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description Publicationkeyboard_double_arrow_right Article 2020 NetherlandsPublisher:IOP Publishing Funded by:EC | Feel your ReachEC| Feel your ReachReinmar J. Kobler; Andreea Ioana Sburlea; Valeria Mondini; Masayuki Hirata; Gernot Müller-Putz;Objective. One of the main goals in brain-computer interface (BCI) research is the replacement or restoration of lost function in individuals with paralysis. One line of research investigates the inference of movement kinematics from brain activity during different volitional states. A growing number of electroencephalography (EEG) and magnetoencephalography (MEG) studies suggest that information about directional (e.g., velocity) and nondirectional (e.g., speed) movement kinematics is accessible noninvasively. We sought to assess if the neural information associated with both types of kinematics can be combined to improve the decoding accuracy. Approach. In an offline analysis, we reanalyzed the data of two previous experiments containing the recordings of 34 healthy participants (15 EEG, 19 MEG). We decoded 2D movement trajectories from low-frequency M/EEG signals in executed and observed tracking movements, and compared the accuracy of an unscented Kalman filter (UKF) that explicitly modeled the nonlinear relation between directional and nondirectional kinematics to the accuracies of linear Kalman (KF) and Wiener filters (WF) which did not combine both types of kinematics. Main results. At the group level, posterior-parietal and parieto-occipital (executed and observed movements) and sensorimotor areas (executed movements) encoded kinematic information. Correlations between the recorded position and velocity trajectories and the UKF decoded ones were on average 0.49 during executed and 0.36 during observed movements. Compared to the other filters, the UKF could achieve the best trade-off between maximizing the signal to noise ratio and minimizing the amplitude mismatch between the recorded and decoded trajectories. Significance. We present direct evidence that directional and nondirectional kinematic information is simultaneously detectable in low-frequency M/EEG signals. Moreover, combining directional and nondirectional kinematic information significantly improves the decoding accuracy upon a linear KF.
NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Review 2019 NetherlandsPublisher:Wiley Funded by:EC | NOMA-MRIEC| NOMA-MRIAuthors: José P. Marques; Frank F.J. Simonis; Andrew G. Webb;José P. Marques; Frank F.J. Simonis; Andrew G. Webb;Historically, clinical MRI started with main magnetic field strengths in the ∼0.05–0.35T range. In the past 40 years there have been considerable developments in MRI hardware, with one of the primary ones being the trend to higher magnetic fields. While resulting in large improvements in data quality and diagnostic value, such developments have meant that conventional systems at 1.5 and 3T remain relatively expensive pieces of medical imaging equipment, and are out of the financial reach for much of the world. In this review we describe the current state‐of‐the‐art of low‐field systems (defined as 0.25–1T), both with respect to its low cost, low foot‐print, and subject accessibility. Furthermore, we discuss how low field could potentially benefit from many of the developments that have occurred in higher‐field MRI.In the first section, the signal‐to‐noise ratio (SNR) dependence on the static magnetic field and its impact on the achievable contrast, resolution, and acquisition times are discussed from a theoretical perspective. In the second section, developments in hardware (eg, magnet, gradient, and RF coils) used both in experimental low‐field scanners and also those that are currently in the market are reviewed. In the final section the potential roles of new acquisition readouts, motion tracking, and image reconstruction strategies, currently being developed primarily at higher fields, are presented.Level of Evidence: 5Technical Efficacy Stage: 1J. Magn. Reson. Imaging 2019.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6590434Data sources: PubMed CentralJournal of Magnetic Resonance ImagingOther literature type . Article . 2019 . 2018 . Peer-reviewedLicense: CC BY NCJournal of Magnetic Resonance ImagingReview . 2019Data sources: University of Twente Research InformationLUMC Scholarly Publications; NARCISOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 194 citations 194 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 1visibility views 1 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6590434Data sources: PubMed CentralJournal of Magnetic Resonance ImagingOther literature type . Article . 2019 . 2018 . Peer-reviewedLicense: CC BY NCJournal of Magnetic Resonance ImagingReview . 2019Data sources: University of Twente Research InformationLUMC Scholarly Publications; NARCISOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 NetherlandsPublisher:Springer Science and Business Media LLC Funded by:EC | NEUROMICS, EC | RD-CONNECTEC| NEUROMICS ,EC| RD-CONNECTLodewijk J.A. Toonen; Maurice Overzier; Melvin M. Evers; Leticia G. Leon; Sander A.J. van der Zeeuw; Hailiang Mei; Szymon M. Kielbasa; Jelle J. Goeman; Kristina Hettne; Olafur T. Magnusson; Marion Poirel; Alexandre Seyer; Peter A C 't Hoen; Willeke M. C. van Roon-Mom;pmc: PMC6013885
pmid: 29929540
Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in transcriptional dysregulation, which can contribute to the cellular toxicity and neurodegeneration. Since the exact causative mechanisms underlying this process have not been fully elucidated, gene expression analyses in brains of transgenic SCA3 mouse models may provide useful insights. Methods Here we characterised the MJD84.2 SCA3 mouse model expressing the mutant human ataxin-3 gene using a multi-omics approach on brain and blood. Gene expression changes in brainstem, cerebellum, striatum and cortex were used to study pathological changes in brain, while blood gene expression and metabolites/lipids levels were examined as potential biomarkers for disease. Results Despite normal motor performance at 17.5 months of age, transcriptional changes in brain tissue of the SCA3 mice were observed. Most transcriptional changes occurred in brainstem and striatum, whilst cerebellum and cortex were only modestly affected. The most significantly altered genes in SCA3 mouse brain were Tmc3, Zfp488, Car2, and Chdh. Based on the transcriptional changes, α-adrenergic and CREB pathways were most consistently altered for combined analysis of the four brain regions. When examining individual brain regions, axon guidance and synaptic transmission pathways were most strongly altered in striatum, whilst brainstem presented with strongest alterations in the pi-3 k cascade and cholesterol biosynthesis pathways. Similar to other neurodegenerative diseases, reduced levels of tryptophan and increased levels of ceramides, di- and triglycerides were observed in SCA3 mouse blood. Conclusions The observed transcriptional changes in SCA3 mouse brain reveal parallels with previous reported neuropathology in patients, but also shows brain region specific effects as well as involvement of adrenergic signalling and CREB pathway changes in SCA3. Importantly, the transcriptional changes occur prior to onset of motor- and coordination deficits. Electronic supplementary material The online version of this article (10.1186/s13024-018-0261-9) contains supplementary material, which is available to authorized users.