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description Publicationkeyboard_double_arrow_right Article 2012 FrancePublisher:Oxford University Press (OUP) Funded by:WT, EC | NEUROXSYSWT ,EC| NEUROXSYSAuthors: Louis A; Muffato M; Roest Crollius H;Louis A; Muffato M; Roest Crollius H;Genomicus (http://www.dyogen.ens.fr/genomicus/) is a database and an online tool that allows easy comparative genomic visualization in >150 eukaryote genomes. It provides a way to explore spatial information related to gene organization within and between genomes and temporal relationships related to gene and genome evolution. For the specific vertebrate phylum, it also provides access to ancestral gene order reconstructions and conserved non-coding elements information. We extended the Genomicus database originally dedicated to vertebrate to four new clades, including plants, non-vertebrate metazoa, protists and fungi. This visualization tool allows evolutionary phylogenomics analysis and exploration. Here, we describe the graphical modules of Genomicus and show how it is capable of revealing differential gene loss and gain, segmental or genome duplications and study the evolution of a locus through homology relationships.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3531091Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gks1156&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 155 citations 155 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3531091Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gks1156&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Netherlands, Netherlands, Italy, United Kingdom, United Kingdom, Netherlands, Netherlands, France, United Kingdom, Spain EnglishPublisher:HAL CCSD Funded by:EC | PhenoMeNalEC| PhenoMeNalvan Rijswijk, M; van Rijswijk, M; Beirnaert, C; Beirnaert, C; Caron, C; Cascante, M; Dominguez, V; Dunn, WB; Ebbels, TMD; Giacomoni, F; Gonzalez-Beltran, A; Hankemeier, T; Haug, K; Haug, K; Izquierdo-Garcia, JL; Jimenez, RC; Jimenez, RC; Jourdan, F; Kale, N; Klapa, MI; Kohlbacher, O; Koort, K; Kultima, K; Le Corguillé, G; Moreno, P; Moschonas, NK; Moschonas, NK; Neumann, S; O'Donovan, C; Reczko, M; Rocca-Serra, P; Rosato, A; Rosato, A; Rosato, A; Salek, RM; Salek, RM; Sansone, S-A; Satagopam, V; Schober, D; Shimmo, R; Spicer, RA; Spicer, RA; Spjuth, O; Spjuth, O; Spjuth, O; Thévenot, EA; Thévenot, EA; Viant, MR; Weber, RJM; Willighagen, EL; Willighagen, EL; Zanetti, G; Steinbeck, C; Steinbeck, C;Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for metabolomics within Europe, a workshop on the "Future of metabolomics in ELIXIR" was organised at Frankfurt Airport in Germany. This one-day strategic workshop involved representatives of ELIXIR Nodes, members of the PhenoMeNal consortium developing an e-infrastructure that supports workflow-based metabolomics analysis pipelines, and experts from the international metabolomics community. The workshop established metabolite identification as the critical area, where a maximal impact of computational metabolomics and data management on other fields could be achieved. In particular, the existing four ELIXIR Use Cases, where the metabolomics community - both industry and academia - would benefit most, and which could be exhaustively mapped onto the current five ELIXIR Platforms were discussed. This opinion article is a call for support for a new ELIXIR metabolomics Use Case, which aligns with and complements the existing and planned ELIXIR Platforms and Use Cases. The meeting was funded by PhenoMeNal, European Commission's Horizon2020 programme, grant agreement number 654241 Sí
HAL - UPEC / UPEM; H... arrow_drop_down Europe PubMed CentralArticle . 2017 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC5627583Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTAFlore (Florence Research Repository)Article . 2017Data sources: Flore (Florence Research Repository)Oxford University Research Archive; F1000ResearchOther literature type . Article . 2017 . 2018 . Peer-reviewedLicense: CC BYSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 34visibility views 34 download downloads 65 Powered bymore_vert HAL - UPEC / UPEM; H... arrow_drop_down Europe PubMed CentralArticle . 2017 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC5627583Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTAFlore (Florence Research Repository)Article . 2017Data sources: Flore (Florence Research Repository)Oxford University Research Archive; F1000ResearchOther literature type . Article . 2017 . 2018 . Peer-reviewedLicense: CC BYSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2016 France, Switzerland, Brazil, Denmark, United Kingdom, GermanyPublisher:Springer Science and Business Media LLC Funded by:EC | PHARMASEAEC| PHARMASEAMingxun Wang; Jeremy Carver; Vanessa V. Phelan; Laura M. Sanchez; Neha Garg; Yao Peng; Don D. Nguyen; Jeramie D. Watrous; Clifford A. Kapono; Tal Luzzatto-Knaan; Carla Porto; Amina Bouslimani; Alexey V. Melnik; Michael J. Meehan; Wei-Ting Liu; Max Crüsemann; Paul D. Boudreau; Eduardo Esquenazi; Mario Sandoval-Calderón; Roland D. Kersten; Laura A. Pace; Robert A. Quinn; Katherine R. Duncan; Cheng-Chih Hsu; Dimitrios J. Floros; Ronnie G. Gavilan; Karin Kleigrewe; Trent R. Northen; Rachel J. Dutton; Delphine Parrot; Erin E. Carlson; Bertrand Aigle; Charlotte Frydenlund Michelsen; Lars Jelsbak; Christian Sohlenkamp; Pavel A. Pevzner; Anna Edlund; Jeffrey S. McLean; Jörn Piel; Brian T. Murphy; Lena Gerwick; Chih-Chuang Liaw; Yu-Liang Yang; Hans-Ulrich Humpf; Maria Maansson; Robert A. Keyzers; Amy C. Sims; Andrew R. Johnson; Ashley M. Sidebottom; Brian E. Sedio; Andreas Klitgaard; Charles B. Larson; Cristopher A. Boya P.; Daniel Torres-Mendoza; David Gonzalez; Denise Brentan Silva; Lucas Miranda Marques; Daniel P. Demarque; Egle Pociute; Ellis C. O’Neill; Enora Briand; Eric J. N. Helfrich; Eve A. Granatosky; Evgenia Glukhov; Florian Ryffel; Hailey Houson; Hosein Mohimani; Jenan J. Kharbush; Yi Zeng; Julia A. Vorholt; Kenji L. Kurita; Pep Charusanti; Kerry L. McPhail; Kristian Fog Nielsen; Lisa Vuong; Maryam Elfeki; Matthew F. Traxler; Niclas Engene; Nobuhiro Koyama; Oliver B. Vining; Ralph S. Baric; Ricardo Pianta Rodrigues da Silva; Samantha J. Mascuch; Sophie Tomasi; Stefan Jenkins; Venkat R. Macherla; Thomas Hoffman; Vinayak Agarwal; Philip G. Williams; Jingqui Dai; Ram P. Neupane; Joshua R. Gurr; Andrés M. C. Rodríguez; Anne Lamsa; Chen Zhang; Kathleen Dorrestein; Brendan M. Duggan; Jehad Almaliti; Pierre-Marie Allard; Prasad Phapale; Louis-Félix Nothias; Theodore Alexandrov; Marc Litaudon; Jean-Luc Wolfender; Jennifer E. Kyle; Thomas O. Metz; Tyler Peryea; Dac-Trung Nguyen; Danielle VanLeer; Paul Shinn; Ajit Jadhav; Rolf Müller; Katrina M. Waters; Wenyuan Shi; Xueting Liu; Lixin Zhang; Rob Knight; Paul R. Jensen; Bernhard O. Palsson; Kit Pogliano; Roger G. Linington; Marcelino Gutiérrez; Norberto Peporine Lopes; William H. Gerwick; Bradley S. Moore; Pieter C. Dorrestein; Nuno Bandeira;International audience; The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data.
