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description Publicationkeyboard_double_arrow_right Article , Preprint 2023 NetherlandsPublisher:American Physical Society (APS) Funded by:EC | OpaqueFlowsEC| OpaqueFlowsWillian Hogendoorn; Wim-Paul Breugem; David Frank; Martin Bruschewski; Sven Grundmann; Christian Poelma;Magnetic resonance imaging (MRI) experiments have been performed in conjunction with direct numerical simulations (DNS) to study neutrally buoyant particle-laden pipe flows. The flows are characterized by the suspension liquid Reynolds number (Res), based on the bulk liquid velocity and suspension viscosity obtained from Eilers' correlation, the bulk solid volume fraction (φb), and the particle-to-pipe diameter ratio (d/D). Six different cases have been studied, each with a unique combination of Res and φ, while d/D is kept constant at 0.058. The selected cases ensure that the comparison is performed across different flow regimes, each exhibiting characteristic behavior. In general, an excellent agreement is found between experiment and simulation for the average liquid velocity and solid volume fraction profiles. Root-mean-square errors as low as 1.7% and 5.3% are found for the velocity and volume fraction profiles, respectively. This study presents accurate and quantitative velocity and volume fraction profiles of semidilute up to dense suspension flows using both experimental and numerical methods. Three different flow regimes are identified, based on the experimental and numerical solid volume fraction profiles. These profiles explain observations in the drag change. For low bulk solid volume fractions a drag increase (with respect to an equal Res single-phase case) is observed. For moderate volume fraction distributions the drag is found to decrease, due to particle accumulation at the pipe center. For high volume fractions the drag is found to decrease further. For solid volume fractions of 0.4 a drag reduction higher than 25% is found. This drag reduction is linked to the strong viscosity gradient in the radial direction, where the relatively low viscosity near the pipe wall acts as a lubrication layer between the pipe wall and the dense core. Complex Fluid Processing Multi Phase Systems Process and Energy
TU Delft Repository arrow_drop_down Physical Review FluidsArticle . 2023 . Peer-reviewedLicense: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1103/physrevfluids.8.124302&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert TU Delft Repository arrow_drop_down Physical Review FluidsArticle . 2023 . Peer-reviewedLicense: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1103/physrevfluids.8.124302&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 NetherlandsPublisher:MDPI AG Funded by:EC | WATER-MINING, EC | CMMI – MaRITeC-X, EC | IDREEMEC| WATER-MINING ,EC| CMMI – MaRITeC-X ,EC| IDREEMMaria Rousou; Joachim Langeneck; Chara Apserou; Christos Arvanitidis; Stephanos Charalambous; Kyproula Chrysanthou; George Constantinides; Panagiotis D. Dimitriou; Sergio Carlos García Gómez; Soteria Irene Hadjieftychiou; Nikolaos Katsiaras; Periklis Kleitou; Demetris Kletou; Frithjof C. Küpper; Paraskevi Louizidou; Roberto Martins; Manos L. Moraitis; Nafsika Papageorgiou; Magdalene Papatheodoulou; Antonis Petrou; Dimitris Xevgenos; Lavrentios Vasiliades; Eleni Voultsiadou; Chariton Charles Chintiroglou; Alberto Castelli;doi: 10.3390/d15080941
The diversity and distribution of polychaetes in the coastal area and the EEZ of the Republic of Cyprus is presented based on both the literature records and new data acquired in a wide range of environmental monitoring programmes and research projects. A total of 585 polychaete species belonging to 49 families were reported in Cyprus waters; among them, 205 species (34%) were recorded based on the literature only, 149 (26%) were new records based on our own data, and a total of 231 spp. (40%) were recorded from both the literature and new data. A total of 51 polychaete species were identified as non-indigenous; among them, 32 were confirmed as alien species, 4 were considered cryptogenic, and 15 were considered questionable as there were doubts about their identity. The Indo-Pacific Schistomeringos loveni was reported for the first time in the Mediterranean Sea, while four species already reported in the literature, namely, Bispira melanostigma, Fimbriosthenelais longipinnis Leonnates aylaoberi, and Rhodopsis pusilla, were added to the list of non-indigenous polychaetes in the Mediterranean Sea. The current work highlights the importance of implementing environmental monitoring programmes and carrying out research surveys targeting benthic macrofauna assemblages.
Diversity arrow_drop_down DiversityOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYFull-Text: https://www.mdpi.com/1424-2818/15/8/941/pdfadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/d15080941&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Diversity arrow_drop_down DiversityOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYFull-Text: https://www.mdpi.com/1424-2818/15/8/941/pdfadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/d15080941&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 NetherlandsPublisher:Oxford University Press (OUP) Funded by:NWO | Selection of microbial ce..., EC | GREENERNWO| Selection of microbial cells with increased product-yield for industrial fermentations ,EC| GREENERRinke J. van Tatenhove-Pel; Tomaž Rijavec; Aleš Lapanje; Iris van Swam; Emile Zwering; Jhonatan A. Hernandez-Valdes; Oscar P. Kuipers; Cristian Picioreanu; Bas Teusink; Herwig Bachmann;pmid: 33077887
pmc: PMC8027890
Abstract Metabolic interactions between cells affect microbial community compositions and hence their function in ecosystems. It is well-known that under competition for the exchanged metabolite, concentration gradients constrain the distances over which interactions can occur. However, interaction distances are typically quantified in two-dimensional systems or without accounting for competition or other metabolite-removal, conditions which may not very often match natural ecosystems. We here analyze the impact of cell-to-cell distance on unidirectional cross-feeding in a three-dimensional aqueous system with competition for the exchanged metabolite. Effective interaction distances were computed with a reaction-diffusion model and experimentally verified by growing a synthetic consortium of 1 µm-sized metabolite producer, receiver, and competitor cells in different spatial structures. We show that receivers cannot interact with producers located on average 15 µm away from them, as product concentration gradients flatten close to producer cells. We developed an aggregation protocol and varied the receiver cells’ product affinity, to show that within producer–receiver aggregates even low-affinity receiver cells could interact with producers. These results show that competition or other metabolite-removal of a public good in a three-dimensional system reduces metabolic interaction distances to the low µm-range, highlighting the importance of concentration gradients as physical constraint for cellular interactions.
NARCIS; The ISME Jou... arrow_drop_down NARCIS; The ISME JournalArticle . 2020 . 2021Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8027890Data sources: PubMed CentralNARCIS; TU Delft RepositoryArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41396-020-00806-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 17visibility views 17 download downloads 29 Powered bymore_vert NARCIS; The ISME Jou... arrow_drop_down NARCIS; The ISME JournalArticle . 2020 . 2021Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8027890Data sources: PubMed CentralNARCIS; TU Delft RepositoryArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41396-020-00806-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Contribution for newspaper or weekly magazine 2019 Denmark, NetherlandsPublisher:IEEE Funded by:EC | ERIGrid, EC | RE-SERVEEC| ERIGrid ,EC| RE-SERVEAuthors: Vogel, S. (author); Subramaniam Rajkumar, Vetrivel (author); Thi Nguyen, Ha (author); Stevic, M. (author); +4 AuthorsVogel, S. (author); Subramaniam Rajkumar, Vetrivel (author); Thi Nguyen, Ha (author); Stevic, M. (author); Bhandia, R. (author); Heussen, Kai (author); Palensky, P. (author); Monti, Antonello (author);As future power systems become increasingly complex and interconnected to other energy carriers, a single research infrastructure can rarely provide the required test-beds to study a complete energy system, especially if different types of real power hardware are expected to be in-the-loop. Therefore, virtual interconnection of laboratories for large-scale systems plays an important role for geographically distributed realtime simulation. This paper presents the improvements made in simulation fidelity as well as usability for establishing future simulator and laboratory connections. A general procedure is proposed and analyzed for geographically distributed real-time simulation, which allows users easily to adapt this procedure to specific test cases. A systematic and comprehensive analysis of a dynamic phasor based co-simulation interface algorithm and its improvements are provided to demonstrate the advantages as well as limitations of this approach. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Intelligent Electrical Power Grids
NARCIS; TU Delft Rep... arrow_drop_down NARCIS; TU Delft RepositoryConference object . 2019Online Research Database In TechnologyContribution for newspaper or weekly magazine . 2020Data sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/iecon.2019.8926918&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 10visibility views 10 download downloads 49 Powered bymore_vert NARCIS; TU Delft Rep... arrow_drop_down NARCIS; TU Delft RepositoryConference object . 2019Online Research Database In TechnologyContribution for newspaper or weekly magazine . 2020Data sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/iecon.2019.8926918&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 NetherlandsPublisher:Springer Science and Business Media LLC Funded by:EC | ECOPOTENTIALEC| ECOPOTENTIALAuthors: Solveig Höfer; Alex Ziemba; Ghada El Serafy;Solveig Höfer; Alex Ziemba; Ghada El Serafy;Abstract The concept of ecosystem services is gaining attention in the context of sustainable resource management. However, it is inherently difficult to account for tangible and intangible services in a combined model. The aim of this study is to extend the definition of ecosystem service trade-offs by using Bayesian Networks to capture the relationship between tangible and intangible ecosystem services. Tested is the potential of creating such a network based on existing literature and enhancement via expert elicitation. This study discusses the significance of expert elicitation to enhance the value of a Bayesian Network in data-restricted case studies, underlines the importance of inclusion of experts’ certainty, and demonstrates how multiple sources of knowledge can be combined into one model accounting for both tangible and intangible ecosystem services. Bayesian Networks appear to be a promising tool in this context, nevertheless, this approach is still in need of further refinement in structure and applicable guidelines for expert involvement and elicitation for a more unified methodology.
NARCIS; Environment ... arrow_drop_down Environment Systems & DecisionsOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10669-019-09742-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 26visibility views 26 download downloads 31 Powered bymore_vert NARCIS; Environment ... arrow_drop_down Environment Systems & DecisionsOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10669-019-09742-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Argentina, Germany, United Kingdom, Spain, Denmark, Belgium, Spain, Netherlands, United Kingdom, Italy, United Kingdom, DenmarkPublisher:Springer Science and Business Media LLC Funded by:NIH | Genome wide SNP analysis ..., NWO | NCHA Subsidiebesluit 2008..., NIH | Identifying genes and Pat... +21 projectsNIH| Genome wide SNP analysis in Parkinson's disease ,NWO| NCHA Subsidiebesluit 2008-2012 ,NIH| Identifying genes and Pathways that impact Tau Toxicity in FTD ,NWO| Collectin-Derivatives Innovative Multifunctional Drugs with Broad-Range Protection against Influenza A Viruses ,WT| Nuclear genomic control of mitochondrial DNA heteroplasmy in humans: population genetics & disease ,NIH| Gene discovery in PSP by transcriptome, neuropathology and sequence analysis ,NIH| Genetic characterization of atypical parkinsonism ,EC| JPco-fuND ,EC| IDEAL ,NIH| ALZHEIMERS DISEASE AND ANIMAL MODELS ,NIH| A system approach to targeting innate immunity in AD ,WT| Genome-wide association study of extreme obesity in young adults. ,NIH| Genetic characterization of atypical parkinsonism ,NIH| Genome wide SNP analysis in Parkinson's disease ,NIH| CORE--TRANSGENIC AND NEUROBEHAVIOR FACILITY ,NIH| Understanding the role of MAPT in Parkinsonian disorders ,EC| MultipleMS ,UKRI| Understanding genetic mechanisms modulating the clinical expression of mitochondrial disease. ,NIH| Identification of novel Parkinsonian genes by wholegenome ,NWO| Blue Action ,NWO| Cluster computing in genetic linkage studies on human complex traits ,EC| ADAPTED ,NIH| Integrative translational discovery of vascular risk factors in aging and dementia ,NIH| OLDEST-OLD MORTALITY AND DISABILITY AMONG DANISH TWINSvan der Lee, Sven J; Conway, Olivia J; Zettergren, Anna; Christensen, Kaare; Ertekin-Taner, Nilüfer; Scholz, Sonja W; Ramirez, Alfredo; Ruiz, Agustín; Slagboom, Eline; van der Flier, Wiesje M; Holstege, Henne; Mead, S.; Synofzik, M.; Andlauer, Till F M; van Swieten, J. C.; Leber, I.; Ferrari, R.; Hernandez, D. G.; Nalls, M. A.; Rohrer, J. D.; Ramasamy, A.; Kwok, J. B. J.; Dobson-Stone, C.; Schofield, P. R.; Diez-Fairen, Monica; Halliday, G. M.; Hodges, J. R.; Piguet, O.; Bartley, L.; Thompson, E.; Borroni, B.; Padovani, A.; Cruchaga, C.; Cairns, N. J.; Benussi, L.; Simon-Sanchez, Javier; Binetti, G.; Ghidoni, R.; Forloni, G.; Albani, D.; Galimberti, D.; Fenoglio, C.; Serpente, M.; Scarpini, E.; Blesa, R.; Landqvist Waldö, M.; Lleó, Alberto; Nilsson, K.; Nilsson, C.; Mackenzie, I. R. A.; Hsiung, G-Y R; Mann, D. M. A.; Grafman, J.; Morris, C. M.; Attems, J.; Griffiths, T. D.; McKeith, I. G.; Zetterberg, Henrik; Thomas, A. J.; Pietrini, P.; Huey, E. D.; Wassermann, E. M.; Baborie, A.; Jaros, E.; Tierney, M. C.; Razquin, C.; Ortega-Cubero, S.; Alonso, E.; Nygaard, Marianne; Perneczky, R.; Diehl-Schmid, J.; Alexopoulos, P.; Kurz, A.; Rainero, I.; Rubino, E.; Pinessi, L.; Rogaeva, E.; St George-Hyslop, P.; Rossi, G.; Blauwendraat, Cornelis; Tagliavini, F.; Giaccone, G.; Rowe, J. B.; Schlachetzki, J. C. M.; Uphill, J.; Collinge, J.; Danek, A.; Van Deerlin, V. M.; Grossman, M.; Trojanowski, J. Q.; Savage, Jeanne E; van der Zee, J.; Van Broeckhoven, C.; Cappa, S. F.; Hannequin, D.; Golfier, V.; Vercelletto, M.; Brice, A.; Nacmias, B.; Sorbi, S.; Bagnoli, S.; Mengel-From, Jonas; Piaceri, I.; Nielsen, J. E.; Hjermind, L. E.; Riemenschneider, M.; Mayhaus, M.; Ibach, B.; Gasparoni, G.; Pichler, S.; Gu, W.; Rossor, M. N.; Jansen, Iris; Moreno-Grau, Sonia; Fox, N. C.; Warren, J. D.; Spillantini, M. G.; Morris, H. R.; Rizzu, P.; Snowden, J. S.; Rollinson, S.; Richardson, A.; Gerhard, A.; Bruni, A. C.; Wagner, Michael; Maletta, R.; Frangipane, F.; Cupidi, C.; Bernardi, L.; Anfossi, M.; Gallo, M.; Conidi, M. E.; Smirne, N.; Baker, M.; Josephs, K. A.; Fortea, Juan; Parisi, J. E.; Seeley, W. W.; Miller, B. L.; Karydas, A. M.; Rosen, H.; Dopper, E. G. P.; Seelaar, H.; Logroscino, G.; Capozzo, R.; Novelli, V.; Keogh, Michael J; Puca, A. A.; Franceschi, M.; Postiglione, A.; Milan, G.; Sorrentino, P.; Kristiansen, M.; Chiang, H-H; Graff, C.; Pasquier, F.; Rollin, A.; Blennow, Kaj; Deramecourt, V.; Lebouvier, T.; Kapogiannis, D.; Ferrucci, L.; Pickering-Brown, S.; Singleton, A. B.; Hardy, J.; Momeni, P.; Coppola, G.; Karydas, A. M.; Skoog, Ingmar; Varpetian, A.; Foroud, T. M.; Levey, A. I.; Kukull, W. A.; Mendez, M. F.; Ringman, J.; Chui, H.; Cotman, C.; DeCarli, C.; Miller, B. L.; Friese, Manuel A; Geschwind, D. H.; Pletnikova, Olga; Zulaica, Miren; Lage, Carmen; Carrasquillo, Minerva M; de Rojas, Itziar; Riedel-Heller, Steffi; Illán-Gala, Ignacio; Wei, Wei; Jeune, Bernard; Orellana, Adelina; Then Bergh, Florian; Wang, Xue; Hulsman, Marc; Beker, Nina; Kleineidam, Luca; Tesi, Niccolo; Morris, Christopher M; Indakoetxea, Begoña; Collij, Lyduine E; Ironside, James W; Alcolea, Daniel; Pastor, Pau; Dalmasso, Maria Carolina; Boada, Mercè; van Schoor, Natasja M; Beekman, Marian; Pantelyat, Alexander; Ross, Owen A; Lemstra, Afina W; Pijnenburg, Yolande A L; Scheltens, Philip; Gasser, Thomas; Chinnery, Patrick F; Huisman, Martijn A; Nohr, Ellen A; Heutink, Peter; Sánchez-Juan, Pascual; Posthuma, Danielle;The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.
NARCIS; TU Delft Rep... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6660501Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7181435Data sources: PubMed CentralArchivio Istituzionale (AperTO); Archivio IstituzionaleArticle . 2019Copenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2019License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2020License: CC BYLUMC Scholarly Publications; NARCISOther literature type . Article . 2019Acta NeuropathologicaArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00401-019-02026-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 88 citations 88 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 81visibility views 81 download downloads 129 Powered bymore_vert NARCIS; TU Delft Rep... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6660501Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7181435Data sources: PubMed CentralArchivio Istituzionale (AperTO); Archivio IstituzionaleArticle . 2019Copenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2019License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2020License: CC BYLUMC Scholarly Publications; NARCISOther literature type . Article . 2019Acta NeuropathologicaArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Review , Other literature type 2018 Spain, Switzerland, Netherlands, Italy, Italy, Italy, Italy, ItalyPublisher:Wiley Funded by:EC | ECOPOTENTIALEC| ECOPOTENTIALPasetto, D.; Pasetto, D.; Arenas-Castro, S.; Bustamante, Javier; Bustamante, Javier; Casagrandi, R.; Chrysoulakis, N.; Cord, A.F.; Dittrich, A.; Domingo-Marimon, Cristina; El Serafy, G.; Karnieli, A.; Kordelas, G.A.; Manakos, I.; Mari, L.; Monteiro, A.; Palazzi, E.; Poursanidis, Dimitris; Rinaldo, A.; Terzago, S.; Ziemba, A.; Ziv, G.;handle: 10261/201829 , 10278/3722247 , 11311/1058698 , 2318/1849783
Abstract Spatiotemporal ecological modelling of terrestrial ecosystems relies on climatological and biophysical Earth observations. Due to their increasing availability, global coverage, frequent acquisition and high spatial resolution, satellite remote sensing (SRS) products are frequently integrated to in situ data in the development of ecosystem models (EMs) quantifying the interaction among the vegetation component and the hydrological, energy and nutrient cycles. This review highlights the main advances achieved in the last decade in combining SRS data with EMs, with particular attention to the challenges modellers face for applications at local scales (e.g. small watersheds). We critically review the literature on progress made towards integration of SRS data into terrestrial EMs: (1) as input to define model drivers; (2) as reference to validate model results; and (3) as a tool to sequentially update the state variables, and to quantify and reduce model uncertainty. The number of applications provided in the literature shows that EMs may profit greatly from the inclusion of spatial parameters and forcings provided by vegetation and climatic‐related SRS products. Limiting factors for the application of such models to local scales are: (1) mismatch between the resolution of SRS products and model grid; (2) unavailability of specific products in free and public online repositories; (3) temporal gaps in SRS data; and (4) quantification of model and measurement uncertainties. This review provides examples of possible solutions adopted in recent literature, with particular reference to the spatiotemporal scales of analysis and data accuracy. We propose that analysis methods such as stochastic downscaling techniques and multi‐sensor/multi‐platform fusion approaches are necessary to improve the quality of SRS data for local applications. Moreover, we suggest coupling models with data assimilation techniques to improve their forecast abilities. This review encourages the use of SRS data in EMs for local applications, and underlines the necessity for a closer collaboration among EM developers and remote sensing scientists. With more upcoming satellite missions, especially the Sentinel platforms, concerted efforts to further integrate SRS into modelling are in great demand and these types of applications will certainly proliferate.
Methods in Ecology a... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2018License: CC BYFull-Text: https://eprints.whiterose.ac.uk/144757/7/Pasetto_et_al-2018-Methods_in_Ecology_and_Evolution.pdfData sources: CORE (RIOXX-UK Aggregator)NARCIS; TU Delft RepositoryReview . 2018RE.PUBLIC@POLIMI Research Publications at Politecnico di MilanoOther literature type . Article . 2018 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2018Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 50visibility views 50 download downloads 130 Powered bymore_vert Methods in Ecology a... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2018License: CC BYFull-Text: https://eprints.whiterose.ac.uk/144757/7/Pasetto_et_al-2018-Methods_in_Ecology_and_Evolution.pdfData sources: CORE (RIOXX-UK Aggregator)NARCIS; TU Delft RepositoryReview . 2018RE.PUBLIC@POLIMI Research Publications at Politecnico di MilanoOther literature type . Article . 2018 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2018Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2017 Netherlands English Funded by:AKA | Integrated Biodiversity C..., EC | ECOPOTENTIAL, EC | GLOBIS-B +2 projectsAKA| Integrated Biodiversity Conservation and Carbon Sequestration in the Changing Environment (IBC-CARBON) / Consortium: IBC-CARBON ,EC| ECOPOTENTIAL ,EC| GLOBIS-B ,EC| ODYSSEA ,NSF| Collaborative Research: ABI Development: Advancing Map of Life's Impact and Capacity for Sharing, Integrating, and Using Global Spatial Biodiversity KnowledgeAuthors: Navarro, Laetitia M. (author); Fernandez, Nestor (author); Guerra, Carlos (author); Guralnick, Rob (author); +6 AuthorsNavarro, Laetitia M. (author); Fernandez, Nestor (author); Guerra, Carlos (author); Guralnick, Rob (author); Kissling, W. Daniel (author); Londono, Maria Cecilia (author); Muller-Karger, Frank (author); Turak, Eren (author); El Serafy, G.Y.H. (author); Balvanera, Patricia (author);The ability to monitor changes in biodiversity, and their societal impact, is critical to conserving species and managing ecosystems. While emerging technologies increase the breadth and reach of data acquisition, monitoring efforts are still spatially and temporally fragmented, and taxonomically biased. Appropriate long-term information remains therefore limited. The Group on Earth Observations Biodiversity Observation Network (GEO BON) aims to provide a general framework for biodiversity monitoring to support decision-makers. Here, we discuss the coordinated observing system adopted by GEO BON, and review challenges and advances in its implementation, focusing on two interconnected core components — the Essential Biodiversity Variables as a standard framework for biodiversity monitoring, and the Biodiversity Observation Networks that support harmonized observation systems — while highlighting their societal relevance. Mathematical Physics
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______571::51e71df7a6117e5a06cf5ebfff898391&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Preprint 2023 NetherlandsPublisher:American Physical Society (APS) Funded by:EC | OpaqueFlowsEC| OpaqueFlowsWillian Hogendoorn; Wim-Paul Breugem; David Frank; Martin Bruschewski; Sven Grundmann; Christian Poelma;Magnetic resonance imaging (MRI) experiments have been performed in conjunction with direct numerical simulations (DNS) to study neutrally buoyant particle-laden pipe flows. The flows are characterized by the suspension liquid Reynolds number (Res), based on the bulk liquid velocity and suspension viscosity obtained from Eilers' correlation, the bulk solid volume fraction (φb), and the particle-to-pipe diameter ratio (d/D). Six different cases have been studied, each with a unique combination of Res and φ, while d/D is kept constant at 0.058. The selected cases ensure that the comparison is performed across different flow regimes, each exhibiting characteristic behavior. In general, an excellent agreement is found between experiment and simulation for the average liquid velocity and solid volume fraction profiles. Root-mean-square errors as low as 1.7% and 5.3% are found for the velocity and volume fraction profiles, respectively. This study presents accurate and quantitative velocity and volume fraction profiles of semidilute up to dense suspension flows using both experimental and numerical methods. Three different flow regimes are identified, based on the experimental and numerical solid volume fraction profiles. These profiles explain observations in the drag change. For low bulk solid volume fractions a drag increase (with respect to an equal Res single-phase case) is observed. For moderate volume fraction distributions the drag is found to decrease, due to particle accumulation at the pipe center. For high volume fractions the drag is found to decrease further. For solid volume fractions of 0.4 a drag reduction higher than 25% is found. This drag reduction is linked to the strong viscosity gradient in the radial direction, where the relatively low viscosity near the pipe wall acts as a lubrication layer between the pipe wall and the dense core. Complex Fluid Processing Multi Phase Systems Process and Energy
TU Delft Repository arrow_drop_down Physical Review FluidsArticle . 2023 . Peer-reviewedLicense: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert TU Delft Repository arrow_drop_down Physical Review FluidsArticle . 2023 . Peer-reviewedLicense: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1103/physrevfluids.8.124302&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 NetherlandsPublisher:MDPI AG Funded by:EC | WATER-MINING, EC | CMMI – MaRITeC-X, EC | IDREEMEC| WATER-MINING ,EC| CMMI – MaRITeC-X ,EC| IDREEMMaria Rousou; Joachim Langeneck; Chara Apserou; Christos Arvanitidis; Stephanos Charalambous; Kyproula Chrysanthou; George Constantinides; Panagiotis D. Dimitriou; Sergio Carlos García Gómez; Soteria Irene Hadjieftychiou; Nikolaos Katsiaras; Periklis Kleitou; Demetris Kletou; Frithjof C. Küpper; Paraskevi Louizidou; Roberto Martins; Manos L. Moraitis; Nafsika Papageorgiou; Magdalene Papatheodoulou; Antonis Petrou; Dimitris Xevgenos; Lavrentios Vasiliades; Eleni Voultsiadou; Chariton Charles Chintiroglou; Alberto Castelli;doi: 10.3390/d15080941
The diversity and distribution of polychaetes in the coastal area and the EEZ of the Republic of Cyprus is presented based on both the literature records and new data acquired in a wide range of environmental monitoring programmes and research projects. A total of 585 polychaete species belonging to 49 families were reported in Cyprus waters; among them, 205 species (34%) were recorded based on the literature only, 149 (26%) were new records based on our own data, and a total of 231 spp. (40%) were recorded from both the literature and new data. A total of 51 polychaete species were identified as non-indigenous; among them, 32 were confirmed as alien species, 4 were considered cryptogenic, and 15 were considered questionable as there were doubts about their identity. The Indo-Pacific Schistomeringos loveni was reported for the first time in the Mediterranean Sea, while four species already reported in the literature, namely, Bispira melanostigma, Fimbriosthenelais longipinnis Leonnates aylaoberi, and Rhodopsis pusilla, were added to the list of non-indigenous polychaetes in the Mediterranean Sea. The current work highlights the importance of implementing environmental monitoring programmes and carrying out research surveys targeting benthic macrofauna assemblages.
Diversity arrow_drop_down DiversityOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYFull-Text: https://www.mdpi.com/1424-2818/15/8/941/pdfadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/d15080941&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Diversity arrow_drop_down DiversityOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYFull-Text: https://www.mdpi.com/1424-2818/15/8/941/pdfadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/d15080941&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 NetherlandsPublisher:Oxford University Press (OUP) Funded by:NWO | Selection of microbial ce..., EC | GREENERNWO| Selection of microbial cells with increased product-yield for industrial fermentations ,EC| GREENERRinke J. van Tatenhove-Pel; Tomaž Rijavec; Aleš Lapanje; Iris van Swam; Emile Zwering; Jhonatan A. Hernandez-Valdes; Oscar P. Kuipers; Cristian Picioreanu; Bas Teusink; Herwig Bachmann;pmid: 33077887
pmc: PMC8027890
Abstract Metabolic interactions between cells affect microbial community compositions and hence their function in ecosystems. It is well-known that under competition for the exchanged metabolite, concentration gradients constrain the distances over which interactions can occur. However, interaction distances are typically quantified in two-dimensional systems or without accounting for competition or other metabolite-removal, conditions which may not very often match natural ecosystems. We here analyze the impact of cell-to-cell distance on unidirectional cross-feeding in a three-dimensional aqueous system with competition for the exchanged metabolite. Effective interaction distances were computed with a reaction-diffusion model and experimentally verified by growing a synthetic consortium of 1 µm-sized metabolite producer, receiver, and competitor cells in different spatial structures. We show that receivers cannot interact with producers located on average 15 µm away from them, as product concentration gradients flatten close to producer cells. We developed an aggregation protocol and varied the receiver cells’ product affinity, to show that within producer–receiver aggregates even low-affinity receiver cells could interact with producers. These results show that competition or other metabolite-removal of a public good in a three-dimensional system reduces metabolic interaction distances to the low µm-range, highlighting the importance of concentration gradients as physical constraint for cellular interactions.
NARCIS; The ISME Jou... arrow_drop_down NARCIS; The ISME JournalArticle . 2020 . 2021Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8027890Data sources: PubMed CentralNARCIS; TU Delft RepositoryArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 25 citations 25 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 17visibility views 17 download downloads 29 Powered bymore_vert NARCIS; The ISME Jou... arrow_drop_down NARCIS; The ISME JournalArticle . 2020 . 2021Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8027890Data sources: PubMed CentralNARCIS; TU Delft RepositoryArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41396-020-00806-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Contribution for newspaper or weekly magazine 2019 Denmark, NetherlandsPublisher:IEEE Funded by:EC | ERIGrid, EC | RE-SERVEEC| ERIGrid ,EC| RE-SERVEAuthors: Vogel, S. (author); Subramaniam Rajkumar, Vetrivel (author); Thi Nguyen, Ha (author); Stevic, M. (author); +4 AuthorsVogel, S. (author); Subramaniam Rajkumar, Vetrivel (author); Thi Nguyen, Ha (author); Stevic, M. (author); Bhandia, R. (author); Heussen, Kai (author); Palensky, P. (author); Monti, Antonello (author);As future power systems become increasingly complex and interconnected to other energy carriers, a single research infrastructure can rarely provide the required test-beds to study a complete energy system, especially if different types of real power hardware are expected to be in-the-loop. Therefore, virtual interconnection of laboratories for large-scale systems plays an important role for geographically distributed realtime simulation. This paper presents the improvements made in simulation fidelity as well as usability for establishing future simulator and laboratory connections. A general procedure is proposed and analyzed for geographically distributed real-time simulation, which allows users easily to adapt this procedure to specific test cases. A systematic and comprehensive analysis of a dynamic phasor based co-simulation interface algorithm and its improvements are provided to demonstrate the advantages as well as limitations of this approach. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Intelligent Electrical Power Grids
NARCIS; TU Delft Rep... arrow_drop_down NARCIS; TU Delft RepositoryConference object . 2019Online Research Database In TechnologyContribution for newspaper or weekly magazine . 2020Data sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/iecon.2019.8926918&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 10visibility views 10 download downloads 49 Powered bymore_vert NARCIS; TU Delft Rep... arrow_drop_down NARCIS; TU Delft RepositoryConference object . 2019Online Research Database In TechnologyContribution for newspaper or weekly magazine . 2020Data sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/iecon.2019.8926918&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 NetherlandsPublisher:Springer Science and Business Media LLC Funded by:EC | ECOPOTENTIALEC| ECOPOTENTIALAuthors: Solveig Höfer; Alex Ziemba; Ghada El Serafy;Solveig Höfer; Alex Ziemba; Ghada El Serafy;Abstract The concept of ecosystem services is gaining attention in the context of sustainable resource management. However, it is inherently difficult to account for tangible and intangible services in a combined model. The aim of this study is to extend the definition of ecosystem service trade-offs by using Bayesian Networks to capture the relationship between tangible and intangible ecosystem services. Tested is the potential of creating such a network based on existing literature and enhancement via expert elicitation. This study discusses the significance of expert elicitation to enhance the value of a Bayesian Network in data-restricted case studies, underlines the importance of inclusion of experts’ certainty, and demonstrates how multiple sources of knowledge can be combined into one model accounting for both tangible and intangible ecosystem services. Bayesian Networks appear to be a promising tool in this context, nevertheless, this approach is still in need of further refinement in structure and applicable guidelines for expert involvement and elicitation for a more unified methodology.
NARCIS; Environment ... arrow_drop_down Environment Systems & DecisionsOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 26visibility views 26 download downloads 31 Powered bymore_vert NARCIS; Environment ... arrow_drop_down Environment Systems & DecisionsOther literature type . Article . 2019 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Argentina, Germany, United Kingdom, Spain, Denmark, Belgium, Spain, Netherlands, United Kingdom, Italy, United Kingdom, DenmarkPublisher:Springer Science and Business Media LLC Funded by:NIH | Genome wide SNP analysis ..., NWO | NCHA Subsidiebesluit 2008..., NIH | Identifying genes and Pat... +21 projectsNIH| Genome wide SNP analysis in Parkinson's disease ,NWO| NCHA Subsidiebesluit 2008-2012 ,NIH| Identifying genes and Pathways that impact Tau Toxicity in FTD ,NWO| Collectin-Derivatives Innovative Multifunctional Drugs with Broad-Range Protection against Influenza A Viruses ,WT| Nuclear genomic control of mitochondrial DNA heteroplasmy in humans: population genetics & disease ,NIH| Gene discovery in PSP by transcriptome, neuropathology and sequence analysis ,NIH| Genetic characterization of atypical parkinsonism ,EC| JPco-fuND ,EC| IDEAL ,NIH| ALZHEIMERS DISEASE AND ANIMAL MODELS ,NIH| A system approach to targeting innate immunity in AD ,WT| Genome-wide association study of extreme obesity in young adults. ,NIH| Genetic characterization of atypical parkinsonism ,NIH| Genome wide SNP analysis in Parkinson's disease ,NIH| CORE--TRANSGENIC AND NEUROBEHAVIOR FACILITY ,NIH| Understanding the role of MAPT in Parkinsonian disorders ,EC| MultipleMS ,UKRI| Understanding genetic mechanisms modulating the clinical expression of mitochondrial disease. ,NIH| Identification of novel Parkinsonian genes by wholegenome ,NWO| Blue Action ,NWO| Cluster computing in genetic linkage studies on human complex traits ,EC| ADAPTED ,NIH| Integrative translational discovery of vascular risk factors in aging and dementia ,NIH| OLDEST-OLD MORTALITY AND DISABILITY AMONG DANISH TWINSvan der Lee, Sven J; Conway, Olivia J; Zettergren, Anna; Christensen, Kaare; Ertekin-Taner, Nilüfer; Scholz, Sonja W; Ramirez, Alfredo; Ruiz, Agustín; Slagboom, Eline; van der Flier, Wiesje M; Holstege, Henne; Mead, S.; Synofzik, M.; Andlauer, Till F M; van Swieten, J. C.; Leber, I.; Ferrari, R.; Hernandez, D. G.; Nalls, M. A.; Rohrer, J. D.; Ramasamy, A.; Kwok, J. B. J.; Dobson-Stone, C.; Schofield, P. R.; Diez-Fairen, Monica; Halliday, G. M.; Hodges, J. R.; Piguet, O.; Bartley, L.; Thompson, E.; Borroni, B.; Padovani, A.; Cruchaga, C.; Cairns, N. J.; Benussi, L.; Simon-Sanchez, Javier; Binetti, G.; Ghidoni, R.; Forloni, G.; Albani, D.; Galimberti, D.; Fenoglio, C.; Serpente, M.; Scarpini, E.; Blesa, R.; Landqvist Waldö, M.; Lleó, Alberto; Nilsson, K.; Nilsson, C.; Mackenzie, I. R. A.; Hsiung, G-Y R; Mann, D. M. A.; Grafman, J.; Morris, C. M.; Attems, J.; Griffiths, T. D.; McKeith, I. G.; Zetterberg, Henrik; Thomas, A. J.; Pietrini, P.; Huey, E. D.; Wassermann, E. M.; Baborie, A.; Jaros, E.; Tierney, M. C.; Razquin, C.; Ortega-Cubero, S.; Alonso, E.; Nygaard, Marianne; Perneczky, R.; Diehl-Schmid, J.; Alexopoulos, P.; Kurz, A.; Rainero, I.; Rubino, E.; Pinessi, L.; Rogaeva, E.; St George-Hyslop, P.; Rossi, G.; Blauwendraat, Cornelis; Tagliavini, F.; Giaccone, G.; Rowe, J. B.; Schlachetzki, J. C. M.; Uphill, J.; Collinge, J.; Danek, A.; Van Deerlin, V. M.; Grossman, M.; Trojanowski, J. Q.; Savage, Jeanne E; van der Zee, J.; Van Broeckhoven, C.; Cappa, S. F.; Hannequin, D.; Golfier, V.; Vercelletto, M.; Brice, A.; Nacmias, B.; Sorbi, S.; Bagnoli, S.; Mengel-From, Jonas; Piaceri, I.; Nielsen, J. E.; Hjermind, L. E.; Riemenschneider, M.; Mayhaus, M.; Ibach, B.; Gasparoni, G.; Pichler, S.; Gu, W.; Rossor, M. N.; Jansen, Iris; Moreno-Grau, Sonia; Fox, N. C.; Warren, J. D.; Spillantini, M. G.; Morris, H. R.; Rizzu, P.; Snowden, J. S.; Rollinson, S.; Richardson, A.; Gerhard, A.; Bruni, A. C.; Wagner, Michael; Maletta, R.; Frangipane, F.; Cupidi, C.; Bernardi, L.; Anfossi, M.; Gallo, M.; Conidi, M. E.; Smirne, N.; Baker, M.; Josephs, K. A.; Fortea, Juan; Parisi, J. E.; Seeley, W. W.; Miller, B. L.; Karydas, A. M.; Rosen, H.; Dopper, E. G. P.; Seelaar, H.; Logroscino, G.; Capozzo, R.; Novelli, V.; Keogh, Michael J; Puca, A. A.; Franceschi, M.; Postiglione, A.; Milan, G.; Sorrentino, P.; Kristiansen, M.; Chiang, H-H; Graff, C.; Pasquier, F.; Rollin, A.; Blennow, Kaj; Deramecourt, V.; Lebouvier, T.; Kapogiannis, D.; Ferrucci, L.; Pickering-Brown, S.; Singleton, A. B.; Hardy, J.; Momeni, P.; Coppola, G.; Karydas, A. M.; Skoog, Ingmar; Varpetian, A.; Foroud, T. M.; Levey, A. I.; Kukull, W. A.; Mendez, M. F.; Ringman, J.; Chui, H.; Cotman, C.; DeCarli, C.; Miller, B. L.; Friese, Manuel A; Geschwind, D. H.; Pletnikova, Olga; Zulaica, Miren; Lage, Carmen; Carrasquillo, Minerva M; de Rojas, Itziar; Riedel-Heller, Steffi; Illán-Gala, Ignacio; Wei, Wei; Jeune, Bernard; Orellana, Adelina; Then Bergh, Florian; Wang, Xue; Hulsman, Marc; Beker, Nina; Kleineidam, Luca; Tesi, Niccolo; Morris, Christopher M; Indakoetxea, Begoña; Collij, Lyduine E; Ironside, James W; Alcolea, Daniel; Pastor, Pau; Dalmasso, Maria Carolina; Boada, Mercè; van Schoor, Natasja M; Beekman, Marian; Pantelyat, Alexander; Ross, Owen A; Lemstra, Afina W; Pijnenburg, Yolande A L; Scheltens, Philip; Gasser, Thomas; Chinnery, Patrick F; Huisman, Martijn A; Nohr, Ellen A; Heutink, Peter; Sánchez-Juan, Pascual; Posthuma, Danielle;The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.
NARCIS; TU Delft Rep... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6660501Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7181435Data sources: PubMed CentralArchivio Istituzionale (AperTO); Archivio IstituzionaleArticle . 2019Copenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2019License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2020License: CC BYLUMC Scholarly Publications; NARCISOther literature type . Article . 2019Acta NeuropathologicaArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00401-019-02026-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 88 citations 88 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 81visibility views 81 download downloads 129 Powered bymore_vert NARCIS; TU Delft Rep... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6660501Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7181435Data sources: PubMed CentralArchivio Istituzionale (AperTO); Archivio IstituzionaleArticle . 2019Copenhagen University Research Information SystemArticle . 2019Data sources: Copenhagen University Research Information SystemUniversity of Southern Denmark Research OutputArticle . 2019Data sources: University of Southern Denmark Research OutputRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2019License: CC BYRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2020License: CC BYLUMC Scholarly Publications; NARCISOther literature type . Article . 2019Acta NeuropathologicaArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00401-019-02026-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Review , Other literature type 2018 Spain, Switzerland, Netherlands, Italy, Italy, Italy, Italy, ItalyPublisher:Wiley Funded by:EC | ECOPOTENTIALEC| ECOPOTENTIALPasetto, D.; Pasetto, D.; Arenas-Castro, S.; Bustamante, Javier; Bustamante, Javier; Casagrandi, R.; Chrysoulakis, N.; Cord, A.F.; Dittrich, A.; Domingo-Marimon, Cristina; El Serafy, G.; Karnieli, A.; Kordelas, G.A.; Manakos, I.; Mari, L.; Monteiro, A.; Palazzi, E.; Poursanidis, Dimitris; Rinaldo, A.; Terzago, S.; Ziemba, A.; Ziv, G.;handle: 10261/201829 , 10278/3722247 , 11311/1058698 , 2318/1849783
Abstract Spatiotemporal ecological modelling of terrestrial ecosystems relies on climatological and biophysical Earth observations. Due to their increasing availability, global coverage, frequent acquisition and high spatial resolution, satellite remote sensing (SRS) products are frequently integrated to in situ data in the development of ecosystem models (EMs) quantifying the interaction among the vegetation component and the hydrological, energy and nutrient cycles. This review highlights the main advances achieved in the last decade in combining SRS data with EMs, with particular attention to the challenges modellers face for applications at local scales (e.g. small watersheds). We critically review the literature on progress made towards integration of SRS data into terrestrial EMs: (1) as input to define model drivers; (2) as reference to validate model results; and (3) as a tool to sequentially update the state variables, and to quantify and reduce model uncertainty. The number of applications provided in the literature shows that EMs may profit greatly from the inclusion of spatial parameters and forcings provided by vegetation and climatic‐related SRS products. Limiting factors for the application of such models to local scales are: (1) mismatch between the resolution of SRS products and model grid; (2) unavailability of specific products in free and public online repositories; (3) temporal gaps in SRS data; and (4) quantification of model and measurement uncertainties. This review provides examples of possible solutions adopted in recent literature, with particular reference to the spatiotemporal scales of analysis and data accuracy. We propose that analysis methods such as stochastic downscaling techniques and multi‐sensor/multi‐platform fusion approaches are necessary to improve the quality of SRS data for local applications. Moreover, we suggest coupling models with data assimilation techniques to improve their forecast abilities. This review encourages the use of SRS data in EMs for local applications, and underlines the necessity for a closer collaboration among EM developers and remote sensing scientists. With more upcoming satellite missions, especially the Sentinel platforms, concerted efforts to further integrate SRS into modelling are in great demand and these types of applications will certainly proliferate.
Methods in Ecology a... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2018License: CC BYFull-Text: https://eprints.whiterose.ac.uk/144757/7/Pasetto_et_al-2018-Methods_in_Ecology_and_Evolution.pdfData sources: CORE (RIOXX-UK Aggregator)NARCIS; TU Delft RepositoryReview . 2018RE.PUBLIC@POLIMI Research Publications at Politecnico di MilanoOther literature type . Article . 2018 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2018Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/2041-210x.13018&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 50visibility views 50 download downloads 130 Powered bymore_vert Methods in Ecology a... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2018License: CC BYFull-Text: https://eprints.whiterose.ac.uk/144757/7/Pasetto_et_al-2018-Methods_in_Ecology_and_Evolution.pdfData sources: CORE (RIOXX-UK Aggregator)NARCIS; TU Delft RepositoryReview . 2018RE.PUBLIC@POLIMI Research Publications at Politecnico di MilanoOther literature type . Article . 2018 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2018Infoscience - EPFL scientific publicationsOther literature typeData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/2041-210x.13018&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Review 2017 Netherlands English Funded by:AKA | Integrated Biodiversity C..., EC | ECOPOTENTIAL, EC | GLOBIS-B +2 projectsAKA| Integrated Biodiversity Conservation and Carbon Sequestration in the Changing Environment (IBC-CARBON) / Consortium: IBC-CARBON ,EC| ECOPOTENTIAL ,EC| GLOBIS-B ,EC| ODYSSEA ,NSF| Collaborative Research: ABI Development: Advancing Map of Life's Impact and Capacity for Sharing, Integrating, and Using Global Spatial Biodiversity KnowledgeAuthors: Navarro, Laetitia M. (author); Fernandez, Nestor (author); Guerra, Carlos (author); Guralnick, Rob (author); +6 AuthorsNavarro, Laetitia M. (author); Fernandez, Nestor (author); Guerra, Carlos (author); Guralnick, Rob (author); Kissling, W. Daniel (author); Londono, Maria Cecilia (author); Muller-Karger, Frank (author); Turak, Eren (author); El Serafy, G.Y.H. (author); Balvanera, Patricia (author);The ability to monitor changes in biodiversity, and their societal impact, is critical to conserving species and managing ecosystems. While emerging technologies increase the breadth and reach of data acquisition, monitoring efforts are still spatially and temporally fragmented, and taxonomically biased. Appropriate long-term information remains therefore limited. The Group on Earth Observations Biodiversity Observation Network (GEO BON) aims to provide a general framework for biodiversity monitoring to support decision-makers. Here, we discuss the coordinated observing system adopted by GEO BON, and review challenges and advances in its implementation, focusing on two interconnected core components — the Essential Biodiversity Variables as a standard framework for biodiversity monitoring, and the Biodiversity Observation Networks that support harmonized observation systems — while highlighting their societal relevance. Mathematical Physics
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______571::51e71df7a6117e5a06cf5ebfff898391&type=result"></script>'); --> </script>
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