the Center for Disease Control and Prevention (CDC), the coronavirus disease 2019, a respiratory viral illness linked to significant morbidity, mortality, production loss, and severe economic depression, was the third-largest cause of death in 2020. Respiratory viruses such as influenza, respiratory syncytial virus, SARS-CoV-2, and adenovirus, are among the most common causes of respiratory illness in humans, spreading as pandemics or epidemics throughout all continents. Nanotechnologies are particles in the nanometer range made from various compositions. They can be lipid-based, polymer-based, protein-based, or inorganic in nature, but they are all bioinspired and virus-like. In this review, we aimed to present a short review of the different nanoparticles currently studied, in particular those which led to publications in the field of respiratory viruses. We evaluated those which could be beneficial for respiratory disease-based viruses; those which already have contributed, such as lipid nanoparticles in the context of COVID-19; and those which will contribute in the future either as vaccines or antiviral drug delivery systems. We present a short assessment based on a critical selection of evidence indicating nanotechnology’s promise in the prevention and treatment of respiratory infections.

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    Article . 2021 . Peer-reviewed
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    Authors: Yang, Fan; Pahlavan, Amir A.; Mendez, Simon; Abkarian, Manouk; +1 Authors

    It is now recognized that aerosol transport contributes to the transmission of the SARS-CoV-2 virus. Here we improve existing social distancing guidelines for airborne pathogens, which are typically given in terms of distance with vague statements (if any) about contact times. Also, estimates of inhalation of virus in a contaminated space usually assume a well-mixed environment, which is realistic for some, but not all, situations. In particular, we consider a local casual interaction of an infected individual and a susceptible individual, both maskless, account for the air flow and aerosol transport characteristics of speaking and breathing, and propose social distancing guidelines that involve both space and contact time, based on a conservative model of the interactions.

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    Physical Review Fluids
    Article . 2020 . Peer-reviewed
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      Physical Review Fluids
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