CORE (RIOXX-UK Aggre... arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveArchiMer - Institutional Archive of IfremerOther literature type . 2016Data sources: ArchiMer - Institutional Archive of IfremerOnline Research Database In TechnologyArticle . 2016Data sources: Online Research Database In TechnologyRepositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); Nature BiotechnologyOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMHelmholtz Zentrum für Infektionsforschung RepositoryArticle . 2016License: CC BY NC SAData sources: Helmholtz Zentrum für Infektionsforschung RepositoryHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nbt.3597&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 3K citations 2,812 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!visibility 19visibility views 19 download downloads 417 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveArchiMer - Institutional Archive of IfremerOther literature type . 2016Data sources: ArchiMer - Institutional Archive of IfremerOnline Research Database In TechnologyArticle . 2016Data sources: Online Research Database In TechnologyRepositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); Nature BiotechnologyOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMHelmholtz Zentrum für Infektionsforschung RepositoryArticle . 2016License: CC BY NC SAData sources: Helmholtz Zentrum für Infektionsforschung RepositoryHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nbt.3597&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United Kingdom, France, DenmarkPublisher:Oxford University Press (OUP) Funded by:EC | ZF-HEALTH, NSERC, CIHREC| ZF-HEALTH ,NSERC ,CIHRMathelier, A; Fornes, O; Arenillas, DJ; Chen, CY; Denay, G; Lee, J; Shi, W; Shyr, C; Tan, G; Worsley-Hunt, R; Zhang, AW; Parcy, F; Lenhard, B; Sandelin, A; Wasserman, WW;International audience; JASPAR (http://jaspar.genereg.net) is an open-access database storing curated, non-redundant transcription factor (TF) binding profiles representing transcription factor binding preferences as position frequency matrices for multiple species in six taxonomic groups. For this 2016 release, we expanded the JASPAR CORE collection with 494 new TF binding profiles (315 in vertebrates, 11 in nematodes, 3 in insects, 1 in fungi and 164 in plants) and updated 59 profiles (58 in vertebrates and 1 in fungi). The introduced profiles represent an 83% expansion and 10% update when compared to the previous release. We updated the structural annotation of the TF DNA binding domains (DBDs) following a published hierarchical structural classification. In addition, we introduced 130 transcription factor flexible models trained on ChIP-seq data for vertebrates, which capture dinucleotide dependencies within TF binding sites. This new JASPAR release is accompanied by a new web tool to infer JASPAR TF binding profiles recognized by a given TF protein sequence. Moreover, we provide the users with a Ruby module complementing the JASPAR API to ease programmatic access and use of the JASPAR collection of profiles. Finally, we provide the JASPAR2016 R/Bioconductor data package with the data of this release.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4702842Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2016Data sources: Copenhagen University Research Information SystemSpiral - Imperial College Digital RepositoryArticle . 2015Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2016License: CC BY NCFull-Text: https://hal.science/hal-01281181/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkv1176&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 920 citations 920 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 5visibility views 5 download downloads 154 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4702842Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2016Data sources: Copenhagen University Research Information SystemSpiral - Imperial College Digital RepositoryArticle . 2015Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2016License: CC BY NCFull-Text: https://hal.science/hal-01281181/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkv1176&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2017 France, United Kingdom, Netherlands, United Kingdom, France, Italy, FrancePublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:CIHR, EC | SYSCILIA, NWO | VIRGO Subsidiebesluit 200... +4 projectsCIHR ,EC| SYSCILIA ,NWO| VIRGO Subsidiebesluit 2008-2012 ,EC| TREATCilia ,EC| PROPANE STUDY ,EC| PRIMES ,NWO| Deciphering ciliary signal transductionvan Dam, T.J.P.; Kennedy, J.; van der Lee, R.; de Vrieze, E.; de Vrieze, E.; Wunderlich, K.A.; Rix, S.; Dougherty, G.W.; Lambacher, N.J.; Li, C.; Jensen, V.L.; Leroux, M.R.; Hjeij, R.; Horn, N.; Texier, Y.; Wissinger, Y.; van Reeuwijk, J.; Wheway, G.; Knapp, B.; Scheel, J.F.; Franco, B.; Mans, D.A.; van WIjk, E.; van WIjk, E.; Kepes, F.; Slaats, G.G.; Toedt, G.; Kremer, H.; Kremer, H.; Omran, H.; Szymanska, K.; Koutroumpas, K.; Ueffing, M.; Nguyen, T.T.M.; Letteboer, S.J.F.; Oud, M.M.; van Beersum, S.E.C.; Schmidts, M.; Beales, P.L.; Lu, Q.; Giles, R.H.; Szklarczyk, R.; Russell, R.B.; Gibson, T.J.; Johnson, C.A.; Blacque, O.E.; Wolfrum, U.; Boldt, K.; Roepman, R.; Hernandez-Hernandez, V.; Huynen, M.A.;pmid: 31095607
pmc: PMC6522010
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies. The current rate at which new ciliopathy genes are identified suggests that many ciliary components remain undiscovered. We generated and rigorously analyzed genomic, proteomic, transcriptomic and evolutionary data and systematically integrated these using Bayesian statistics into a predictive score for ciliary function. This resulted in 285 candidate ciliary genes. We generated independent experimental evidence of ciliary associations for 24 out of 36 analyzed candidate proteins using multiple cell and animal model systems (mouse, zebrafish and nematode) and techniques. For example, we show that OSCP1, which has previously been implicated in two distinct non-ciliary processes, causes ciliogenic and ciliopathy-associated tissue phenotypes when depleted in zebrafish. The candidate list forms the basis of CiliaCarta, a comprehensive ciliary compendium covering 956 genes. The resource can be used to objectively prioritize candidate genes in whole exome or genome sequencing of ciliopathy patients and can be accessed at http://bioinformatics.bio.uu.nl/john/syscilia/ciliacarta/. Contains fulltext : 204265.pdf (Publisher’s version ) (Open Access)
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6522010Data sources: PubMed CentralbioRxivPreprint . 2017NARCIS; PLoS ONEArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/123455&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 102 citations 102 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 21visibility views 21 download downloads 8 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6522010Data sources: PubMed CentralbioRxivPreprint . 2017NARCIS; PLoS ONEArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/123455&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Denmark, Italy, Norway, Denmark, Netherlands, Denmark, Spain, France, Netherlands, Sweden, Netherlands EnglishPublisher:Springer Science and Business Media LLC Funded by:EC | OLISSIPO, EC | ELIXIR-EXCELERATE, WTEC| OLISSIPO ,EC| ELIXIR-EXCELERATE ,WTJon Ison; Hans Ienasescu; Piotr Jaroslaw Chmura; Emil Karol Rydza; Hervé Ménager; Matúš Kalaš; Veit Schwämmle; Björn Grüning; Niall Beard; Rodrigo Lopez; Séverine Duvaud; Heinz Stockinger; Bengt Persson; Radka Svobodová Vařeková; Tomáš Raček; Jiří Vondrášek; Hedi Peterson; Ahto Salumets; Inge Jonassen; Rob Hooft; Tommi Nyrönen; Alfonso Valencia; Salvador Capella; Josep Lluís Gelpí; Federico Zambelli; Babis Savakis; Brane Leskošek; Kristoffer Rapacki; Christophe Blanchet; Rafael C. Jimenez; Arlindo L. Oliveira; Gert Vriend; Olivier Collin; Jacques van Helden; Peter Løngreen; Søren Brunak;Bioinformaticians and biologists rely increasingly upon workflows for the flexible utilization of the many life science tools that are needed to optimally convert data into knowledge. We outline a pan-European enterprise to provide a catalogue ( https://bio.tools ) of tools and databases that can be used in these workflows. bio.tools not only lists where to find resources, but also provides a wide variety of practical information. Contains fulltext : 208582.pdf (Publisher’s version ) (Open Access)
NARCIS arrow_drop_down Genome BiologyArticle . 2019Full-Text: http://europepmc.org/articles/PMC6691543Data sources: PubMed CentralRadboud Repository; Genome Biology; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYDiposit Digital de la Universitat de Barcelona; Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BYOnline Research Database In TechnologyArticle . 2019Data sources: Online Research Database In TechnologyCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputBergen Open Research Archive - UiBArticle . 2019 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13059-019-1772-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 34 citations 34 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 56visibility views 56 download downloads 103 Powered bymore_vert NARCIS arrow_drop_down Genome BiologyArticle . 2019Full-Text: http://europepmc.org/articles/PMC6691543Data sources: PubMed CentralRadboud Repository; Genome Biology; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYDiposit Digital de la Universitat de Barcelona; Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BYOnline Research Database In TechnologyArticle . 2019Data sources: Online Research Database In TechnologyCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputBergen Open Research Archive - UiBArticle . 2019 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13059-019-1772-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Cyprus, Portugal, France, Serbia, France, Denmark, Italy, Spain, Belgium EnglishPublisher:HAL CCSD Funded by:MESTD | Application of the EIIP/I..., EC | IDPfunMESTD| Application of the EIIP/ISM bioinformatics platform in discovery of novel therapeutic targets and potential therapeutic molecules ,EC| IDPfunAuthors: Hatos, András; Hajdu-Soltész, Borbála; Monzon, Alexander M.; Palopoli, Nicolas; +124 AuthorsHatos, András; Hajdu-Soltész, Borbála; Monzon, Alexander M.; Palopoli, Nicolas; Álvarez, Lucía; Aykac-Fas, Burcu; Bassot, Claudio; Benítez, Guillermo I.; Bevilacqua, Martina; Chasapi, Anastasia; Chemes, Lucia; Davey, Norman E.; Davidović, Radoslav; Dunker, A. Keith; Elofsson, Arne; Gobeill, Julien; Foutel, Nicolás S. González; Sudha, Govindarajan; Guharoy, Mainak; Horvath, Tamas; Iglesias, Valentin; Kajava, Andrey V.; Kovacs, Orsolya P.; Lamb, John; Lambrughi, Matteo; Lazar, Tamas; Leclercq, Jeremy Y.; Leonardi, Emanuela; Macedo-Ribeiro, Sandra; Macossay-Castillo, Mauricio; Maiani, Emiliano; Manso, José A.; Marino-Buslje, Cristina; Martínez-Pérez, Elizabeth; Mészáros, Bálint; Mičetić, Ivan; Minervini, Giovanni; Murvai, Nikoletta; Necci, Marco; Ouzounis, Christos A.; Pajkos, Mátyás; Paladin, Lisanna; Pancsa, Rita; Papaleo, Elena; Parisi, Gustavo; Pasche, Emilie; Barbosa Pereira, Pedro J.; Promponas, Vasilis J.; Pujols, Jordi; Quaglia, Federica; Ruch, Patrick; Salvatore, Marco; Schad, Eva; Szabo, Beata; Szaniszló, Tamás; Tamana, Stella; Tantos, Agnes; Veljkovic, Nevena; Ventura, Salvador; Vranken, Wim; Dosztányi, Zsuzsanna; Tompa, Peter; Tosatto, Silvio C. E.; Piovesan, Damiano; Hatos, András; Hajdu-Soltész, Borbála; Monzon, Alexander M.; Palopoli, Nicolas; Álvarez, Lucía; Aykac-Fas, Burcu; Bassot, Claudio; Benítez, Guillermo I.; Bevilacqua, Martina; Chasapi, Anastasia; Chemes, Lucia; Davey, Norman E.; Davidović, Radoslav; Dunker, A. Keith; Elofsson, Arne; Gobeill, Julien; Foutel, Nicolás S. González; Sudha, Govindarajan; Guharoy, Mainak; Horvath, Tamas; Iglesias, Valentin; Kajava, Andrey V.; Kovacs, Orsolya P.; Lamb, John; Lambrughi, Matteo; Lazar, Tamas; Leclercq, Jeremy Y.; Leonardi, Emanuela; Macedo-Ribeiro, Sandra; Macossay-Castillo, Mauricio; Maiani, Emiliano; Manso, José A.; Marino-Buslje, Cristina; Martínez-Pérez, Elizabeth; Mészáros, Bálint; Mičetić, Ivan; Minervini, Giovanni; Murvai, Nikoletta; Necci, Marco; Ouzounis, Christos A.; Pajkos, Mátyás; Paladin, Lisanna; Pancsa, Rita; Papaleo, Elena; Parisi, Gustavo; Pasche, Emilie; Barbosa Pereira, Pedro J.; Promponas, Vasilis J.; Pujols, Jordi; Quaglia, Federica; Ruch, Patrick; Salvatore, Marco; Schad, Eva; Szabo, Beata; Szaniszló, Tamás; Tamana, Stella; Tantos, Agnes; Veljkovic, Nevena; Ventura, Salvador; Vranken, Wim; Dosztányi, Zsuzsanna; Tompa, Peter; Tosatto, Silvio C. E.; Piovesan, Damiano;The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome. Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) of Argentina [PICT-2015/3367, PICT-2017/1924]; Ministry of Education, Science and Technological Development of the Republic of Serbia [ON173001]; Vetenskapsrådet [2016-03798]; Hungarian National Research, Development, and Innovation Office (NKFIH) [FK-128133]; Italian Ministry of Health Young Investigator Grant [GR-2011-02347754]; Ministerio de Economía y Competitividad (MINECO) [BIO2016-78310-R]; ICREA (ICREA-Academia 2015); Fundac¸ão para a Ciência e a Tecnologia (FCT, Portugal); European Regional Development Fund [POCI-01-0145-FEDER-031173, POCI-01-0145-FEDER-029221]; Mexican National Council of Science and Technology (CONACYT) [215503]; Elixir-GR, Action ‘Reinforcement of the Research and Innovation Infrastructure’, Operational Programme ‘Competitiveness, Entrepreneurship and Innovation’ [NSRF 2014-2020]. co-financed by Greece and the European Union (European Regional Development Fund); Hungarian Academy of Sciences [PREMIUM-2017-48]; Carlsberg Distinguished Fellowship [CF18-0314]; Danmarks Grundforskningsfond [DNRF125]; National Research, Development and Innovation Office [K-125340]; Research Foundation Flanders (FWO) [G.0328.16N]; Hungarian Academy of Sciences [LP2014-18]; OTKA [K108798 and K124670]. This project has received funding from the European Union’s Horizon 2020 research and innovation programme [778247]. Funding for open access charge: European Union’s Horizon 2020 research and innovation programme [778247]. Conflict of interest statement. None declared.
Nucleic Acids Resear... arrow_drop_down Nucleic Acids Research; Archivio istituzionale della ricerca - Università di PadovaOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC7145575Data sources: PubMed CentralVrije Universiteit Brussel Research PortalOther literature type . 2020Data sources: Vrije Universiteit Brussel Research PortalRepositório Aberto da Universidade do PortoArticle . 2020Data sources: Repositório Aberto da Universidade do PortoOpenAIRE; Copenhagen University Research Information SystemArticle . 2020 . 2019Recolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2020License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkz975&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 154 citations 154 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 71visibility views 71 download downloads 172 Powered bymore_vert Nucleic Acids Resear... arrow_drop_down Nucleic Acids Research; Archivio istituzionale della ricerca - Università di PadovaOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC7145575Data sources: PubMed CentralVrije Universiteit Brussel Research PortalOther literature type . 2020Data sources: Vrije Universiteit Brussel Research PortalRepositório Aberto da Universidade do PortoArticle . 2020Data sources: Repositório Aberto da Universidade do PortoOpenAIRE; Copenhagen University Research Information SystemArticle . 2020 . 2019Recolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2020License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkz975&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 FrancePublisher:Springer Science and Business Media LLC Funded by:EC | CY-BIOBANKEC| CY-BIOBANKAuthors: Apostolos Malatras; Stephanie Duguez; William Duddy;Apostolos Malatras; Stephanie Duguez; William Duddy;Background The approach of building large collections of gene sets and then systematically testing hypotheses across these collections is a powerful tool in functional genomics, both in the pathway analysis of omics data and to uncover the polygenic effects associated with complex diseases in genome-wide association study. The Molecular Signatures Database includes collections of oncogenic and immunologic signatures enabling researchers to compare transcriptional datasets across hundreds of previous studies and leading to important insights in these fields, but such a resource does not currently exist for neuromuscular research. In previous work, we have shown the utility of gene set approaches to understand muscle cell physiology and pathology. Methods Following a systematic survey of public muscle data, we passed gene expression profiles from 4305 samples through a robust pre-processing and standardized data analysis pipeline. Two hundred eighty-two samples were discarded based on a battery of rigorous global quality controls. From among the remaining studies, 578 comparisons of interest were identified by a combination of text mining and manual curation of the study meta-data. For each comparison, significantly dysregulated genes (FDR adjusted p < 0.05) were identified. Results Lists of dysregulated genes were divided between upregulated and downregulated to give 1156 Muscle Gene Sets (MGS). This resource is available for download (www.sys-myo.com/muscle_gene_sets) and is accessible through three commonly used functional genomics platforms (GSEA, EnrichR, and WebGestalt). Basic guidance and recommendations are provided for the use of MGS through these platforms. In addition, consensus muscle gene sets were created to capture the overlap between the results of similar studies, and analysis of these highlighted the potential for novel disease-relevant findings. Conclusions The MGS resource can be used to investigate the behaviour of any list of genes across previous comparisons of muscle conditions, to compare previous studies to one another, and to explore the functional relationship of muscle dysregulation to the Gene Ontology. Its major intended use is in enrichment testing for functional genomics analysis. Electronic supplementary material The online version of this article (10.1186/s13395-019-0196-z) contains supplementary material, which is available to authorized users.
Skeletal Muscle arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6498474Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13395-019-0196-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Skeletal Muscle arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6498474Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13395-019-0196-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 FrancePublisher:Springer Science and Business Media LLC Funded by:EC | SYSTEMS MICROSCOPYEC| SYSTEMS MICROSCOPYGregoire Pau; Thomas Walter; Beate Neumann; Jean-Karim Hériché; Jan Ellenberg; Wolfgang Huber;Abstract Background The combination of time-lapse imaging of live cells with high-throughput perturbation assays is a powerful tool for genetics and cell biology. The Mitocheck project employed this technique to associate thousands of genes with transient biological phenotypes in cell division, cell death and migration. The original analysis of these data proceeded by assigning nuclear morphologies to cells at each time-point using automated image classification, followed by description of population frequencies and temporal distribution of cellular states through event-order maps. One of the choices made by that analysis was not to rely on temporal tracking of the individual cells, due to the relatively low image sampling frequency, and to focus on effects that could be discerned from population-level behaviour. Results Here, we present a variation of this approach that employs explicit modelling by dynamic differential equations of the cellular state populations. Model fitting to the time course data allowed reliable estimation of the penetrance and time of appearance of four types of disruption of the cell cycle: quiescence, mitotic arrest, polynucleation and cell death. Model parameters yielded estimates of the duration of the interphase and mitosis phases. We identified 2190 siRNAs that induced a disruption of the cell cycle at reproducible times, or increased the durations of the interphase or mitosis phases. Conclusions We quantified the dynamic effects of the siRNAs and compiled them as a resource that can be used to characterize the role of their target genes in cell death, mitosis and cell cycle regulation. The described population-based modelling method might be applicable to other large-scale cell-based assays with temporal readout when only population-level measures are available.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2013Full-Text: http://europepmc.org/articles/PMC3827932Data sources: PubMed CentralBMC BioinformaticsOther literature type . Article . 2013 . Peer-reviewedHAL-Inserm; Hal-DiderotArticle . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/1471-2105-14-308&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2013Full-Text: http://europepmc.org/articles/PMC3827932Data sources: PubMed CentralBMC BioinformaticsOther literature type . Article . 2013 . Peer-reviewedHAL-Inserm; Hal-DiderotArticle . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/1471-2105-14-308&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2014 Netherlands, France, France, FrancePublisher:Springer Science and Business Media LLC Funded by:EC | EURENOMICS, EC | RD-CONNECTEC| EURENOMICS ,EC| RD-CONNECTThompson, Rachel; Johnston, Louise; Taruscio, Domenica; Monaco, Lucia; Béroud, Christophe; Gut, Ivo G; Hansson, Mats G; 'T Hoen, Peter-Bram A; Patrinos, George P; Dawkins, Hugh; Ensini, Monica; Zatloukal, Kurt; Koubi, David; Heslop, Emma; Paschall, Justin E; Posada, Manuel; Robinson, Peter N; Bushby, Kate; Lochmuller, Hanns; Gut, Ivo G.; Hansson, Mats G.; ’t Hoen, Peter-Bram A.; Patrinos, George P.; Paschall, Justin E.; Robinson, Peter N.;International audience; Research into rare diseases is typically fragmented by data type and disease. Individual efforts often have poor interoperability and do not systematically connect data across clinical phenotype, genomic data, biomaterial availability, and research/trial data sets. Such data must be linked at both an individual-patient and whole-cohort level to enable researchers to gain a complete view of their disease and patient population of interest. Data access and authorization procedures are required to allow researchers in multiple institutions to securely compare results and gain new insights. Funded by the European Union's Seventh Framework Programme under the International Rare Diseases Research Consortium (IRDiRC), RD-Connect is a global infrastructure project initiated in November 2012 that links genomic data with registries, biobanks, and clinical bioinformatics tools to produce a central research resource for rare diseases.
Journal of General I... arrow_drop_down Journal of General Internal Medicine; NARCISOther literature type . Article . 2014 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11606-014-2908-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 163 citations 163 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Journal of General I... arrow_drop_down Journal of General Internal Medicine; NARCISOther literature type . Article . 2014 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11606-014-2908-8&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2012 FrancePublisher:Oxford University Press (OUP) Funded by:WT, EC | NEUROXSYSWT ,EC| NEUROXSYSAuthors: Louis A; Muffato M; Roest Crollius H;Louis A; Muffato M; Roest Crollius H;Genomicus (http://www.dyogen.ens.fr/genomicus/) is a database and an online tool that allows easy comparative genomic visualization in >150 eukaryote genomes. It provides a way to explore spatial information related to gene organization within and between genomes and temporal relationships related to gene and genome evolution. For the specific vertebrate phylum, it also provides access to ancestral gene order reconstructions and conserved non-coding elements information. We extended the Genomicus database originally dedicated to vertebrate to four new clades, including plants, non-vertebrate metazoa, protists and fungi. This visualization tool allows evolutionary phylogenomics analysis and exploration. Here, we describe the graphical modules of Genomicus and show how it is capable of revealing differential gene loss and gain, segmental or genome duplications and study the evolution of a locus through homology relationships.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3531091Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gks1156&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 155 citations 155 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3531091Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gks1156&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Netherlands, Netherlands, Italy, United Kingdom, United Kingdom, Netherlands, Netherlands, France, United Kingdom, Spain EnglishPublisher:HAL CCSD Funded by:EC | PhenoMeNalEC| PhenoMeNalvan Rijswijk, M; van Rijswijk, M; Beirnaert, C; Beirnaert, C; Caron, C; Cascante, M; Dominguez, V; Dunn, WB; Ebbels, TMD; Giacomoni, F; Gonzalez-Beltran, A; Hankemeier, T; Haug, K; Haug, K; Izquierdo-Garcia, JL; Jimenez, RC; Jimenez, RC; Jourdan, F; Kale, N; Klapa, MI; Kohlbacher, O; Koort, K; Kultima, K; Le Corguillé, G; Moreno, P; Moschonas, NK; Moschonas, NK; Neumann, S; O'Donovan, C; Reczko, M; Rocca-Serra, P; Rosato, A; Rosato, A; Rosato, A; Salek, RM; Salek, RM; Sansone, S-A; Satagopam, V; Schober, D; Shimmo, R; Spicer, RA; Spicer, RA; Spjuth, O; Spjuth, O; Spjuth, O; Thévenot, EA; Thévenot, EA; Viant, MR; Weber, RJM; Willighagen, EL; Willighagen, EL; Zanetti, G; Steinbeck, C; Steinbeck, C;Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for metabolomics within Europe, a workshop on the "Future of metabolomics in ELIXIR" was organised at Frankfurt Airport in Germany. This one-day strategic workshop involved representatives of ELIXIR Nodes, members of the PhenoMeNal consortium developing an e-infrastructure that supports workflow-based metabolomics analysis pipelines, and experts from the international metabolomics community. The workshop established metabolite identification as the critical area, where a maximal impact of computational metabolomics and data management on other fields could be achieved. In particular, the existing four ELIXIR Use Cases, where the metabolomics community - both industry and academia - would benefit most, and which could be exhaustively mapped onto the current five ELIXIR Platforms were discussed. This opinion article is a call for support for a new ELIXIR metabolomics Use Case, which aligns with and complements the existing and planned ELIXIR Platforms and Use Cases. The meeting was funded by PhenoMeNal, European Commission's Horizon2020 programme, grant agreement number 654241 Sí
HAL - UPEC / UPEM; H... arrow_drop_down Europe PubMed CentralArticle . 2017 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC5627583Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTAFlore (Florence Research Repository)Article . 2017Data sources: Flore (Florence Research Repository)Oxford University Research Archive; F1000ResearchOther literature type . Article . 2017 . 2018 . Peer-reviewedLicense: CC BYSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.12342.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 34visibility views 34 download downloads 65 Powered bymore_vert HAL - UPEC / UPEM; H... arrow_drop_down Europe PubMed CentralArticle . 2017 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC5627583Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2017Data sources: Recolector de Ciencia Abierta, RECOLECTAFlore (Florence Research Repository)Article . 2017Data sources: Flore (Florence Research Repository)Oxford University Research Archive; F1000ResearchOther literature type . Article . 2017 . 2018 . Peer-reviewedLicense: CC BYSpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositorySpiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.12342.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2016 France, Switzerland, Brazil, Denmark, United Kingdom, GermanyPublisher:Springer Science and Business Media LLC Funded by:EC | PHARMASEAEC| PHARMASEAMingxun Wang; Jeremy Carver; Vanessa V. Phelan; Laura M. Sanchez; Neha Garg; Yao Peng; Don D. Nguyen; Jeramie D. Watrous; Clifford A. Kapono; Tal Luzzatto-Knaan; Carla Porto; Amina Bouslimani; Alexey V. Melnik; Michael J. Meehan; Wei-Ting Liu; Max Crüsemann; Paul D. Boudreau; Eduardo Esquenazi; Mario Sandoval-Calderón; Roland D. Kersten; Laura A. Pace; Robert A. Quinn; Katherine R. Duncan; Cheng-Chih Hsu; Dimitrios J. Floros; Ronnie G. Gavilan; Karin Kleigrewe; Trent R. Northen; Rachel J. Dutton; Delphine Parrot; Erin E. Carlson; Bertrand Aigle; Charlotte Frydenlund Michelsen; Lars Jelsbak; Christian Sohlenkamp; Pavel A. Pevzner; Anna Edlund; Jeffrey S. McLean; Jörn Piel; Brian T. Murphy; Lena Gerwick; Chih-Chuang Liaw; Yu-Liang Yang; Hans-Ulrich Humpf; Maria Maansson; Robert A. Keyzers; Amy C. Sims; Andrew R. Johnson; Ashley M. Sidebottom; Brian E. Sedio; Andreas Klitgaard; Charles B. Larson; Cristopher A. Boya P.; Daniel Torres-Mendoza; David Gonzalez; Denise Brentan Silva; Lucas Miranda Marques; Daniel P. Demarque; Egle Pociute; Ellis C. O’Neill; Enora Briand; Eric J. N. Helfrich; Eve A. Granatosky; Evgenia Glukhov; Florian Ryffel; Hailey Houson; Hosein Mohimani; Jenan J. Kharbush; Yi Zeng; Julia A. Vorholt; Kenji L. Kurita; Pep Charusanti; Kerry L. McPhail; Kristian Fog Nielsen; Lisa Vuong; Maryam Elfeki; Matthew F. Traxler; Niclas Engene; Nobuhiro Koyama; Oliver B. Vining; Ralph S. Baric; Ricardo Pianta Rodrigues da Silva; Samantha J. Mascuch; Sophie Tomasi; Stefan Jenkins; Venkat R. Macherla; Thomas Hoffman; Vinayak Agarwal; Philip G. Williams; Jingqui Dai; Ram P. Neupane; Joshua R. Gurr; Andrés M. C. Rodríguez; Anne Lamsa; Chen Zhang; Kathleen Dorrestein; Brendan M. Duggan; Jehad Almaliti; Pierre-Marie Allard; Prasad Phapale; Louis-Félix Nothias; Theodore Alexandrov; Marc Litaudon; Jean-Luc Wolfender; Jennifer E. Kyle; Thomas O. Metz; Tyler Peryea; Dac-Trung Nguyen; Danielle VanLeer; Paul Shinn; Ajit Jadhav; Rolf Müller; Katrina M. Waters; Wenyuan Shi; Xueting Liu; Lixin Zhang; Rob Knight; Paul R. Jensen; Bernhard O. Palsson; Kit Pogliano; Roger G. Linington; Marcelino Gutiérrez; Norberto Peporine Lopes; William H. Gerwick; Bradley S. Moore; Pieter C. Dorrestein; Nuno Bandeira;International audience; The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data.
CORE (RIOXX-UK Aggre... arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveArchiMer - Institutional Archive of IfremerOther literature type . 2016Data sources: ArchiMer - Institutional Archive of IfremerOnline Research Database In TechnologyArticle . 2016Data sources: Online Research Database In TechnologyRepositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); Nature BiotechnologyOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMHelmholtz Zentrum für Infektionsforschung RepositoryArticle . 2016License: CC BY NC SAData sources: Helmholtz Zentrum für Infektionsforschung RepositoryHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nbt.3597&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 3K citations 2,812 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!visibility 19visibility views 19 download downloads 417 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveArchiMer - Institutional Archive of IfremerOther literature type . 2016Data sources: ArchiMer - Institutional Archive of IfremerOnline Research Database In TechnologyArticle . 2016Data sources: Online Research Database In TechnologyRepositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); Nature BiotechnologyOther literature type . Article . 2016 . Peer-reviewedLicense: Springer TDMHelmholtz Zentrum für Infektionsforschung RepositoryArticle . 2016License: CC BY NC SAData sources: Helmholtz Zentrum für Infektionsforschung RepositoryHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nbt.3597&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 United Kingdom, France, DenmarkPublisher:Oxford University Press (OUP) Funded by:EC | ZF-HEALTH, NSERC, CIHREC| ZF-HEALTH ,NSERC ,CIHRMathelier, A; Fornes, O; Arenillas, DJ; Chen, CY; Denay, G; Lee, J; Shi, W; Shyr, C; Tan, G; Worsley-Hunt, R; Zhang, AW; Parcy, F; Lenhard, B; Sandelin, A; Wasserman, WW;International audience; JASPAR (http://jaspar.genereg.net) is an open-access database storing curated, non-redundant transcription factor (TF) binding profiles representing transcription factor binding preferences as position frequency matrices for multiple species in six taxonomic groups. For this 2016 release, we expanded the JASPAR CORE collection with 494 new TF binding profiles (315 in vertebrates, 11 in nematodes, 3 in insects, 1 in fungi and 164 in plants) and updated 59 profiles (58 in vertebrates and 1 in fungi). The introduced profiles represent an 83% expansion and 10% update when compared to the previous release. We updated the structural annotation of the TF DNA binding domains (DBDs) following a published hierarchical structural classification. In addition, we introduced 130 transcription factor flexible models trained on ChIP-seq data for vertebrates, which capture dinucleotide dependencies within TF binding sites. This new JASPAR release is accompanied by a new web tool to infer JASPAR TF binding profiles recognized by a given TF protein sequence. Moreover, we provide the users with a Ruby module complementing the JASPAR API to ease programmatic access and use of the JASPAR collection of profiles. Finally, we provide the JASPAR2016 R/Bioconductor data package with the data of this release.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4702842Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2016Data sources: Copenhagen University Research Information SystemSpiral - Imperial College Digital RepositoryArticle . 2015Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2016License: CC BY NCFull-Text: https://hal.science/hal-01281181/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkv1176&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 920 citations 920 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 5visibility views 5 download downloads 154 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4702842Data sources: PubMed CentralCopenhagen University Research Information SystemArticle . 2016Data sources: Copenhagen University Research Information SystemSpiral - Imperial College Digital RepositoryArticle . 2015Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2016License: CC BY NCFull-Text: https://hal.science/hal-01281181/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkv1176&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2017 France, United Kingdom, Netherlands, United Kingdom, France, Italy, FrancePublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:CIHR, EC | SYSCILIA, NWO | VIRGO Subsidiebesluit 200... +4 projectsCIHR ,EC| SYSCILIA ,NWO| VIRGO Subsidiebesluit 2008-2012 ,EC| TREATCilia ,EC| PROPANE STUDY ,EC| PRIMES ,NWO| Deciphering ciliary signal transductionvan Dam, T.J.P.; Kennedy, J.; van der Lee, R.; de Vrieze, E.; de Vrieze, E.; Wunderlich, K.A.; Rix, S.; Dougherty, G.W.; Lambacher, N.J.; Li, C.; Jensen, V.L.; Leroux, M.R.; Hjeij, R.; Horn, N.; Texier, Y.; Wissinger, Y.; van Reeuwijk, J.; Wheway, G.; Knapp, B.; Scheel, J.F.; Franco, B.; Mans, D.A.; van WIjk, E.; van WIjk, E.; Kepes, F.; Slaats, G.G.; Toedt, G.; Kremer, H.; Kremer, H.; Omran, H.; Szymanska, K.; Koutroumpas, K.; Ueffing, M.; Nguyen, T.T.M.; Letteboer, S.J.F.; Oud, M.M.; van Beersum, S.E.C.; Schmidts, M.; Beales, P.L.; Lu, Q.; Giles, R.H.; Szklarczyk, R.; Russell, R.B.; Gibson, T.J.; Johnson, C.A.; Blacque, O.E.; Wolfrum, U.; Boldt, K.; Roepman, R.; Hernandez-Hernandez, V.; Huynen, M.A.;pmid: 31095607
pmc: PMC6522010
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies. The current rate at which new ciliopathy genes are identified suggests that many ciliary components remain undiscovered. We generated and rigorously analyzed genomic, proteomic, transcriptomic and evolutionary data and systematically integrated these using Bayesian statistics into a predictive score for ciliary function. This resulted in 285 candidate ciliary genes. We generated independent experimental evidence of ciliary associations for 24 out of 36 analyzed candidate proteins using multiple cell and animal model systems (mouse, zebrafish and nematode) and techniques. For example, we show that OSCP1, which has previously been implicated in two distinct non-ciliary processes, causes ciliogenic and ciliopathy-associated tissue phenotypes when depleted in zebrafish. The candidate list forms the basis of CiliaCarta, a comprehensive ciliary compendium covering 956 genes. The resource can be used to objectively prioritize candidate genes in whole exome or genome sequencing of ciliopathy patients and can be accessed at http://bioinformatics.bio.uu.nl/john/syscilia/ciliacarta/. Contains fulltext : 204265.pdf (Publisher’s version ) (Open Access)
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6522010Data sources: PubMed CentralbioRxivPreprint . 2017NARCIS; PLoS ONEArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/123455&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 102 citations 102 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 21visibility views 21 download downloads 8 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6522010Data sources: PubMed CentralbioRxivPreprint . 2017NARCIS; PLoS ONEArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/123455&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Denmark, Italy, Norway, Denmark, Netherlands, Denmark, Spain, France, Netherlands, Sweden, Netherlands EnglishPublisher:Springer Science and Business Media LLC Funded by:EC | OLISSIPO, EC | ELIXIR-EXCELERATE, WTEC| OLISSIPO ,EC| ELIXIR-EXCELERATE ,WTJon Ison; Hans Ienasescu; Piotr Jaroslaw Chmura; Emil Karol Rydza; Hervé Ménager; Matúš Kalaš; Veit Schwämmle; Björn Grüning; Niall Beard; Rodrigo Lopez; Séverine Duvaud; Heinz Stockinger; Bengt Persson; Radka Svobodová Vařeková; Tomáš Raček; Jiří Vondrášek; Hedi Peterson; Ahto Salumets; Inge Jonassen; Rob Hooft; Tommi Nyrönen; Alfonso Valencia; Salvador Capella; Josep Lluís Gelpí; Federico Zambelli; Babis Savakis; Brane Leskošek; Kristoffer Rapacki; Christophe Blanchet; Rafael C. Jimenez; Arlindo L. Oliveira; Gert Vriend; Olivier Collin; Jacques van Helden; Peter Løngreen; Søren Brunak;Bioinformaticians and biologists rely increasingly upon workflows for the flexible utilization of the many life science tools that are needed to optimally convert data into knowledge. We outline a pan-European enterprise to provide a catalogue ( https://bio.tools ) of tools and databases that can be used in these workflows. bio.tools not only lists where to find resources, but also provides a wide variety of practical information. Contains fulltext : 208582.pdf (Publisher’s version ) (Open Access)
NARCIS arrow_drop_down Genome BiologyArticle . 2019Full-Text: http://europepmc.org/articles/PMC6691543Data sources: PubMed CentralRadboud Repository; Genome Biology; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYDiposit Digital de la Universitat de Barcelona; Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BYOnline Research Database In TechnologyArticle . 2019Data sources: Online Research Database In TechnologyCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputBergen Open Research Archive - UiBArticle . 2019 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13059-019-1772-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 34 citations 34 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!visibility 56visibility views 56 download downloads 103 Powered bymore_vert NARCIS arrow_drop_down Genome BiologyArticle . 2019Full-Text: http://europepmc.org/articles/PMC6691543Data sources: PubMed CentralRadboud Repository; Genome Biology; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYDiposit Digital de la Universitat de Barcelona; Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BYOnline Research Database In TechnologyArticle . 2019Data sources: Online Research Database In TechnologyCopenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputBergen Open Research Archive - UiBArticle . 2019 . Peer-reviewedLicense: CC BYData sources: Bergen Open Research Archive - UiBadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13059-019-1772-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Cyprus, Portugal, France, Serbia, France, Denmark, Italy, Spain, Belgium EnglishPublisher:HAL CCSD Funded by:MESTD | Application of the EIIP/I..., EC | IDPfunMESTD| Application of the EIIP/ISM bioinformatics platform in discovery of novel therapeutic targets and potential therapeutic molecules ,EC| IDPfunAuthors: Hatos, András; Hajdu-Soltész, Borbála; Monzon, Alexander M.; Palopoli, Nicolas; +124 AuthorsHatos, András; Hajdu-Soltész, Borbála; Monzon, Alexander M.; Palopoli, Nicolas; Álvarez, Lucía; Aykac-Fas, Burcu; Bassot, Claudio; Benítez, Guillermo I.; Bevilacqua, Martina; Chasapi, Anastasia; Chemes, Lucia; Davey, Norman E.; Davidović, Radoslav; Dunker, A. Keith; Elofsson, Arne; Gobeill, Julien; Foutel, Nicolás S. González; Sudha, Govindarajan; Guharoy, Mainak; Horvath, Tamas; Iglesias, Valentin; Kajava, Andrey V.; Kovacs, Orsolya P.; Lamb, John; Lambrughi, Matteo; Lazar, Tamas; Leclercq, Jeremy Y.; Leonardi, Emanuela; Macedo-Ribeiro, Sandra; Macossay-Castillo, Mauricio; Maiani, Emiliano; Manso, José A.; Marino-Buslje, Cristina; Martínez-Pérez, Elizabeth; Mészáros, Bálint; Mičetić, Ivan; Minervini, Giovanni; Murvai, Nikoletta; Necci, Marco; Ouzounis, Christos A.; Pajkos, Mátyás; Paladin, Lisanna; Pancsa, Rita; Papaleo, Elena; Parisi, Gustavo; Pasche, Emilie; Barbosa Pereira, Pedro J.; Promponas, Vasilis J.; Pujols, Jordi; Quaglia, Federica; Ruch, Patrick; Salvatore, Marco; Schad, Eva; Szabo, Beata; Szaniszló, Tamás; Tamana, Stella; Tantos, Agnes; Veljkovic, Nevena; Ventura, Salvador; Vranken, Wim; Dosztányi, Zsuzsanna; Tompa, Peter; Tosatto, Silvio C. E.; Piovesan, Damiano; Hatos, András; Hajdu-Soltész, Borbála; Monzon, Alexander M.; Palopoli, Nicolas; Álvarez, Lucía; Aykac-Fas, Burcu; Bassot, Claudio; Benítez, Guillermo I.; Bevilacqua, Martina; Chasapi, Anastasia; Chemes, Lucia; Davey, Norman E.; Davidović, Radoslav; Dunker, A. Keith; Elofsson, Arne; Gobeill, Julien; Foutel, Nicolás S. González; Sudha, Govindarajan; Guharoy, Mainak; Horvath, Tamas; Iglesias, Valentin; Kajava, Andrey V.; Kovacs, Orsolya P.; Lamb, John; Lambrughi, Matteo; Lazar, Tamas; Leclercq, Jeremy Y.; Leonardi, Emanuela; Macedo-Ribeiro, Sandra; Macossay-Castillo, Mauricio; Maiani, Emiliano; Manso, José A.; Marino-Buslje, Cristina; Martínez-Pérez, Elizabeth; Mészáros, Bálint; Mičetić, Ivan; Minervini, Giovanni; Murvai, Nikoletta; Necci, Marco; Ouzounis, Christos A.; Pajkos, Mátyás; Paladin, Lisanna; Pancsa, Rita; Papaleo, Elena; Parisi, Gustavo; Pasche, Emilie; Barbosa Pereira, Pedro J.; Promponas, Vasilis J.; Pujols, Jordi; Quaglia, Federica; Ruch, Patrick; Salvatore, Marco; Schad, Eva; Szabo, Beata; Szaniszló, Tamás; Tamana, Stella; Tantos, Agnes; Veljkovic, Nevena; Ventura, Salvador; Vranken, Wim; Dosztányi, Zsuzsanna; Tompa, Peter; Tosatto, Silvio C. E.; Piovesan, Damiano;The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome. Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) of Argentina [PICT-2015/3367, PICT-2017/1924]; Ministry of Education, Science and Technological Development of the Republic of Serbia [ON173001]; Vetenskapsrådet [2016-03798]; Hungarian National Research, Development, and Innovation Office (NKFIH) [FK-128133]; Italian Ministry of Health Young Investigator Grant [GR-2011-02347754]; Ministerio de Economía y Competitividad (MINECO) [BIO2016-78310-R]; ICREA (ICREA-Academia 2015); Fundac¸ão para a Ciência e a Tecnologia (FCT, Portugal); European Regional Development Fund [POCI-01-0145-FEDER-031173, POCI-01-0145-FEDER-029221]; Mexican National Council of Science and Technology (CONACYT) [215503]; Elixir-GR, Action ‘Reinforcement of the Research and Innovation Infrastructure’, Operational Programme ‘Competitiveness, Entrepreneurship and Innovation’ [NSRF 2014-2020]. co-financed by Greece and the European Union (European Regional Development Fund); Hungarian Academy of Sciences [PREMIUM-2017-48]; Carlsberg Distinguished Fellowship [CF18-0314]; Danmarks Grundforskningsfond [DNRF125]; National Research, Development and Innovation Office [K-125340]; Research Foundation Flanders (FWO) [G.0328.16N]; Hungarian Academy of Sciences [LP2014-18]; OTKA [K108798 and K124670]. This project has received funding from the European Union’s Horizon 2020 research and innovation programme [778247]. Funding for open access charge: European Union’s Horizon 2020 research and innovation programme [778247]. Conflict of interest statement. None declared.
Nucleic Acids Resear... arrow_drop_down Nucleic Acids Research; Archivio istituzionale della ricerca - Università di PadovaOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC7145575Data sources: PubMed CentralVrije Universiteit Brussel Research PortalOther literature type . 2020Data sources: Vrije Universiteit Brussel Research PortalRepositório Aberto da Universidade do PortoArticle . 2020Data sources: Repositório Aberto da Universidade do PortoOpenAIRE; Copenhagen University Research Information SystemArticle . 2020 . 2019Recolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2020License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkz975&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 154 citations 154 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 71visibility views 71 download downloads 172 Powered bymore_vert Nucleic Acids Resear... arrow_drop_down Nucleic Acids Research; Archivio istituzionale della ricerca - Università di PadovaOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC7145575Data sources: PubMed CentralVrije Universiteit Brussel Research PortalOther literature type . 2020Data sources: Vrije Universiteit Brussel Research PortalRepositório Aberto da Universidade do PortoArticle . 2020Data sources: Repositório Aberto da Universidade do PortoOpenAIRE; Copenhagen University Research Information SystemArticle . 2020 . 2019Recolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2020License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkz975&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 FrancePublisher:Springer Science and Business Media LLC Funded by:EC | CY-BIOBANKEC| CY-BIOBANKAuthors: Apostolos Malatras; Stephanie Duguez; William Duddy;Apostolos Malatras; Stephanie Duguez; William Duddy;Background The approach of building large collections of gene sets and then systematically testing hypotheses across these collections is a powerful tool in functional genomics, both in the pathway analysis of omics data and to uncover the polygenic effects associated with complex diseases in genome-wide association study. The Molecular Signatures Database includes collections of oncogenic and immunologic signatures enabling researchers to compare transcriptional datasets across hundreds of previous studies and leading to important insights in these fields, but such a resource does not currently exist for neuromuscular research. In previous work, we have shown the utility of gene set approaches to understand muscle cell physiology and pathology. Methods Following a systematic survey of public muscle data, we passed gene expression profiles from 4305 samples through a robust pre-processing and standardized data analysis pipeline. Two hundred eighty-two samples were discarded based on a battery of rigorous global quality controls. From among the remaining studies, 578 comparisons of interest were identified by a combination of text mining and manual curation of the study meta-data. For each comparison, significantly dysregulated genes (FDR adjusted p < 0.05) were identified. Results Lists of dysregulated genes were divided between upregulated and downregulated to give 1156 Muscle Gene Sets (MGS). This resource is available for download (www.sys-myo.com/muscle_gene_sets) and is accessible through three commonly used functional genomics platforms (GSEA, EnrichR, and WebGestalt). Basic guidance and recommendations are provided for the use of MGS through these platforms. In addition, consensus muscle gene sets were created to capture the overlap between the results of similar studies, and analysis of these highlighted the potential for novel disease-relevant findings. Conclusions The MGS resource can be used to investigate the behaviour of any list of genes across previous comparisons of muscle conditions, to compare previous studies to one another, and to explore the functional relationship of muscle dysregulation to the Gene Ontology. Its major intended use is in enrichment testing for functional genomics analysis. Electronic supplementary material The online version of this article (10.1186/s13395-019-0196-z) contains supplementary material, which is available to authorized users.
Skeletal Muscle arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6498474Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13395-019-0196-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Skeletal Muscle arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6498474Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13395-019-0196-z&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 FrancePublisher:Springer Science and Business Media LLC Funded by:EC | SYSTEMS MICROSCOPYEC| SYSTEMS MICROSCOPYGregoire Pau; Thomas Walter; Beate Neumann; Jean-Karim Hériché; Jan Ellenberg; Wolfgang Huber;Abstract Background The combination of time-lapse imaging of live cells with high-throughput perturbation assays is a powerful tool for genetics and cell biology. The Mitocheck project employed this technique to associate thousands of genes with transient biological phenotypes in cell division, cell death and migration. The original analysis of these data proceeded by assigning nuclear morphologies to cells at each time-point using automated image classification, followed by description of population frequencies and temporal distribution of cellular states through event-order maps. One of the choices made by that analysis was not to rely on temporal tracking of the individual cells, due to the relatively low image sampling frequency, and to focus on effects that could be discerned from population-level behaviour. Results Here, we present a variation of this approach that employs explicit modelling by dynamic differential equations of the cellular state populations. Model fitting to the time course data allowed reliable estimation of the penetrance and time of appearance of four types of disruption of the cell cycle: quiescence, mitotic arrest, polynucleation and cell death. Model parameters yielded estimates of the duration of the interphase and mitosis phases. We identified 2190 siRNAs that induced a disruption of the cell cycle at reproducible times, or increased the durations of the interphase or mitosis phases. Conclusions We quantified the dynamic effects of the siRNAs and compiled them as a resource that can be used to characterize the role of their target genes in cell death, mitosis and cell cycle regulation. The described population-based modelling method might be applicable to other large-scale cell-based assays with temporal readout when only population-level measures are available.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2013Full-Text: http://europepmc.org/articles/PMC3827932Data sources: PubMed CentralBMC BioinformaticsOther literature type . Article . 2013 . Peer-reviewedHAL-Inserm; Hal-DiderotArticle . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/1471-2105-14-308&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2013Full-Text: http://europepmc.org/articles/PMC3827932Data sources: PubMed CentralBMC BioinformaticsOther literature type . Article . 2013 . Peer-reviewedHAL-Inserm; Hal-DiderotArticle . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/1471-2105-14-308&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2014 Netherlands, France, France, FrancePublisher:Springer Science and Business Media LLC Funded by:EC | EURENOMICS, EC | RD-CONNECTEC| EURENOMICS ,EC| RD-CONNECTThompson, Rachel; Johnston, Louise; Taruscio, Domenica; Monaco, Lucia; Béroud, Christophe; Gut, Ivo G; Hansson, Mats G; 'T Hoen, Peter-Bram A; Patrinos, George P; Dawkins, Hugh; Ensini, Monica; Zatloukal, Kurt; Koubi, David; Heslop, Emma; Paschall, Justin E; Posada, Manuel; Robinson, Peter N; Bushby, Kate; Lochmuller, Hanns; Gut, Ivo G.; Hansson, Mats G.; ’t Hoen, Peter-Bram A.; Patrinos, George P.; Paschall, Justin E.; Robinson, Peter N.;International audience; Research into rare diseases is typically fragmented by data type and disease. Individual efforts often have poor interoperability and do not systematically connect data across clinical phenotype, genomic data, biomaterial availability, and research/trial data sets. Such data must be linked at both an individual-patient and whole-cohort level to enable researchers to gain a complete view of their disease and patient population of interest. Data access and authorization procedures are required to allow researchers in multiple institutions to securely compare results and gain new insights. Funded by the European Union's Seventh Framework Programme under the International Rare Diseases Research Consortium (IRDiRC), RD-Connect is a global infrastructure project initiated in November 2012 that links genomic data with registries, biobanks, and clinical bioinformatics tools to produce a central research resource for rare diseases.
Journal of General I... arrow_drop_down Journal of General Internal Medicine; NARCISOther literature type . Article . 2014 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11606-014-2908-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 163 citations 163 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Journal of General I... arrow_drop_down Journal of General Internal Medicine; NARCISOther literature type . Article . 2014 . Peer-reviewedLicense: Springer TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11606-014-2908-8&type=result"></script>'); --> </script>
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