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6013885Data sources: PubMed CentralZENODO; Molecular Neurodegeneration; NARCISOther literature type . Article . 2018 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 58 citations 58 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 106visibility views 106 download downloads 104 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6013885Data sources: PubMed CentralZENODO; Molecular Neurodegeneration; NARCISOther literature type . Article . 2018 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13024-018-0261-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Book , Conference object , Preprint , Article , Report , Other literature type 2011 France, Italy, Germany, France, France, NetherlandsPublisher:Office of Scientific and Technical Information (OSTI) Funded by:UKRI | SemenRate Canada/UK: Tran..., UKRI | RootDetect: Remote Detect...UKRI| SemenRate Canada/UK: Transforming Germplasm and Genetic Quality to Drive Livestock Productivity ,UKRI| RootDetect: Remote Detection and Precision Management of Root HealthBoer, Daniel; Diehl, Markus; Milner, Richard; Venugopalan, Raju; Vogelsang, Werner; Kaplan, David; Montgomery, Hugh; Vigdor, Steven; Accardi, A.; Aschenauer, E.C.; Burkardt, M.; Ent, R.; Guzey, V.; Hasch, D.; Kumar, K.; Lamont, M.A.C.; Li, Ying-chuan; Marciano, W.; Marquet, C.; Sabatie, F.; Stratmann, M.; Yuan, F.; Sassot, R.; Zurita, P.; Cherednikov, I.O.; Goncalves, V.P.; Sandapen, R.; Kopeliovich, B.Z.; Gao, J.-H.; Liang, Z.-T.; Passek-Kumericki, K.; Kumericki, K.; Lappi, T.; Wallon, S.; Pire, B.; Geraud, R.; Moutarde, H.; Gelis, F.; Soyez, G.; Meskauskas, M.; Mueller, Dieter; Stefanis, N.G.; Gallmeister, K.; Mosel, U.; Diehl, M.; Bartels, J.; Pirner, H.J.; Hagler, P.; Jager, B.; Spiesberger, H.; Lautenschlager, T.; Schafer, A.; Ringer, F.; Vogelsang, W.; Kroll, P.; Alekhin, S.; Blumlein, J; Moch, S.-O.; Pisano, C.; Rojo, J.; Bacchetta, A.; Pasquini, B.; Radici, M.; Ciofi degli Atti, C.; Mezzetti, C.B.; Kaptari, L.P.; Anselmino, M.; Tanaka, K.; Koike, Y.; Kumano, S.; Motyka, L.; Golec-Biernat, K.; Stasto, A.M.; Golec-Biernat, K.; Szymanowski, L.; Cherednikov, I.O.; Kaptari, L.P.; Radyushkin, A.; Alekhin, S.; Kondratenko, A.; Horowitz, W.A.; Schnell, G.; Chevtsov, P.; Mulders, P.J.; Rogers, T.C.; Boer, D.; Forshaw, J.R.; Cooper-Sarkar, A.; Chirilli, G.A.; Muller, D.; Wang, X.-N.; Yuan, F.; Qian, X.; Brodsky, S.J.; Schweitzer, P.; Horn, T.; Tuchin, K.; Dupre, R.; Erdelyi, B.; Manikonda, S.; Ostrumov, P.N.; Abeyratne, S.; Erdelyi, B.; Vossen, A.; Riordan, S.; Tsentalovich, E.; Goldstein, G.R.; Pozdeyev, E.; Huang, M.; Aidala, C.; Dumitru, A.; Dominguez, F.; Ben-Zvi, I.; Deshpande, A.; Faroughy, C.; Hammons, L.; Hao, Y.; Johnson, E.C.; Litvinenko, V.N.; Taneja, S.; Tsoupas, N.; Webb, S.; Beebe-Wang, J.; Belomestnykh, S.; Ben-Zvi, I.; Blaskiewicz, M.M.; Calaga, R.; Chang, X.; Fedotov, A.; Gassner, D.; Hahn, H.; Hammons, L.; Hao, Y.; He, P.; Jackson, W.; Jain, A.; Johnson, E.C.; Kayran, D.; Kewisch, J.; Litvinenko, V.N.; Luo, Y.; Mahler, G.; McIntyre, G.; Meng, W.; Minty, M.; Parker, B.; Pikin, A.; Ptitsyn, V.; Rao, T.; Roser, T.; Sheehy, B.; Skaritka, J.; Tepikian, S.; Than, Y.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J.; Wang, G.; Webb, S.; Wu, Q.; Xu, W.; Zelenski, A.; Beuf, G.; Burton, T.; Debbe, R.; Fazio, S.; Marciano, W.J.; Qiu, J.-W.; Toll, T.; Ullrich, T.; Deshpande, A.; Dumitru, A.; Kang, Z.-B.; Stasto, A.M.; Yuan, F.; Kovchegov, Y.V.; Majumder, A; Metz, A.; Zhou, J.; Gamberg, L.; Stasto, A.M.; Strikman, M.; Xiao, B.-W.; Guzzi, M.; Nadolsky, P.; Olness, F.; BC, H.; Liuti, S.; Ahmed, S.; Bogacz, A.; Derbenev, Ya.; Hutton, A.; Krafft, G.; Li, R.; Marhauser, F.; Morozov, V.; Pilat, F.; Rimmer, R.; Satogata, T.; Sullivan, M.;This report is based on a ten-week program on "Gluons and the quark sea at high-energies", which took place at the Institute for Nuclear Theory in Seattle in Fall 2010. The principal aim of the program was to develop and sharpen the science case for an Electron-Ion Collider (EIC), a facility that will be able to collide electrons and positrons with polarized protons and with light to heavy nuclei at high energies, offering unprecedented possibilities for in-depth studies of quantum chromodynamics. This report is organized around four major themes: i) the spin and flavor structure of the proton, ii) three-dimensional structure of nucleons and nuclei in momentum and configuration space, iii) QCD matter in nuclei, and iv) Electroweak physics and the search for physics beyond the Standard Model. Beginning with an executive summary, the report contains tables of key measurements, chapter overviews for each of the major scientific themes, and detailed individual contributions on various aspects of the scientific opportunities presented by an EIC. Comment: 547 pages, A report on the joint BNL/INT/Jlab program on the science case for an Electron-Ion Collider, September 13 to November 19, 2010, Institute for Nuclear Theory, Seattle; v2 with minor changes, matches printed version
NARCIS; University o... arrow_drop_down NARCIS; University of Groningen Research PortalConference object . 2011Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-UPMCOther literature type . Preprint . 2011https://doi.org/10.48550/arxiv...Article . 2011License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 100 citations 100 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert NARCIS; University o... arrow_drop_down NARCIS; University of Groningen Research PortalConference object . 2011Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-UPMCOther literature type . Preprint . 2011https://doi.org/10.48550/arxiv...Article . 2011License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2172/1034033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Other literature type 2015 Netherlands, FrancePublisher:IEEE Funded by:NWO | Wireless Control Systems:...NWO| Wireless Control Systems: A New Frontier in AutomationAuthors: Postoyan, R.; Biemond, J.J.B.; Heemels, W.P.M.H.; van de Wouw, N.;Postoyan, R.; Biemond, J.J.B.; Heemels, W.P.M.H.; van de Wouw, N.;International audience; The analysis of incremental stability properties typically involves measuring the distance between any pair of solutions of a given dynamical system, corresponding to different initial conditions, at the same time instant. This approach is not directly applicable for hybrid systems in general. Indeed, hybrid systems generate solutions that are defined with respect to hybrid times, which consist of both the continuous time elapsed and the discrete time, that is the number of jumps the solution has experienced. Two solutions of a hybrid system do not a priori have the same time domain, and we may therefore not be able to compare them at the same hybrid time instant. To overcome this issue, we invoke graphical closeness concepts. We present definitions for incremental stability depending on whether incremental asymptotic stability properties hold with respect to the hybrid time, the continuous time, or the discrete time, respectively. Examples are provided throughout the paper to illustrate these definitions, and the relations between these three incremental stability notions are investigated. The definitions are shown to be consistent with those available in the literature for continuous-time and discrete-time systems.
https://hal.archives... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2015Full-Text: https://hal.science/hal-01204822/documentEindhoven University of Technology Research PortalConference object . 2015Data sources: Eindhoven University of Technology Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/cdc.2015.7403088&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu7 citations 7 popularity Average influence Average impulse Average Powered by BIP!more_vert https://hal.archives... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2015Full-Text: https://hal.science/hal-01204822/documentEindhoven University of Technology Research PortalConference object . 2015Data sources: Eindhoven University of Technology Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/cdc.2015.7403088&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Italy, France, Netherlands, Netherlands, Netherlands, Netherlands, Netherlands, Ireland, Canada, Netherlands, Netherlands, Netherlands, United Kingdom, Netherlands, Netherlands, Ireland, Netherlands, Netherlands, Germany, Netherlands, United KingdomPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | MATRICSEC| MATRICSAuthors: Hibar, Derrek P; Stein, Jason L; Aribisala, Benjamin S; de Zubicaray, Greig I; +244 AuthorsHibar, Derrek P; Stein, Jason L; Aribisala, Benjamin S; de Zubicaray, Greig I; Dillman, Allissa; Duggirala, Ravi; Dyer, Thomas D; Erk, Susanne; Fedko, Iryna O; Ferrucci, Luigi; Foroud, Tatiana M; Fox, Peter T; Fukunaga, Masaki; Armstrong, Nicola J; Gibbs, J Raphael; Göring, Harald H H; Green, Robert C; Guelfi, Sebastian; Hansell, Narelle K; Hartman, Catharina A; Hegenscheid, Katrin; Heinz, Andreas; Hernandez, Dena G; Heslenfeld, Dirk J; Bernard, Manon; Hoekstra, Pieter J; Holsboer, Florian; Homuth, Georg; Hottenga, Jouke-Jan; Ikeda, Masashi; Jack, Clifford R; Jenkinson, Mark; Johnson, Robert; Kanai, Ryota; Keil, Maria; Bohlken, Marc M; Kent, Jack W; Kochunov, Peter; Kwok, John B; Lawrie, Stephen M; Liu, Xinmin; Longo, Dan L; McMahon, Katie L; Meisenzahl, Eva; Melle, Ingrid; Mohnke, Sebastian; Boks, Marco P; Montgomery, Grant W; Mostert, Jeanette C; Mühleisen, Thomas W; Nalls, Michael A; Nichols, Thomas E; Nilsson, Lars G; Nöthen, Markus M; Ohi, Kazutaka; Olvera, Rene L; Perez-Iglesias, Rocio; Bralten, Janita; Pike, G Bruce; Potkin, Steven G; Reinvang, Ivar; Reppermund, Simone; Rietschel, Marcella; Romanczuk-Seiferth, Nina; Rosen, Glenn D; Rujescu, Dan; Schnell, Knut; Schofield, Peter R; Brown, Andrew A; Smith, Colin; Steen, Vidar M; Sussmann, Jessika E; Thalamuthu, Anbupalam; Toga, Arthur W; Traynor, Bryan J; Troncoso, Juan; Turner, Jessica A; Valdés Hernández, Maria C; van 't Ent, Dennis; Chakravarty, M Mallar; van der Brug, Marcel; van der Wee, Nic J A; van Tol, Marie-Jose; Veltman, Dick J; Wassink, Thomas H; Westman, Eric; Zielke, Ronald H; Zonderman, Alan B; Ashbrook, David G; Hager, Reinmar; Chen, Qiang; Lu, Lu; McMahon, Francis J; Morris, Derek W; Williams, Robert W; Brunner, Han G; Buckner, Randy L; Buitelaar, Jan K; Cahn, Wiepke; Calhoun, Vince D; Cavalleri, Gianpiero L; Ching, Christopher R K; Crespo-Facorro, Benedicto; Dale, Anders M; Davies, Gareth E; Delanty, Norman; Depondt, Chantal; Djurovic, Srdjan; Drevets, Wayne C; Espeseth, Thomas; Gollub, Randy L; Ho, Beng-Choon; Renteria, Miguel E; Cuellar-Partida, Gabriel; Hoffmann, Wolfgang; Hosten, Norbert; Kahn, René S; Le Hellard, Stephanie; Meyer-Lindenberg, Andreas; Müller-Myhsok, Bertram; Nauck, Matthias; Nyberg, Lars; Pandolfo, Massimo; Penninx, Brenda W J H; den Braber, Anouk; Roffman, Joshua L; Sisodiya, Sanjay M; Smoller, Jordan W; van Bokhoven, Hans; van Haren, Neeltje E M; Völzke, Henry; Walter, Henrik; Weiner, Michael W; Wen, Wei; White, Tonya; Giddaluru, Sudheer; Agartz, Ingrid; Andreassen, Ole A; Blangero, John; Boomsma, Dorret I; Brouwer, Rachel M; Cannon, Dara M; Cookson, Mark R; de Geus, Eco J C; Deary, Ian J; Donohoe, Gary; Goldman, Aaron L; Fernández, Guillén; Fisher, Simon E; Francks, Clyde; Glahn, David C; Grabe, Hans J; Gruber, Oliver; Hardy, John; Hashimoto, Ryota; Hulshoff Pol, Hilleke E; Jönsson, Erik G; Grimm, Oliver; Kloszewska, Iwona; Lovestone, Simon; Mattay, Venkata S; Mecocci, Patrizia; McDonald, Colm; McIntosh, Andrew M; Ophoff, Roel A; Paus, Tomas; Pausova, Zdenka; Ryten, Mina; Guadalupe, Tulio; Sachdev, Perminder S; Saykin, Andrew J; Simmons, Andy; Singleton, Andrew; Soininen, Hilkka; Wardlaw, Joanna M; Weale, Michael E; Weinberger, Daniel R; Adams, Hieab H H; Launer, Lenore J; Hass, Johanna; Seiler, Stephan; Schmidt, Reinhold; Chauhan, Ganesh; Satizabal, Claudia L; Becker, James T; Yanek, Lisa; van der Lee, Sven J; Ebling, Maritza; Fischl, Bruce; Longstreth, W. T.; Woldehawariat, Girma; Greve, Douglas; Schmidt, Helena; Nyquist, Paul; Vinke, Louis N; van Duijn, Cornelia M; Xue, Luting; Mazoyer, Bernard; Bis, Joshua C; Gudnason, Vilmundur; Seshadri, Sudha; Martin, Nicholas G; Wright, Margaret J; Franke, Barbara; Thompson, Paul M; Medland, Sarah E; Arias-Vasquez, Alejandro; Jia, Tianye; Shen, Li; Mather, Karen A; Desrivières, Sylvane; Mattheisen, Manuel; Ramasamy, Adaikalavan; Risacher, Shannon L; Roiz-Santiañez, Roberto; Rose, Emma J; Schmaal, Lianne; Schork, Andrew J; Strike, Lachlan T; Teumer, Alexander; Preda, Adrian; Westlye, Lars T; Whelan, Christopher D; Toro, Roberto; Winkler, Anderson M; Beiser, Alexa; DeStefano, Anita; Vaidya, Dhananjay; Vernooij, Meike W; Artiges, Eric; Ehrlich, Stefan; Banaschewski, Tobias; Boddaert, Nathalie; Bokde, Arun; Flor, Herta; Haukvik, Unn K; Miranda, Ruben; Nees, Frauke; Lopez, Lorna M; Williams, Steve; Nugent, Allison C; Sprooten, Emma; Walton, Esther; Bastin, Mark E; Carless, Melanie A; Cichon, Sven; Corvin, Aiden; Curran, Joanne E;doi: 10.1038/nature14101
pmc: PMC4393366
pmid: 25607358
handle: 1765/82772 , 1871.1/9d055530-aea0-4fb7-b981-9d4a79dc4178 , 20.500.11820/77342012-02ed-419b-904f-c5fc42863c81 , 1887/102856 , 1866/20931 , 2066/144426 , 11370/bfe12ff1-5687-4a14-82bb-57f7052a91de , 11391/1316701 , https://repository.ubn.ru.nl/handle/2066/144426 , 11858/00-001M-0000-0024-A204-2 , 11858/00-001M-0000-0026-D061-9 , 1874/331330
doi: 10.1038/nature14101
pmc: PMC4393366
pmid: 25607358
handle: 1765/82772 , 1871.1/9d055530-aea0-4fb7-b981-9d4a79dc4178 , 20.500.11820/77342012-02ed-419b-904f-c5fc42863c81 , 1887/102856 , 1866/20931 , 2066/144426 , 11370/bfe12ff1-5687-4a14-82bb-57f7052a91de , 11391/1316701 , https://repository.ubn.ru.nl/handle/2066/144426 , 11858/00-001M-0000-0024-A204-2 , 11858/00-001M-0000-0026-D061-9 , 1874/331330
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 x 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction. Contains fulltext : 144426.pdf (Publisher’s version ) (Closed access) Contains fulltext : 144426pre.pdf (Author’s version preprint ) (Open Access) 6 p.
Maynooth University ... arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2015 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveCORE (RIOXX-UK Aggregator)Article . 2015Full-Text: http://sro.sussex.ac.uk/id/eprint/87473/1/__smbhome.uscs.susx.ac.uk_tjk30_Documents_untitled.pdfData sources: CORE (RIOXX-UK Aggregator)Papyrus : Dépôt institutionnel - Université de Montréal; Nature; METIS Research Information System; NARCISOther literature type . Article . 2015 . Peer-reviewedLicense: Springer TDMOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveNARCIS; NatureArticle . 2015HAL Descartes; HAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature14101&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 749 citations 749 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 2visibility views 2 download downloads 7 Powered bymore_vert Maynooth University ... arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2015 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveCORE (RIOXX-UK Aggregator)Article . 2015Full-Text: http://sro.sussex.ac.uk/id/eprint/87473/1/__smbhome.uscs.susx.ac.uk_tjk30_Documents_untitled.pdfData sources: CORE (RIOXX-UK Aggregator)Papyrus : Dépôt institutionnel - Université de Montréal; Nature; METIS Research Information System; NARCISOther literature type . Article . 2015 . Peer-reviewedLicense: Springer TDMOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveNARCIS; NatureArticle . 2015HAL Descartes; HAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 NetherlandsPublisher:Public Library of Science (PLoS) Funded by:EC | BRAINPATHEC| BRAINPATHDzyubachyk, O.; Khmelinskii, A.; Plenge, E.; Kok, P.; Snoeks, T.J.A.; Poot, D.H.J.; Lowik, C.W.G.M.; Botha, C.P.; Niessen, W.J.; Weerd, L. van der; Meijering, E.; Lelieveldt, B.P.F.;In small animal imaging studies, when the locations of the micro-structures of interest are unknown a priori, there is a simultaneous need for full-body coverage and high resolution. In MRI, additional requirements to image contrast and acquisition time will often make it impossible to acquire such images directly. Recently, a resolution enhancing post-processing technique called super-resolution reconstruction (SRR) has been demonstrated to improve visualization and localization of micro-structures in small animal MRI by combining multiple low-resolution acquisitions. However, when the field-of-view is large relative to the desired voxel size, solving the SRR problem becomes very expensive, in terms of both memory requirements and computation time. In this paper we introduce a novel local approach to SRR that aims to overcome the computational problems and allow researchers to efficiently explore both global and local characteristics in whole-body small animal MRI. The method integrates state-of-the-art image processing techniques from the areas of articulated atlas-based segmentation, planar reformation, and SRR. A proof-of-concept is provided with two case studies involving CT, BLI, and MRI data of bone and kidney tumors in a mouse model. We show that local SRR-MRI is a computationally efficient complementary imaging modality for the precise characterization of tumor metastases, and that the method provides a feasible high-resolution alternative to conventional MRI. ImPhys/Imaging Physics Applied Sciences
NARCIS; PLoS ONE; TU... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4181866Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0108730&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!visibility 23visibility views 23 download downloads 34 Powered bymore_vert NARCIS; PLoS ONE; TU... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4181866Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0108730&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 NetherlandsPublisher:Public Library of Science (PLoS) Funded by:IRC, EC | EU-AIMS, EC | TACTICS +1 projectsIRC ,EC| EU-AIMS ,EC| TACTICS ,NIH| International Multi-Center ADHD Genetics ProjectLaurence O'Dwyer; Colby J. Tanner; Eelco V. van Dongen; Corina U. Greven; Janita Bralten; Marcel P. Zwiers; Barbara Franke; Jaap Oosterlaan; Dirk J. Heslenfeld; Pieter J. Hoekstra; Catharina A. Hartman; Nanda Rommelse; Jan K. Buitelaar;Autism spectrum disorder (ASD) symptoms frequently occur in subjects with attention deficit/hyperactivity disorder (ADHD). While there is evidence that both ADHD and ASD have differential structural correlates, no study to date has investigated these structural correlates within a framework that robustly accounts for the phenotypic overlap between the two disorders. The presence of ASD symptoms was measured by the parent-reported Children's Social and Behavioural Questionnaire (CSBQ) in ADHD subjects (n = 180), their unaffected siblings (n = 118) and healthy controls (n = 146). ADHD symptoms were assessed by a structured interview (K-SADS-PL) and the Conners' ADHD questionnaires. Whole brain T1-weighted MPRAGE images were acquired and the structural MRI correlates of ASD symptom scores were analysed by modelling ASD symptom scores against white matter (WM) and grey matter (GM) volumes using mixed effects models which controlled for ADHD symptom levels. ASD symptoms were significantly elevated in ADHD subjects relative to both controls and unaffected siblings. ASD scores were predicted by the interaction between WM and GM volumes. Increasing ASD score was associated with greater GM volume. Equivocal results from previous structural studies in ADHD and ASD may be due to the fact that comorbidity has not been taken into account in studies to date. The current findings stress the need to account for issues of ASD comorbidity in ADHD. Contains fulltext : 136213.pdf (Publisher’s version ) (Open Access)
NARCIS; PLoS ONE arrow_drop_down NARCIS; PLoS ONEArticle . 2014Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4076257Data sources: PubMed CentralRadboud Repository; PLoS ONE; NARCISOther literature type . Article . 2014 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0101130&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 27 citations 27 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS; PLoS ONE arrow_drop_down NARCIS; PLoS ONEArticle . 2014Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4076257Data sources: PubMed CentralRadboud Repository; PLoS ONE; NARCISOther literature type . Article . 2014 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 Italy, Netherlands, France Dutch; FlemishAuthors: Dagnino, Roberto; Freschi, Valentina; Paris, Franco;Dagnino, Roberto; Freschi, Valentina; Paris, Franco;This article is a first-hand presentation of the history, the activities and the current developments of the Steunpunt Literair Vertalen (Literary Translation Support Office), which operates a coordinated training programme aimed at improving the linguistic skills of would-be as well as experienced translators. The Support Office is a co-operative venture involving the University of Utrecht and the Lessius Hogeschool in Antwerp and sponsored by the Nederlandse Taalunie (Dutch Language Union). Among other activities, the Steunpunt organized a successful summer course on literary translation held at the Lessius Hogeschool in Antwerp aimed at improving the skills of young literary translators from Dutch into Italian. The first two authors of this contribution,in fact, were selected as young translators for the training and the seminars held during that course, while Paris was involved as an experienced teacher and translator in the development of the linguistic skills of the participants. In giving their presentation, the authors focus in particular on their experience during the 2006 summer course.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=11370/92d5cd7b-25ce-4e54-95cd-dddcf971074f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 NetherlandsPublisher:Cold Spring Harbor Laboratory Funded by:NWO | Technology in motion, NWO | Visual analytics for 3DOM...NWO| Technology in motion ,NWO| Visual analytics for 3DOMICS: from single cell to tissue and backArlin Keo; Arlin Keo; Oleh Dzyubachyk; Jeroen van der Grond; Jacobus J. van Hilten; Marcel J. T. Reinders; Marcel J. T. Reinders; Marcel J. T. Reinders; Ahmed Mahfouz; Ahmed Mahfouz; Ahmed Mahfouz;AbstractCortical atrophy is a common manifestation in Parkinson’s disease, particularly in later disease stages. Here, we investigated patterns of cortical thickness using T1-weighted anatomical MRI data of 149 Parkinson’s disease patients and 369 controls. To elucidate the molecular underpinnings of cortical thickness changes in Parkinson’s disease, we performed an integrated analysis of brain-wide healthy transcriptomic data from the Allen Human Brain Atlas and neuroimaging features. For this purpose, we used partial least squares regression to identify gene expression patterns correlated with cortical thickness changes. In addition, we identified gene expression patterns underlying the relationship between cortical thickness and clinical domains of Parkinson’s disease. Our results show that genes whose expression in the healthy brain is associated with cortical thickness changes in Parkinson’s disease are enriched in biological pathways related to sumoylation, regulation of mitotic cell cycle, mitochondrial translation, DNA damage responses, and ER-Golgi traffic. The associated pathways were highly related to each other and all belong to cellular maintenance mechanisms. The expression of genes within most pathways was negatively correlated with cortical thickness changes, showing higher expression in regions associated with decreased cortical thickness (atrophy). On the other hand, sumoylation pathways were positively correlated with cortical thickness changes, showing higher expression in regions with increased cortical thickness (hypertrophy). Our findings suggest that alterations in the balanced interplay of these mechanisms play a role in changes of cortical thickness in Parkinson’s disease and possibly influence motor and cognitive functions.
NARCIS; Frontiers in... arrow_drop_down Frontiers in NeuroscienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8519261Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.06.19.158808&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!visibility 9visibility views 9 download downloads 19 Powered bymore_vert NARCIS; Frontiers in... arrow_drop_down Frontiers in NeuroscienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8519261Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2020 NetherlandsPublisher:IOP Publishing Funded by:EC | Feel your ReachEC| Feel your ReachReinmar J. Kobler; Andreea Ioana Sburlea; Valeria Mondini; Masayuki Hirata; Gernot Müller-Putz;Objective. One of the main goals in brain-computer interface (BCI) research is the replacement or restoration of lost function in individuals with paralysis. One line of research investigates the inference of movement kinematics from brain activity during different volitional states. A growing number of electroencephalography (EEG) and magnetoencephalography (MEG) studies suggest that information about directional (e.g., velocity) and nondirectional (e.g., speed) movement kinematics is accessible noninvasively. We sought to assess if the neural information associated with both types of kinematics can be combined to improve the decoding accuracy. Approach. In an offline analysis, we reanalyzed the data of two previous experiments containing the recordings of 34 healthy participants (15 EEG, 19 MEG). We decoded 2D movement trajectories from low-frequency M/EEG signals in executed and observed tracking movements, and compared the accuracy of an unscented Kalman filter (UKF) that explicitly modeled the nonlinear relation between directional and nondirectional kinematics to the accuracies of linear Kalman (KF) and Wiener filters (WF) which did not combine both types of kinematics. Main results. At the group level, posterior-parietal and parieto-occipital (executed and observed movements) and sensorimotor areas (executed movements) encoded kinematic information. Correlations between the recorded position and velocity trajectories and the UKF decoded ones were on average 0.49 during executed and 0.36 during observed movements. Compared to the other filters, the UKF could achieve the best trade-off between maximizing the signal to noise ratio and minimizing the amplitude mismatch between the recorded and decoded trajectories. Significance. We present direct evidence that directional and nondirectional kinematic information is simultaneously detectable in low-frequency M/EEG signals. Moreover, combining directional and nondirectional kinematic information significantly improves the decoding accuracy upon a linear KF.
NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1741-2552/abb3b3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1741-2552/abb3b3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Review 2019 NetherlandsPublisher:Wiley Funded by:EC | NOMA-MRIEC| NOMA-MRIAuthors: José P. Marques; Frank F.J. Simonis; Andrew G. Webb;José P. Marques; Frank F.J. Simonis; Andrew G. Webb;Historically, clinical MRI started with main magnetic field strengths in the ∼0.05–0.35T range. In the past 40 years there have been considerable developments in MRI hardware, with one of the primary ones being the trend to higher magnetic fields. While resulting in large improvements in data quality and diagnostic value, such developments have meant that conventional systems at 1.5 and 3T remain relatively expensive pieces of medical imaging equipment, and are out of the financial reach for much of the world. In this review we describe the current state‐of‐the‐art of low‐field systems (defined as 0.25–1T), both with respect to its low cost, low foot‐print, and subject accessibility. Furthermore, we discuss how low field could potentially benefit from many of the developments that have occurred in higher‐field MRI.In the first section, the signal‐to‐noise ratio (SNR) dependence on the static magnetic field and its impact on the achievable contrast, resolution, and acquisition times are discussed from a theoretical perspective. In the second section, developments in hardware (eg, magnet, gradient, and RF coils) used both in experimental low‐field scanners and also those that are currently in the market are reviewed. In the final section the potential roles of new acquisition readouts, motion tracking, and image reconstruction strategies, currently being developed primarily at higher fields, are presented.Level of Evidence: 5Technical Efficacy Stage: 1J. Magn. Reson. Imaging 2019.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6590434Data sources: PubMed CentralJournal of Magnetic Resonance ImagingOther literature type . Article . 2019 . 2018 . Peer-reviewedLicense: CC BY NCJournal of Magnetic Resonance ImagingReview . 2019Data sources: University of Twente Research InformationLUMC Scholarly Publications; NARCISOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/jmri.26637&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 194 citations 194 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 1visibility views 1 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6590434Data sources: PubMed CentralJournal of Magnetic Resonance ImagingOther literature type . Article . 2019 . 2018 . Peer-reviewedLicense: CC BY NCJournal of Magnetic Resonance ImagingReview . 2019Data sources: University of Twente Research InformationLUMC Scholarly Publications; NARCISOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/jmri.26637&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 NetherlandsPublisher:Springer Science and Business Media LLC Funded by:EC | NEUROMICS, EC | RD-CONNECTEC| NEUROMICS ,EC| RD-CONNECTLodewijk J.A. Toonen; Maurice Overzier; Melvin M. Evers; Leticia G. Leon; Sander A.J. van der Zeeuw; Hailiang Mei; Szymon M. Kielbasa; Jelle J. Goeman; Kristina Hettne; Olafur T. Magnusson; Marion Poirel; Alexandre Seyer; Peter A C 't Hoen; Willeke M. C. van Roon-Mom;pmc: PMC6013885
pmid: 29929540
Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in transcriptional dysregulation, which can contribute to the cellular toxicity and neurodegeneration. Since the exact causative mechanisms underlying this process have not been fully elucidated, gene expression analyses in brains of transgenic SCA3 mouse models may provide useful insights. Methods Here we characterised the MJD84.2 SCA3 mouse model expressing the mutant human ataxin-3 gene using a multi-omics approach on brain and blood. Gene expression changes in brainstem, cerebellum, striatum and cortex were used to study pathological changes in brain, while blood gene expression and metabolites/lipids levels were examined as potential biomarkers for disease. Results Despite normal motor performance at 17.5 months of age, transcriptional changes in brain tissue of the SCA3 mice were observed. Most transcriptional changes occurred in brainstem and striatum, whilst cerebellum and cortex were only modestly affected. The most significantly altered genes in SCA3 mouse brain were Tmc3, Zfp488, Car2, and Chdh. Based on the transcriptional changes, α-adrenergic and CREB pathways were most consistently altered for combined analysis of the four brain regions. When examining individual brain regions, axon guidance and synaptic transmission pathways were most strongly altered in striatum, whilst brainstem presented with strongest alterations in the pi-3 k cascade and cholesterol biosynthesis pathways. Similar to other neurodegenerative diseases, reduced levels of tryptophan and increased levels of ceramides, di- and triglycerides were observed in SCA3 mouse blood. Conclusions The observed transcriptional changes in SCA3 mouse brain reveal parallels with previous reported neuropathology in patients, but also shows brain region specific effects as well as involvement of adrenergic signalling and CREB pathway changes in SCA3. Importantly, the transcriptional changes occur prior to onset of motor- and coordination deficits. Electronic supplementary material The online version of this article (10.1186/s13024-018-0261-9) contains supplementary material, which is available to authorized users.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6013885Data sources: PubMed CentralZENODO; Molecular Neurodegeneration; NARCISOther literature type . Article . 2018 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13024-018-0261-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 58 citations 58 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 106visibility views 106 download downloads 104 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6013885Data sources: PubMed CentralZENODO; Molecular Neurodegeneration; NARCISOther literature type . Article . 2018 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Book , Conference object , Preprint , Article , Report , Other literature type 2011 France, Italy, Germany, France, France, NetherlandsPublisher:Office of Scientific and Technical Information (OSTI) Funded by:UKRI | SemenRate Canada/UK: Tran..., UKRI | RootDetect: Remote Detect...UKRI| SemenRate Canada/UK: Transforming Germplasm and Genetic Quality to Drive Livestock Productivity ,UKRI| RootDetect: Remote Detection and Precision Management of Root HealthBoer, Daniel; Diehl, Markus; Milner, Richard; Venugopalan, Raju; Vogelsang, Werner; Kaplan, David; Montgomery, Hugh; Vigdor, Steven; Accardi, A.; Aschenauer, E.C.; Burkardt, M.; Ent, R.; Guzey, V.; Hasch, D.; Kumar, K.; Lamont, M.A.C.; Li, Ying-chuan; Marciano, W.; Marquet, C.; Sabatie, F.; Stratmann, M.; Yuan, F.; Sassot, R.; Zurita, P.; Cherednikov, I.O.; Goncalves, V.P.; Sandapen, R.; Kopeliovich, B.Z.; Gao, J.-H.; Liang, Z.-T.; Passek-Kumericki, K.; Kumericki, K.; Lappi, T.; Wallon, S.; Pire, B.; Geraud, R.; Moutarde, H.; Gelis, F.; Soyez, G.; Meskauskas, M.; Mueller, Dieter; Stefanis, N.G.; Gallmeister, K.; Mosel, U.; Diehl, M.; Bartels, J.; Pirner, H.J.; Hagler, P.; Jager, B.; Spiesberger, H.; Lautenschlager, T.; Schafer, A.; Ringer, F.; Vogelsang, W.; Kroll, P.; Alekhin, S.; Blumlein, J; Moch, S.-O.; Pisano, C.; Rojo, J.; Bacchetta, A.; Pasquini, B.; Radici, M.; Ciofi degli Atti, C.; Mezzetti, C.B.; Kaptari, L.P.; Anselmino, M.; Tanaka, K.; Koike, Y.; Kumano, S.; Motyka, L.; Golec-Biernat, K.; Stasto, A.M.; Golec-Biernat, K.; Szymanowski, L.; Cherednikov, I.O.; Kaptari, L.P.; Radyushkin, A.; Alekhin, S.; Kondratenko, A.; Horowitz, W.A.; Schnell, G.; Chevtsov, P.; Mulders, P.J.; Rogers, T.C.; Boer, D.; Forshaw, J.R.; Cooper-Sarkar, A.; Chirilli, G.A.; Muller, D.; Wang, X.-N.; Yuan, F.; Qian, X.; Brodsky, S.J.; Schweitzer, P.; Horn, T.; Tuchin, K.; Dupre, R.; Erdelyi, B.; Manikonda, S.; Ostrumov, P.N.; Abeyratne, S.; Erdelyi, B.; Vossen, A.; Riordan, S.; Tsentalovich, E.; Goldstein, G.R.; Pozdeyev, E.; Huang, M.; Aidala, C.; Dumitru, A.; Dominguez, F.; Ben-Zvi, I.; Deshpande, A.; Faroughy, C.; Hammons, L.; Hao, Y.; Johnson, E.C.; Litvinenko, V.N.; Taneja, S.; Tsoupas, N.; Webb, S.; Beebe-Wang, J.; Belomestnykh, S.; Ben-Zvi, I.; Blaskiewicz, M.M.; Calaga, R.; Chang, X.; Fedotov, A.; Gassner, D.; Hahn, H.; Hammons, L.; Hao, Y.; He, P.; Jackson, W.; Jain, A.; Johnson, E.C.; Kayran, D.; Kewisch, J.; Litvinenko, V.N.; Luo, Y.; Mahler, G.; McIntyre, G.; Meng, W.; Minty, M.; Parker, B.; Pikin, A.; Ptitsyn, V.; Rao, T.; Roser, T.; Sheehy, B.; Skaritka, J.; Tepikian, S.; Than, Y.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J.; Wang, G.; Webb, S.; Wu, Q.; Xu, W.; Zelenski, A.; Beuf, G.; Burton, T.; Debbe, R.; Fazio, S.; Marciano, W.J.; Qiu, J.-W.; Toll, T.; Ullrich, T.; Deshpande, A.; Dumitru, A.; Kang, Z.-B.; Stasto, A.M.; Yuan, F.; Kovchegov, Y.V.; Majumder, A; Metz, A.; Zhou, J.; Gamberg, L.; Stasto, A.M.; Strikman, M.; Xiao, B.-W.; Guzzi, M.; Nadolsky, P.; Olness, F.; BC, H.; Liuti, S.; Ahmed, S.; Bogacz, A.; Derbenev, Ya.; Hutton, A.; Krafft, G.; Li, R.; Marhauser, F.; Morozov, V.; Pilat, F.; Rimmer, R.; Satogata, T.; Sullivan, M.;This report is based on a ten-week program on "Gluons and the quark sea at high-energies", which took place at the Institute for Nuclear Theory in Seattle in Fall 2010. The principal aim of the program was to develop and sharpen the science case for an Electron-Ion Collider (EIC), a facility that will be able to collide electrons and positrons with polarized protons and with light to heavy nuclei at high energies, offering unprecedented possibilities for in-depth studies of quantum chromodynamics. This report is organized around four major themes: i) the spin and flavor structure of the proton, ii) three-dimensional structure of nucleons and nuclei in momentum and configuration space, iii) QCD matter in nuclei, and iv) Electroweak physics and the search for physics beyond the Standard Model. Beginning with an executive summary, the report contains tables of key measurements, chapter overviews for each of the major scientific themes, and detailed individual contributions on various aspects of the scientific opportunities presented by an EIC. Comment: 547 pages, A report on the joint BNL/INT/Jlab program on the science case for an Electron-Ion Collider, September 13 to November 19, 2010, Institute for Nuclear Theory, Seattle; v2 with minor changes, matches printed version
NARCIS; University o... arrow_drop_down NARCIS; University of Groningen Research PortalConference object . 2011Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-UPMCOther literature type . Preprint . 2011https://doi.org/10.48550/arxiv...Article . 2011License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2172/1034033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 100 citations 100 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert NARCIS; University o... arrow_drop_down NARCIS; University of Groningen Research PortalConference object . 2011Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-UPMCOther literature type . Preprint . 2011https://doi.org/10.48550/arxiv...Article . 2011License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2172/1034033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Other literature type 2015 Netherlands, FrancePublisher:IEEE Funded by:NWO | Wireless Control Systems:...NWO| Wireless Control Systems: A New Frontier in AutomationAuthors: Postoyan, R.; Biemond, J.J.B.; Heemels, W.P.M.H.; van de Wouw, N.;Postoyan, R.; Biemond, J.J.B.; Heemels, W.P.M.H.; van de Wouw, N.;International audience; The analysis of incremental stability properties typically involves measuring the distance between any pair of solutions of a given dynamical system, corresponding to different initial conditions, at the same time instant. This approach is not directly applicable for hybrid systems in general. Indeed, hybrid systems generate solutions that are defined with respect to hybrid times, which consist of both the continuous time elapsed and the discrete time, that is the number of jumps the solution has experienced. Two solutions of a hybrid system do not a priori have the same time domain, and we may therefore not be able to compare them at the same hybrid time instant. To overcome this issue, we invoke graphical closeness concepts. We present definitions for incremental stability depending on whether incremental asymptotic stability properties hold with respect to the hybrid time, the continuous time, or the discrete time, respectively. Examples are provided throughout the paper to illustrate these definitions, and the relations between these three incremental stability notions are investigated. The definitions are shown to be consistent with those available in the literature for continuous-time and discrete-time systems.
https://hal.archives... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2015Full-Text: https://hal.science/hal-01204822/documentEindhoven University of Technology Research PortalConference object . 2015Data sources: Eindhoven University of Technology Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/cdc.2015.7403088&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu7 citations 7 popularity Average influence Average impulse Average Powered by BIP!more_vert https://hal.archives... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2015Full-Text: https://hal.science/hal-01204822/documentEindhoven University of Technology Research PortalConference object . 2015Data sources: Eindhoven University of Technology Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/cdc.2015.7403088&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Italy, France, Netherlands, Netherlands, Netherlands, Netherlands, Netherlands, Ireland, Canada, Netherlands, Netherlands, Netherlands, United Kingdom, Netherlands, Netherlands, Ireland, Netherlands, Netherlands, Germany, Netherlands, United KingdomPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | MATRICSEC| MATRICSAuthors: Hibar, Derrek P; Stein, Jason L; Aribisala, Benjamin S; de Zubicaray, Greig I; +244 AuthorsHibar, Derrek P; Stein, Jason L; Aribisala, Benjamin S; de Zubicaray, Greig I; Dillman, Allissa; Duggirala, Ravi; Dyer, Thomas D; Erk, Susanne; Fedko, Iryna O; Ferrucci, Luigi; Foroud, Tatiana M; Fox, Peter T; Fukunaga, Masaki; Armstrong, Nicola J; Gibbs, J Raphael; Göring, Harald H H; Green, Robert C; Guelfi, Sebastian; Hansell, Narelle K; Hartman, Catharina A; Hegenscheid, Katrin; Heinz, Andreas; Hernandez, Dena G; Heslenfeld, Dirk J; Bernard, Manon; Hoekstra, Pieter J; Holsboer, Florian; Homuth, Georg; Hottenga, Jouke-Jan; Ikeda, Masashi; Jack, Clifford R; Jenkinson, Mark; Johnson, Robert; Kanai, Ryota; Keil, Maria; Bohlken, Marc M; Kent, Jack W; Kochunov, Peter; Kwok, John B; Lawrie, Stephen M; Liu, Xinmin; Longo, Dan L; McMahon, Katie L; Meisenzahl, Eva; Melle, Ingrid; Mohnke, Sebastian; Boks, Marco P; Montgomery, Grant W; Mostert, Jeanette C; Mühleisen, Thomas W; Nalls, Michael A; Nichols, Thomas E; Nilsson, Lars G; Nöthen, Markus M; Ohi, Kazutaka; Olvera, Rene L; Perez-Iglesias, Rocio; Bralten, Janita; Pike, G Bruce; Potkin, Steven G; Reinvang, Ivar; Reppermund, Simone; Rietschel, Marcella; Romanczuk-Seiferth, Nina; Rosen, Glenn D; Rujescu, Dan; Schnell, Knut; Schofield, Peter R; Brown, Andrew A; Smith, Colin; Steen, Vidar M; Sussmann, Jessika E; Thalamuthu, Anbupalam; Toga, Arthur W; Traynor, Bryan J; Troncoso, Juan; Turner, Jessica A; Valdés Hernández, Maria C; van 't Ent, Dennis; Chakravarty, M Mallar; van der Brug, Marcel; van der Wee, Nic J A; van Tol, Marie-Jose; Veltman, Dick J; Wassink, Thomas H; Westman, Eric; Zielke, Ronald H; Zonderman, Alan B; Ashbrook, David G; Hager, Reinmar; Chen, Qiang; Lu, Lu; McMahon, Francis J; Morris, Derek W; Williams, Robert W; Brunner, Han G; Buckner, Randy L; Buitelaar, Jan K; Cahn, Wiepke; Calhoun, Vince D; Cavalleri, Gianpiero L; Ching, Christopher R K; Crespo-Facorro, Benedicto; Dale, Anders M; Davies, Gareth E; Delanty, Norman; Depondt, Chantal; Djurovic, Srdjan; Drevets, Wayne C; Espeseth, Thomas; Gollub, Randy L; Ho, Beng-Choon; Renteria, Miguel E; Cuellar-Partida, Gabriel; Hoffmann, Wolfgang; Hosten, Norbert; Kahn, René S; Le Hellard, Stephanie; Meyer-Lindenberg, Andreas; Müller-Myhsok, Bertram; Nauck, Matthias; Nyberg, Lars; Pandolfo, Massimo; Penninx, Brenda W J H; den Braber, Anouk; Roffman, Joshua L; Sisodiya, Sanjay M; Smoller, Jordan W; van Bokhoven, Hans; van Haren, Neeltje E M; Völzke, Henry; Walter, Henrik; Weiner, Michael W; Wen, Wei; White, Tonya; Giddaluru, Sudheer; Agartz, Ingrid; Andreassen, Ole A; Blangero, John; Boomsma, Dorret I; Brouwer, Rachel M; Cannon, Dara M; Cookson, Mark R; de Geus, Eco J C; Deary, Ian J; Donohoe, Gary; Goldman, Aaron L; Fernández, Guillén; Fisher, Simon E; Francks, Clyde; Glahn, David C; Grabe, Hans J; Gruber, Oliver; Hardy, John; Hashimoto, Ryota; Hulshoff Pol, Hilleke E; Jönsson, Erik G; Grimm, Oliver; Kloszewska, Iwona; Lovestone, Simon; Mattay, Venkata S; Mecocci, Patrizia; McDonald, Colm; McIntosh, Andrew M; Ophoff, Roel A; Paus, Tomas; Pausova, Zdenka; Ryten, Mina; Guadalupe, Tulio; Sachdev, Perminder S; Saykin, Andrew J; Simmons, Andy; Singleton, Andrew; Soininen, Hilkka; Wardlaw, Joanna M; Weale, Michael E; Weinberger, Daniel R; Adams, Hieab H H; Launer, Lenore J; Hass, Johanna; Seiler, Stephan; Schmidt, Reinhold; Chauhan, Ganesh; Satizabal, Claudia L; Becker, James T; Yanek, Lisa; van der Lee, Sven J; Ebling, Maritza; Fischl, Bruce; Longstreth, W. T.; Woldehawariat, Girma; Greve, Douglas; Schmidt, Helena; Nyquist, Paul; Vinke, Louis N; van Duijn, Cornelia M; Xue, Luting; Mazoyer, Bernard; Bis, Joshua C; Gudnason, Vilmundur; Seshadri, Sudha; Martin, Nicholas G; Wright, Margaret J; Franke, Barbara; Thompson, Paul M; Medland, Sarah E; Arias-Vasquez, Alejandro; Jia, Tianye; Shen, Li; Mather, Karen A; Desrivières, Sylvane; Mattheisen, Manuel; Ramasamy, Adaikalavan; Risacher, Shannon L; Roiz-Santiañez, Roberto; Rose, Emma J; Schmaal, Lianne; Schork, Andrew J; Strike, Lachlan T; Teumer, Alexander; Preda, Adrian; Westlye, Lars T; Whelan, Christopher D; Toro, Roberto; Winkler, Anderson M; Beiser, Alexa; DeStefano, Anita; Vaidya, Dhananjay; Vernooij, Meike W; Artiges, Eric; Ehrlich, Stefan; Banaschewski, Tobias; Boddaert, Nathalie; Bokde, Arun; Flor, Herta; Haukvik, Unn K; Miranda, Ruben; Nees, Frauke; Lopez, Lorna M; Williams, Steve; Nugent, Allison C; Sprooten, Emma; Walton, Esther; Bastin, Mark E; Carless, Melanie A; Cichon, Sven; Corvin, Aiden; Curran, Joanne E;doi: 10.1038/nature14101
pmc: PMC4393366
pmid: 25607358
handle: 1765/82772 , 1871.1/9d055530-aea0-4fb7-b981-9d4a79dc4178 , 20.500.11820/77342012-02ed-419b-904f-c5fc42863c81 , 1887/102856 , 1866/20931 , 2066/144426 , 11370/bfe12ff1-5687-4a14-82bb-57f7052a91de , 11391/1316701 , https://repository.ubn.ru.nl/handle/2066/144426 , 11858/00-001M-0000-0024-A204-2 , 11858/00-001M-0000-0026-D061-9 , 1874/331330
doi: 10.1038/nature14101
pmc: PMC4393366
pmid: 25607358
handle: 1765/82772 , 1871.1/9d055530-aea0-4fb7-b981-9d4a79dc4178 , 20.500.11820/77342012-02ed-419b-904f-c5fc42863c81 , 1887/102856 , 1866/20931 , 2066/144426 , 11370/bfe12ff1-5687-4a14-82bb-57f7052a91de , 11391/1316701 , https://repository.ubn.ru.nl/handle/2066/144426 , 11858/00-001M-0000-0024-A204-2 , 11858/00-001M-0000-0026-D061-9 , 1874/331330
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 x 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction. Contains fulltext : 144426.pdf (Publisher’s version ) (Closed access) Contains fulltext : 144426pre.pdf (Author’s version preprint ) (Open Access) 6 p.
Maynooth University ... arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2015 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveCORE (RIOXX-UK Aggregator)Article . 2015Full-Text: http://sro.sussex.ac.uk/id/eprint/87473/1/__smbhome.uscs.susx.ac.uk_tjk30_Documents_untitled.pdfData sources: CORE (RIOXX-UK Aggregator)Papyrus : Dépôt institutionnel - Université de Montréal; Nature; METIS Research Information System; NARCISOther literature type . Article . 2015 . Peer-reviewedLicense: Springer TDMOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveNARCIS; NatureArticle . 2015HAL Descartes; HAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature14101&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 749 citations 749 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 2visibility views 2 download downloads 7 Powered bymore_vert Maynooth University ... arrow_drop_down Maynooth University ePrints & eTheses ArchiveArticle . 2015 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveCORE (RIOXX-UK Aggregator)Article . 2015Full-Text: http://sro.sussex.ac.uk/id/eprint/87473/1/__smbhome.uscs.susx.ac.uk_tjk30_Documents_untitled.pdfData sources: CORE (RIOXX-UK Aggregator)Papyrus : Dépôt institutionnel - Université de Montréal; Nature; METIS Research Information System; NARCISOther literature type . Article . 2015 . Peer-reviewedLicense: Springer TDMOxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveNARCIS; NatureArticle . 2015HAL Descartes; HAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature14101&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 NetherlandsPublisher:Public Library of Science (PLoS) Funded by:EC | BRAINPATHEC| BRAINPATHDzyubachyk, O.; Khmelinskii, A.; Plenge, E.; Kok, P.; Snoeks, T.J.A.; Poot, D.H.J.; Lowik, C.W.G.M.; Botha, C.P.; Niessen, W.J.; Weerd, L. van der; Meijering, E.; Lelieveldt, B.P.F.;In small animal imaging studies, when the locations of the micro-structures of interest are unknown a priori, there is a simultaneous need for full-body coverage and high resolution. In MRI, additional requirements to image contrast and acquisition time will often make it impossible to acquire such images directly. Recently, a resolution enhancing post-processing technique called super-resolution reconstruction (SRR) has been demonstrated to improve visualization and localization of micro-structures in small animal MRI by combining multiple low-resolution acquisitions. However, when the field-of-view is large relative to the desired voxel size, solving the SRR problem becomes very expensive, in terms of both memory requirements and computation time. In this paper we introduce a novel local approach to SRR that aims to overcome the computational problems and allow researchers to efficiently explore both global and local characteristics in whole-body small animal MRI. The method integrates state-of-the-art image processing techniques from the areas of articulated atlas-based segmentation, planar reformation, and SRR. A proof-of-concept is provided with two case studies involving CT, BLI, and MRI data of bone and kidney tumors in a mouse model. We show that local SRR-MRI is a computationally efficient complementary imaging modality for the precise characterization of tumor metastases, and that the method provides a feasible high-resolution alternative to conventional MRI. ImPhys/Imaging Physics Applied Sciences
NARCIS; PLoS ONE; TU... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4181866Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0108730&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!visibility 23visibility views 23 download downloads 34 Powered bymore_vert NARCIS; PLoS ONE; TU... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4181866Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0108730&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 NetherlandsPublisher:Public Library of Science (PLoS) Funded by:IRC, EC | EU-AIMS, EC | TACTICS +1 projectsIRC ,EC| EU-AIMS ,EC| TACTICS ,NIH| International Multi-Center ADHD Genetics ProjectLaurence O'Dwyer; Colby J. Tanner; Eelco V. van Dongen; Corina U. Greven; Janita Bralten; Marcel P. Zwiers; Barbara Franke; Jaap Oosterlaan; Dirk J. Heslenfeld; Pieter J. Hoekstra; Catharina A. Hartman; Nanda Rommelse; Jan K. Buitelaar;Autism spectrum disorder (ASD) symptoms frequently occur in subjects with attention deficit/hyperactivity disorder (ADHD). While there is evidence that both ADHD and ASD have differential structural correlates, no study to date has investigated these structural correlates within a framework that robustly accounts for the phenotypic overlap between the two disorders. The presence of ASD symptoms was measured by the parent-reported Children's Social and Behavioural Questionnaire (CSBQ) in ADHD subjects (n = 180), their unaffected siblings (n = 118) and healthy controls (n = 146). ADHD symptoms were assessed by a structured interview (K-SADS-PL) and the Conners' ADHD questionnaires. Whole brain T1-weighted MPRAGE images were acquired and the structural MRI correlates of ASD symptom scores were analysed by modelling ASD symptom scores against white matter (WM) and grey matter (GM) volumes using mixed effects models which controlled for ADHD symptom levels. ASD symptoms were significantly elevated in ADHD subjects relative to both controls and unaffected siblings. ASD scores were predicted by the interaction between WM and GM volumes. Increasing ASD score was associated with greater GM volume. Equivocal results from previous structural studies in ADHD and ASD may be due to the fact that comorbidity has not been taken into account in studies to date. The current findings stress the need to account for issues of ASD comorbidity in ADHD. Contains fulltext : 136213.pdf (Publisher’s version ) (Open Access)
NARCIS; PLoS ONE arrow_drop_down NARCIS; PLoS ONEArticle . 2014Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4076257Data sources: PubMed CentralRadboud Repository; PLoS ONE; NARCISOther literature type . Article . 2014 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0101130&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 27 citations 27 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS; PLoS ONE arrow_drop_down NARCIS; PLoS ONEArticle . 2014Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4076257Data sources: PubMed CentralRadboud Repository; PLoS ONE; NARCISOther literature type . Article . 2014 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0101130&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 Italy, Netherlands, France Dutch; FlemishAuthors: Dagnino, Roberto; Freschi, Valentina; Paris, Franco;Dagnino, Roberto; Freschi, Valentina; Paris, Franco;This article is a first-hand presentation of the history, the activities and the current developments of the Steunpunt Literair Vertalen (Literary Translation Support Office), which operates a coordinated training programme aimed at improving the linguistic skills of would-be as well as experienced translators. The Support Office is a co-operative venture involving the University of Utrecht and the Lessius Hogeschool in Antwerp and sponsored by the Nederlandse Taalunie (Dutch Language Union). Among other activities, the Steunpunt organized a successful summer course on literary translation held at the Lessius Hogeschool in Antwerp aimed at improving the skills of young literary translators from Dutch into Italian. The first two authors of this contribution,in fact, were selected as young translators for the training and the seminars held during that course, while Paris was involved as an experienced teacher and translator in the development of the linguistic skills of the participants. In giving their presentation, the authors focus in particular on their experience during the 2006 summer course.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=11370/92d5cd7b-25ce-4e54-95cd-dddcf971074f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=11370/92d5cd7b-25ce-4e54-95cd-dddcf971074f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 NetherlandsPublisher:Cold Spring Harbor Laboratory Funded by:NWO | Technology in motion, NWO | Visual analytics for 3DOM...NWO| Technology in motion ,NWO| Visual analytics for 3DOMICS: from single cell to tissue and backArlin Keo; Arlin Keo; Oleh Dzyubachyk; Jeroen van der Grond; Jacobus J. van Hilten; Marcel J. T. Reinders; Marcel J. T. Reinders; Marcel J. T. Reinders; Ahmed Mahfouz; Ahmed Mahfouz; Ahmed Mahfouz;AbstractCortical atrophy is a common manifestation in Parkinson’s disease, particularly in later disease stages. Here, we investigated patterns of cortical thickness using T1-weighted anatomical MRI data of 149 Parkinson’s disease patients and 369 controls. To elucidate the molecular underpinnings of cortical thickness changes in Parkinson’s disease, we performed an integrated analysis of brain-wide healthy transcriptomic data from the Allen Human Brain Atlas and neuroimaging features. For this purpose, we used partial least squares regression to identify gene expression patterns correlated with cortical thickness changes. In addition, we identified gene expression patterns underlying the relationship between cortical thickness and clinical domains of Parkinson’s disease. Our results show that genes whose expression in the healthy brain is associated with cortical thickness changes in Parkinson’s disease are enriched in biological pathways related to sumoylation, regulation of mitotic cell cycle, mitochondrial translation, DNA damage responses, and ER-Golgi traffic. The associated pathways were highly related to each other and all belong to cellular maintenance mechanisms. The expression of genes within most pathways was negatively correlated with cortical thickness changes, showing higher expression in regions associated with decreased cortical thickness (atrophy). On the other hand, sumoylation pathways were positively correlated with cortical thickness changes, showing higher expression in regions with increased cortical thickness (hypertrophy). Our findings suggest that alterations in the balanced interplay of these mechanisms play a role in changes of cortical thickness in Parkinson’s disease and possibly influence motor and cognitive functions.
NARCIS; Frontiers in... arrow_drop_down Frontiers in NeuroscienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8519261Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.06.19.158808&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!visibility 9visibility views 9 download downloads 19 Powered bymore_vert NARCIS; Frontiers in... arrow_drop_down Frontiers in NeuroscienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8519261Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.06.19.158808&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu