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description Publicationkeyboard_double_arrow_right Article , Other literature type 2021 NetherlandsPublisher:Oxford University Press (OUP) Authors: Lucy Sinke; Davy Cats; Bastiaan T. Heijmans;Lucy Sinke; Davy Cats; Bastiaan T. Heijmans;Abstract Motivation Batch effects heavily impact results in omics studies, causing bias and false positive results, but software to control them preemptively is lacking. Sample randomization prior to measurement is vital for minimizing these effects, but current approaches are often ad hoc, poorly documented and ill-equipped to handle multiple batches and outcomes. Results We developed Omixer—a Bioconductor package implementing multivariate and reproducible sample randomization for omics studies. It proactively counters correlations between technical factors and biological variables of interest by optimizing sample distribution across batches. Availabilityand implementation Omixer is available from Bioconductor at http://bioconductor.org/packages/release/bioc/html/Omixer.html. Scripts and data used to generate figures available upon request. Supplementary information Supplementary data are available at Bioinformatics online.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btab159&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btab159&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 NetherlandsPublisher:Public Library of Science (PLoS) Authors: Maurits, Luke; Forkel, Robert; Kaiping, Gereon A.; Atkinson, Quentin D.;Maurits, Luke; Forkel, Robert; Kaiping, Gereon A.; Atkinson, Quentin D.;pmc: PMC5552126
pmid: 28796784
We present a new open source software tool called BEASTling, designed to simplify the preparation of Bayesian phylogenetic analyses of linguistic data using the BEAST 2 platform. BEASTling transforms comparatively short and human-readable configuration files into the XML files used by BEAST to specify analyses. By taking advantage of Creative Commons-licensed data from the Glottolog language catalog, BEASTling allows the user to conveniently filter datasets using names for recognised language families, to impose monophyly constraints so that inferred language trees are backward compatible with Glottolog classifications, or to assign geographic location data to languages for phylogeographic analyses. Support for the emerging cross-linguistic linked data format (CLDF) permits easy incorporation of data published in cross-linguistic linked databases into analyses. BEASTling is intended to make the power of Bayesian analysis more accessible to historical linguists without strong programming backgrounds, in the hopes of encouraging communication and collaboration between those developing computational models of language evolution (who are typically not linguists) and relevant domain experts.
NARCIS arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5552126Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0180908&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5552126Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0180908&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 NetherlandsPublisher:Oxford University Press (OUP) Funded by:NWO | Visual Analysis in Popula..., NWO | Genes in spaceNWO| Visual Analysis in Population Imaging Research (VAnPIRe) ,NWO| Genes in spaceSjoerd M. H. Huisman; Baldur van Lew; Ahmed Mahfouz; Nicola Pezzotti; Thomas Höllt; Lieke Michielsen; Anna Vilanova; Marcel J. T. Reinders; Boudewijn P. F. Lelieveldt;Spatial and temporal brain transcriptomics has recently emerged as an invaluable data source for molecular neuroscience. The complexity of such data poses considerable challenges for analysis and visualization. We present BrainScope: A web portal for fast, interactive visual exploration of the Allen Atlases of the adult and developing human brain transcriptome. Through a novel methodology to explore high-dimensional data (dual t-SNE), BrainScope enables the linked, all-in-one visualization of genes and samples across the whole brain and genome, and across developmental stages. We show that densities in t-SNE scatter plots of the spatial samples coincide with anatomical regions, and that densities in t-SNE scatter plots of the genes represent gene co-expression modules that are significantly enriched for biological functions. We also show that the topography of the gene t-SNE maps reflect brain region-specific gene functions, enabling hypothesis and data driven research. We demonstrate the discovery potential of BrainScope through three examples: (i) analysis of cell type specific gene sets, (ii) analysis of a set of stable gene co-expression modules across the adult human donors and (iii) analysis of the evolution of co-expression of oligodendrocyte specific genes over developmental stages. Brain- Scope is publicly accessible at www.brainscope.nl. Pattern Recognition and Bioinformatics Computer Graphics and Visualisation
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5449549Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2017Nucleic Acids ResearchArticle . 2017Data sources: Eindhoven University of Technology Research PortalLeiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkx046&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 62visibility views 62 download downloads 48 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5449549Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2017Nucleic Acids ResearchArticle . 2017Data sources: Eindhoven University of Technology Research PortalLeiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkx046&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Netherlands, Netherlands, Italy, United Kingdom, United Kingdom, Netherlands, Netherlands, France, United Kingdom, Spain EnglishPublisher:HAL CCSD Funded by:EC | PhenoMeNalEC| PhenoMeNalvan Rijswijk, M; van Rijswijk, M; Beirnaert, C; Beirnaert, C; Caron, C; Cascante, M; Dominguez, V; Dunn, WB; Ebbels, TMD; Giacomoni, F; Gonzalez-Beltran, A; Hankemeier, T; Haug, K; Haug, K; Izquierdo-Garcia, JL; Jimenez, RC; Jimenez, RC; Jourdan, F; Kale, N; Klapa, MI; Kohlbacher, O; Koort, K; Kultima, K; Le Corguillé, G; Moreno, P; Moschonas, NK; Moschonas, NK; Neumann, S; O'Donovan, C; Reczko, M; Rocca-Serra, P; Rosato, A; Rosato, A; Rosato, A; Salek, RM; Salek, RM; Sansone, S-A; Satagopam, V; Schober, D; Shimmo, R; Spicer, RA; Spicer, RA; Spjuth, O; Spjuth, O; Spjuth, O; Thévenot, EA; Thévenot, EA; Viant, MR; Weber, RJM; Willighagen, EL; Willighagen, EL; Zanetti, G; Steinbeck, C; Steinbeck, C;Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for metabolomics within Europe, a workshop on the "Future of metabolomics in ELIXIR" was organised at Frankfurt Airport in Germany. This one-day strategic workshop involved representatives of ELIXIR Nodes, members of the PhenoMeNal consortium developing an e-infrastructure that supports workflow-based metabolomics analysis pipelines, and experts from the international metabolomics community. The workshop established metabolite identification as the critical area, where a maximal impact of computational metabolomics and data management on other fields could be achieved. In particular, the existing four ELIXIR Use Cases, where the metabolomics community - both industry and academia - would benefit most, and which could be exhaustively mapped onto the current five ELIXIR Platforms were discussed. This opinion article is a call for support for a new ELIXIR metabolomics Use Case, which aligns with and complements the existing and planned ELIXIR Platforms and Use Cases. The meeting was funded by PhenoMeNal, European Commission's Horizon2020 programme, grant agreement number 654241 Sí
HAL - UPEC / UPEM; H... arrow_drop_down Europe PubMed CentralArticle . 2017 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC5627583Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTAFlore (Florence Research Repository)Article . 2017Data sources: Flore (Florence Research Repository)Oxford University Research Archive; F1000ResearchOther literature type . Article . 2017 . 2018 . Peer-reviewedLicense: CC BYSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.12342.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 34visibility views 34 download downloads 65 Powered bymore_vert HAL - UPEC / UPEM; H... arrow_drop_down Europe PubMed CentralArticle . 2017 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC5627583Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTAFlore (Florence Research Repository)Article . 2017Data sources: Flore (Florence Research Repository)Oxford University Research Archive; F1000ResearchOther literature type . Article . 2017 . 2018 . Peer-reviewedLicense: CC BYSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.12342.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euintegration_instructions Research softwarekeyboard_double_arrow_right Software 2018 NetherlandsPublisher:Zenodo Authors: Ranguelova, Elena;Ranguelova, Elena;OCTSEG (Optical Coherence Tomography Segmentation and Evaluation GUI) is a GUI and function collection to segment and visualize retinal layers on OCT data.
ZENODO arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.1464025&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 22Kvisibility views 21,526 download downloads 14 Powered bymore_vert ZENODO arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.1464025&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2014 NetherlandsPublisher:Oxford University Press (OUP) Funded by:EC | IDEALEC| IDEALIterson, M. van; Tobi, E.W.; Slieker, R.C.; Hollander, W. den; Luijk, R.; Slagboom, P.E.; Heijmans, B.T.;Abstract Summary: The Illumina 450k array is a frequently used platform for large-scale genome-wide DNA methylation studies, i.e. epigenome-wide association studies. Currently, quality control of 450k data can be performed with Illumina’s GenomeStudio and is part of a limited number 450k analysis pipelines. However, GenomeStudio cannot handle large-scale studies, and existing pipelines provide limited options for quality control and neither support interactive exploration by the user. To aid the detection of bad-quality samples in large-scale genome-wide DNA methylation studies as flexible and transparent as possible, we have developed MethylAid; a visual and interactive Web application using RStudio’s shiny package. Bad-quality samples are detected using sample-dependent and sample-independent quality control probes present on the array and user-adjustable thresholds. In-depth exploration of bad-quality samples can be performed using several interactive diagnostic plots. Furthermore, plots can be annotated with user-provided metadata, for example, to identify outlying batches. Our new tool makes quality assessment of 450k array data interactive, flexible and efficient and is, therefore, expected to be useful for both data analysts and core facilities. Availability and implementation: MethylAid is implemented as an R/Bioconductor package (www.bioconductor.org/packages/3.0/bioc/html/MethylAid.html). A demo application is available from shiny.bioexp.nl/MethylAid. Contact: m.van_iterson@lumc.nl
Bioinformatics arrow_drop_down NARCIS; BioinformaticsOther literature type . Article . 2014 . Peer-reviewedLUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btu566&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 129 citations 129 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert Bioinformatics arrow_drop_down NARCIS; BioinformaticsOther literature type . Article . 2014 . Peer-reviewedLUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btu566&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Spain, Netherlands, Germany, Germany, United Kingdom, Luxembourg, Spain, Sweden, United Kingdom, United Kingdom, United Kingdom EnglishPublisher:Springer Science and Business Media LLC Funded by:EC | BLUEPRINT, EC | SYSMEDIBD, EC | P-MEDICINE +34 projectsEC| BLUEPRINT ,EC| SYSMEDIBD ,EC| P-MEDICINE ,EC| ERA-IB-2 ,EC| PSIMEX ,EC| DECIPHER ,EC| ESGI ,EC| EPIGENESYS ,EC| MEDALL ,EC| ERASYSAPP ,EC| PREDEMICS ,EC| CASYM ,EC| EMIF ,EC| ELIXIR ,EC| MIMOMICS ,EC| TRANSLOCATION ,EC| VPH-SHARE ,EC| BRIDGES ,EC| ASTERIX ,EC| SEMCARE ,EC| IDEAL ,EC| MedBioinformatics ,EC| STATEGRA ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,EC| U-BIOPRED ,EC| ECHO ,WT ,EC| CANCER-ID ,EC| PROTEOMEXCHANGE ,EC| COMBIMS ,EC| ERASYNBIO ,EC| KConnect ,EC| READNA ,EC| PREPARE ,EC| MULTIMOD ,EC| RADIANT ,EC| CHAARMCharles Auffray; Rudi Balling; Inês Barroso; László Bencze; Mikael Benson; Jay M. Bergeron; Enrique Bernal-Delgado; Niklas Blomberg; Christoph Bock; Ana Conesa; Susanna Del Signore; Christophe Delogne; Peter Devilee; Alberto Di Meglio; Marinus J.C. Eijkemans; Paul Flicek; Norbert Graf; Vera Grimm; Henk-Jan Guchelaar; Yike Guo; Ivo Gut; Allan Hanbury; Shahid Hanif; Ralf-Dieter Hilgers; Angel Honrado; D. Rod Hose; Jeanine J. Houwing-Duistermaat; Tim Hubbard; Sophie Helen Janacek; Haralampos Karanikas; Tim Kievits; Manfred Kohler; Andreas Kremer; Jerry Lanfear; Thomas Lengauer; Edith Maes; Theo F. Meert; Werner Müller; Dörthe Nickel; Peter Oledzki; Bertrand Pedersen; Milan Petkovic; Konstantinos Pliakos; Magnus Rattray; Josep Redón Más; Reinhard Schneider; Thierry Sengstag; Xavier Serra-Picamal; Wouter Spek; Lea A. I. Vaas; Okker van Batenburg; Marc Vandelaer; Péter Várnai; Pablo Villoslada; Juan Antonio Vizcaíno; John Peter Mary Wubbe; Gianluigi Zanetti;doi: 10.1186/s13073-016-0323-y , 10.1186/s13073-016-0376-y , 10.18154/rwth-conv-213156 , 10.17863/cam.42076 , 10.18154/rwth-conv-213157
handle: 11858/00-001M-0000-002C-1D02-C , 11858/00-001M-0000-002C-1D04-8 , 1887/99384 , 11858/00-001M-0000-002A-F90A-4 , 11858/00-001M-0000-002A-F908-8 , 1874/337769
pmc: PMC5100330 , PMC4919856
doi: 10.1186/s13073-016-0323-y , 10.1186/s13073-016-0376-y , 10.18154/rwth-conv-213156 , 10.17863/cam.42076 , 10.18154/rwth-conv-213157
handle: 11858/00-001M-0000-002C-1D02-C , 11858/00-001M-0000-002C-1D04-8 , 1887/99384 , 11858/00-001M-0000-002A-F90A-4 , 11858/00-001M-0000-002A-F908-8 , 1874/337769
pmc: PMC5100330 , PMC4919856
Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health arid healthcare for all Europearis. Funding Agencies|European Union [115568, 603160, 282510, 664691, 115749, 305033, 305397, 288028, 242189, 211601]; European Molecular Biology Laboratory; Wellcome Trust [WT098051]; [115372]; [257082]; [291814]; [291728]; [321567]; [262055]; [115446]; [602552]; [644753]; [634143]; [261357]; [305280]; [115525]; [2011 23 02]; [270089]; [278433]; [602525]; [201418]; [242135]; [260558]; [223411]; [305626]; [115621]; [611388]; [306000]; [354457]; [305564]; [115010]; [269978]
Genome Medicine arrow_drop_down Genome MedicineOther literature type . Article . 2016 . Peer-reviewedEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4919856Data sources: PubMed CentralEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5100330Data sources: PubMed CentralPublikationsserver der RWTH Aachen UniversityArticle . 2016Data sources: Publikationsserver der RWTH Aachen UniversitySpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2016License: CC BYThe University of Manchester - Institutional RepositoryArticle . 2016Data sources: The University of Manchester - Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTAOpen Repository and Bibliography - LuxembourgArticle . 2016Data sources: Open Repository and Bibliography - LuxembourgLUMC Scholarly Publications; NARCISOther literature type . Article . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13073-016-0323-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 206 citations 206 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!visibility 31visibility views 31 download downloads 150 Powered bymore_vert Genome Medicine arrow_drop_down Genome MedicineOther literature type . Article . 2016 . Peer-reviewedEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4919856Data sources: PubMed CentralEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5100330Data sources: PubMed CentralPublikationsserver der RWTH Aachen UniversityArticle . 2016Data sources: Publikationsserver der RWTH Aachen UniversitySpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2016License: CC BYThe University of Manchester - Institutional RepositoryArticle . 2016Data sources: The University of Manchester - Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTAOpen Repository and Bibliography - LuxembourgArticle . 2016Data sources: Open Repository and Bibliography - LuxembourgLUMC Scholarly Publications; NARCISOther literature type . Article . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13073-016-0323-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2012 NetherlandsPublisher:Elsevier BV Funded by:EC | OPEN PHACTSEC| OPEN PHACTSAntony J. Williams; Lee Harland; Paul Groth; Stephen Pettifer; Christine Chichester; Egon Willighagen; Chris T. Evelo; Niklas Blomberg; Gerhard F. Ecker; Carole Goble; Barend Mons;Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies. It is focused on practical and robust applications to solve specific questions in drug discovery research. OPS is intended to facilitate improvements in drug discovery in academia and industry and to support open innovation and in-house non-public drug discovery research. This paper lays out the challenges and how the Open PHACTS project is hoping to address these challenges technically and socially. © 2012 Elsevier Ltd.
NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.drudis.2012.05.016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 265 citations 265 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 NetherlandsPublisher:Springer Science and Business Media LLC Funded by:NWO | BBMRI-NLNWO| BBMRI-NLAuthors: Maarten van Iterson; Erik W. van Zwet; Bastiaan T. Heijmans; Peter A C 't Hoen; +47 AuthorsMaarten van Iterson; Erik W. van Zwet; Bastiaan T. Heijmans; Peter A C 't Hoen; Joyce B. J. van Meurs; Rick Jansen; Lude Franke; Dorret I. Boomsma; René Pool; Jenny van Dongen; Jouke J. Hottenga; Marleen J. van Greevenbroek; Coen D.A. Stehouwer; Carla J.H. van der Kallen; Casper G. Schalkwijk; Cisca Wijmenga; Sasha Zhernakova; Ettje F. Tigchelaar; P. Eline Slagboom; Marian Beekman; Joris Deelen; Diana van Heemst; Jan H. Veldink; Leonard H. van den Berg; Cornelia M. van Duijn; Bert A. Hofman; Aaron Isaacs; André G. Uitterlinden; P. Mila Jhamai; Michael M. P. J. Verbiest; H. Eka D. Suchiman; Marijn Verkerk; Ruud van der Breggen; Jeroen van Rooij; Nico Lakenberg; Hailiang Mei; Michiel van Galen; Jan Bot; Dasha V. Zhernakova; Peter Van ‘t Hof; Patrick Deelen; Irene Nooren; Matthijs Moed; Martijn Vermaat; René Luijk; Marc Jan Bonder; Freerk van Dijk; Wibowo Arindrarto; Szymon M. Kielbasa; Morris A. Swertz; Peter Bram 't Hoen;pmid: 28129774
pmc: PMC5273857
We show that epigenome- and transcriptome-wide association studies (EWAS and TWAS) are prone to significant inflation and bias of test statistics, an unrecognized phenomenon introducing spurious findings if left unaddressed. Neither GWAS-based methodology nor state-of-the-art confounder adjustment methods completely remove bias and inflation. We propose a Bayesian method to control bias and inflation in EWAS and TWAS based on estimation of the empirical null distribution. Using simulations and real data, we demonstrate that our method maximizes power while properly controlling the false positive rate. We illustrate the utility of our method in large-scale EWAS and TWAS meta-analyses of age and smoking. Electronic supplementary material The online version of this article (doi:10.1186/s13059-016-1131-9) contains supplementary material, which is available to authorized users.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5273857Data sources: PubMed CentralGenome Biology; NARCISArticle . 2017 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13059-016-1131-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 244 citations 244 popularity Top 0.1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5273857Data sources: PubMed CentralGenome Biology; NARCISArticle . 2017 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13059-016-1131-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Netherlands, BelgiumPublisher:Frontiers Media SA Jeroen Van Houtte; Filip Vandenberghe; Guoyan Zheng; Toon Huysmans; Toon Huysmans; Jan Sijbers;Most digital models of the equine distal limb that are available in the community are static and/or subject specific; hence, they have limited applications in veterinary research. In this paper, we present an articulatable model of the entire equine distal limb based on statistical shape modeling. The model describes the inter-subject variability in bone geometry while maintaining proper jointspace distances to support model articulation toward different poses. Shape variation modes are explained in terms of common biometrics in order to ease model interpretation from a veterinary point of view. The model is publicly available through a graphical user interface (https://github.com/jvhoutte/equisim) in order to facilitate future digitalization in veterinary research, such as computer-aided designs, three-dimensional printing of bone implants, bone fracture risk assessment through finite element methods, and data registration and segmentation problems for clinical practices.
Frontiers in Veterin... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7982960Data sources: PubMed CentralNARCIS; TU Delft RepositoryArticle . 2021Frontiers in Veterinary ScienceArticle . 2021Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fvets.2021.623318&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!visibility 70visibility views 70 download downloads 20 Powered bymore_vert Frontiers in Veterin... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7982960Data sources: PubMed CentralNARCIS; TU Delft RepositoryArticle . 2021Frontiers in Veterinary ScienceArticle . 2021Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fvets.2021.623318&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2021 NetherlandsPublisher:Oxford University Press (OUP) Authors: Lucy Sinke; Davy Cats; Bastiaan T. Heijmans;Lucy Sinke; Davy Cats; Bastiaan T. Heijmans;Abstract Motivation Batch effects heavily impact results in omics studies, causing bias and false positive results, but software to control them preemptively is lacking. Sample randomization prior to measurement is vital for minimizing these effects, but current approaches are often ad hoc, poorly documented and ill-equipped to handle multiple batches and outcomes. Results We developed Omixer—a Bioconductor package implementing multivariate and reproducible sample randomization for omics studies. It proactively counters correlations between technical factors and biological variables of interest by optimizing sample distribution across batches. Availabilityand implementation Omixer is available from Bioconductor at http://bioconductor.org/packages/release/bioc/html/Omixer.html. Scripts and data used to generate figures available upon request. Supplementary information Supplementary data are available at Bioinformatics online.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btab159&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btab159&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 NetherlandsPublisher:Public Library of Science (PLoS) Authors: Maurits, Luke; Forkel, Robert; Kaiping, Gereon A.; Atkinson, Quentin D.;Maurits, Luke; Forkel, Robert; Kaiping, Gereon A.; Atkinson, Quentin D.;pmc: PMC5552126
pmid: 28796784
We present a new open source software tool called BEASTling, designed to simplify the preparation of Bayesian phylogenetic analyses of linguistic data using the BEAST 2 platform. BEASTling transforms comparatively short and human-readable configuration files into the XML files used by BEAST to specify analyses. By taking advantage of Creative Commons-licensed data from the Glottolog language catalog, BEASTling allows the user to conveniently filter datasets using names for recognised language families, to impose monophyly constraints so that inferred language trees are backward compatible with Glottolog classifications, or to assign geographic location data to languages for phylogeographic analyses. Support for the emerging cross-linguistic linked data format (CLDF) permits easy incorporation of data published in cross-linguistic linked databases into analyses. BEASTling is intended to make the power of Bayesian analysis more accessible to historical linguists without strong programming backgrounds, in the hopes of encouraging communication and collaboration between those developing computational models of language evolution (who are typically not linguists) and relevant domain experts.
NARCIS arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5552126Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0180908&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5552126Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0180908&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 NetherlandsPublisher:Oxford University Press (OUP) Funded by:NWO | Visual Analysis in Popula..., NWO | Genes in spaceNWO| Visual Analysis in Population Imaging Research (VAnPIRe) ,NWO| Genes in spaceSjoerd M. H. Huisman; Baldur van Lew; Ahmed Mahfouz; Nicola Pezzotti; Thomas Höllt; Lieke Michielsen; Anna Vilanova; Marcel J. T. Reinders; Boudewijn P. F. Lelieveldt;Spatial and temporal brain transcriptomics has recently emerged as an invaluable data source for molecular neuroscience. The complexity of such data poses considerable challenges for analysis and visualization. We present BrainScope: A web portal for fast, interactive visual exploration of the Allen Atlases of the adult and developing human brain transcriptome. Through a novel methodology to explore high-dimensional data (dual t-SNE), BrainScope enables the linked, all-in-one visualization of genes and samples across the whole brain and genome, and across developmental stages. We show that densities in t-SNE scatter plots of the spatial samples coincide with anatomical regions, and that densities in t-SNE scatter plots of the genes represent gene co-expression modules that are significantly enriched for biological functions. We also show that the topography of the gene t-SNE maps reflect brain region-specific gene functions, enabling hypothesis and data driven research. We demonstrate the discovery potential of BrainScope through three examples: (i) analysis of cell type specific gene sets, (ii) analysis of a set of stable gene co-expression modules across the adult human donors and (iii) analysis of the evolution of co-expression of oligodendrocyte specific genes over developmental stages. Brain- Scope is publicly accessible at www.brainscope.nl. Pattern Recognition and Bioinformatics Computer Graphics and Visualisation
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5449549Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2017Nucleic Acids ResearchArticle . 2017Data sources: Eindhoven University of Technology Research PortalLeiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkx046&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 62visibility views 62 download downloads 48 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5449549Data sources: PubMed CentralLUMC Scholarly Publications; NARCISOther literature type . Article . 2017Nucleic Acids ResearchArticle . 2017Data sources: Eindhoven University of Technology Research PortalLeiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkx046&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Netherlands, Netherlands, Italy, United Kingdom, United Kingdom, Netherlands, Netherlands, France, United Kingdom, Spain EnglishPublisher:HAL CCSD Funded by:EC | PhenoMeNalEC| PhenoMeNalvan Rijswijk, M; van Rijswijk, M; Beirnaert, C; Beirnaert, C; Caron, C; Cascante, M; Dominguez, V; Dunn, WB; Ebbels, TMD; Giacomoni, F; Gonzalez-Beltran, A; Hankemeier, T; Haug, K; Haug, K; Izquierdo-Garcia, JL; Jimenez, RC; Jimenez, RC; Jourdan, F; Kale, N; Klapa, MI; Kohlbacher, O; Koort, K; Kultima, K; Le Corguillé, G; Moreno, P; Moschonas, NK; Moschonas, NK; Neumann, S; O'Donovan, C; Reczko, M; Rocca-Serra, P; Rosato, A; Rosato, A; Rosato, A; Salek, RM; Salek, RM; Sansone, S-A; Satagopam, V; Schober, D; Shimmo, R; Spicer, RA; Spicer, RA; Spjuth, O; Spjuth, O; Spjuth, O; Thévenot, EA; Thévenot, EA; Viant, MR; Weber, RJM; Willighagen, EL; Willighagen, EL; Zanetti, G; Steinbeck, C; Steinbeck, C;Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for metabolomics within Europe, a workshop on the "Future of metabolomics in ELIXIR" was organised at Frankfurt Airport in Germany. This one-day strategic workshop involved representatives of ELIXIR Nodes, members of the PhenoMeNal consortium developing an e-infrastructure that supports workflow-based metabolomics analysis pipelines, and experts from the international metabolomics community. The workshop established metabolite identification as the critical area, where a maximal impact of computational metabolomics and data management on other fields could be achieved. In particular, the existing four ELIXIR Use Cases, where the metabolomics community - both industry and academia - would benefit most, and which could be exhaustively mapped onto the current five ELIXIR Platforms were discussed. This opinion article is a call for support for a new ELIXIR metabolomics Use Case, which aligns with and complements the existing and planned ELIXIR Platforms and Use Cases. The meeting was funded by PhenoMeNal, European Commission's Horizon2020 programme, grant agreement number 654241 Sí
HAL - UPEC / UPEM; H... arrow_drop_down Europe PubMed CentralArticle . 2017 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC5627583Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTAFlore (Florence Research Repository)Article . 2017Data sources: Flore (Florence Research Repository)Oxford University Research Archive; F1000ResearchOther literature type . Article . 2017 . 2018 . Peer-reviewedLicense: CC BYSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.12342.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 34visibility views 34 download downloads 65 Powered bymore_vert HAL - UPEC / UPEM; H... arrow_drop_down Europe PubMed CentralArticle . 2017 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC5627583Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTAFlore (Florence Research Repository)Article . 2017Data sources: Flore (Florence Research Repository)Oxford University Research Archive; F1000ResearchOther literature type . Article . 2017 . 2018 . Peer-reviewedLicense: CC BYSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.12342.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euintegration_instructions Research softwarekeyboard_double_arrow_right Software 2018 NetherlandsPublisher:Zenodo Authors: Ranguelova, Elena;Ranguelova, Elena;OCTSEG (Optical Coherence Tomography Segmentation and Evaluation GUI) is a GUI and function collection to segment and visualize retinal layers on OCT data.
ZENODO arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.1464025&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 22Kvisibility views 21,526 download downloads 14 Powered bymore_vert ZENODO arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.1464025&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2014 NetherlandsPublisher:Oxford University Press (OUP) Funded by:EC | IDEALEC| IDEALIterson, M. van; Tobi, E.W.; Slieker, R.C.; Hollander, W. den; Luijk, R.; Slagboom, P.E.; Heijmans, B.T.;Abstract Summary: The Illumina 450k array is a frequently used platform for large-scale genome-wide DNA methylation studies, i.e. epigenome-wide association studies. Currently, quality control of 450k data can be performed with Illumina’s GenomeStudio and is part of a limited number 450k analysis pipelines. However, GenomeStudio cannot handle large-scale studies, and existing pipelines provide limited options for quality control and neither support interactive exploration by the user. To aid the detection of bad-quality samples in large-scale genome-wide DNA methylation studies as flexible and transparent as possible, we have developed MethylAid; a visual and interactive Web application using RStudio’s shiny package. Bad-quality samples are detected using sample-dependent and sample-independent quality control probes present on the array and user-adjustable thresholds. In-depth exploration of bad-quality samples can be performed using several interactive diagnostic plots. Furthermore, plots can be annotated with user-provided metadata, for example, to identify outlying batches. Our new tool makes quality assessment of 450k array data interactive, flexible and efficient and is, therefore, expected to be useful for both data analysts and core facilities. Availability and implementation: MethylAid is implemented as an R/Bioconductor package (www.bioconductor.org/packages/3.0/bioc/html/MethylAid.html). A demo application is available from shiny.bioexp.nl/MethylAid. Contact: m.van_iterson@lumc.nl
Bioinformatics arrow_drop_down NARCIS; BioinformaticsOther literature type . Article . 2014 . Peer-reviewedLUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/bioinformatics/btu566&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 129 citations 129 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert Bioinformatics arrow_drop_down NARCIS; BioinformaticsOther literature type . Article . 2014 . Peer-reviewedLUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2014add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Spain, Netherlands, Germany, Germany, United Kingdom, Luxembourg, Spain, Sweden, United Kingdom, United Kingdom, United Kingdom EnglishPublisher:Springer Science and Business Media LLC Funded by:EC | BLUEPRINT, EC | SYSMEDIBD, EC | P-MEDICINE +34 projectsEC| BLUEPRINT ,EC| SYSMEDIBD ,EC| P-MEDICINE ,EC| ERA-IB-2 ,EC| PSIMEX ,EC| DECIPHER ,EC| ESGI ,EC| EPIGENESYS ,EC| MEDALL ,EC| ERASYSAPP ,EC| PREDEMICS ,EC| CASYM ,EC| EMIF ,EC| ELIXIR ,EC| MIMOMICS ,EC| TRANSLOCATION ,EC| VPH-SHARE ,EC| BRIDGES ,EC| ASTERIX ,EC| SEMCARE ,EC| IDEAL ,EC| MedBioinformatics ,EC| STATEGRA ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers ,EC| U-BIOPRED ,EC| ECHO ,WT ,EC| CANCER-ID ,EC| PROTEOMEXCHANGE ,EC| COMBIMS ,EC| ERASYNBIO ,EC| KConnect ,EC| READNA ,EC| PREPARE ,EC| MULTIMOD ,EC| RADIANT ,EC| CHAARMCharles Auffray; Rudi Balling; Inês Barroso; László Bencze; Mikael Benson; Jay M. Bergeron; Enrique Bernal-Delgado; Niklas Blomberg; Christoph Bock; Ana Conesa; Susanna Del Signore; Christophe Delogne; Peter Devilee; Alberto Di Meglio; Marinus J.C. Eijkemans; Paul Flicek; Norbert Graf; Vera Grimm; Henk-Jan Guchelaar; Yike Guo; Ivo Gut; Allan Hanbury; Shahid Hanif; Ralf-Dieter Hilgers; Angel Honrado; D. Rod Hose; Jeanine J. Houwing-Duistermaat; Tim Hubbard; Sophie Helen Janacek; Haralampos Karanikas; Tim Kievits; Manfred Kohler; Andreas Kremer; Jerry Lanfear; Thomas Lengauer; Edith Maes; Theo F. Meert; Werner Müller; Dörthe Nickel; Peter Oledzki; Bertrand Pedersen; Milan Petkovic; Konstantinos Pliakos; Magnus Rattray; Josep Redón Más; Reinhard Schneider; Thierry Sengstag; Xavier Serra-Picamal; Wouter Spek; Lea A. I. Vaas; Okker van Batenburg; Marc Vandelaer; Péter Várnai; Pablo Villoslada; Juan Antonio Vizcaíno; John Peter Mary Wubbe; Gianluigi Zanetti;doi: 10.1186/s13073-016-0323-y , 10.1186/s13073-016-0376-y , 10.18154/rwth-conv-213156 , 10.17863/cam.42076 , 10.18154/rwth-conv-213157
handle: 11858/00-001M-0000-002C-1D02-C , 11858/00-001M-0000-002C-1D04-8 , 1887/99384 , 11858/00-001M-0000-002A-F90A-4 , 11858/00-001M-0000-002A-F908-8 , 1874/337769
pmc: PMC5100330 , PMC4919856
doi: 10.1186/s13073-016-0323-y , 10.1186/s13073-016-0376-y , 10.18154/rwth-conv-213156 , 10.17863/cam.42076 , 10.18154/rwth-conv-213157
handle: 11858/00-001M-0000-002C-1D02-C , 11858/00-001M-0000-002C-1D04-8 , 1887/99384 , 11858/00-001M-0000-002A-F90A-4 , 11858/00-001M-0000-002A-F908-8 , 1874/337769
pmc: PMC5100330 , PMC4919856
Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health arid healthcare for all Europearis. Funding Agencies|European Union [115568, 603160, 282510, 664691, 115749, 305033, 305397, 288028, 242189, 211601]; European Molecular Biology Laboratory; Wellcome Trust [WT098051]; [115372]; [257082]; [291814]; [291728]; [321567]; [262055]; [115446]; [602552]; [644753]; [634143]; [261357]; [305280]; [115525]; [2011 23 02]; [270089]; [278433]; [602525]; [201418]; [242135]; [260558]; [223411]; [305626]; [115621]; [611388]; [306000]; [354457]; [305564]; [115010]; [269978]
Genome Medicine arrow_drop_down Genome MedicineOther literature type . Article . 2016 . Peer-reviewedEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4919856Data sources: PubMed CentralEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5100330Data sources: PubMed CentralPublikationsserver der RWTH Aachen UniversityArticle . 2016Data sources: Publikationsserver der RWTH Aachen UniversitySpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2016License: CC BYThe University of Manchester - Institutional RepositoryArticle . 2016Data sources: The University of Manchester - Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTAOpen Repository and Bibliography - LuxembourgArticle . 2016Data sources: Open Repository and Bibliography - LuxembourgLUMC Scholarly Publications; NARCISOther literature type . Article . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13073-016-0323-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 206 citations 206 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!visibility 31visibility views 31 download downloads 150 Powered bymore_vert Genome Medicine arrow_drop_down Genome MedicineOther literature type . Article . 2016 . Peer-reviewedEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC4919856Data sources: PubMed CentralEurope PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5100330Data sources: PubMed CentralPublikationsserver der RWTH Aachen UniversityArticle . 2016Data sources: Publikationsserver der RWTH Aachen UniversitySpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2016License: CC BYThe University of Manchester - Institutional RepositoryArticle . 2016Data sources: The University of Manchester - Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2016Data sources: Recolector de Ciencia Abierta, RECOLECTAOpen Repository and Bibliography - LuxembourgArticle . 2016Data sources: Open Repository and Bibliography - LuxembourgLUMC Scholarly Publications; NARCISOther literature type . Article . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13073-016-0323-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2012 NetherlandsPublisher:Elsevier BV Funded by:EC | OPEN PHACTSEC| OPEN PHACTSAntony J. Williams; Lee Harland; Paul Groth; Stephen Pettifer; Christine Chichester; Egon Willighagen; Chris T. Evelo; Niklas Blomberg; Gerhard F. Ecker; Carole Goble; Barend Mons;Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies. It is focused on practical and robust applications to solve specific questions in drug discovery research. OPS is intended to facilitate improvements in drug discovery in academia and industry and to support open innovation and in-house non-public drug discovery research. This paper lays out the challenges and how the Open PHACTS project is hoping to address these challenges technically and socially. © 2012 Elsevier Ltd.
NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.drudis.2012.05.016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 265 citations 265 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.drudis.2012.05.016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 NetherlandsPublisher:Springer Science and Business Media LLC Funded by:NWO | BBMRI-NLNWO| BBMRI-NLAuthors: Maarten van Iterson; Erik W. van Zwet; Bastiaan T. Heijmans; Peter A C 't Hoen; +47 AuthorsMaarten van Iterson; Erik W. van Zwet; Bastiaan T. Heijmans; Peter A C 't Hoen; Joyce B. J. van Meurs; Rick Jansen; Lude Franke; Dorret I. Boomsma; René Pool; Jenny van Dongen; Jouke J. Hottenga; Marleen J. van Greevenbroek; Coen D.A. Stehouwer; Carla J.H. van der Kallen; Casper G. Schalkwijk; Cisca Wijmenga; Sasha Zhernakova; Ettje F. Tigchelaar; P. Eline Slagboom; Marian Beekman; Joris Deelen; Diana van Heemst; Jan H. Veldink; Leonard H. van den Berg; Cornelia M. van Duijn; Bert A. Hofman; Aaron Isaacs; André G. Uitterlinden; P. Mila Jhamai; Michael M. P. J. Verbiest; H. Eka D. Suchiman; Marijn Verkerk; Ruud van der Breggen; Jeroen van Rooij; Nico Lakenberg; Hailiang Mei; Michiel van Galen; Jan Bot; Dasha V. Zhernakova; Peter Van ‘t Hof; Patrick Deelen; Irene Nooren; Matthijs Moed; Martijn Vermaat; René Luijk; Marc Jan Bonder; Freerk van Dijk; Wibowo Arindrarto; Szymon M. Kielbasa; Morris A. Swertz; Peter Bram 't Hoen;pmid: 28129774
pmc: PMC5273857
We show that epigenome- and transcriptome-wide association studies (EWAS and TWAS) are prone to significant inflation and bias of test statistics, an unrecognized phenomenon introducing spurious findings if left unaddressed. Neither GWAS-based methodology nor state-of-the-art confounder adjustment methods completely remove bias and inflation. We propose a Bayesian method to control bias and inflation in EWAS and TWAS based on estimation of the empirical null distribution. Using simulations and real data, we demonstrate that our method maximizes power while properly controlling the false positive rate. We illustrate the utility of our method in large-scale EWAS and TWAS meta-analyses of age and smoking. Electronic supplementary material The online version of this article (doi:10.1186/s13059-016-1131-9) contains supplementary material, which is available to authorized users.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5273857Data sources: PubMed CentralGenome Biology; NARCISArticle . 2017 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13059-016-1131-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 244 citations 244 popularity Top 0.1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5273857Data sources: PubMed CentralGenome Biology; NARCISArticle . 2017 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13059-016-1131-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Netherlands, BelgiumPublisher:Frontiers Media SA Jeroen Van Houtte; Filip Vandenberghe; Guoyan Zheng; Toon Huysmans; Toon Huysmans; Jan Sijbers;Most digital models of the equine distal limb that are available in the community are static and/or subject specific; hence, they have limited applications in veterinary research. In this paper, we present an articulatable model of the entire equine distal limb based on statistical shape modeling. The model describes the inter-subject variability in bone geometry while maintaining proper jointspace distances to support model articulation toward different poses. Shape variation modes are explained in terms of common biometrics in order to ease model interpretation from a veterinary point of view. The model is publicly available through a graphical user interface (https://github.com/jvhoutte/equisim) in order to facilitate future digitalization in veterinary research, such as computer-aided designs, three-dimensional printing of bone implants, bone fracture risk assessment through finite element methods, and data registration and segmentation problems for clinical practices.
Frontiers in Veterin... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7982960Data sources: PubMed CentralNARCIS; TU Delft RepositoryArticle . 2021Frontiers in Veterinary ScienceArticle . 2021Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fvets.2021.623318&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!visibility 70visibility views 70 download downloads 20 Powered bymore_vert Frontiers in Veterin... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7982960Data sources: PubMed CentralNARCIS; TU Delft RepositoryArticle . 2021Frontiers in Veterinary ScienceArticle . 2021Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fvets.2021.623318&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu