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description Publicationkeyboard_double_arrow_right Article , Other literature type 2023 Italy, Portugal, Finland, PolandPublisher:SAGE Publications Funded by:EC | VAX-TRUSTEC| VAX-TRUSTAna Patrícia Hilário; Alice Scavarda; Dino Numerato; Joana Mendonça; Mario Cardano; Jaroslava Marhankova; Luigi Gariglio; Pia Vuolanto; Alistair Anderson; Petra Auvinen; Piet Bracke; Tom Douglass; Pru Hobson-West; Esther Lermytte; Paulina Polak; Tadeusz Rudek;While recruitment is an essential aspect of any research project, its challenges are rarely acknowledged. We intend to address this gap by discussing the challenges to the participation of vaccine-hesitant parents defined here as a hard-to-reach, hidden and vulnerable population drawing on extensive empirical qualitative evidence from seven European countries. The difficulties in reaching vaccine-hesitant parents were very much related to issues concerning trust, as there appears to be a growing distrust in experts, which is extended to the work developed by researchers and their funding bodies. These difficulties have been accentuated by the public debate around COVID-19 vaccination, as it seems to have increased parents’ hesitancy to participate. Findings from recruiting 167 vaccine-hesitant parents in seven European countries suggest that reflexive and sensible recruitment approaches should be developed.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Qualitative Health ResearchArticle . 2023 . Peer-reviewedLicense: CC BYTrepo - Institutional Repository of Tampere UniversityArticle . 2023 . Peer-reviewedData sources: Trepo - Institutional Repository of Tampere UniversityUniversidade de Lisboa: Repositório.ULOther literature type . 2023License: CC BYData sources: Universidade de Lisboa: Repositório.ULadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!visibility 30visibility views 30 download downloads 9 Powered bymore_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Qualitative Health ResearchArticle . 2023 . Peer-reviewedLicense: CC BYTrepo - Institutional Repository of Tampere UniversityArticle . 2023 . Peer-reviewedData sources: Trepo - Institutional Repository of Tampere UniversityUniversidade de Lisboa: Repositório.ULOther literature type . 2023License: CC BYData sources: Universidade de Lisboa: Repositório.ULadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/10497323231196439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Netherlands, Spain, ItalyPublisher:MDPI AG Funded by:EC | RADAR-CNSEC| RADAR-CNSLavalle, Raffaele; Condominas, Elena; Haro, Josep Maria; Giné-Vázquez, Iago; Bailon, Raquel; Laporta, Estela; Garcia, Ester; Kontaxis, Spyridon; Alacid, Gemma Riquelme; Lombardini, Federica; Preti, Antonio; Peñarrubia-Maria, Maria Teresa; Coromina, Marta; Arranz, Belén; Vilella, Elisabet; Rubio-Alacid, Elena; Radar-Mdd Spain; Matcham, Faith; Lamers, Femke; Hotopf, Matthew; Penninx, Brenda W. J. H.; Annas, Peter; Narayan, Vaibhav; Simblett, Sara K.; Siddi, Sara; The Radar-Cns Consortium;The present study analyzes the effects of each containment phase of the first COVID-19 wave on depression levels in a cohort of 121 adults with a history of major depressive disorder (MDD) from Catalonia recruited from 1 November 2019, to 16 October 2020. This analysis is part of the Remote Assessment of Disease and Relapse-MDD (RADAR-MDD) study. Depression was evaluated with the Patient Health Questionnaire-8 (PHQ-8), and anxiety was evaluated with the Generalized Anxiety Disorder-7 (GAD-7). Depression’s levels were explored across the phases (pre-lockdown, lockdown, and four post-lockdown phases) according to the restrictions of Spanish/Catalan governments. Then, a mixed model was fitted to estimate how depression varied over the phases. A significant rise in depression severity was found during the lockdown and phase 0 (early post-lockdown), compared with the pre-lockdown. Those with low pre-lockdown depression experienced an increase in depression severity during the “new normality”, while those with high pre-lockdown depression decreased compared with the pre-lockdown. These findings suggest that COVID-19 restrictions affected the depression level depending on their pre-lockdown depression severity. Individuals with low levels of depression are more reactive to external stimuli than those with more severe depression, so the lockdown may have worse detrimental effects on them.
International Journa... arrow_drop_down International Journal of Environmental Research and Public Health; Archivio IstituzionaleOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2023License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2023Data sources: Europe PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2023Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public Health; Archivio IstituzionaleOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2023License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2023Data sources: Europe PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2023Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph20065161&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Italy, United Kingdom, Italy, France, Netherlands, Italy, Netherlands, ItalyPublisher:Oxford University Press (OUP) Funded by:University College Dublin, ARC | ARC Centres of Excellence..., EC | ECRAID-Base +7 projectsUniversity College Dublin ,ARC| ARC Centres of Excellence - Grant ID: CE170100009 ,EC| ECRAID-Base ,WT| Understanding cross-reactive immunity to Japanese encephalitis virus ,WT| ISARIC ,WT ,WT| Malawi-Liverpool-Wellcome Trust COVID-19 Epidemic Preparedness ,EC| RECoVER ,UKRI| ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) ,CIHRAuthors: Christiana Kartsonaki; J Kenneth Baillie; Noelia García Barrio; Joaquín Baruch; +251 AuthorsChristiana Kartsonaki; J Kenneth Baillie; Noelia García Barrio; Joaquín Baruch; Abigail Beane; Lucille Blumberg; Fernando Bozza; Tessa Broadley; Aidan Burrell; Gail Carson; Barbara Wanjiru Citarella; Andrew Dagens; Emmanuelle A Dankwa; Christl A Donnelly; Jake Dunning; Loubna Elotmani; Martina Escher; Nataly Farshait; Jean-Christophe Goffard; Bronner P Gonçalves; Matthew Hall; Madiha Hashmi; Benedict Sim Lim Heng; Antonia Ho; Waasila Jassat; Miguel Pedrera Jiménez; Cedric Laouenan; Samantha Lissauer; Ignacio Martin-Loeches; France Mentré; Laura Merson; Ben Morton; Daniel Munblit; Nikita A Nekliudov; Alistair D Nichol; Budha Charan Singh Oinam; David Ong; Prasan Kumar Panda; Michele Petrovic; Mark G Pritchard; Nagarajan Ramakrishnan; Grazielle Viana Ramos; Claire Roger; Oana Sandulescu; Malcolm G Semple; Pratima Sharma; Louise Sigfrid; Emily C Somers; Anca Streinu-Cercel; Fabio Taccone; Pavan Kumar Vecham; Bharath Kumar Tirupakuzhi Vijayaraghavan; Jia Wei; Evert-Jan Wils; Xin Ci Wong; Peter Horby; Amanda Rojek; Piero L Olliaro; Ali Abbas; Sheryl Ann Abdukahil; Nurul Najmee Abdulkadir; Ryuzo Abe; Laurent Abel; Lara Absil; Subhash Acharya; Andrew Acker; Elisabeth Adam; Diana Adrião; Saleh Al Ageel; Shakeel Ahmed; Kate Ainscough; Eka Airlangga; Tharwat Aisa; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Eman Al Qasim; Razi Alalqam; Angela Alberti; Tala Al-dabbous; Senthilkumar Alegesan; Cynthia Alegre; Marta Alessi; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Huda Alfoudri; Imran Ali; Adam Ali; Naseem Ali Shah; Kazali Enagnon Alidjnou; Jeffrey Aliudin; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; Aneela Altaf; João Alves; Rita Alves; João Melo Alves; Maria Amaral; Nur Amira; Phoebe Ampaw; Roberto Andini; Claire Andréjak; Andrea Angheben; François Angoulvant; Séverine Ansart; Sivanesen Anthonidass; Massimo Antonelli; Carlos Alexandre Antunes de Brito; Ardiyan Apriyana; Yaseen Arabi; Irene Aragao; Francisco Arancibia; Carolline Araujo; Antonio Arcadipane; Patrick Archambault; Lukas Arenz; Jean-Benoît Arlet; Christel Arnold-Day; Lovkesh Arora; Rakesh Arora; Elise Artaud-Macari; Diptesh Aryal; Angel Asensio; Muhammad Ashraf; Namra Asif; Mohammad Asim; Jean Baptiste Assie; Amirul Asyraf; Anika Atique; A M Udara Lakshan Attanyake; Johann Auchabie; Hugues Aumaitre; Adrien Auvet; Laurène Azemar; Cecile Azoulay; Benjamin Bach; Delphine Bachelet; Claudine Badr; Nadia Baig; J Kevin Baird; Erica Bak; Agamemnon Bakakos; Nazreen Abu Bakar; Andriy Bal; Mohanaprasanth Balakrishnan; Valeria Balan; Firouzé Bani-Sadr; Renata Barbalho; Nicholas Yuri Barbosa; Wendy S Barclay; Saef Umar Barnett; Michaela Barnikel; Helena Barrasa; Audrey Barrelet; Cleide Barrigoto; Marie Bartoli; Mustehan Bashir; Romain Basmaci; Muhammad Fadhli Hassin Basri; Denise Battaglini; Jules Bauer; Diego Fernando Bautista Rincon; Denisse Bazan Dow; Alexandra Bedossa; Ker Hong Bee; Husna Begum; Sylvie Behilill; Albertus Beishuizen; Aleksandr Beljantsev; David Bellemare; Anna Beltrame; Beatriz Amorim Beltrão; Marine Beluze; Nicolas Benech; Lionel Eric Benjiman; Dehbia Benkerrou; Suzanne Bennett; Luís Bento; Jan-Erik Berdal; Delphine Bergeaud; Hazel Bergin; José Luis Bernal Sobrino; Giulia Bertoli; Lorenzo Bertolino; Simon Bessis; Sybille Bevilcaqua; Karine Bezulier; Amar Bhatt; Krishna Bhavsar; Claudia Bianco; Farah Nadiah Bidin; Moirangthem Bikram Singh; Felwa Bin Humaid; Mohd Nazlin Bin Kamarudin; François Bissuel; Patrick Biston; Laurent Bitker; Marjolein Brusse-Keizer; Yih-Sharng Chen; Sung-Min Cho; Sebastiano Maria Colombo; Amanda Corley; Rafael Freitas de Oliveira França; Dominique Deplanque; Eric D'Ortenzio; Susanne Dudman; Ilka Engelmann; Manuel Etienne; Jorge Fernandes; Christopher A Green; Ewen M Harrison; Leanne Hays; Mariachiara Ippolito; Nina Jamieson; Todd Karsies; Kalynn Kennon; Anders Benjamin Kildal; Demetrios Kutsogiannis; John G Laffey; Eka Yudha Lantang; Andreas Lind; Antonio Loforte; Dalia Lopez-Colon; Alejandro Martin-Quiros; Kenneth A McLean; Mary Mone; Srinivas Murthy; Jamel Ortoleva; Patricia Patricio; Scott Pharand; Sergio Poli; Jolanta Popielska; Pedro Povoa; Maia Rabaa; Cornelius Rau; Luis Felipe Reyes; Jordi Riera; Justin Schaffer; Tjard Schermer; Filipa Sequeira; Pablo Serrano Balazote; Hoi Ping Shum; Jacky Y Suen; Sofia Tejada; Olivier Terrier; Nicolas Terzi; Emma C Thomson; Ioannis Trontzas; Anders Tveita; Job van der Palen; Hugo Van Willigen; Sara Ventura;Abstract Background We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death.
Archivio istituziona... arrow_drop_down Archivio istituzionale della ricerca - Università di Padova; International Journal of Epidemiology; Archivio IstituzionaleArticle . 2023 . Peer-reviewedLicense: CC BYInternational Journal of EpidemiologyArticle . 2023Data sources: University of Groningen Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 14 citations 14 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Archivio istituziona... arrow_drop_down Archivio istituzionale della ricerca - Università di Padova; International Journal of Epidemiology; Archivio IstituzionaleArticle . 2023 . Peer-reviewedLicense: CC BYInternational Journal of EpidemiologyArticle . 2023Data sources: University of Groningen Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Denmark, United Kingdom, Netherlands, Italy, Australia, ItalyPublisher:Institute of Electrical and Electronics Engineers (IEEE) Funded by:EC | PERISCOPE, EC | XAI, EC | CompuLaw +2 projectsEC| PERISCOPE ,EC| XAI ,EC| CompuLaw ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers. ,EC| PRECISE4QAllahabadi, Himanshi; Amann, Julia; Balot, Isabelle; Beretta, Andrea; Binkley, Charles; Bozenhard, Jonas; Bruneault, Frederick; Brusseau, James; Candemir, Sema; Cappellini, Luca Alessandro; Castagnet, Genevieve Fieux; Chakraborty, Subrata; Cherciu, Nicoleta; Cociancig, Christina; Coffee, Megan; Ek, Irene; Espinosa-Leal, Leonardo; Farina, Davide; Fieux-Castagnet, Genevieve; Frauenfelder, Thomas; Gallucci, Alessio; Giuliani, Guya; Golda, Adam; van Halem, Irmhild; Hildt, Elisabeth; Holm, Sune; Kararigas, Georgios; Krier, Sebastien A.; Kuhne, Ulrich; Lizzi, Francesca; Madai, Vince I.; Markus, Aniek F.; Masis, Serg; Mathez, Emilie Wiinblad; Mureddu, Francesco; Neri, Emanuele; Osika, Walter; Ozols, Matiss; Panigutti, Cecilia; Parent, Brendan; Pratesi, Francesca; Moreno-Sanchez, Pedro A.; Sartor, Giovanni; Savardi, Mattia; Signoroni, Alberto; Sormunen, Hanna; Spezzatti, Andy; Srivastava, Adarsh; Stephansen, Annette F.; Theng, Lau Bee; Tithi, Jesmin Jahan; Tuominen, Jarno; Umbrello, Steven; Vaccher, Filippo; Vetter, Dennis; Westerlund, Magnus; Wurth, Renee; Zicari, Roberto V.;This article’s main contributions are twofold: 1) to demonstrate how to apply the general European Union’s High-Level Expert Group’s (EU HLEG) guidelines for trustworthy AI in practice for the domain of healthcare and 2) to investigate the research question of what does “trustworthy AI” mean at the time of the COVID-19 pandemic. To this end, we present the results of a post-hoc self-assessment to evaluate the trustworthiness of an AI system for predicting a multiregional score conveying the degree of lung compromise in COVID-19 patients, developed and verified by an interdisciplinary team with members from academia, public hospitals, and industry in time of pandemic. The AI system aims to help radiologists to estimate and communicate the severity of damage in a patient’s lung from Chest X-rays. It has been experimentally deployed in the radiology department of the ASST Spedali Civili clinic in Brescia, Italy, since December 2020 during pandemic time. The methodology we have applied for our post-hoc assessment, called Z-Inspection®, uses sociotechnical scenarios to identify ethical, technical, and domain-specific issues in the use of the AI system in the context of the pandemic. Ethics & Philosophy of Technology
IEEE Transactions on... arrow_drop_down IEEE Transactions on Technology and Society; IEEE Technology and Society MagazineOther literature type . Article . 2022 . Peer-reviewedLicense: CC BY NC NDArchivio istituzionale della ricerca - Università di BresciaArticle . 2022IEEE Transactions on Technology and SocietyArticle . 2022Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 9visibility views 9 download downloads 5 Powered bymore_vert IEEE Transactions on... arrow_drop_down IEEE Transactions on Technology and Society; IEEE Technology and Society MagazineOther literature type . Article . 2022 . Peer-reviewedLicense: CC BY NC NDArchivio istituzionale della ricerca - Università di BresciaArticle . 2022IEEE Transactions on Technology and SocietyArticle . 2022Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 Spain, Germany, Germany, ItalyPublisher:Wiley Funded by:EC | EOSC Future, EC | BY-COVID, SNSF | Exploring protein dynamic... +2 projectsEC| EOSC Future ,EC| BY-COVID ,SNSF| Exploring protein dynamics with atomic resolution ,EC| iNEXT-Discovery ,EC| SEE-DRUGHannes Berg; Maria A. Wirtz Martin; Nadide Altincekic; Islam Alshamleh; Jasleen Kaur Bains; Julius Blechar; Betül Ceylan; Vanessa de Jesus; Karthikeyan Dhamotharan; Christin Fuks; Santosh L. Gande; Bruno Hargittay; Katharina F. Hohmann; Marie T. Hutchison; Sophie Marianne Korn; Robin Krishnathas; Felicitas Kutz; Verena Linhard; Tobias Matzel; Nathalie Meiser; Anna Niesteruk; Dennis J. Pyper; Linda Schulte; Sven Trucks; Kamal Azzaoui; Marcel J. J. Blommers; Yojana Gadiya; Reagon Karki; Andrea Zaliani; Philip Gribbon; Marcius da Silva Almeida; Cristiane Dinis Anobom; Anna L. Bula; Matthias Bütikofer; Ícaro Putinhon Caruso; Isabella Caterina Felli; Andrea T. Da Poian; Gisele Cardoso de Amorim; Nikolaos K. Fourkiotis; Angelo Gallo; Dhiman Ghosh; Francisco Gomes‐Neto; Oksana Gorbatyuk; Bing Hao; Vilius Kurauskas; Lauriane Lecoq; Yunfeng Li; Nathane Cunha Mebus‐Antunes; Miguel Mompeán; Thais Cristtina Neves‐Martins; Martí Ninot‐Pedrosa; Anderson S. Pinheiro; Letizia Pontoriero; Yulia Pustovalova; Roland Riek; Angus J. Robertson; Marie Jose Abi Saad; Miguel Á. Treviño; Aikaterini C. Tsika; Fabio C. L. Almeida; Ad Bax; Katherine Henzler‐Wildman; Jeffrey C. Hoch; Kristaps Jaudzems; Douglas V. Laurents; Julien Orts; Roberta Pierattelli; Georgios A. Spyroulias; Elke Duchardt‐Ferner; Jan Ferner; Boris Fürtig; Martin Hengesbach; Frank Löhr; Nusrat Qureshi; Christian Richter; Krishna Saxena; Andreas Schlundt; Sridhar Sreeramulu; Anna Wacker; Julia E. Weigand; Julia Wirmer‐Bartoschek; Jens Wöhnert; Harald Schwalbe;Work at BMRZ is supported by the state of Hesse. Work in Covid19-NMR was supported by the Goethe Corona Funds, by the IWBEFRE-program 20007375 of state of Hesse, the DFG through CRC902: “Molecular Principles of RNA-based regulation.” and through infrastructure funds (project numbers: 277478796, 277479031, 392682309, 452632086, 70653611) and by European Union’s Horizon 2020 research and innovation program iNEXT-discovery under grant agreement No 871037. BY-COVID receives funding from the European Union’s Horizon Europe Research and Innovation Programme under grant agreement number 101046203. “INSPIRED” (MIS 5002550) project, implemented under the Action “Reinforcement of the Research and Innovation Infrastructure,” funded by the Operational Program “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014–2020) and co-financed by Greece and the EU (European Regional Development Fund) and the FP7 REGPOT CT-2011-285950—“SEE-DRUG” project (purchase of UPAT’s 700 MHz NMR equipment). The support of the CERM/CIRMMP center of Instruct-ERIC is gratefully acknowledged. This work has been funded in part by a grant of the Italian Ministry of University and Research (FISR2020IP_02112, ID-COVID) and by Fondazione CR Firenze. A.S. is supported by the Deutsche Forschungsgemeinschaft [SFB902/B16, SCHL2062/2-1] and the Johanna Quandt Young Academy at Goethe [2019/AS01]. M.H. and C.F. thank SFB902 and the Stiftung Polytechnische Gesellschaft for the Scholarship. L.L. work was supported by the French National Research Agency (ANR, NMR-SCoV2-ORF8), the Fondation de la Recherche Médicale (FRM, NMR-SCoV2-ORF8), FINOVI and the IR-RMN-THC Fr3050 CNRS. Work at UConn Health was supported by grants from the US National Institutes of Health (R01 GM135592 to B.H., P41 GM111135 and R01 GM123249 to J.C.H.) and the US National Science Foundation (DBI 2030601 to J.C.H.). Latvian Council of Science Grant No. VPP-COVID-2020/1-0014. National Science Foundation EAGER MCB-2031269. This work was supported by the grant Krebsliga KFS-4903-08-2019 and SNF-311030_192646 to J.O. P.G. (ITMP) The EOSC Future project is co-funded by the European Union Horizon Programme call INFRAEOSC-03-2020—Grant Agreement Number 101017536. Open Access funding enabled and organized by Projekt DEAL SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti-virals. Within the international Covid19-NMR consortium, we have identified binders targeting the RNA genome of SCoV2. We established protocols for the production and NMR characterization of more than 80 % of all SCoV2 proteins. Here, we performed an NMR screening using a fragment library for binding to 25 SCoV2 proteins and identified hits also against previously unexplored SCoV2 proteins. Computational mapping was used to predict binding sites and identify functional moieties (chemotypes) of the ligands occupying these pockets. Striking consensus was observed between NMR-detected binding sites of the main protease and the computational procedure. Our investigation provides novel structural and chemical space for structure-based drug design against the SCoV2 proteome. 12 pags., 4 figs., 3 tabs. Peer reviewed
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Flore (Florence Research Repository); Angewandte Chemie International EditionOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYFlore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . 2023 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 23visibility views 23 download downloads 99 Powered bymore_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Flore (Florence Research Repository); Angewandte Chemie International EditionOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYFlore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . 2023 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2022 ItalyPublisher:IEEE Funded by:EC | NextPerceptionEC| NextPerceptionAmparore, Elvio G.; Botta, Marco; Drago, Idilio; Donatelli, Susanna; Mazzone, Giuseppe;handle: 2318/1880491
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO)Conference object . 2022Data sources: Archivio Istituzionale (AperTO)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO)Conference object . 2022Data sources: Archivio Istituzionale (AperTO)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 France, United Kingdom, France, Italy, Italy, Italy, France, United Kingdom, Italy, Italy, United Kingdom, Netherlands, FrancePublisher:Springer Science and Business Media LLC Funded by:WT | Understanding cross-react..., WT | ISARIC, EC | ECRAID-Base +3 projectsWT| Understanding cross-reactive immunity to Japanese encephalitis virus ,WT| ISARIC ,EC| ECRAID-Base ,UKRI| ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) ,CIHR ,EC| RECoVERReyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Merson, Laura; Ibáñez-Prada, Elsa; Rello, Jordi; Fuentes, Yuli; Martin-Loeches, Ignacio; Bozza, Fernando; Duque, Sara; Taccone, Fabio; Fowler, Robert; Kartsonaki, Christiana; Gonçalves, Bronner; Citarella, Barbara Wanjiru; Aryal, Diptesh; Burhan, Erlina; Cummings, Matthew; Delmas, Christelle; Diaz, Rodrigo; Figueiredo-Mello, Claudia; Hashmi, Madiha; Panda, Prasan Kumar; Jiménez, Miguel Pedrera; Rincon, Diego Fernando Bautista; Thomson, David; Nichol, Alistair; Marshall, John; Olliaro, Piero; Abbas, Ali; Abdukahil, Sheryl Ann; Abe, Ryuzo; Abel, Laurent; Absil, Lara; Acharya, Subhash; Acker, Andrew; Adrião, Diana; Al Ageel, Saleh; Ahmed, Shakeel; Ainscough, Kate; Aisa, Tharwat; Hssain, Ali Ait; Tamlihat, Younes Ait; Akimoto, Takako; Akmal, Ernita; Al Qasim, Eman; Alalqam, Razi; Al-Dabbous, Tala; Alegesan, Senthilkumar; Alegre, Cynthia; Alessi, Marta; Alex, Beatrice; Alexandre, Kévin; Al-Fares, Abdulrahman; Alfoudri, Huda; Ali, Imran; Shah, Naseem Ali; Alidjnou, Kazali Enagnon; Aliudin, Jeffrey; Alkhafajee, Qabas; Allavena, Clotilde; Allou, Nathalie; Altaf, Aneela; Alves, João; Alves, João Melo; Alves, Rita; Cabrita, Joana Alves; Amaral, Maria; Ampaw, Phoebe; Andini, Roberto; Andréjak, Claire; Angheben, Andrea; Angoulvant, François; Ansart, Séverine; Antonelli, Massimo; de Brito, Carlos Alexandre Antunes; Apriyana, Ardiyan; Arabi, Yaseen; Aragao, Irene; Araujo, Carolline; Arcadipane, Antonio; Archambault, Patrick; Arenz, Lukas; Arlet, Jean-Benoît; Arnold-Day, Christel; Arora, Lovkesh; Arora, Rakesh; Artaud-Macari, Elise; Aryal, Diptesh; Asensio, Angel; Asif, Namra; Asim, Mohammad; Assie, Jean Baptiste; Atique, Anika; Attanyake, A.; Auchabie, Johann; Aumaitre, Hugues; Auvet, Adrien; Azemar, Laurène; Azoulay, Cecile; Bach, Benjamin; Bachelet, Delphine; Badr, Claudine; Baig, Nadia; Baillie, J. Kenneth; Bak, Erica; Bakakos, Agamemnon; Bal, Andriy; Balan, Valeria; Bani-Sadr, Firouzé; Barbalho, Renata; Barclay, Wendy; Barnikel, Michaela; Barrasa, Helena; Barrelet, Audrey; Barrigoto, Cleide; Bartoli, Marie; Baruch, Joaquín; Basmaci, Romain; Battaglini, Denise; Bauer, Jules; Dow, Denisse Bazan; Beane, Abigail; Bedossa, Alexandra; Begum, Husna; Behilill, Sylvie; Beishuizen, Albertus; Beljantsev, Aleksandr; Bellemare, David; Beltrame, Anna; Beluze, Marine; Benech, Nicolas; Benkerrou, Dehbia; Bennett, Suzanne; Bento, Luís; Berdal, Jan-Erik; Bergeaud, Delphine; Bergin, Hazel; Sobrino, José Luis Bernal; Bertoli, Giulia; Bertolino, Lorenzo; Bessis, Simon; Bevilcaqua, Sybille; Bezulier, Karine; Bhatt, Amar; Bhavsar, Krishna; Bianco, Claudia; Singh, Moirangthem Bikram; Humaid, Felwa Bin; Bissuel, François; Bitker, Laurent; Bitton, Jonathan; Blanco-Schweizer, Pablo; Blier, Catherine; Bloos, Frank; Blot, Mathieu; Boccia, Filomena; Bodenes, Laetitia; Bogaert, Debby; Boivin, Anne-Hélène; Bolze, Pierre-Adrien; Bompart, François; Borges, Diogo; Borie, Raphaël; Bosse, Hans Martin; Botelho-Nevers, Elisabeth; Bouadma, Lila; Bouchaud, Olivier; Bouchez, Sabelline; Bouhmani, Dounia; Bouhour, Damien; Bouiller, Kévin; Bouillet, Laurence; Bouisse, Camile; Boureau, Anne-Sophie; Bourke, John; Bouscambert, Maude; Bousquet, Aurore; Bouziotis, Jason; Boxma, Bianca; Boyer-Besseyre, Marielle; Boylan, Maria; Braconnier, Axelle; Braga, Cynthia; Brandenburger, Timo; Monteiro, Filipa Brás; Brazzi, Luca; Breen, Dorothy; Breen, Patrick; Brickell, Kathy; Browne, Alex; Browne, Shaunagh; Brusse-Keizer, Marjolein; Buchtele, Nina; Buesaquillo, Christian; Bugaeva, Polina; Buisson, Marielle; Burrell, Aidan; Bustos, Ingrid; Butnaru, Denis; Caceres, Eder; Cattaneo, Paolo; Chen, Yih-Sharng; Cho, Sung-Min; Colombo, Sebastiano Maria; Corley, Amanda; Dahly, Darren; Denis, Emmanuelle; Deplanque, Dominique; Dondorp, Arjen; Dudman, Susanne; Durante-Mangoni, Emanuele; Engelmann, Ilka; Etienne, Manuel; Fernandes, Jorge; Gaymard, Alexandre; Green, Christopher; Haidri, Fakhir; Harrison, Ewen; Hays, Leanne; Hitoto, Hikombo; Ippolito, Mariachiara; Jamieson, Nina; Kelly, Yvelynne; Kennon, Kalynn; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Laffey, John; Lantang, Eka Yudha; Le Turnier, Paul; Lind, Andreas; Loforte, Antonio; Machado, Sara; Martucci, Gennaro; Masood, Sobia; Mclean, Kenneth; Mone, Mary; Motos, Ana; Munblit, Daniel; Noursadeghi, Mahdad; Ortoleva, Jamel; Patricio, Patricia; Pharand, Scott; Poli, Sergio; Povoa, Pedro; Rau, Cornelius; Riera, Jordi; Sandulescu, Oana; Schaffer, Justin; Schermer, Tjard; Semple, Malcolm; Sequeira, Filipa; Balazote, Pablo Serrano; Shum, Hoi Ping; Streinu-Cercel, Adrian; Suen, Jacky; Summers, Charlotte; Sztajnbok, Jaques; Tejada, Sofia; Terrier, Olivier; Terzi, Nicolas; Thomson, Emma; Trontzas, Ioannis; Turtle, Lance; van der Palen, Job; Ventura, Sara; Shukeri, Wan Fadzlina Wan Muhd; West, T. Eoin; Wils, Evert-Jan;pmid: 36100904
pmc: PMC9469080
Invasive mechanical ventilation; COVID-19; Critical care Ventilación mecánica invasiva; COVID-19; Cuidado crítico Ventilació mecànica invasiva; COVID-19; Atenció crítica Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. This work was supported by the UK Foreign, Commonwealth, and Development Office and Wellcome [215091/Z/18/Z] and the Bill & Melinda Gates Foundation [OPP1209135]; CIHR Coronavirus Rapid Research Funding Opportunity OV2170359; Grants from Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 Project 101003589] and European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313]; The Imperial NIHR Biomedical Research Centre; The Cambridge NIHR Biomedical Research Centre; and Endorsed by the Irish Critical Care-Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care-Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12]. This work uses Data/Materials provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The Data/materials used for this research were obtained from ISARIC4C. The COVID-19 Clinical Information Network (CO-CIN) data was collated by ISARIC4C Investigators. Data and Material provision were supported by grants from: the National Institute for Health Research (NIHR; award CO-CIN-01), the Medical Research Council (MRC; Grant MC_PC_19059), and the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE), (Award 200907), Wellcome Trust [Turtle, Lance-fellowship 205228/Z/16/Z], NIHR HPRU in Respiratory Infections at Imperial College London with PHE (Award 200927), Liverpool Experimental Cancer Medicine Centre (Grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (Award IS-BRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. This work was possible due to the dedication and hard work of the Norwegian SARS-CoV-2 study team and supported by grants from Research Council of Norway Grant No. 312780 and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; The dedication and hard work of the Groote Schuur Hospital Covid ICU Team, and supported by the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town; and supported by the COVID clinical management team, AIIMS, Rishikesh, India.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Archivio istituzionale della ricerca - Università di Palermo; Oxford University Research Archive; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"; Critical CareOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYData sources: Archivio Istituzionale (AperTO); European Union Open Data Portal; University of Twente Research Information ; University of Groningen Research Portal; Archivio istituzionale della ricerca - Università di Palermo; Oxford University Research Archive; Crossref; NARCIS; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"Spiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositoryHAL DescartesArticle . 2022License: CC BYFull-Text: https://hal.science/hal-04372985/documentData sources: HAL DescartesHAL Descartes; HAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Archivio istituzionale della ricerca - Università di Palermo; Oxford University Research Archive; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"; Critical CareOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYData sources: Archivio Istituzionale (AperTO); European Union Open Data Portal; University of Twente Research Information ; University of Groningen Research Portal; Archivio istituzionale della ricerca - Università di Palermo; Oxford University Research Archive; Crossref; NARCIS; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"Spiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositoryHAL DescartesArticle . 2022License: CC BYFull-Text: https://hal.science/hal-04372985/documentData sources: HAL DescartesHAL Descartes; HAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Netherlands, Italy, United Kingdom, France, Italy, Italy, Italy, FrancePublisher:Oxford University Press (OUP) Funded by:CIHR, ARC | ARC Centres of Excellence..., WT | Malawi-Liverpool-Wellcome... +7 projectsCIHR ,ARC| ARC Centres of Excellence - Grant ID: CE170100009 ,WT| Malawi-Liverpool-Wellcome Trust COVID-19 Epidemic Preparedness ,NIH| CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) study ,EC| RECoVER ,WT| Understanding cross-reactive immunity to Japanese encephalitis virus ,EC| ECRAID-Base ,UKRI| ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) ,WT| The ISARIC data platform: Optimizing data-driven pandemic preparedness and response ,WT| ISARICSung-Min Cho; Nicole White; Lavienraj Premraj; Denise Battaglini; Jonathon Fanning; Jacky Suen; Gianluigi Li Bassi; John Fraser; Chiara Robba; Matthew Griffee; Bhagteshwar Singh; ;?>Barbara Wanjiru Citarella; Laura Merson; Tom Solomon; David Thomson; Ali Abbas; Nurul Najmee Abdulkadir; Ryuzo Abe; Laurent Abel; Lara Absil; Subhash Acharya; Andrew Acker; Diana Adrião; Saleh Al Ageel; Shakeel Ahmed; Kate Ainscough; Tharwat Aisa; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Razi Alalqam; Tala Al-dabbous; Senthilkumar Alegesan; Cynthia Alegre; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Huda Alfoudri; Imran Ali; Naseem Ali Shah; Kazali Enagnon Alidjnou; Jeffrey Aliudin; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; Aneela Altaf; João Alves; Rita Alves; João Melo Alves; Maria Amaral; Nur Amira; Phoebe Ampaw; Roberto Andini; Claire Andrejak; Andrea Angheben; François Angoulvant; Séverine Ansart; Sivanesen Anthonidass; Massimo Antonelli; Carlos Alexandre Antunes de Brito; Ardiyan Apriyana; Irene Aragao; Francisco Arancibia; Carolline Araujo; Antonio Arcadipane; Patrick Archambault; Lukas Arenz; Jean-Benoît Arlet; Christel Arnold-Day; Lovkesh Arora; Rakesh Arora; Elise Artaud-Macari; Diptesh Aryal; Angel Asensio; Muhammad Ashraf; Namra Asif; Mohammad Asim; Jean Baptiste Assie; Amirul Asyraf; Anika Atique; AM Udara Lakshan Attanyake; Johann Auchabie; Hugues Aumaitre; Adrien Auvet; Laurène Azemar; Cecile Azoulay; Benjamin Bach; Delphine Bachelet; Claudine Badr; Nadia Baig; J Kenneth Baillie; Erica Bak; Agamemnon Bakakos; Nazreen Abu Bakar; Andriy Bal; Mohanaprasanth Balakrishnan; Valeria Balan; Firouzé Bani-Sadr; Renata Barbalho; Wendy S Barclay; Saef Umar Barnett; Michaela Barnikel; Audrey Barrelet; Cleide Barrigoto; Marie Bartoli; Joaquín Baruch; Romain Basmaci; Muhammad Fadhli Hassin Basri; Denise Battaglini; Jules Bauer; Diego Fernando Bautista Rincon; Abigail Beane; Alexandra Bedossa; Ker Hong Bee; Husna Begum; Sylvie Behilill; Albertus Beishuizen; Aleksandr Beljantsev; David Bellemare; Anna Beltrame; Marine Beluze; Nicolas Benech; Lionel Eric Benjiman; Dehbia Benkerrou; Suzanne Bennett; Luís Bento; Jan-Erik Berdal; Delphine Bergeaud; Hazel Bergin; José Luis Bernal Sobrino; Giulia Bertoli; Lorenzo Bertolino; Simon Bessis; Sybille Bevilcaqua; Karine Bezulier; Amar Bhatt; Krishna Bhavsar; Claudia Bianco; Farah Nadiah Bidin; Moirangthem Bikram Singh; Mohd Nazlin Bin Kamarudin; François Bissuel; Laurent Bitker; Jonathan Bitton; Pablo Blanco-Schweizer; Catherine Blier; Frank Bloos; Mathieu Blot; Filomena Boccia; Laetitia Bodenes; Alice Bogaarts; Debby Bogaert; Anne-Hélène Boivin; Pierre-Adrien Bolze; François Bompart; Diogo Borges; Raphaël Borie; Hans Martin Bosse; Elisabeth Botelho-Nevers; Lila Bouadma; Olivier Bouchaud; Sabelline Bouchez; Dounia Bouhmani; Damien Bouhour; Kévin Bouiller; Laurence Bouillet; Camile Bouisse; Anne-Sophie Boureau; John Bourke; Maude Bouscambert; Aurore Bousquet; Jason Bouziotis; Bianca Boxma; Marielle Boyer-Besseyre; Maria Boylan; Fernando Augusto Bozza; Axelle Braconnier; Cynthia Braga; Timo Brandenburger; Filipa Brás Monteiro; Luca Brazzi; Patrick Breen; Dorothy Breen; Patrick Breen; Kathy Brickell; Shaunagh Browne; Nicolas Brozzi; Marjolein Brusse-Keizer; Nina Buchtele; Christian Buesaquillo; Marielle Buisson; Erlina Burhan; Aidan Burrell; Ingrid G Bustos; André Cabie; Susana Cabral; Eder Caceres; Cyril Cadoz; Jose Andres Calvache; Yih-Sharng Chen; Sebastiano Maria Colombo; Amanda Corley; Dominique Deplanque; Susanne Dudman; Christopher A Green; Ewen M Harrison; Leanne Hays; Nina Jamieson; Ravi Kant; Kalynn Kennon; Anders Benjamin Kildal; Demetrios Kutsogiannis; John G Laffey; Eka Yudha Lantang; Antonio Loforte; Kenneth A McLean; Mary Mone; Srinivas Murthy; Alistair Nichol; Jamel Ortoleva; Patricia Patricio; Scott Pharand; Sergio Poli; Jolanta Popielska; Pedro Povoa; Cornelius Rau; Luis Felipe Reyes; Jordi Riera; Oana Sandulescu; Justin Schaffer; Tjard Schermer; Malcolm G Semple; Filipa Sequeira; Pablo Serrano Balazote; Hoi Ping Shum; Adrian Streinu-Cercel; Jaques Sztajnbok; Olivier Terrier; Nicolas Terzi; Emma C Thomson; Anders Tveita; Sara Ventura;pmid: 36087305
pmc: PMC9494397
AbstractDifferent neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models.Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001).Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke. All in-hospital neurological complications were associated with increased odds of death. The likelihood of death rose with increasing age, especially after 25 years of age.In conclusion, adults and children have different neurological manifestations and in-hospital complications associated with COVID-19. Stroke risk increased with increasing age, while CNS infection and seizure risk decreased with age.
Archivio Istituziona... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2022License: CC BY NCData sources: Spiral - Imperial College Digital RepositoryOxford University Research ArchiveOther literature type . 2022License: CC BY NCData sources: Oxford University Research ArchiveBrain; Archivio istituzionale della ricerca - Università di Genova; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"Article . 2023 . 2022 . Peer-reviewedLicense: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2022License: CC BY NCData sources: Spiral - Imperial College Digital RepositoryOxford University Research ArchiveOther literature type . 2022License: CC BY NCData sources: Oxford University Research ArchiveBrain; Archivio istituzionale della ricerca - Università di Genova; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"Article . 2023 . 2022 . Peer-reviewedLicense: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, GermanyPublisher:Elsevier BV Funded by:EC | iNEXT-Discovery, EC | EUbOPEN, EC | SEE-DRUGEC| iNEXT-Discovery ,EC| EUbOPEN ,EC| SEE-DRUGAuthors: Tsika, Aikaterini C; Gallo, Angelo; Fourkiotis, Nikolaos K; Argyriou, Aikaterini I; +13 AuthorsTsika, Aikaterini C; Gallo, Angelo; Fourkiotis, Nikolaos K; Argyriou, Aikaterini I; Sreeramulu, Sridhar; Löhr, Frank; Rogov, Vladimir V; Richter, Christian; Linhard, Verena; Gande, Santosh L; Altincekic, Nadide; Krishnathas, Robin; Elamri, Isam; Schwalbe, Harald; Wollenhaupt, Jan; Weiss, Manfred S; Spyroulias, Georgios A;Viral infection in cells triggers a cascade of molecular defense mechanisms to maintain host-cell homoeostasis. One of these mechanisms is ADP-ribosylation, a fundamental post-translational modification (PTM) characterized by the addition of ADP-ribose (ADPr) on substrates. Poly(ADP-ribose) polymerases (PARPs) are implicated in this process and they perform ADP-ribosylation on host and pathogen proteins. Some viral families contain structural motifs that can reverse this PTM. These motifs known as macro domains (MDs) are evolutionarily conserved protein domains found in all kingdoms of life. They are divided in different classes with the viral belonging to Macro-D-type class because of their properties to recognize and revert the ADP-ribosylation. Viral MDs are potential pharmaceutical targets, capable to counteract host immune response. Sequence and structural homology between viral and human MDs are an impediment for the development of new active compounds against their function. Remdesivir, is a drug administrated in viral infections inhibiting viral replication through RNA-dependent RNA polymerase (RdRp). Herein, GS-441524, the active metabolite of the remdesivir, is tested as a hydrolase inhibitor for several viral MDs and for its binding to human homologs found in PARPs. This study presents biochemical and biophysical studies, which indicate that GS-441524 selectively modifies SARS-CoV-2 MD de-MARylation activity, while it does not interact with hPARP14 MD2 and hPARP15 MD2. The structural investigation of MD•GS-441524 complexes, using solution NMR and X-ray crystallography, discloses the impact of certain amino acids in ADPr binding cavity suggesting that F360 and its adjacent residues tune the selective binding of the inhibitor to SARS-CoV-2 MD.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Molecular BiologyOther literature type . Article . 2022 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jmb.2022.167720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Molecular BiologyOther literature type . Article . 2022 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Switzerland, Italy, Italy, Italy, ItalyPublisher:Elsevier BV Funded by:EC | MARVELEC| MARVELBurrello, Jacopo; Caporali, Elena; Gauthier, Lorenzo Grazioli; Pianezzi, Enea; Balbi, Carolina; Rigamonti, Elia; Bolis, Sara; Lazzarini, Edoardo; Biemmi, Vanessa; Burrello, Alessio; Frigerio, Roberto; Martinetti, Gladys; Fusi-Schmidhauser, Tanja; Vassalli, Giuseppe; Ferrari, Enrico; Moccetti, Tiziano; Gori, Alessandro; Cretich, Marina; Melli, Giorgia; Monticone, Silvia; Barile, Lucio;Inflammatory response following SARS-CoV-2 infection results in substantial increase of amounts of intravascular pro-coagulant extracellular vesicles (EVs) expressing tissue factor (CD142) on their surface. CD142-EV turned out to be useful as diagnostic biomarker in COVID-19 patients. Here we aimed at studying the prognostic capacity of CD142-EV in SARS-CoV-2 infection. Expression of CD142-EV was evaluated in 261 subjects admitted to hospital for pneumonia and with a positive molecular test for SARS-CoV-2. The study population consisted of a discovery cohort of selected patients (n = 60) and an independent validation cohort including unselected consecutive enrolled patients (n = 201). CD142-EV levels were correlated with post-hospitalization course of the disease and compared to the clinically available 4C Mortality Score as referral. CD142-EV showed a reliable performance to predict patient prognosis in the discovery cohort (AUC = 0.906) with an accuracy of 81.7%, that was confirmed in the validation cohort (AUC = 0.736). Kaplan-Meier curves highlighted a high discrimination power in unselected subjects with CD142-EV being able to stratify the majority of patients according to their prognosis. We obtained a comparable accuracy, being not inferior in terms of prediction of patients' prognosis and risk of mortality, with 4C Mortality Score. The expression of surface vesicular CD142 and its reliability as prognostic marker was technically validated using different immunocapture strategies and assays. The detection of CD142 on EV surface gains considerable interest as risk stratification tool to support clinical decision making in COVID-19.
ZENODO; Vascular Pha... arrow_drop_down ZENODO; Vascular Pharmacology; Publications Open Repository TOrinoArticle . 2022 . Peer-reviewedLicense: Elsevier TDMZurich Open Repository and ArchiveOther literature type . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.vph.2022.106999&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 10visibility views 10 download downloads 32 Powered bymore_vert ZENODO; Vascular Pha... arrow_drop_down ZENODO; Vascular Pharmacology; Publications Open Repository TOrinoArticle . 2022 . Peer-reviewedLicense: Elsevier TDMZurich Open Repository and ArchiveOther literature type . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2023 Italy, Portugal, Finland, PolandPublisher:SAGE Publications Funded by:EC | VAX-TRUSTEC| VAX-TRUSTAna Patrícia Hilário; Alice Scavarda; Dino Numerato; Joana Mendonça; Mario Cardano; Jaroslava Marhankova; Luigi Gariglio; Pia Vuolanto; Alistair Anderson; Petra Auvinen; Piet Bracke; Tom Douglass; Pru Hobson-West; Esther Lermytte; Paulina Polak; Tadeusz Rudek;While recruitment is an essential aspect of any research project, its challenges are rarely acknowledged. We intend to address this gap by discussing the challenges to the participation of vaccine-hesitant parents defined here as a hard-to-reach, hidden and vulnerable population drawing on extensive empirical qualitative evidence from seven European countries. The difficulties in reaching vaccine-hesitant parents were very much related to issues concerning trust, as there appears to be a growing distrust in experts, which is extended to the work developed by researchers and their funding bodies. These difficulties have been accentuated by the public debate around COVID-19 vaccination, as it seems to have increased parents’ hesitancy to participate. Findings from recruiting 167 vaccine-hesitant parents in seven European countries suggest that reflexive and sensible recruitment approaches should be developed.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Qualitative Health ResearchArticle . 2023 . Peer-reviewedLicense: CC BYTrepo - Institutional Repository of Tampere UniversityArticle . 2023 . Peer-reviewedData sources: Trepo - Institutional Repository of Tampere UniversityUniversidade de Lisboa: Repositório.ULOther literature type . 2023License: CC BYData sources: Universidade de Lisboa: Repositório.ULadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/10497323231196439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!visibility 30visibility views 30 download downloads 9 Powered bymore_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Qualitative Health ResearchArticle . 2023 . Peer-reviewedLicense: CC BYTrepo - Institutional Repository of Tampere UniversityArticle . 2023 . Peer-reviewedData sources: Trepo - Institutional Repository of Tampere UniversityUniversidade de Lisboa: Repositório.ULOther literature type . 2023License: CC BYData sources: Universidade de Lisboa: Repositório.ULadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/10497323231196439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Netherlands, Spain, ItalyPublisher:MDPI AG Funded by:EC | RADAR-CNSEC| RADAR-CNSLavalle, Raffaele; Condominas, Elena; Haro, Josep Maria; Giné-Vázquez, Iago; Bailon, Raquel; Laporta, Estela; Garcia, Ester; Kontaxis, Spyridon; Alacid, Gemma Riquelme; Lombardini, Federica; Preti, Antonio; Peñarrubia-Maria, Maria Teresa; Coromina, Marta; Arranz, Belén; Vilella, Elisabet; Rubio-Alacid, Elena; Radar-Mdd Spain; Matcham, Faith; Lamers, Femke; Hotopf, Matthew; Penninx, Brenda W. J. H.; Annas, Peter; Narayan, Vaibhav; Simblett, Sara K.; Siddi, Sara; The Radar-Cns Consortium;The present study analyzes the effects of each containment phase of the first COVID-19 wave on depression levels in a cohort of 121 adults with a history of major depressive disorder (MDD) from Catalonia recruited from 1 November 2019, to 16 October 2020. This analysis is part of the Remote Assessment of Disease and Relapse-MDD (RADAR-MDD) study. Depression was evaluated with the Patient Health Questionnaire-8 (PHQ-8), and anxiety was evaluated with the Generalized Anxiety Disorder-7 (GAD-7). Depression’s levels were explored across the phases (pre-lockdown, lockdown, and four post-lockdown phases) according to the restrictions of Spanish/Catalan governments. Then, a mixed model was fitted to estimate how depression varied over the phases. A significant rise in depression severity was found during the lockdown and phase 0 (early post-lockdown), compared with the pre-lockdown. Those with low pre-lockdown depression experienced an increase in depression severity during the “new normality”, while those with high pre-lockdown depression decreased compared with the pre-lockdown. These findings suggest that COVID-19 restrictions affected the depression level depending on their pre-lockdown depression severity. Individuals with low levels of depression are more reactive to external stimuli than those with more severe depression, so the lockdown may have worse detrimental effects on them.
International Journa... arrow_drop_down International Journal of Environmental Research and Public Health; Archivio IstituzionaleOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2023License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2023Data sources: Europe PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2023Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph20065161&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public Health; Archivio IstituzionaleOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2023License: CC BYInternational Journal of Environmental Research and Public HealthArticle . 2023Data sources: Europe PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2023Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph20065161&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Italy, United Kingdom, Italy, France, Netherlands, Italy, Netherlands, ItalyPublisher:Oxford University Press (OUP) Funded by:University College Dublin, ARC | ARC Centres of Excellence..., EC | ECRAID-Base +7 projectsUniversity College Dublin ,ARC| ARC Centres of Excellence - Grant ID: CE170100009 ,EC| ECRAID-Base ,WT| Understanding cross-reactive immunity to Japanese encephalitis virus ,WT| ISARIC ,WT ,WT| Malawi-Liverpool-Wellcome Trust COVID-19 Epidemic Preparedness ,EC| RECoVER ,UKRI| ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) ,CIHRAuthors: Christiana Kartsonaki; J Kenneth Baillie; Noelia García Barrio; Joaquín Baruch; +251 AuthorsChristiana Kartsonaki; J Kenneth Baillie; Noelia García Barrio; Joaquín Baruch; Abigail Beane; Lucille Blumberg; Fernando Bozza; Tessa Broadley; Aidan Burrell; Gail Carson; Barbara Wanjiru Citarella; Andrew Dagens; Emmanuelle A Dankwa; Christl A Donnelly; Jake Dunning; Loubna Elotmani; Martina Escher; Nataly Farshait; Jean-Christophe Goffard; Bronner P Gonçalves; Matthew Hall; Madiha Hashmi; Benedict Sim Lim Heng; Antonia Ho; Waasila Jassat; Miguel Pedrera Jiménez; Cedric Laouenan; Samantha Lissauer; Ignacio Martin-Loeches; France Mentré; Laura Merson; Ben Morton; Daniel Munblit; Nikita A Nekliudov; Alistair D Nichol; Budha Charan Singh Oinam; David Ong; Prasan Kumar Panda; Michele Petrovic; Mark G Pritchard; Nagarajan Ramakrishnan; Grazielle Viana Ramos; Claire Roger; Oana Sandulescu; Malcolm G Semple; Pratima Sharma; Louise Sigfrid; Emily C Somers; Anca Streinu-Cercel; Fabio Taccone; Pavan Kumar Vecham; Bharath Kumar Tirupakuzhi Vijayaraghavan; Jia Wei; Evert-Jan Wils; Xin Ci Wong; Peter Horby; Amanda Rojek; Piero L Olliaro; Ali Abbas; Sheryl Ann Abdukahil; Nurul Najmee Abdulkadir; Ryuzo Abe; Laurent Abel; Lara Absil; Subhash Acharya; Andrew Acker; Elisabeth Adam; Diana Adrião; Saleh Al Ageel; Shakeel Ahmed; Kate Ainscough; Eka Airlangga; Tharwat Aisa; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Eman Al Qasim; Razi Alalqam; Angela Alberti; Tala Al-dabbous; Senthilkumar Alegesan; Cynthia Alegre; Marta Alessi; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Huda Alfoudri; Imran Ali; Adam Ali; Naseem Ali Shah; Kazali Enagnon Alidjnou; Jeffrey Aliudin; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; Aneela Altaf; João Alves; Rita Alves; João Melo Alves; Maria Amaral; Nur Amira; Phoebe Ampaw; Roberto Andini; Claire Andréjak; Andrea Angheben; François Angoulvant; Séverine Ansart; Sivanesen Anthonidass; Massimo Antonelli; Carlos Alexandre Antunes de Brito; Ardiyan Apriyana; Yaseen Arabi; Irene Aragao; Francisco Arancibia; Carolline Araujo; Antonio Arcadipane; Patrick Archambault; Lukas Arenz; Jean-Benoît Arlet; Christel Arnold-Day; Lovkesh Arora; Rakesh Arora; Elise Artaud-Macari; Diptesh Aryal; Angel Asensio; Muhammad Ashraf; Namra Asif; Mohammad Asim; Jean Baptiste Assie; Amirul Asyraf; Anika Atique; A M Udara Lakshan Attanyake; Johann Auchabie; Hugues Aumaitre; Adrien Auvet; Laurène Azemar; Cecile Azoulay; Benjamin Bach; Delphine Bachelet; Claudine Badr; Nadia Baig; J Kevin Baird; Erica Bak; Agamemnon Bakakos; Nazreen Abu Bakar; Andriy Bal; Mohanaprasanth Balakrishnan; Valeria Balan; Firouzé Bani-Sadr; Renata Barbalho; Nicholas Yuri Barbosa; Wendy S Barclay; Saef Umar Barnett; Michaela Barnikel; Helena Barrasa; Audrey Barrelet; Cleide Barrigoto; Marie Bartoli; Mustehan Bashir; Romain Basmaci; Muhammad Fadhli Hassin Basri; Denise Battaglini; Jules Bauer; Diego Fernando Bautista Rincon; Denisse Bazan Dow; Alexandra Bedossa; Ker Hong Bee; Husna Begum; Sylvie Behilill; Albertus Beishuizen; Aleksandr Beljantsev; David Bellemare; Anna Beltrame; Beatriz Amorim Beltrão; Marine Beluze; Nicolas Benech; Lionel Eric Benjiman; Dehbia Benkerrou; Suzanne Bennett; Luís Bento; Jan-Erik Berdal; Delphine Bergeaud; Hazel Bergin; José Luis Bernal Sobrino; Giulia Bertoli; Lorenzo Bertolino; Simon Bessis; Sybille Bevilcaqua; Karine Bezulier; Amar Bhatt; Krishna Bhavsar; Claudia Bianco; Farah Nadiah Bidin; Moirangthem Bikram Singh; Felwa Bin Humaid; Mohd Nazlin Bin Kamarudin; François Bissuel; Patrick Biston; Laurent Bitker; Marjolein Brusse-Keizer; Yih-Sharng Chen; Sung-Min Cho; Sebastiano Maria Colombo; Amanda Corley; Rafael Freitas de Oliveira França; Dominique Deplanque; Eric D'Ortenzio; Susanne Dudman; Ilka Engelmann; Manuel Etienne; Jorge Fernandes; Christopher A Green; Ewen M Harrison; Leanne Hays; Mariachiara Ippolito; Nina Jamieson; Todd Karsies; Kalynn Kennon; Anders Benjamin Kildal; Demetrios Kutsogiannis; John G Laffey; Eka Yudha Lantang; Andreas Lind; Antonio Loforte; Dalia Lopez-Colon; Alejandro Martin-Quiros; Kenneth A McLean; Mary Mone; Srinivas Murthy; Jamel Ortoleva; Patricia Patricio; Scott Pharand; Sergio Poli; Jolanta Popielska; Pedro Povoa; Maia Rabaa; Cornelius Rau; Luis Felipe Reyes; Jordi Riera; Justin Schaffer; Tjard Schermer; Filipa Sequeira; Pablo Serrano Balazote; Hoi Ping Shum; Jacky Y Suen; Sofia Tejada; Olivier Terrier; Nicolas Terzi; Emma C Thomson; Ioannis Trontzas; Anders Tveita; Job van der Palen; Hugo Van Willigen; Sara Ventura;Abstract Background We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death.
Archivio istituziona... arrow_drop_down Archivio istituzionale della ricerca - Università di Padova; International Journal of Epidemiology; Archivio IstituzionaleArticle . 2023 . Peer-reviewedLicense: CC BYInternational Journal of EpidemiologyArticle . 2023Data sources: University of Groningen Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 14 citations 14 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Archivio istituziona... arrow_drop_down Archivio istituzionale della ricerca - Università di Padova; International Journal of Epidemiology; Archivio IstituzionaleArticle . 2023 . Peer-reviewedLicense: CC BYInternational Journal of EpidemiologyArticle . 2023Data sources: University of Groningen Research Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Denmark, United Kingdom, Netherlands, Italy, Australia, ItalyPublisher:Institute of Electrical and Electronics Engineers (IEEE) Funded by:EC | PERISCOPE, EC | XAI, EC | CompuLaw +2 projectsEC| PERISCOPE ,EC| XAI ,EC| CompuLaw ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers. ,EC| PRECISE4QAllahabadi, Himanshi; Amann, Julia; Balot, Isabelle; Beretta, Andrea; Binkley, Charles; Bozenhard, Jonas; Bruneault, Frederick; Brusseau, James; Candemir, Sema; Cappellini, Luca Alessandro; Castagnet, Genevieve Fieux; Chakraborty, Subrata; Cherciu, Nicoleta; Cociancig, Christina; Coffee, Megan; Ek, Irene; Espinosa-Leal, Leonardo; Farina, Davide; Fieux-Castagnet, Genevieve; Frauenfelder, Thomas; Gallucci, Alessio; Giuliani, Guya; Golda, Adam; van Halem, Irmhild; Hildt, Elisabeth; Holm, Sune; Kararigas, Georgios; Krier, Sebastien A.; Kuhne, Ulrich; Lizzi, Francesca; Madai, Vince I.; Markus, Aniek F.; Masis, Serg; Mathez, Emilie Wiinblad; Mureddu, Francesco; Neri, Emanuele; Osika, Walter; Ozols, Matiss; Panigutti, Cecilia; Parent, Brendan; Pratesi, Francesca; Moreno-Sanchez, Pedro A.; Sartor, Giovanni; Savardi, Mattia; Signoroni, Alberto; Sormunen, Hanna; Spezzatti, Andy; Srivastava, Adarsh; Stephansen, Annette F.; Theng, Lau Bee; Tithi, Jesmin Jahan; Tuominen, Jarno; Umbrello, Steven; Vaccher, Filippo; Vetter, Dennis; Westerlund, Magnus; Wurth, Renee; Zicari, Roberto V.;This article’s main contributions are twofold: 1) to demonstrate how to apply the general European Union’s High-Level Expert Group’s (EU HLEG) guidelines for trustworthy AI in practice for the domain of healthcare and 2) to investigate the research question of what does “trustworthy AI” mean at the time of the COVID-19 pandemic. To this end, we present the results of a post-hoc self-assessment to evaluate the trustworthiness of an AI system for predicting a multiregional score conveying the degree of lung compromise in COVID-19 patients, developed and verified by an interdisciplinary team with members from academia, public hospitals, and industry in time of pandemic. The AI system aims to help radiologists to estimate and communicate the severity of damage in a patient’s lung from Chest X-rays. It has been experimentally deployed in the radiology department of the ASST Spedali Civili clinic in Brescia, Italy, since December 2020 during pandemic time. The methodology we have applied for our post-hoc assessment, called Z-Inspection®, uses sociotechnical scenarios to identify ethical, technical, and domain-specific issues in the use of the AI system in the context of the pandemic. Ethics & Philosophy of Technology
IEEE Transactions on... arrow_drop_down IEEE Transactions on Technology and Society; IEEE Technology and Society MagazineOther literature type . Article . 2022 . Peer-reviewedLicense: CC BY NC NDArchivio istituzionale della ricerca - Università di BresciaArticle . 2022IEEE Transactions on Technology and SocietyArticle . 2022Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 9visibility views 9 download downloads 5 Powered bymore_vert IEEE Transactions on... arrow_drop_down IEEE Transactions on Technology and Society; IEEE Technology and Society MagazineOther literature type . Article . 2022 . Peer-reviewedLicense: CC BY NC NDArchivio istituzionale della ricerca - Università di BresciaArticle . 2022IEEE Transactions on Technology and SocietyArticle . 2022Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 Spain, Germany, Germany, ItalyPublisher:Wiley Funded by:EC | EOSC Future, EC | BY-COVID, SNSF | Exploring protein dynamic... +2 projectsEC| EOSC Future ,EC| BY-COVID ,SNSF| Exploring protein dynamics with atomic resolution ,EC| iNEXT-Discovery ,EC| SEE-DRUGHannes Berg; Maria A. Wirtz Martin; Nadide Altincekic; Islam Alshamleh; Jasleen Kaur Bains; Julius Blechar; Betül Ceylan; Vanessa de Jesus; Karthikeyan Dhamotharan; Christin Fuks; Santosh L. Gande; Bruno Hargittay; Katharina F. Hohmann; Marie T. Hutchison; Sophie Marianne Korn; Robin Krishnathas; Felicitas Kutz; Verena Linhard; Tobias Matzel; Nathalie Meiser; Anna Niesteruk; Dennis J. Pyper; Linda Schulte; Sven Trucks; Kamal Azzaoui; Marcel J. J. Blommers; Yojana Gadiya; Reagon Karki; Andrea Zaliani; Philip Gribbon; Marcius da Silva Almeida; Cristiane Dinis Anobom; Anna L. Bula; Matthias Bütikofer; Ícaro Putinhon Caruso; Isabella Caterina Felli; Andrea T. Da Poian; Gisele Cardoso de Amorim; Nikolaos K. Fourkiotis; Angelo Gallo; Dhiman Ghosh; Francisco Gomes‐Neto; Oksana Gorbatyuk; Bing Hao; Vilius Kurauskas; Lauriane Lecoq; Yunfeng Li; Nathane Cunha Mebus‐Antunes; Miguel Mompeán; Thais Cristtina Neves‐Martins; Martí Ninot‐Pedrosa; Anderson S. Pinheiro; Letizia Pontoriero; Yulia Pustovalova; Roland Riek; Angus J. Robertson; Marie Jose Abi Saad; Miguel Á. Treviño; Aikaterini C. Tsika; Fabio C. L. Almeida; Ad Bax; Katherine Henzler‐Wildman; Jeffrey C. Hoch; Kristaps Jaudzems; Douglas V. Laurents; Julien Orts; Roberta Pierattelli; Georgios A. Spyroulias; Elke Duchardt‐Ferner; Jan Ferner; Boris Fürtig; Martin Hengesbach; Frank Löhr; Nusrat Qureshi; Christian Richter; Krishna Saxena; Andreas Schlundt; Sridhar Sreeramulu; Anna Wacker; Julia E. Weigand; Julia Wirmer‐Bartoschek; Jens Wöhnert; Harald Schwalbe;Work at BMRZ is supported by the state of Hesse. Work in Covid19-NMR was supported by the Goethe Corona Funds, by the IWBEFRE-program 20007375 of state of Hesse, the DFG through CRC902: “Molecular Principles of RNA-based regulation.” and through infrastructure funds (project numbers: 277478796, 277479031, 392682309, 452632086, 70653611) and by European Union’s Horizon 2020 research and innovation program iNEXT-discovery under grant agreement No 871037. BY-COVID receives funding from the European Union’s Horizon Europe Research and Innovation Programme under grant agreement number 101046203. “INSPIRED” (MIS 5002550) project, implemented under the Action “Reinforcement of the Research and Innovation Infrastructure,” funded by the Operational Program “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014–2020) and co-financed by Greece and the EU (European Regional Development Fund) and the FP7 REGPOT CT-2011-285950—“SEE-DRUG” project (purchase of UPAT’s 700 MHz NMR equipment). The support of the CERM/CIRMMP center of Instruct-ERIC is gratefully acknowledged. This work has been funded in part by a grant of the Italian Ministry of University and Research (FISR2020IP_02112, ID-COVID) and by Fondazione CR Firenze. A.S. is supported by the Deutsche Forschungsgemeinschaft [SFB902/B16, SCHL2062/2-1] and the Johanna Quandt Young Academy at Goethe [2019/AS01]. M.H. and C.F. thank SFB902 and the Stiftung Polytechnische Gesellschaft for the Scholarship. L.L. work was supported by the French National Research Agency (ANR, NMR-SCoV2-ORF8), the Fondation de la Recherche Médicale (FRM, NMR-SCoV2-ORF8), FINOVI and the IR-RMN-THC Fr3050 CNRS. Work at UConn Health was supported by grants from the US National Institutes of Health (R01 GM135592 to B.H., P41 GM111135 and R01 GM123249 to J.C.H.) and the US National Science Foundation (DBI 2030601 to J.C.H.). Latvian Council of Science Grant No. VPP-COVID-2020/1-0014. National Science Foundation EAGER MCB-2031269. This work was supported by the grant Krebsliga KFS-4903-08-2019 and SNF-311030_192646 to J.O. P.G. (ITMP) The EOSC Future project is co-funded by the European Union Horizon Programme call INFRAEOSC-03-2020—Grant Agreement Number 101017536. Open Access funding enabled and organized by Projekt DEAL SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti-virals. Within the international Covid19-NMR consortium, we have identified binders targeting the RNA genome of SCoV2. We established protocols for the production and NMR characterization of more than 80 % of all SCoV2 proteins. Here, we performed an NMR screening using a fragment library for binding to 25 SCoV2 proteins and identified hits also against previously unexplored SCoV2 proteins. Computational mapping was used to predict binding sites and identify functional moieties (chemotypes) of the ligands occupying these pockets. Striking consensus was observed between NMR-detected binding sites of the main protease and the computational procedure. Our investigation provides novel structural and chemical space for structure-based drug design against the SCoV2 proteome. 12 pags., 4 figs., 3 tabs. Peer reviewed
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Flore (Florence Research Repository); Angewandte Chemie International EditionOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYFlore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . 2023 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 23visibility views 23 download downloads 99 Powered bymore_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Flore (Florence Research Repository); Angewandte Chemie International EditionOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYFlore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . 2023 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2022 ItalyPublisher:IEEE Funded by:EC | NextPerceptionEC| NextPerceptionAmparore, Elvio G.; Botta, Marco; Drago, Idilio; Donatelli, Susanna; Mazzone, Giuseppe;handle: 2318/1880491
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO)Conference object . 2022Data sources: Archivio Istituzionale (AperTO)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO)Conference object . 2022Data sources: Archivio Istituzionale (AperTO)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 France, United Kingdom, France, Italy, Italy, Italy, France, United Kingdom, Italy, Italy, United Kingdom, Netherlands, FrancePublisher:Springer Science and Business Media LLC Funded by:WT | Understanding cross-react..., WT | ISARIC, EC | ECRAID-Base +3 projectsWT| Understanding cross-reactive immunity to Japanese encephalitis virus ,WT| ISARIC ,EC| ECRAID-Base ,UKRI| ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) ,CIHR ,EC| RECoVERReyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Merson, Laura; Ibáñez-Prada, Elsa; Rello, Jordi; Fuentes, Yuli; Martin-Loeches, Ignacio; Bozza, Fernando; Duque, Sara; Taccone, Fabio; Fowler, Robert; Kartsonaki, Christiana; Gonçalves, Bronner; Citarella, Barbara Wanjiru; Aryal, Diptesh; Burhan, Erlina; Cummings, Matthew; Delmas, Christelle; Diaz, Rodrigo; Figueiredo-Mello, Claudia; Hashmi, Madiha; Panda, Prasan Kumar; Jiménez, Miguel Pedrera; Rincon, Diego Fernando Bautista; Thomson, David; Nichol, Alistair; Marshall, John; Olliaro, Piero; Abbas, Ali; Abdukahil, Sheryl Ann; Abe, Ryuzo; Abel, Laurent; Absil, Lara; Acharya, Subhash; Acker, Andrew; Adrião, Diana; Al Ageel, Saleh; Ahmed, Shakeel; Ainscough, Kate; Aisa, Tharwat; Hssain, Ali Ait; Tamlihat, Younes Ait; Akimoto, Takako; Akmal, Ernita; Al Qasim, Eman; Alalqam, Razi; Al-Dabbous, Tala; Alegesan, Senthilkumar; Alegre, Cynthia; Alessi, Marta; Alex, Beatrice; Alexandre, Kévin; Al-Fares, Abdulrahman; Alfoudri, Huda; Ali, Imran; Shah, Naseem Ali; Alidjnou, Kazali Enagnon; Aliudin, Jeffrey; Alkhafajee, Qabas; Allavena, Clotilde; Allou, Nathalie; Altaf, Aneela; Alves, João; Alves, João Melo; Alves, Rita; Cabrita, Joana Alves; Amaral, Maria; Ampaw, Phoebe; Andini, Roberto; Andréjak, Claire; Angheben, Andrea; Angoulvant, François; Ansart, Séverine; Antonelli, Massimo; de Brito, Carlos Alexandre Antunes; Apriyana, Ardiyan; Arabi, Yaseen; Aragao, Irene; Araujo, Carolline; Arcadipane, Antonio; Archambault, Patrick; Arenz, Lukas; Arlet, Jean-Benoît; Arnold-Day, Christel; Arora, Lovkesh; Arora, Rakesh; Artaud-Macari, Elise; Aryal, Diptesh; Asensio, Angel; Asif, Namra; Asim, Mohammad; Assie, Jean Baptiste; Atique, Anika; Attanyake, A.; Auchabie, Johann; Aumaitre, Hugues; Auvet, Adrien; Azemar, Laurène; Azoulay, Cecile; Bach, Benjamin; Bachelet, Delphine; Badr, Claudine; Baig, Nadia; Baillie, J. Kenneth; Bak, Erica; Bakakos, Agamemnon; Bal, Andriy; Balan, Valeria; Bani-Sadr, Firouzé; Barbalho, Renata; Barclay, Wendy; Barnikel, Michaela; Barrasa, Helena; Barrelet, Audrey; Barrigoto, Cleide; Bartoli, Marie; Baruch, Joaquín; Basmaci, Romain; Battaglini, Denise; Bauer, Jules; Dow, Denisse Bazan; Beane, Abigail; Bedossa, Alexandra; Begum, Husna; Behilill, Sylvie; Beishuizen, Albertus; Beljantsev, Aleksandr; Bellemare, David; Beltrame, Anna; Beluze, Marine; Benech, Nicolas; Benkerrou, Dehbia; Bennett, Suzanne; Bento, Luís; Berdal, Jan-Erik; Bergeaud, Delphine; Bergin, Hazel; Sobrino, José Luis Bernal; Bertoli, Giulia; Bertolino, Lorenzo; Bessis, Simon; Bevilcaqua, Sybille; Bezulier, Karine; Bhatt, Amar; Bhavsar, Krishna; Bianco, Claudia; Singh, Moirangthem Bikram; Humaid, Felwa Bin; Bissuel, François; Bitker, Laurent; Bitton, Jonathan; Blanco-Schweizer, Pablo; Blier, Catherine; Bloos, Frank; Blot, Mathieu; Boccia, Filomena; Bodenes, Laetitia; Bogaert, Debby; Boivin, Anne-Hélène; Bolze, Pierre-Adrien; Bompart, François; Borges, Diogo; Borie, Raphaël; Bosse, Hans Martin; Botelho-Nevers, Elisabeth; Bouadma, Lila; Bouchaud, Olivier; Bouchez, Sabelline; Bouhmani, Dounia; Bouhour, Damien; Bouiller, Kévin; Bouillet, Laurence; Bouisse, Camile; Boureau, Anne-Sophie; Bourke, John; Bouscambert, Maude; Bousquet, Aurore; Bouziotis, Jason; Boxma, Bianca; Boyer-Besseyre, Marielle; Boylan, Maria; Braconnier, Axelle; Braga, Cynthia; Brandenburger, Timo; Monteiro, Filipa Brás; Brazzi, Luca; Breen, Dorothy; Breen, Patrick; Brickell, Kathy; Browne, Alex; Browne, Shaunagh; Brusse-Keizer, Marjolein; Buchtele, Nina; Buesaquillo, Christian; Bugaeva, Polina; Buisson, Marielle; Burrell, Aidan; Bustos, Ingrid; Butnaru, Denis; Caceres, Eder; Cattaneo, Paolo; Chen, Yih-Sharng; Cho, Sung-Min; Colombo, Sebastiano Maria; Corley, Amanda; Dahly, Darren; Denis, Emmanuelle; Deplanque, Dominique; Dondorp, Arjen; Dudman, Susanne; Durante-Mangoni, Emanuele; Engelmann, Ilka; Etienne, Manuel; Fernandes, Jorge; Gaymard, Alexandre; Green, Christopher; Haidri, Fakhir; Harrison, Ewen; Hays, Leanne; Hitoto, Hikombo; Ippolito, Mariachiara; Jamieson, Nina; Kelly, Yvelynne; Kennon, Kalynn; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Laffey, John; Lantang, Eka Yudha; Le Turnier, Paul; Lind, Andreas; Loforte, Antonio; Machado, Sara; Martucci, Gennaro; Masood, Sobia; Mclean, Kenneth; Mone, Mary; Motos, Ana; Munblit, Daniel; Noursadeghi, Mahdad; Ortoleva, Jamel; Patricio, Patricia; Pharand, Scott; Poli, Sergio; Povoa, Pedro; Rau, Cornelius; Riera, Jordi; Sandulescu, Oana; Schaffer, Justin; Schermer, Tjard; Semple, Malcolm; Sequeira, Filipa; Balazote, Pablo Serrano; Shum, Hoi Ping; Streinu-Cercel, Adrian; Suen, Jacky; Summers, Charlotte; Sztajnbok, Jaques; Tejada, Sofia; Terrier, Olivier; Terzi, Nicolas; Thomson, Emma; Trontzas, Ioannis; Turtle, Lance; van der Palen, Job; Ventura, Sara; Shukeri, Wan Fadzlina Wan Muhd; West, T. Eoin; Wils, Evert-Jan;pmid: 36100904
pmc: PMC9469080
Invasive mechanical ventilation; COVID-19; Critical care Ventilación mecánica invasiva; COVID-19; Cuidado crítico Ventilació mecànica invasiva; COVID-19; Atenció crítica Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. This work was supported by the UK Foreign, Commonwealth, and Development Office and Wellcome [215091/Z/18/Z] and the Bill & Melinda Gates Foundation [OPP1209135]; CIHR Coronavirus Rapid Research Funding Opportunity OV2170359; Grants from Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 Project 101003589] and European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313]; The Imperial NIHR Biomedical Research Centre; The Cambridge NIHR Biomedical Research Centre; and Endorsed by the Irish Critical Care-Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care-Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12]. This work uses Data/Materials provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The Data/materials used for this research were obtained from ISARIC4C. The COVID-19 Clinical Information Network (CO-CIN) data was collated by ISARIC4C Investigators. Data and Material provision were supported by grants from: the National Institute for Health Research (NIHR; award CO-CIN-01), the Medical Research Council (MRC; Grant MC_PC_19059), and the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE), (Award 200907), Wellcome Trust [Turtle, Lance-fellowship 205228/Z/16/Z], NIHR HPRU in Respiratory Infections at Imperial College London with PHE (Award 200927), Liverpool Experimental Cancer Medicine Centre (Grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (Award IS-BRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. This work was possible due to the dedication and hard work of the Norwegian SARS-CoV-2 study team and supported by grants from Research Council of Norway Grant No. 312780 and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; The dedication and hard work of the Groote Schuur Hospital Covid ICU Team, and supported by the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town; and supported by the COVID clinical management team, AIIMS, Rishikesh, India.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Archivio istituzionale della ricerca - Università di Palermo; Oxford University Research Archive; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"; Critical CareOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYData sources: Archivio Istituzionale (AperTO); European Union Open Data Portal; University of Twente Research Information ; University of Groningen Research Portal; Archivio istituzionale della ricerca - Università di Palermo; Oxford University Research Archive; Crossref; NARCIS; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"Spiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositoryHAL DescartesArticle . 2022License: CC BYFull-Text: https://hal.science/hal-04372985/documentData sources: HAL DescartesHAL Descartes; HAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Archivio istituzionale della ricerca - Università di Palermo; Oxford University Research Archive; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"; Critical CareOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYData sources: Archivio Istituzionale (AperTO); European Union Open Data Portal; University of Twente Research Information ; University of Groningen Research Portal; Archivio istituzionale della ricerca - Università di Palermo; Oxford University Research Archive; Crossref; NARCIS; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"Spiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital RepositoryHAL DescartesArticle . 2022License: CC BYFull-Text: https://hal.science/hal-04372985/documentData sources: HAL DescartesHAL Descartes; HAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Netherlands, Italy, United Kingdom, France, Italy, Italy, Italy, FrancePublisher:Oxford University Press (OUP) