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description Publicationkeyboard_double_arrow_right Article , Other literature type 2012 Switzerland, Netherlands, France, FrancePublisher:Public Library of Science (PLoS) Funded by:SNSF | The SAPALDIA II Cohort St..., SNSF | The SAPALDIA II Cohort St..., SNSF | SAPALDIA COHORT STUDY: Im... +9 projectsSNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| Swiss study on air pollution and lung diseases in adults (SAPALDIA study) ,SNSF| Gene-environment interactions in the Etiology of Chronic Obstructive Pulmonary Disease (COPD); the SAPALDIA Biobank ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension. ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis. ,SNSF| SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases. ,SNSF| SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis ,WT| A second-generation genome-wide association study for asthma.Ivan Curjuric; Medea Imboden; Rachel Nadif; Ashok Kumar; Christian Schindler; Margot Haun; Florian Kronenberg; Nino Künzli; Harish C. Phuleria; Dirkje S. Postma; Erich W. Russi; Thierry Rochat; Florence Demenais; Nicole Probst-Hensch;pmc: PMC3391223
pmid: 22792237
Background: Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes.Objectives: We studied the interaction of both exposures with a broad set of oxidative-stress related candidate genes and pathways on lung function decline and contrasted interactions between exposures.Methods: For 12679 single nucleotide polymorphisms (SNP5), change in forced expiratory volume in one second (FEV1), FEV1 over forced vital capacity (FEV1/FVC), and mean forced expiratory flow between 25 and 75% of the FVC (FEF25-75) was regressed on interval exposure to particulate matter <10 mu m in diameter (PM10) or packyears smoked (a), additive SNP effects (b), and interaction terms between (a) and (b) in 669 adults with GWAS data. Interaction p-values for 152 genes and 14 pathways were calculated by the adaptive rank truncation product (ARTP) method, and compared between exposures. Interaction effect sizes were contrasted for the strongest SNPs of nominally significant genes (p(interaction) <0.05). Replication was attempted for SNPs with MAF > 10% in 3320 SAPALDIA participants without GWAS.Results: On the SNP-level, rs2035268 in gene SNCA accelerated FEV1/FVC decline by 3.8% (p(interaction) = 2.5 x 10(-6)), and rs12190800 in PARK2 attenuated FEV1 decline by 95.1 ml p(interaction) = 9.7 x 10(-8)) over 11 years, while interacting with PM10. Genes and pathways nominally interacting with PM10 and packyears exposure differed substantially. Gene CRISP2 presented a significant interaction with PM10 (p(interaction) = 3.0 x 10(-4)) on FEV1/FVC decline. Pathway interactions were weak. Replications for the strongest SNPs in PARK2 and CRISP2 were not successful.Conclusions: Consistent with a stratified response to increasing oxidative stress, different genes and pathways potentially mediate PM10 and tobacco smoke effects on lung function decline. Ignoring environmental exposures would miss these patterns, but achieving sufficient sample size and comparability across study samples is challenging.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3391223Data sources: PubMed CentralNARCISArticle . 2012Full-Text: https://pure.rug.nl/ws/files/48876890/Curjuric_2012_Different_genes_interact_with_parti.pdfData sources: NARCISHAL-Inserm; Hal-DiderotArticle . 2012add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 45 citations 45 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3391223Data sources: PubMed CentralNARCISArticle . 2012Full-Text: https://pure.rug.nl/ws/files/48876890/Curjuric_2012_Different_genes_interact_with_parti.pdfData sources: NARCISHAL-Inserm; Hal-DiderotArticle . 2012add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 FrancePublisher:Elsevier BV Funded by:WT | Multi-species transmissio...WT| Multi-species transmission of Echinococcus on the Tibetan Plateau.Marston, CG; Giraudoux, P; Armitage, RP; Danson, FM; Reynolds, SC; Wang, Q; Qiu, J; Craig, PS;International audience; Echinococcus multilocularis (Em), a parasitic tapeworm, is responsible for a significant burden of human disease across continental Asia. Here, we use a time-series of MODIS 16-day 250 m Enhanced Vegetation Index (EVI) satellite data to quantify the seasonal vegetation dynamics across a study area in Serxu County, Sichuan Province, China, in relation to the presence of the Em intermediate host Ochotona curzoniae (plateau pika) and Ochotona cansus (Gansu pika) (here merged to Ochotona spp.). A series of derived phenological metrics are analysed using the random forests statistical method to determine the relative importance of seasonal vegetation characteristics. Results indicate negative relationships between Ochotona spp. presence and EVI showing a preference for low-biomass habitats. However, EVI values during green-up and senescence periods are also shown to be important, potentially resulting from improved detectability of low-biomass grassland habitats at these times. Improved detection of Ochotona spp. preferred habitats via time-series EVI imagery offers better understanding of the distributions of this Em host, and the potential for monitoring the changes in Ochotona spp. optimal habitat distributions resulting from landscape change. This could aid the identification of villages at increased risk of infection, enabling preventive strategies to be adopted.
CORE (RIOXX-UK Aggre... arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rse.2016.02.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 8 citations 8 popularity Average influence Average impulse Top 10% Powered by BIP!visibility 2visibility views 2 download downloads 107 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rse.2016.02.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Italy, France, Italy, United Kingdom, Spain, Netherlands, AustraliaPublisher:Elsevier BV Funded by:WT | Life course inequalities ..., EC | ESCAPE, WTWT| Life course inequalities in asthma: estimating its burden and understanding its aetiology. ,EC| ESCAPE ,WTSofia Temam; Emilie Burte; Martin Adam; Josep M. Antó; Xavier Basagaña; Jean Bousquet; Anne-Elie Carsin; Bruna Galobardes; Dirk Keidel; Nino Künzli; Nicole Le Moual; Margaux Sanchez; Jordi Sunyer; Roberto Bono; Bert Brunekreef; Joachim Heinrich; Kees de Hoogh; Deborah Jarvis; Alessandro Marcon; Lars Modig; Rachel Nadif; Mark J. Nieuwenhuijsen; Isabelle Pin; Valérie Siroux; Morgane Stempfelet; Ming-Yi Tsai; Nicole Probst-Hensch; Bénédicte Jacquemin;handle: 2318/1621048 , 1874/360387 , 11562/961836
Background: Inconsistent associations between socioeconomic position (SEP) and outdoor air pollution have been reported in Europe, but methodological differences prevent any direct between-study comparison. Objectives: Assess and compare the association between SEP and outdoor nitrogen dioxide (NO2) exposure as a marker of traffic exhaust, in 16 cities from eight Western European countries. Methods: Three SEP indicators, two defined at individual-level (education and occupation) and one at neighborhood-level (unemployment rate) were assessed in three European multicenter cohorts. NO2 annual concentration exposure was estimated at participants' addresses with land use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE; http://www.escapeproject.eu/). Pooled and city-specific linear regressions were used to analyze associations between each SEP indicator and NO2. Heterogeneity across cities was assessed using the Higgins' I-squared test (I2). Results: The study population included 5692 participants. Pooled analysis showed that participants with lower individual-SEP were less exposed to NO2. Conversely, participants living in neighborhoods with higher unemployment rate were more exposed. City-specific results exhibited strong heterogeneity (I2 > 76% for the three SEP indicators) resulting in variation of the individual- and neighborhood-SEP patterns of NO2 exposure across cities. The coefficients from a model that included both individual- and neighborhood-SEP indicators were similar to the unadjusted coefficients, suggesting independent associations. Conclusions: Our study showed for the first time using homogenized measures of outcome and exposure across 16 cities the important heterogeneity regarding the association between SEP and NO2 in Western Europe. Importantly, our results showed that individual- and neighborhood-SEP indicators capture different aspects of the association between SEP and exposure to air pollution, stressing the importance of considering both in air pollution health effects studies. The ESCAPE study, funded by the European Community's Seventh Framework Program (FP7/2007-2011) under grant agreement no. 211250 (http://www.escapeproject.eu/).
Archivio Istituziona... arrow_drop_down IRIS - Università degli Studi di Verona; Environment InternationalArticle . 2017 . Peer-reviewedLicense: Elsevier TDMSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryNARCIS; Utrecht University RepositoryArticle . 2017IRIS - Università degli Studi di VeronaArticle . 2017Data sources: IRIS - Università degli Studi di VeronaMémoires en Sciences de l'Information et de la CommunicationArticle . 2017Full-Text: https://hal.science/hal-01784629/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 5visibility views 5 download downloads 101 Powered bymore_vert Archivio Istituziona... arrow_drop_down IRIS - Università degli Studi di Verona; Environment InternationalArticle . 2017 . Peer-reviewedLicense: Elsevier TDMSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryNARCIS; Utrecht University RepositoryArticle . 2017IRIS - Università degli Studi di VeronaArticle . 2017Data sources: IRIS - Università degli Studi di VeronaMémoires en Sciences de l'Information et de la CommunicationArticle . 2017Full-Text: https://hal.science/hal-01784629/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Spain, Spain, Spain, Netherlands, France, France, Australia, FrancePublisher:Elsevier BV Funded by:WT | The Born in Bradford (BiB..., NIH | Effects of DDE exposure o..., NIH | Pilot Project Program +6 projectsWT| The Born in Bradford (BiB) Study an international biomedical resource for exploring genetic and early life determinants of health and development in a deprived multi-ethnic population. ,NIH| Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals ,NIH| Pilot Project Program ,NIH| Hepatotoxic effects of perfluoroalkyl substances: a new epidemiological approach for studying environmental fatty liver disease ,EC| EUCAN-Connect ,NIH| Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in Youth ,NHMRC| An evaluation of bone density screening in premenopausal women ,EC| DENAMIC ,EC| HELIXAuthors: Binter, Anne-Claire; Bernard, Jonathan Y.; Mon-Williams, Mark; Andiarena, Ainara; +15 AuthorsBinter, Anne-Claire; Bernard, Jonathan Y.; Mon-Williams, Mark; Andiarena, Ainara; González-Safont, Llúcia; Vafeiadi, Marina; Lepeule, Johanna; Soler-Blasco, Raquel; Alonso, Lucia; Kampouri, Mariza; Mceachan, Rosie; Santa-Marina, Loreto; Wright, John; Chatzi, Leda; Sunyer, Jordi; Philippat, Claire; Nieuwenhuijsen, Mark; Vrijheid, Martine; Guxens, Mònica;Acknowledgements We are grateful to all the participating children, parents, practi-tioners and researchers in the four countries who took part in this study. This work was supported by funding from the European Community's Seventh Framework Programme [FP7/2007-206 n 308333; the HELIX project] . This INMA cohort was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds, FIS PI06/0867, FIS-PI09/00090, FIS and FIS-PI18/01142 incl. FEDER funds, FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI16/00118 and PI17/00663; FIS-FSE: 17/00260; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, and CPII18/00018) , from UE (FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, and H2020 n 824989) , Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundacio La marato de TV3 (090430) , Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249) , Alicia Koplowitz Foundation 2017, CIBERESP, Department of Health of the Basque Government (2013111089, 2009111069, 2013111089, 2015111065 and 2018111086) , Provincial Government of Gipuzkoa (DFG06/002, DFG08/001, DFG15/221 and DFG 89/17) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain) . We acknowledge support from the Spanish Ministry of Science and Inno-vation and the State Research Agency through the "Centro de Excelencia Severo Ochoa 2019-2023" Program (CEX2018-000806-S) , and support from the Generalitat de Catalunya through the CERCA Program. The work was also supported by MICINN [MTM2015-68140-R] and Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII (Spain) . The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; "Rhea Plus": Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15) . This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber (UK) . The EDEN study was supported by Foundation for medical research (FRM) , National Agency for Research (ANR) , National Institute for Research inPublic health (IRESP: TGIR cohorte sante 2008 program) , French Min-istry of Health (DGS) , French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) , and Human Nutrition Na-tional Research Programs, Paris-Sud University, Nestle, French National Institute for Population Health Surveillance (InVS) , French National Institute for Health Education (INPES) , the European Union FP7 pro-grams (ESCAPE, ENRIECO, Medall projects) , Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD) ) , French Agency for Environmental Health Safety and French National Agency for Food Security (now ANSES) , Mutuelle Generale de l'Education Nationale a complementary health insurance (MGEN) , French-speaking association for the study of diabetes and metabolism (ALFEDIAM) . Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597MA, UK) . Born in Bradford (BiB) is only possible because of the enthusiasm and commitment of the children and parents in BiB. We are grateful to all the participants, health professionals, schools and researchers who have made BiB happen. BiB receives funding from the ESRC/MRC, the Wellcome Trust (WT101597MA) and the National Institute for Health Research York-shire and Humber ARC (reference: NIHR20016) . M. Mon-Williams was supported by a Fellowship from the Alan Turing Institute. Additional funding from the National Institute of Environmental Health Science supported Dr Chatzi (R01ES030691, R01ES029944, R01ES030364, R21ES029681, and P30ES007048) . The views expressed are those of the authors, and not necessarily those of the NHS or the NIHR. None of the funders were involved in designing the study, collecting the data, analyzing or interpreting the data, deciding to submit the article for publication, or the writing of the report. Data sharing statement The HELIX data warehouse has been established as an accessible resource for collaborative research involving researchers external to the project. Access to HELIX data is based on approval by the HELIX Project Executive Committee and by the individual cohorts. Further details on the content of the data warehouse (data catalogue) and procedures for external access are described on the project website (http:// www.proj-ecthelix.eu/index.php/es/data-inventory) . [EN]Background: The urban environment may influence neurodevelopment from conception onwards, but there is no evaluation of the impact of multiple groups of exposures simultaneously. We investigated the association between early-life urban environment and cognitive and motor function in children. Methods: We used data from 5403 mother-child pairs from four population-based birth-cohorts (UK, France, Spain, and Greece). We estimated thirteen urban home exposures during pregnancy and childhood, including: built environment, natural spaces, and air pollution. Verbal, non-verbal, gross motor, and fine motor functions were assessed using validated tests at five years old. We ran adjusted multi-exposure models using the Deletion-Substitution-Addition algorithm. Results: Higher greenness exposure within 300 m during pregnancy was associated with higher verbal abilities (1.5 points (95% confidence interval 0.4, 2.7) per 0.20 unit increase in greenness). Higher connectivity density within 100 m and land use diversity during pregnancy were related to lower verbal abilities. Childhood exposure to PM2.5 mediated 74% of the association between greenness during childhood and verbal abilities. Higher exposure to PM2.5 during pregnancy was related to lower fine motor function (-1.2 points (-2.1, -0.4) per 3.2 mu g/m3 increase in PM2.5). No associations were found with non-verbal abilities and gross motor function. Discussion: This study suggests that built environment, greenness, and air pollution may impact child cognitive and motor function at five years old. This study adds evidence that well-designed urban planning may benefit children's cognitive and motor development.
ACU Research Bank arrow_drop_down HAL-Rennes 1; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDFull-Text: https://hal.science/hal-03480282/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert ACU Research Bank arrow_drop_down HAL-Rennes 1; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDFull-Text: https://hal.science/hal-03480282/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 Serbia, FrancePublisher:Public Library of Science (PLoS) Funded by:UKRI | Technologies for the Futu..., EC | BIRTH, UKRI | Core Capability - Univers... +4 projectsUKRI| Technologies for the Future ,EC| BIRTH ,UKRI| Core Capability - University of York ,EC| NEOMILK ,WT ,EC| LIPDAT ,WT| A plaque on both your houses: Exploring the history of urbanisation and infectious diseases through the study of archaeological dental tartar.Darko Stojanovski; Ivana Živaljević; Vesna Dimitrijević; Julie Dunne; Richard P. Evershed; Marie Balasse; Adam Dowle; Jessica Hendy; Krista McGrath; Roman Fischer; Camilla Speller; Jelena Jovanović; Emmanuelle Casanova; Timothy D J Knowles; Lidija Balj; Goce Naumov; Anđelka Putica; Andrej Starović; Sofija Stefanović;International audience; The application of biomolecular techniques to archaeological materials from the Balkans is providing valuable new information on the prehistory of the region. This is especially relevant for the study of the neolithisation process in SE Europe, which gradually affected the rest of the continent. Here, to answer questions regarding diet and subsistence practices in early farming societies in the central Balkans, we combine organic residue analyses of archaeological pottery, taxonomic and isotopic study of domestic animal remains and biomolecular analyses of human dental calculus. The results from the analyses of the lipid residues from pottery suggest that milk was processed in ceramic vessels. Dairy products were shown to be part of the subsistence strategies of the earliest Neolithic communities in the region but were of varying importance in different areas of the Balkan. Conversely, milk proteins were not detected within the dental calculus. The molecular and isotopic identification of meat, dairy, plants and beeswax in the pottery lipids also provided insights into the diversity of diet in these early Neolithic communities, mainly based on terrestrial resources. We also present the first compound-specific radiocarbon dates for the region, obtained directly from absorbed organic residues extracted from pottery, identified as dairy lipids.
CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7444498Data sources: PubMed CentralREFF - University of Belgrade - Faculty of PhilosophyArticle . 2020License: CC BYData sources: REFF - University of Belgrade - Faculty of PhilosophyMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-03028798/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0237608&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 11visibility views 11 download downloads 17 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7444498Data sources: PubMed CentralREFF - University of Belgrade - Faculty of PhilosophyArticle . 2020License: CC BYData sources: REFF - University of Belgrade - Faculty of PhilosophyMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-03028798/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 United Kingdom, France, Italy, Switzerland, Spain, Italy, France, Germany, SwedenPublisher:MDPI AG Funded by:SNSF | SAPALDIA COHORT STUDY: Im..., SNSF | The SAPALDIA II Cohort St..., SNSF | Swiss Cohort Study on Air... +11 projectsSNSF| SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,EC| EXPOSOMICS ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension. ,WT| A second-generation genome-wide association study for asthma. ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis. ,SNSF| SAPALDIA Cohort on Healthy Aging ,SNSF| SAPALDIA 5 - Cohort on Healthy Aging ,EC| ESCAPE ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases. ,SNSF| SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysisDirk Keidel; Josep M. Antó; Xavier Basagaña; Roberto Bono; Emilie Burte; Anne-Elie Carsin; Bertil Forsberg; Elaine Fuertes; Bruna Galobardes; Joachim Heinrich; Kees de Hoogh; Deborah Jarvis; Nino Künzli; Bénédicte Leynaert; Alessandro Marcon; Nicole Le Moual; Audrey de Nazelle; Christian Schindler; Valérie Siroux; Morgane Stempfelet; Jordi Sunyer; Sofia Temam; Ming-Yi Tsai; Raphaëlle Varraso; Bénédicte Jacquemin; Nicole Probst-Hensch;pmc: PMC6603717
pmid: 31146441
Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated with both air pollution exposure and respiratory function. This study assesses the role of SES either as confounder or effect modifier of the association between ambient air pollution and lung function. Cross-sectional data from three European multicenter adult cohorts were pooled to assess factors associated with lung function, including annual means of home outdoor NO2. Pre-bronchodilator lung function was measured according to the ATS-criteria. Multiple mixed linear models with random intercepts for study areas were used. Three different factors (education, occupation and neighborhood unemployment rate) were considered to represent SES. NO2 exposure was negatively associated with lung function. Occupation and neighborhood unemployment rates were not associated with lung function. However, the inclusion of the SES-variable education improved the models and the air pollution-lung function associations got slightly stronger. NO2 associations with lung function were not substantially modified by SES-variables. In this multicenter European study we could show that SES plays a role as a confounder in the association of ambient NO2 exposure with lung function. SAPALDIA Research support: The Swiss National Science Foundation (grants no 33CS30-177506/1, 33CS30-148470/1&2, 33CSCO-134276/1, 33CSCO-108796, 324730_135673, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099, PMPDP3_129021/1, PMPDP3_141671/1), the Federal Office for the Environment, the Federal Office of Public Health, the Federal Office of Roads and Transport, the canton’s government of Aargau, Basel-Stadt, Basel-Land, Geneva, Luzern, Ticino, Valais, and Zürich, the Swiss Lung League, the canton’s Lung League of Basel Stadt/ Basel Landschaft, Geneva, Ticino, Valais, Graubünden and Zurich, Stiftung ehemals Bündner Heilstätten, SUVA, Freiwillige Akademische Gesellschaft, UBS Wealth Foundation, Talecris Biotherapeutics GmbH, Abbott Diagnostics, Klinik Barmelweid, Hirslanden Klinik Aarau, European Commission 018996 (GABRIEL), Wellcome Trust WT 084703MA, Exposomics EC FP7 grant(Grant agreement No: 308610).
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); International Journal of Environmental Research and Public Health; IRIS - Università degli Studi di VeronaOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/1660-4601/16/11/1901/pdfEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6603717Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticle . 2019Data sources: DOAJ-ArticlesPublication Server of Helmholtz Zentrum München (PuSH)Article . 2019Data sources: Publication Server of Helmholtz Zentrum München (PuSH)IRIS - Università degli Studi di VeronaArticle . 2019Data sources: IRIS - Università degli Studi di VeronaHAL-Inserm; Hal-DiderotArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 1visibility views 1 download downloads 9 Powered bymore_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); International Journal of Environmental Research and Public Health; IRIS - Università degli Studi di VeronaOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/1660-4601/16/11/1901/pdfEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6603717Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticle . 2019Data sources: DOAJ-ArticlesPublication Server of Helmholtz Zentrum München (PuSH)Article . 2019Data sources: Publication Server of Helmholtz Zentrum München (PuSH)IRIS - Università degli Studi di VeronaArticle . 2019Data sources: IRIS - Università degli Studi di VeronaHAL-Inserm; Hal-DiderotArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph16111901&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Contribution for newspaper or weekly magazine 2015 Denmark, United Kingdom, Italy, Portugal, United Kingdom, Italy, United Kingdom, Norway, Italy, Turkey, Spain, Germany, Croatia, Croatia, Italy, Spain, Italy, Portugal, France, United KingdomPublisher:Oxford University Press (OUP) Publicly fundedFunded by:EC | CITCLOPS, WT, EC | MICRO B3EC| CITCLOPS ,WT ,EC| MICRO B3Anna Kopf; Mesude Bicak; Renzo Kottmann; Julia Schnetzer; Ivaylo Kostadinov; Katja Lehmann; Antonio Fernandez-Guerra; Christian Jeanthon; Eyal Rahav; Matthias S. Ullrich; Antje Wichels; Gunnar Gerdts; Paraskevi N. Polymenakou; Georgios Kotoulas; Rania Siam; Rehab Z. Abdallah; Eva C. Sonnenschein; Thierry Cariou; Fergal O'Gara; Stephen A. Jackson; Sandi Orlić; Michael Steinke; Julia A. Busch; Bernardo Duarte; Isabel Caçador; João Canning-Clode; Oleksandra Bobrova; Viggo Marteinsson; Eyjólfur Reynisson; Clara Loureiro; Gian Marco Luna; Grazia Marina Quero; Carolin R. Löscher; Anke Kremp; Marie E. DeLorenzo; Lise Øvreås; Jennifer Tolman; Julie LaRoche; Antonella Penna; Marc E. Frischer; Timothy W. Davis; Barker Katherine; Christopher P. Meyer; Sandra Ramos; Catarina Magalhães; Florence Jude-Lemeilleur; Ma. Leopoldina Aguirre-Macedo; Shiao Y. Wang; Nicole J. Poulton; Scott Jones; Rachel Collin; Jed A. Fuhrman; Pascal Conan; Cecilia Alonso; Noga Stambler; Kelly D. Goodwin; Michail M. Yakimov; Federico Baltar; Levente Bodrossy; Jodie van de Kamp; Dion Matthew Frederick Frampton; Martin Ostrowski; Paul D. van Ruth; Paul Malthouse; Simon Claus; Klaas Deneudt; J. Mortelmans; Sophie Pitois; David Wallom; Ian Salter; Rodrigo Costa; Declan C. Schroeder; Mahrous M. Kandil; Valentina Amaral; Florencia Biancalana; Rafael Santana; Maria Luiza Pedrotti; Takashi Yoshida; Hiroyuki Ogata; Tim Ingleton; Kate Munnik; Naiara Rodríguez-Ezpeleta; Véronique Berteaux-Lecellier; Patricia Wecker; Ibon Cancio; Daniel Vaulot; Christina Bienhold; Hassan Ghazal; Bouchra Chaouni; Soumya Essayeh; Sara Ettamimi; El Houcine Zaid; Noureddine Boukhatem; Abderrahim Bouali; Rajaa Chahboune; Said Barrijal; Mohammed Timinouni; Fatima El Otmani; Mohamed Bennani; Marianna Mea; Nadezhda Todorova; Ventzislav Karamfilov; Petra ten Hoopen; Guy Cochrane; Stéphane L'Haridon; Kemal Can Bizsel; Alessandro Vezzi; Federico M. Lauro; Patrick Martin; Rachelle M. Jensen; Jamie Hinks; Susan Gebbels; Riccardo Rosselli; Fabio De Pascale; Riccardo Schiavon; Antonina Dos Santos; Emilie Villar; Stephane Pesant; Bruno Cataletto; Francesca Malfatti; Ranjith Edirisinghe; Jorge A. Herrera Silveira; Michèle Barbier; Valentina Turk; Tinkara Tinta; Wayne J. Fuller; Ilkay Salihoglu; Nedime Serakinci; Mahmut Cerkez Ergoren; Eileen Bresnan; Juan Iriberri; Paul Anders Fronth Nyhus; Edvardsen Bente; Hans Erik Karlsen; Peter N. Golyshin; Josep M. Gasol; Snejana Moncheva; Nina Dzhembekova; Zackary I. Johnson; Christopher D. Sinigalliano; Maribeth L. Gidley; Adriana Zingone; Roberto Danovaro; Georgios Tsiamis; Melody S. Clark; Ana C. Costa; Monia El Bour; Ana Martins; R. Eric Collins; Anne-Lise Ducluzeau; Jonathan A. Martinez; Mark J. Costello; Linda A. Amaral-Zettler; Jack A. Gilbert; Neil M Davies; Dawn Field; Frank Oliver Glöckner;pmc: PMC4473829
pmid: 26097697
Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits This work was supported by the Micro B3 project, which is funded from the European Union’s Seventh Framework Programme (FP7; Joint Call OCEAN.2011‐2: Marine microbial diversity – new insights into marine ecosystems functioning and its biotechnological potential) under the grant agreement no 287589 Kopf, Anna ... et. al.-- 5 pages, 1 figure.-- This manuscript is NOAA-GLERL contribution number 1763 Peer Reviewed
University of East A... arrow_drop_down University of East Anglia digital repositoryArticle . 2015 . Peer-reviewedData sources: University of East Anglia digital repositoryArchivio istituzionale della ricerca - Università di Padova; GigaScience; ZENODO; NERC Open Research Archive; Archivio istituzionale della ricerca - Università di Urbino; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2015 . Peer-reviewedLicense: Springer TDMEurope PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4473829Data sources: PubMed CentralFull-text Institutional Repository of the Ruđer Bošković InstituteContribution for newspaper or weekly magazine . 2015Bergen Open Research Archive - UiBArticle . 2015 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2015License: CC BYOnline Research Database In TechnologyArticle . 2015Data sources: Online Research Database In TechnologyArchiMer - Institutional Archive of IfremerOther literature type . 2015Data sources: ArchiMer - Institutional Archive of IfremerRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2015 . Peer-reviewedOxford University Research ArchiveOther literature type . 2016License: CC BYData sources: Oxford University Research ArchiveDokuz Eylul University Research Information SystemArticle . 2015Data sources: Dokuz Eylul University Research Information SystemMémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-UPMC; Hal-DiderotArticle . 2015License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 172 citations 172 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 1Kvisibility views 1,015 download downloads 785 Powered bymore_vert University of East A... arrow_drop_down University of East Anglia digital repositoryArticle . 2015 . Peer-reviewedData sources: University of East Anglia digital repositoryArchivio istituzionale della ricerca - Università di Padova; GigaScience; ZENODO; NERC Open Research Archive; Archivio istituzionale della ricerca - Università di Urbino; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2015 . Peer-reviewedLicense: Springer TDMEurope PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4473829Data sources: PubMed CentralFull-text Institutional Repository of the Ruđer Bošković InstituteContribution for newspaper or weekly magazine . 2015Bergen Open Research Archive - UiBArticle . 2015 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2015License: CC BYOnline Research Database In TechnologyArticle . 2015Data sources: Online Research Database In TechnologyArchiMer - Institutional Archive of IfremerOther literature type . 2015Data sources: ArchiMer - Institutional Archive of IfremerRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2015 . Peer-reviewedOxford University Research ArchiveOther literature type . 2016License: CC BYData sources: Oxford University Research ArchiveDokuz Eylul University Research Information SystemArticle . 2015Data sources: Dokuz Eylul University Research Information SystemMémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-UPMC; Hal-DiderotArticle . 2015License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2018 United Kingdom, Denmark, United States, United Kingdom, FrancePublisher:Cold Spring Harbor Laboratory Funded by:EC | BEAN, NSERC, UKRI | Deciphering dog domestica... +4 projectsEC| BEAN ,NSERC ,UKRI| Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach ,UKRI| Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,EC| UNDEAD ,WT| Domestic animals as a model to understand the relationship between deleterious mutations, demography and diseaseAuthors: Laurent A. F. Frantz; Anna Rudzinski; Abang Mansyursyah Surya Nugraha; Allowen Evin; +37 AuthorsLaurent A. F. Frantz; Anna Rudzinski; Abang Mansyursyah Surya Nugraha; Allowen Evin; James Burton; Ardern Hulme-Beaman; Anna Linderholm; Ross Barnett; Rodrigo Vega; Evan K. Irving-Pease; James Haile; Richard Allen; Kristin Leus; Jill M. Shephard; Mia J. Hillyer; Sarah Gillemot; Jeroen van den Hurk; Sharron Ogle; Cristina Atofanei; Mark G. Thomas; Friederike Johansson; Abdul Haris Mustari; John L. Williams; Kusdiantoro Mohamad; Chandramaya Siska Damayanti; Ita Djuwita Wiryadi; Dagmar Obbles; Hally Day; Muhammad Yasin; Stefan Meker; Jimmy A. McGuire; Ben J. Evans; Thomas von Rintelen; Simon Y. W. Ho; Jeremy B. Searle; Andrew C. Kitchener; Alastair A. Macdonald; Darren J. Shaw; Robert Hall; Peter Galbusera; Greger Larson;pmc: PMC5904307
pmid: 29643207
The high degree of endemism on Sulawesi has previously been suggested to have vicariant origins, dating back 40 Myr ago. Recent studies, however, suggest that much of Sulawesi’s fauna assembled over the last 15 Myr. Here, we test thehypothesis that more recent uplift of previously submerged portions of land onSulawesi promoted diversification, and that much of its faunal assemblage ismuch younger than the island itself. To do so, we combined palaeogeographicalreconstructions with genetic and morphometric data sets derived fromSulawesi’s three largest mammals: the Babirusa, Anoa, and Sulawesi warty pig.Our results indicate that although these species most likely colonized the areathat is now Sulawesi at different times (14 Myr ago to 2-3 Myr ago), theyexperienced an almost synchronous expansion from the central part of theisland. Geological reconstructions indicate that this area was above sea level formost of the last 4 Myr, unlike most parts of the island. We conclude thatemergence of land on Sulawesi (~1–2 Myr) may have allowed species to expandsynchronously. Altogether, our results indicate that the establishment of thehighly endemic faunal assemblage on Sulawesi was driven by geological eventsover the last few million years.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5904307Data sources: PubMed CentralbioRxivPreprint . 2018Oxford University Research Archive; Proceedings of the Royal Society B Biological SciencesOther literature type . Article . 2018 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaProceedings of the Royal Society B Biological SciencesArticle . PreprintLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/241448&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 5 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5904307Data sources: PubMed CentralbioRxivPreprint . 2018Oxford University Research Archive; Proceedings of the Royal Society B Biological SciencesOther literature type . Article . 2018 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaProceedings of the Royal Society B Biological SciencesArticle . PreprintLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/241448&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 United Kingdom, France, United KingdomPublisher:Public Library of Science (PLoS) Funded by:FWF | Genomic Patterns of Wing ..., ANR | Supergene, UKRI | Peta-5: A National Facili... +5 projectsFWF| Genomic Patterns of Wing Pattern Introgression in Heliconius ,ANR| Supergene ,UKRI| Peta-5: A National Facility for Petascale Data Intensive Computation and Analytics ,EC| SPECIATIONGENETICS ,WT ,ANR| HybEvol ,UKRI| Testing repeatability in the evolution of complex traits: the genetics of convergent structural colour ,SNSF| Genomic Patterns of Adaptive Introgression of Wing Pattern Elements in Heliconius butterfliesMarkus Moest; Steven M. Van Belleghem; Jennifer E. James; Camilo Salazar; Simon H. Martin; Sarah L. Barker; Gilson R. P. Moreira; Claire Mérot; Mathieu Joron; Nicola J. Nadeau; Florian M. Steiner; Chris D. Jiggins;pmid: 32027643
pmc: PMC7029882
Natural selection leaves distinct signatures in the genome that can reveal the targets and history of adaptive evolution. By analysing high-coverage genome sequence data from 4 major colour pattern loci sampled from nearly 600 individuals in 53 populations, we show pervasive selection on wing patterns in the Heliconius adaptive radiation. The strongest signatures correspond to loci with the greatest phenotypic effects, consistent with visual selection by predators, and are found in colour patterns with geographically restricted distributions. These recent sweeps are similar between co-mimics and indicate colour pattern turn-over events despite strong stabilising selection. Using simulations, we compare sweep signatures expected under classic hard sweeps with those resulting from adaptive introgression, an important aspect of mimicry evolution in Heliconius butterflies. Simulated recipient populations show a distinct ‘volcano’ pattern with peaks of increased genetic diversity around the selected target, characteristic of sweeps of introgressed variation and consistent with diversity patterns found in some populations. Our genomic data reveal a surprisingly dynamic history of colour pattern selection and co-evolution in this adaptive radiation. Funder: FP7 Ideas: European Research Council; funder-id: http://dx.doi.org/10.13039/100011199; Grant(s): FP7-IDEAS-ERC 339873 Funder: Isaac Newton Trust; funder-id: http://dx.doi.org/10.13039/501100004815
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7029882Data sources: PubMed CentralLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; PLoS BiologyArticle . 2020 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pbio.3000597&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 57 citations 57 popularity Top 1% influence Average impulse Top 1% Powered by BIP!visibility 58visibility views 58 download downloads 62 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7029882Data sources: PubMed CentralLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; PLoS BiologyArticle . 2020 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United Kingdom, France, France, Australia, Spain, FrancePublisher:Elsevier BV Funded by:WT | The Born in Bradford (BiB..., EC | LIFECYCLE, EC | HELIXWT| The Born in Bradford (BiB) Study an international biomedical resource for exploring genetic and early life determinants of health and development in a deprived multi-ethnic population. ,EC| LIFECYCLE ,EC| HELIXAuthors: Charline, Warembourg; Mark, Nieuwenhuijsen; Ferran, Ballester; Montserrat, de Castro; +12 AuthorsCharline, Warembourg; Mark, Nieuwenhuijsen; Ferran, Ballester; Montserrat, de Castro; Leda, Chatzi; Ana, Esplugues; Barbara, Heude; Léa, Maitre; Rosemary, McEachan; Oliver, Robinson; Rémy, Slama; Jordi, Sunyer; Jose, Urquiza; John, Wright; Xavier, Basagaña; Martine, Vrijheid;pmid: 33099063
Background: The urban environment is characterised by many exposures that may influence hypertension development from early life onwards, but there is no systematic evaluation of their impact on child blood pressure (BP). Methods: Systolic and diastolic blood pressure were measured in 4,279 children aged 4-5 years from a multi-centre European cohort (France, Greece, Spain, and UK). Urban environment exposures were estimated during pregnancy and childhood, including air pollution, built environment, natural spaces, traffic, noise, meteorology, and socioeconomic deprivation index. Single- and multiple-exposure linear regression models and a cluster analysis were carried out. Results: In multiple exposure models, higher child BP, in particular diastolic BP, was observed in association with higher exposure to air pollution, noise and ambient temperature during pregnancy, and with higher exposure to air pollution and higher building density during childhood (e.g., mean change [95% confidence interval] for an interquartile range increase in prenatal NO2 = 0.7 mmHg[0.3;1.2]). Lower BP was observed in association with higher temperature and better street connectivity during childhood (e.g., temperature = -1.1[-1.6;-0.6]). Some of these associations were not robust in the sensitivity analyses. Mother-child pairs were grouped into six urban environment exposure clusters. Compared to the cluster representing the least harmful urban environment, the two clusters representing the most harmful environment (high in air pollution, traffic, noise, and low in green space) were both associated with higher diastolic BP (1.3[0.1;2.6] and 1.5[0.5;2.5]). Conclusion: This first large systematic study suggests that living in a harmful urban environment may impact BP regulation in children. These findings reinforce the importance of designing cities that promote healthy environments to reduce long-term risk of hypertension and other cardiovascular diseases. This work was supported by funding from the European Community’s Seventh Framework Programme [FP7/2007–206 n°308333; the HELIX project], and by the European Union’s Horizon 2020 research and innovation programme [H2020 n°733206; the LifeCycle project]. CW holds a Sara Borrell fellowship from the Instituto de Salud Carlos III [CD18/00132]. INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya- CIRIT (Spain). The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). The work was also supported by MICINN [MTM2015-68140-R] and Centro Nacional de Genotipado- CEGEN- PRB2- ISCIII (Spain). This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber (UK). Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597MA, UK). The EDEN study was supported by Foundation for medical research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A), and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programmes (ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l’Education Nationale a complementary health insurance (MGEN), French national agency for food security, French-speaking association for the study of diabetes and metabolism (ALFEDIAM).
ACU Research Bank arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BY NC NDData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAEnvironment InternationalOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMHAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!download 22download downloads 22 Powered bymore_vert ACU Research Bank arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BY NC NDData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAEnvironment InternationalOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMHAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2012 Switzerland, Netherlands, France, FrancePublisher:Public Library of Science (PLoS) Funded by:SNSF | The SAPALDIA II Cohort St..., SNSF | The SAPALDIA II Cohort St..., SNSF | SAPALDIA COHORT STUDY: Im... +9 projectsSNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| Swiss study on air pollution and lung diseases in adults (SAPALDIA study) ,SNSF| Gene-environment interactions in the Etiology of Chronic Obstructive Pulmonary Disease (COPD); the SAPALDIA Biobank ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension. ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis. ,SNSF| SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases. ,SNSF| SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis ,WT| A second-generation genome-wide association study for asthma.Ivan Curjuric; Medea Imboden; Rachel Nadif; Ashok Kumar; Christian Schindler; Margot Haun; Florian Kronenberg; Nino Künzli; Harish C. Phuleria; Dirkje S. Postma; Erich W. Russi; Thierry Rochat; Florence Demenais; Nicole Probst-Hensch;pmc: PMC3391223
pmid: 22792237
Background: Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes.Objectives: We studied the interaction of both exposures with a broad set of oxidative-stress related candidate genes and pathways on lung function decline and contrasted interactions between exposures.Methods: For 12679 single nucleotide polymorphisms (SNP5), change in forced expiratory volume in one second (FEV1), FEV1 over forced vital capacity (FEV1/FVC), and mean forced expiratory flow between 25 and 75% of the FVC (FEF25-75) was regressed on interval exposure to particulate matter <10 mu m in diameter (PM10) or packyears smoked (a), additive SNP effects (b), and interaction terms between (a) and (b) in 669 adults with GWAS data. Interaction p-values for 152 genes and 14 pathways were calculated by the adaptive rank truncation product (ARTP) method, and compared between exposures. Interaction effect sizes were contrasted for the strongest SNPs of nominally significant genes (p(interaction) <0.05). Replication was attempted for SNPs with MAF > 10% in 3320 SAPALDIA participants without GWAS.Results: On the SNP-level, rs2035268 in gene SNCA accelerated FEV1/FVC decline by 3.8% (p(interaction) = 2.5 x 10(-6)), and rs12190800 in PARK2 attenuated FEV1 decline by 95.1 ml p(interaction) = 9.7 x 10(-8)) over 11 years, while interacting with PM10. Genes and pathways nominally interacting with PM10 and packyears exposure differed substantially. Gene CRISP2 presented a significant interaction with PM10 (p(interaction) = 3.0 x 10(-4)) on FEV1/FVC decline. Pathway interactions were weak. Replications for the strongest SNPs in PARK2 and CRISP2 were not successful.Conclusions: Consistent with a stratified response to increasing oxidative stress, different genes and pathways potentially mediate PM10 and tobacco smoke effects on lung function decline. Ignoring environmental exposures would miss these patterns, but achieving sufficient sample size and comparability across study samples is challenging.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3391223Data sources: PubMed CentralNARCISArticle . 2012Full-Text: https://pure.rug.nl/ws/files/48876890/Curjuric_2012_Different_genes_interact_with_parti.pdfData sources: NARCISHAL-Inserm; Hal-DiderotArticle . 2012add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 45 citations 45 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3391223Data sources: PubMed CentralNARCISArticle . 2012Full-Text: https://pure.rug.nl/ws/files/48876890/Curjuric_2012_Different_genes_interact_with_parti.pdfData sources: NARCISHAL-Inserm; Hal-DiderotArticle . 2012add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 FrancePublisher:Elsevier BV Funded by:WT | Multi-species transmissio...WT| Multi-species transmission of Echinococcus on the Tibetan Plateau.Marston, CG; Giraudoux, P; Armitage, RP; Danson, FM; Reynolds, SC; Wang, Q; Qiu, J; Craig, PS;International audience; Echinococcus multilocularis (Em), a parasitic tapeworm, is responsible for a significant burden of human disease across continental Asia. Here, we use a time-series of MODIS 16-day 250 m Enhanced Vegetation Index (EVI) satellite data to quantify the seasonal vegetation dynamics across a study area in Serxu County, Sichuan Province, China, in relation to the presence of the Em intermediate host Ochotona curzoniae (plateau pika) and Ochotona cansus (Gansu pika) (here merged to Ochotona spp.). A series of derived phenological metrics are analysed using the random forests statistical method to determine the relative importance of seasonal vegetation characteristics. Results indicate negative relationships between Ochotona spp. presence and EVI showing a preference for low-biomass habitats. However, EVI values during green-up and senescence periods are also shown to be important, potentially resulting from improved detectability of low-biomass grassland habitats at these times. Improved detection of Ochotona spp. preferred habitats via time-series EVI imagery offers better understanding of the distributions of this Em host, and the potential for monitoring the changes in Ochotona spp. optimal habitat distributions resulting from landscape change. This could aid the identification of villages at increased risk of infection, enabling preventive strategies to be adopted.
CORE (RIOXX-UK Aggre... arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 8 citations 8 popularity Average influence Average impulse Top 10% Powered by BIP!visibility 2visibility views 2 download downloads 107 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rse.2016.02.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 Italy, France, Italy, United Kingdom, Spain, Netherlands, AustraliaPublisher:Elsevier BV Funded by:WT | Life course inequalities ..., EC | ESCAPE, WTWT| Life course inequalities in asthma: estimating its burden and understanding its aetiology. ,EC| ESCAPE ,WTSofia Temam; Emilie Burte; Martin Adam; Josep M. Antó; Xavier Basagaña; Jean Bousquet; Anne-Elie Carsin; Bruna Galobardes; Dirk Keidel; Nino Künzli; Nicole Le Moual; Margaux Sanchez; Jordi Sunyer; Roberto Bono; Bert Brunekreef; Joachim Heinrich; Kees de Hoogh; Deborah Jarvis; Alessandro Marcon; Lars Modig; Rachel Nadif; Mark J. Nieuwenhuijsen; Isabelle Pin; Valérie Siroux; Morgane Stempfelet; Ming-Yi Tsai; Nicole Probst-Hensch; Bénédicte Jacquemin;handle: 2318/1621048 , 1874/360387 , 11562/961836
Background: Inconsistent associations between socioeconomic position (SEP) and outdoor air pollution have been reported in Europe, but methodological differences prevent any direct between-study comparison. Objectives: Assess and compare the association between SEP and outdoor nitrogen dioxide (NO2) exposure as a marker of traffic exhaust, in 16 cities from eight Western European countries. Methods: Three SEP indicators, two defined at individual-level (education and occupation) and one at neighborhood-level (unemployment rate) were assessed in three European multicenter cohorts. NO2 annual concentration exposure was estimated at participants' addresses with land use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE; http://www.escapeproject.eu/). Pooled and city-specific linear regressions were used to analyze associations between each SEP indicator and NO2. Heterogeneity across cities was assessed using the Higgins' I-squared test (I2). Results: The study population included 5692 participants. Pooled analysis showed that participants with lower individual-SEP were less exposed to NO2. Conversely, participants living in neighborhoods with higher unemployment rate were more exposed. City-specific results exhibited strong heterogeneity (I2 > 76% for the three SEP indicators) resulting in variation of the individual- and neighborhood-SEP patterns of NO2 exposure across cities. The coefficients from a model that included both individual- and neighborhood-SEP indicators were similar to the unadjusted coefficients, suggesting independent associations. Conclusions: Our study showed for the first time using homogenized measures of outcome and exposure across 16 cities the important heterogeneity regarding the association between SEP and NO2 in Western Europe. Importantly, our results showed that individual- and neighborhood-SEP indicators capture different aspects of the association between SEP and exposure to air pollution, stressing the importance of considering both in air pollution health effects studies. The ESCAPE study, funded by the European Community's Seventh Framework Program (FP7/2007-2011) under grant agreement no. 211250 (http://www.escapeproject.eu/).
Archivio Istituziona... arrow_drop_down IRIS - Università degli Studi di Verona; Environment InternationalArticle . 2017 . Peer-reviewedLicense: Elsevier TDMSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryNARCIS; Utrecht University RepositoryArticle . 2017IRIS - Università degli Studi di VeronaArticle . 2017Data sources: IRIS - Università degli Studi di VeronaMémoires en Sciences de l'Information et de la CommunicationArticle . 2017Full-Text: https://hal.science/hal-01784629/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 5visibility views 5 download downloads 101 Powered bymore_vert Archivio Istituziona... arrow_drop_down IRIS - Università degli Studi di Verona; Environment InternationalArticle . 2017 . Peer-reviewedLicense: Elsevier TDMSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryNARCIS; Utrecht University RepositoryArticle . 2017IRIS - Università degli Studi di VeronaArticle . 2017Data sources: IRIS - Università degli Studi di VeronaMémoires en Sciences de l'Information et de la CommunicationArticle . 2017Full-Text: https://hal.science/hal-01784629/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Spain, Spain, Spain, Netherlands, France, France, Australia, FrancePublisher:Elsevier BV Funded by:WT | The Born in Bradford (BiB..., NIH | Effects of DDE exposure o..., NIH | Pilot Project Program +6 projectsWT| The Born in Bradford (BiB) Study an international biomedical resource for exploring genetic and early life determinants of health and development in a deprived multi-ethnic population. ,NIH| Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals ,NIH| Pilot Project Program ,NIH| Hepatotoxic effects of perfluoroalkyl substances: a new epidemiological approach for studying environmental fatty liver disease ,EC| EUCAN-Connect ,NIH| Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in Youth ,NHMRC| An evaluation of bone density screening in premenopausal women ,EC| DENAMIC ,EC| HELIXAuthors: Binter, Anne-Claire; Bernard, Jonathan Y.; Mon-Williams, Mark; Andiarena, Ainara; +15 AuthorsBinter, Anne-Claire; Bernard, Jonathan Y.; Mon-Williams, Mark; Andiarena, Ainara; González-Safont, Llúcia; Vafeiadi, Marina; Lepeule, Johanna; Soler-Blasco, Raquel; Alonso, Lucia; Kampouri, Mariza; Mceachan, Rosie; Santa-Marina, Loreto; Wright, John; Chatzi, Leda; Sunyer, Jordi; Philippat, Claire; Nieuwenhuijsen, Mark; Vrijheid, Martine; Guxens, Mònica;Acknowledgements We are grateful to all the participating children, parents, practi-tioners and researchers in the four countries who took part in this study. This work was supported by funding from the European Community's Seventh Framework Programme [FP7/2007-206 n 308333; the HELIX project] . This INMA cohort was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds, FIS PI06/0867, FIS-PI09/00090, FIS and FIS-PI18/01142 incl. FEDER funds, FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI16/00118 and PI17/00663; FIS-FSE: 17/00260; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, and CPII18/00018) , from UE (FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, and H2020 n 824989) , Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundacio La marato de TV3 (090430) , Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249) , Alicia Koplowitz Foundation 2017, CIBERESP, Department of Health of the Basque Government (2013111089, 2009111069, 2013111089, 2015111065 and 2018111086) , Provincial Government of Gipuzkoa (DFG06/002, DFG08/001, DFG15/221 and DFG 89/17) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain) . We acknowledge support from the Spanish Ministry of Science and Inno-vation and the State Research Agency through the "Centro de Excelencia Severo Ochoa 2019-2023" Program (CEX2018-000806-S) , and support from the Generalitat de Catalunya through the CERCA Program. The work was also supported by MICINN [MTM2015-68140-R] and Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII (Spain) . The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; "Rhea Plus": Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15) . This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber (UK) . The EDEN study was supported by Foundation for medical research (FRM) , National Agency for Research (ANR) , National Institute for Research inPublic health (IRESP: TGIR cohorte sante 2008 program) , French Min-istry of Health (DGS) , French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) , and Human Nutrition Na-tional Research Programs, Paris-Sud University, Nestle, French National Institute for Population Health Surveillance (InVS) , French National Institute for Health Education (INPES) , the European Union FP7 pro-grams (ESCAPE, ENRIECO, Medall projects) , Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD) ) , French Agency for Environmental Health Safety and French National Agency for Food Security (now ANSES) , Mutuelle Generale de l'Education Nationale a complementary health insurance (MGEN) , French-speaking association for the study of diabetes and metabolism (ALFEDIAM) . Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597MA, UK) . Born in Bradford (BiB) is only possible because of the enthusiasm and commitment of the children and parents in BiB. We are grateful to all the participants, health professionals, schools and researchers who have made BiB happen. BiB receives funding from the ESRC/MRC, the Wellcome Trust (WT101597MA) and the National Institute for Health Research York-shire and Humber ARC (reference: NIHR20016) . M. Mon-Williams was supported by a Fellowship from the Alan Turing Institute. Additional funding from the National Institute of Environmental Health Science supported Dr Chatzi (R01ES030691, R01ES029944, R01ES030364, R21ES029681, and P30ES007048) . The views expressed are those of the authors, and not necessarily those of the NHS or the NIHR. None of the funders were involved in designing the study, collecting the data, analyzing or interpreting the data, deciding to submit the article for publication, or the writing of the report. Data sharing statement The HELIX data warehouse has been established as an accessible resource for collaborative research involving researchers external to the project. Access to HELIX data is based on approval by the HELIX Project Executive Committee and by the individual cohorts. Further details on the content of the data warehouse (data catalogue) and procedures for external access are described on the project website (http:// www.proj-ecthelix.eu/index.php/es/data-inventory) . [EN]Background: The urban environment may influence neurodevelopment from conception onwards, but there is no evaluation of the impact of multiple groups of exposures simultaneously. We investigated the association between early-life urban environment and cognitive and motor function in children. Methods: We used data from 5403 mother-child pairs from four population-based birth-cohorts (UK, France, Spain, and Greece). We estimated thirteen urban home exposures during pregnancy and childhood, including: built environment, natural spaces, and air pollution. Verbal, non-verbal, gross motor, and fine motor functions were assessed using validated tests at five years old. We ran adjusted multi-exposure models using the Deletion-Substitution-Addition algorithm. Results: Higher greenness exposure within 300 m during pregnancy was associated with higher verbal abilities (1.5 points (95% confidence interval 0.4, 2.7) per 0.20 unit increase in greenness). Higher connectivity density within 100 m and land use diversity during pregnancy were related to lower verbal abilities. Childhood exposure to PM2.5 mediated 74% of the association between greenness during childhood and verbal abilities. Higher exposure to PM2.5 during pregnancy was related to lower fine motor function (-1.2 points (-2.1, -0.4) per 3.2 mu g/m3 increase in PM2.5). No associations were found with non-verbal abilities and gross motor function. Discussion: This study suggests that built environment, greenness, and air pollution may impact child cognitive and motor function at five years old. This study adds evidence that well-designed urban planning may benefit children's cognitive and motor development.
ACU Research Bank arrow_drop_down HAL-Rennes 1; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDFull-Text: https://hal.science/hal-03480282/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert ACU Research Bank arrow_drop_down HAL-Rennes 1; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDFull-Text: https://hal.science/hal-03480282/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 Serbia, FrancePublisher:Public Library of Science (PLoS) Funded by:UKRI | Technologies for the Futu..., EC | BIRTH, UKRI | Core Capability - Univers... +4 projectsUKRI| Technologies for the Future ,EC| BIRTH ,UKRI| Core Capability - University of York ,EC| NEOMILK ,WT ,EC| LIPDAT ,WT| A plaque on both your houses: Exploring the history of urbanisation and infectious diseases through the study of archaeological dental tartar.Darko Stojanovski; Ivana Živaljević; Vesna Dimitrijević; Julie Dunne; Richard P. Evershed; Marie Balasse; Adam Dowle; Jessica Hendy; Krista McGrath; Roman Fischer; Camilla Speller; Jelena Jovanović; Emmanuelle Casanova; Timothy D J Knowles; Lidija Balj; Goce Naumov; Anđelka Putica; Andrej Starović; Sofija Stefanović;International audience; The application of biomolecular techniques to archaeological materials from the Balkans is providing valuable new information on the prehistory of the region. This is especially relevant for the study of the neolithisation process in SE Europe, which gradually affected the rest of the continent. Here, to answer questions regarding diet and subsistence practices in early farming societies in the central Balkans, we combine organic residue analyses of archaeological pottery, taxonomic and isotopic study of domestic animal remains and biomolecular analyses of human dental calculus. The results from the analyses of the lipid residues from pottery suggest that milk was processed in ceramic vessels. Dairy products were shown to be part of the subsistence strategies of the earliest Neolithic communities in the region but were of varying importance in different areas of the Balkan. Conversely, milk proteins were not detected within the dental calculus. The molecular and isotopic identification of meat, dairy, plants and beeswax in the pottery lipids also provided insights into the diversity of diet in these early Neolithic communities, mainly based on terrestrial resources. We also present the first compound-specific radiocarbon dates for the region, obtained directly from absorbed organic residues extracted from pottery, identified as dairy lipids.
CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7444498Data sources: PubMed CentralREFF - University of Belgrade - Faculty of PhilosophyArticle . 2020License: CC BYData sources: REFF - University of Belgrade - Faculty of PhilosophyMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-03028798/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 23 citations 23 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 11visibility views 11 download downloads 17 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7444498Data sources: PubMed CentralREFF - University of Belgrade - Faculty of PhilosophyArticle . 2020License: CC BYData sources: REFF - University of Belgrade - Faculty of PhilosophyMémoires en Sciences de l'Information et de la CommunicationArticle . 2020Full-Text: https://hal.science/hal-03028798/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 United Kingdom, France, Italy, Switzerland, Spain, Italy, France, Germany, SwedenPublisher:MDPI AG Funded by:SNSF | SAPALDIA COHORT STUDY: Im..., SNSF | The SAPALDIA II Cohort St..., SNSF | Swiss Cohort Study on Air... +11 projectsSNSF| SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,EC| EXPOSOMICS ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension. ,WT| A second-generation genome-wide association study for asthma. ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis. ,SNSF| SAPALDIA Cohort on Healthy Aging ,SNSF| SAPALDIA 5 - Cohort on Healthy Aging ,EC| ESCAPE ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases. ,SNSF| SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysisDirk Keidel; Josep M. Antó; Xavier Basagaña; Roberto Bono; Emilie Burte; Anne-Elie Carsin; Bertil Forsberg; Elaine Fuertes; Bruna Galobardes; Joachim Heinrich; Kees de Hoogh; Deborah Jarvis; Nino Künzli; Bénédicte Leynaert; Alessandro Marcon; Nicole Le Moual; Audrey de Nazelle; Christian Schindler; Valérie Siroux; Morgane Stempfelet; Jordi Sunyer; Sofia Temam; Ming-Yi Tsai; Raphaëlle Varraso; Bénédicte Jacquemin; Nicole Probst-Hensch;pmc: PMC6603717
pmid: 31146441
Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated with both air pollution exposure and respiratory function. This study assesses the role of SES either as confounder or effect modifier of the association between ambient air pollution and lung function. Cross-sectional data from three European multicenter adult cohorts were pooled to assess factors associated with lung function, including annual means of home outdoor NO2. Pre-bronchodilator lung function was measured according to the ATS-criteria. Multiple mixed linear models with random intercepts for study areas were used. Three different factors (education, occupation and neighborhood unemployment rate) were considered to represent SES. NO2 exposure was negatively associated with lung function. Occupation and neighborhood unemployment rates were not associated with lung function. However, the inclusion of the SES-variable education improved the models and the air pollution-lung function associations got slightly stronger. NO2 associations with lung function were not substantially modified by SES-variables. In this multicenter European study we could show that SES plays a role as a confounder in the association of ambient NO2 exposure with lung function. SAPALDIA Research support: The Swiss National Science Foundation (grants no 33CS30-177506/1, 33CS30-148470/1&2, 33CSCO-134276/1, 33CSCO-108796, 324730_135673, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099, PMPDP3_129021/1, PMPDP3_141671/1), the Federal Office for the Environment, the Federal Office of Public Health, the Federal Office of Roads and Transport, the canton’s government of Aargau, Basel-Stadt, Basel-Land, Geneva, Luzern, Ticino, Valais, and Zürich, the Swiss Lung League, the canton’s Lung League of Basel Stadt/ Basel Landschaft, Geneva, Ticino, Valais, Graubünden and Zurich, Stiftung ehemals Bündner Heilstätten, SUVA, Freiwillige Akademische Gesellschaft, UBS Wealth Foundation, Talecris Biotherapeutics GmbH, Abbott Diagnostics, Klinik Barmelweid, Hirslanden Klinik Aarau, European Commission 018996 (GABRIEL), Wellcome Trust WT 084703MA, Exposomics EC FP7 grant(Grant agreement No: 308610).
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); International Journal of Environmental Research and Public Health; IRIS - Università degli Studi di VeronaOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/1660-4601/16/11/1901/pdfEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6603717Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticle . 2019Data sources: DOAJ-ArticlesPublication Server of Helmholtz Zentrum München (PuSH)Article . 2019Data sources: Publication Server of Helmholtz Zentrum München (PuSH)IRIS - Università degli Studi di VeronaArticle . 2019Data sources: IRIS - Università degli Studi di VeronaHAL-Inserm; Hal-DiderotArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 1visibility views 1 download downloads 9 Powered bymore_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); International Journal of Environmental Research and Public Health; IRIS - Università degli Studi di VeronaOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/1660-4601/16/11/1901/pdfEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6603717Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticle . 2019Data sources: DOAJ-ArticlesPublication Server of Helmholtz Zentrum München (PuSH)Article . 2019Data sources: Publication Server of Helmholtz Zentrum München (PuSH)IRIS - Università degli Studi di VeronaArticle . 2019Data sources: IRIS - Università degli Studi di VeronaHAL-Inserm; Hal-DiderotArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Contribution for newspaper or weekly magazine 2015 Denmark, United Kingdom, Italy, Portugal, United Kingdom, Italy, United Kingdom, Norway, Italy, Turkey, Spain, Germany, Croatia, Croatia, Italy, Spain, Italy, Portugal, France, United KingdomPublisher:Oxford University Press (OUP) Publicly fundedFunded by:EC | CITCLOPS, WT, EC | MICRO B3EC| CITCLOPS ,WT ,EC| MICRO B3Anna Kopf; Mesude Bicak; Renzo Kottmann; Julia Schnetzer; Ivaylo Kostadinov; Katja Lehmann; Antonio Fernandez-Guerra; Christian Jeanthon; Eyal Rahav; Matthias S. Ullrich; Antje Wichels; Gunnar Gerdts; Paraskevi N. Polymenakou; Georgios Kotoulas; Rania Siam; Rehab Z. Abdallah; Eva C. Sonnenschein; Thierry Cariou; Fergal O'Gara; Stephen A. Jackson; Sandi Orlić; Michael Steinke; Julia A. Busch; Bernardo Duarte; Isabel Caçador; João Canning-Clode; Oleksandra Bobrova; Viggo Marteinsson; Eyjólfur Reynisson; Clara Loureiro; Gian Marco Luna; Grazia Marina Quero; Carolin R. Löscher; Anke Kremp; Marie E. DeLorenzo; Lise Øvreås; Jennifer Tolman; Julie LaRoche; Antonella Penna; Marc E. Frischer; Timothy W. Davis; Barker Katherine; Christopher P. Meyer; Sandra Ramos; Catarina Magalhães; Florence Jude-Lemeilleur; Ma. Leopoldina Aguirre-Macedo; Shiao Y. Wang; Nicole J. Poulton; Scott Jones; Rachel Collin; Jed A. Fuhrman; Pascal Conan; Cecilia Alonso; Noga Stambler; Kelly D. Goodwin; Michail M. Yakimov; Federico Baltar; Levente Bodrossy; Jodie van de Kamp; Dion Matthew Frederick Frampton; Martin Ostrowski; Paul D. van Ruth; Paul Malthouse; Simon Claus; Klaas Deneudt; J. Mortelmans; Sophie Pitois; David Wallom; Ian Salter; Rodrigo Costa; Declan C. Schroeder; Mahrous M. Kandil; Valentina Amaral; Florencia Biancalana; Rafael Santana; Maria Luiza Pedrotti; Takashi Yoshida; Hiroyuki Ogata; Tim Ingleton; Kate Munnik; Naiara Rodríguez-Ezpeleta; Véronique Berteaux-Lecellier; Patricia Wecker; Ibon Cancio; Daniel Vaulot; Christina Bienhold; Hassan Ghazal; Bouchra Chaouni; Soumya Essayeh; Sara Ettamimi; El Houcine Zaid; Noureddine Boukhatem; Abderrahim Bouali; Rajaa Chahboune; Said Barrijal; Mohammed Timinouni; Fatima El Otmani; Mohamed Bennani; Marianna Mea; Nadezhda Todorova; Ventzislav Karamfilov; Petra ten Hoopen; Guy Cochrane; Stéphane L'Haridon; Kemal Can Bizsel; Alessandro Vezzi; Federico M. Lauro; Patrick Martin; Rachelle M. Jensen; Jamie Hinks; Susan Gebbels; Riccardo Rosselli; Fabio De Pascale; Riccardo Schiavon; Antonina Dos Santos; Emilie Villar; Stephane Pesant; Bruno Cataletto; Francesca Malfatti; Ranjith Edirisinghe; Jorge A. Herrera Silveira; Michèle Barbier; Valentina Turk; Tinkara Tinta; Wayne J. Fuller; Ilkay Salihoglu; Nedime Serakinci; Mahmut Cerkez Ergoren; Eileen Bresnan; Juan Iriberri; Paul Anders Fronth Nyhus; Edvardsen Bente; Hans Erik Karlsen; Peter N. Golyshin; Josep M. Gasol; Snejana Moncheva; Nina Dzhembekova; Zackary I. Johnson; Christopher D. Sinigalliano; Maribeth L. Gidley; Adriana Zingone; Roberto Danovaro; Georgios Tsiamis; Melody S. Clark; Ana C. Costa; Monia El Bour; Ana Martins; R. Eric Collins; Anne-Lise Ducluzeau; Jonathan A. Martinez; Mark J. Costello; Linda A. Amaral-Zettler; Jack A. Gilbert; Neil M Davies; Dawn Field; Frank Oliver Glöckner;pmc: PMC4473829
pmid: 26097697
Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits This work was supported by the Micro B3 project, which is funded from the European Union’s Seventh Framework Programme (FP7; Joint Call OCEAN.2011‐2: Marine microbial diversity – new insights into marine ecosystems functioning and its biotechnological potential) under the grant agreement no 287589 Kopf, Anna ... et. al.-- 5 pages, 1 figure.-- This manuscript is NOAA-GLERL contribution number 1763 Peer Reviewed
University of East A... arrow_drop_down University of East Anglia digital repositoryArticle . 2015 . Peer-reviewedData sources: University of East Anglia digital repositoryArchivio istituzionale della ricerca - Università di Padova; GigaScience; ZENODO; NERC Open Research Archive; Archivio istituzionale della ricerca - Università di Urbino; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2015 . Peer-reviewedLicense: Springer TDMEurope PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4473829Data sources: PubMed CentralFull-text Institutional Repository of the Ruđer Bošković InstituteContribution for newspaper or weekly magazine . 2015Bergen Open Research Archive - UiBArticle . 2015 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2015License: CC BYOnline Research Database In TechnologyArticle . 2015Data sources: Online Research Database In TechnologyArchiMer - Institutional Archive of IfremerOther literature type . 2015Data sources: ArchiMer - Institutional Archive of IfremerRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2015 . Peer-reviewedOxford University Research ArchiveOther literature type . 2016License: CC BYData sources: Oxford University Research ArchiveDokuz Eylul University Research Information SystemArticle . 2015Data sources: Dokuz Eylul University Research Information SystemMémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-UPMC; Hal-DiderotArticle . 2015License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 172 citations 172 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 1Kvisibility views 1,015 download downloads 785 Powered bymore_vert University of East A... arrow_drop_down University of East Anglia digital repositoryArticle . 2015 . Peer-reviewedData sources: University of East Anglia digital repositoryArchivio istituzionale della ricerca - Università di Padova; GigaScience; ZENODO; NERC Open Research Archive; Archivio istituzionale della ricerca - Università di Urbino; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2015 . Peer-reviewedLicense: Springer TDMEurope PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4473829Data sources: PubMed CentralFull-text Institutional Repository of the Ruđer Bošković InstituteContribution for newspaper or weekly magazine . 2015Bergen Open Research Archive - UiBArticle . 2015 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Universidade de Lisboa: Repositório.ULOther literature type . Article . 2015License: CC BYOnline Research Database In TechnologyArticle . 2015Data sources: Online Research Database In TechnologyArchiMer - Institutional Archive of IfremerOther literature type . 2015Data sources: ArchiMer - Institutional Archive of IfremerRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2015 . Peer-reviewedOxford University Research ArchiveOther literature type . 2016License: CC BYData sources: Oxford University Research ArchiveDokuz Eylul University Research Information SystemArticle . 2015Data sources: Dokuz Eylul University Research Information SystemMémoires en Sciences de l'Information et de la Communication; HAL AMU; HAL-UPMC; Hal-DiderotArticle . 2015License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2018 United Kingdom, Denmark, United States, United Kingdom, FrancePublisher:Cold Spring Harbor Laboratory Funded by:EC | BEAN, NSERC, UKRI | Deciphering dog domestica... +4 projectsEC| BEAN ,NSERC ,UKRI| Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach ,UKRI| Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach ,WT| Human Adaptation to Changing Diet and Infectious Disease Loads, from the Origins of Agriculture to the Present. ,EC| UNDEAD ,WT| Domestic animals as a model to understand the relationship between deleterious mutations, demography and diseaseAuthors: Laurent A. F. Frantz; Anna Rudzinski; Abang Mansyursyah Surya Nugraha; Allowen Evin; +37 AuthorsLaurent A. F. Frantz; Anna Rudzinski; Abang Mansyursyah Surya Nugraha; Allowen Evin; James Burton; Ardern Hulme-Beaman; Anna Linderholm; Ross Barnett; Rodrigo Vega; Evan K. Irving-Pease; James Haile; Richard Allen; Kristin Leus; Jill M. Shephard; Mia J. Hillyer; Sarah Gillemot; Jeroen van den Hurk; Sharron Ogle; Cristina Atofanei; Mark G. Thomas; Friederike Johansson; Abdul Haris Mustari; John L. Williams; Kusdiantoro Mohamad; Chandramaya Siska Damayanti; Ita Djuwita Wiryadi; Dagmar Obbles; Hally Day; Muhammad Yasin; Stefan Meker; Jimmy A. McGuire; Ben J. Evans; Thomas von Rintelen; Simon Y. W. Ho; Jeremy B. Searle; Andrew C. Kitchener; Alastair A. Macdonald; Darren J. Shaw; Robert Hall; Peter Galbusera; Greger Larson;pmc: PMC5904307
pmid: 29643207
The high degree of endemism on Sulawesi has previously been suggested to have vicariant origins, dating back 40 Myr ago. Recent studies, however, suggest that much of Sulawesi’s fauna assembled over the last 15 Myr. Here, we test thehypothesis that more recent uplift of previously submerged portions of land onSulawesi promoted diversification, and that much of its faunal assemblage ismuch younger than the island itself. To do so, we combined palaeogeographicalreconstructions with genetic and morphometric data sets derived fromSulawesi’s three largest mammals: the Babirusa, Anoa, and Sulawesi warty pig.Our results indicate that although these species most likely colonized the areathat is now Sulawesi at different times (14 Myr ago to 2-3 Myr ago), theyexperienced an almost synchronous expansion from the central part of theisland. Geological reconstructions indicate that this area was above sea level formost of the last 4 Myr, unlike most parts of the island. We conclude thatemergence of land on Sulawesi (~1–2 Myr) may have allowed species to expandsynchronously. Altogether, our results indicate that the establishment of thehighly endemic faunal assemblage on Sulawesi was driven by geological eventsover the last few million years.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5904307Data sources: PubMed CentralbioRxivPreprint . 2018Oxford University Research Archive; Proceedings of the Royal Society B Biological SciencesOther literature type . Article . 2018 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaProceedings of the Royal Society B Biological SciencesArticle . PreprintLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 5 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5904307Data sources: PubMed CentralbioRxivPreprint . 2018Oxford University Research Archive; Proceedings of the Royal Society B Biological SciencesOther literature type . Article . 2018 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaProceedings of the Royal Society B Biological SciencesArticle . PreprintLicense: CC BYData sources: UnpayWalladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 United Kingdom, France, United KingdomPublisher:Public Library of Science (PLoS) Funded by:FWF | Genomic Patterns of Wing ..., ANR | Supergene, UKRI | Peta-5: A National Facili... +5 projectsFWF| Genomic Patterns of Wing Pattern Introgression in Heliconius ,ANR| Supergene ,UKRI| Peta-5: A National Facility for Petascale Data Intensive Computation and Analytics ,EC| SPECIATIONGENETICS ,WT ,ANR| HybEvol ,UKRI| Testing repeatability in the evolution of complex traits: the genetics of convergent structural colour ,SNSF| Genomic Patterns of Adaptive Introgression of Wing Pattern Elements in Heliconius butterfliesMarkus Moest; Steven M. Van Belleghem; Jennifer E. James; Camilo Salazar; Simon H. Martin; Sarah L. Barker; Gilson R. P. Moreira; Claire Mérot; Mathieu Joron; Nicola J. Nadeau; Florian M. Steiner; Chris D. Jiggins;pmid: 32027643
pmc: PMC7029882
Natural selection leaves distinct signatures in the genome that can reveal the targets and history of adaptive evolution. By analysing high-coverage genome sequence data from 4 major colour pattern loci sampled from nearly 600 individuals in 53 populations, we show pervasive selection on wing patterns in the Heliconius adaptive radiation. The strongest signatures correspond to loci with the greatest phenotypic effects, consistent with visual selection by predators, and are found in colour patterns with geographically restricted distributions. These recent sweeps are similar between co-mimics and indicate colour pattern turn-over events despite strong stabilising selection. Using simulations, we compare sweep signatures expected under classic hard sweeps with those resulting from adaptive introgression, an important aspect of mimicry evolution in Heliconius butterflies. Simulated recipient populations show a distinct ‘volcano’ pattern with peaks of increased genetic diversity around the selected target, characteristic of sweeps of introgressed variation and consistent with diversity patterns found in some populations. Our genomic data reveal a surprisingly dynamic history of colour pattern selection and co-evolution in this adaptive radiation. Funder: FP7 Ideas: European Research Council; funder-id: http://dx.doi.org/10.13039/100011199; Grant(s): FP7-IDEAS-ERC 339873 Funder: Isaac Newton Trust; funder-id: http://dx.doi.org/10.13039/501100004815
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7029882Data sources: PubMed CentralLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; PLoS BiologyArticle . 2020 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pbio.3000597&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 57 citations 57 popularity Top 1% influence Average impulse Top 1% Powered by BIP!visibility 58visibility views 58 download downloads 62 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7029882Data sources: PubMed CentralLAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; PLoS BiologyArticle . 2020 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pbio.3000597&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United Kingdom, France, France, Australia, Spain, FrancePublisher:Elsevier BV Funded by:WT | The Born in Bradford (BiB..., EC | LIFECYCLE, EC | HELIXWT| The Born in Bradford (BiB) Study an international biomedical resource for exploring genetic and early life determinants of health and development in a deprived multi-ethnic population. ,EC| LIFECYCLE ,EC| HELIXAuthors: Charline, Warembourg; Mark, Nieuwenhuijsen; Ferran, Ballester; Montserrat, de Castro; +12 AuthorsCharline, Warembourg; Mark, Nieuwenhuijsen; Ferran, Ballester; Montserrat, de Castro; Leda, Chatzi; Ana, Esplugues; Barbara, Heude; Léa, Maitre; Rosemary, McEachan; Oliver, Robinson; Rémy, Slama; Jordi, Sunyer; Jose, Urquiza; John, Wright; Xavier, Basagaña; Martine, Vrijheid;pmid: 33099063
Background: The urban environment is characterised by many exposures that may influence hypertension development from early life onwards, but there is no systematic evaluation of their impact on child blood pressure (BP). Methods: Systolic and diastolic blood pressure were measured in 4,279 children aged 4-5 years from a multi-centre European cohort (France, Greece, Spain, and UK). Urban environment exposures were estimated during pregnancy and childhood, including air pollution, built environment, natural spaces, traffic, noise, meteorology, and socioeconomic deprivation index. Single- and multiple-exposure linear regression models and a cluster analysis were carried out. Results: In multiple exposure models, higher child BP, in particular diastolic BP, was observed in association with higher exposure to air pollution, noise and ambient temperature during pregnancy, and with higher exposure to air pollution and higher building density during childhood (e.g., mean change [95% confidence interval] for an interquartile range increase in prenatal NO2 = 0.7 mmHg[0.3;1.2]). Lower BP was observed in association with higher temperature and better street connectivity during childhood (e.g., temperature = -1.1[-1.6;-0.6]). Some of these associations were not robust in the sensitivity analyses. Mother-child pairs were grouped into six urban environment exposure clusters. Compared to the cluster representing the least harmful urban environment, the two clusters representing the most harmful environment (high in air pollution, traffic, noise, and low in green space) were both associated with higher diastolic BP (1.3[0.1;2.6] and 1.5[0.5;2.5]). Conclusion: This first large systematic study suggests that living in a harmful urban environment may impact BP regulation in children. These findings reinforce the importance of designing cities that promote healthy environments to reduce long-term risk of hypertension and other cardiovascular diseases. This work was supported by funding from the European Community’s Seventh Framework Programme [FP7/2007–206 n°308333; the HELIX project], and by the European Union’s Horizon 2020 research and innovation programme [H2020 n°733206; the LifeCycle project]. CW holds a Sara Borrell fellowship from the Instituto de Salud Carlos III [CD18/00132]. INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya- CIRIT (Spain). The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). The work was also supported by MICINN [MTM2015-68140-R] and Centro Nacional de Genotipado- CEGEN- PRB2- ISCIII (Spain). This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber (UK). Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597MA, UK). The EDEN study was supported by Foundation for medical research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A), and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programmes (ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l’Education Nationale a complementary health insurance (MGEN), French national agency for food security, French-speaking association for the study of diabetes and metabolism (ALFEDIAM).
ACU Research Bank arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BY NC NDData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAEnvironment InternationalOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMHAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envint.2020.106174&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!download 22download downloads 22 Powered bymore_vert ACU Research Bank arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BY NC NDData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAEnvironment InternationalOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMHAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envint.2020.106174&type=result"></script>'); --> </script>
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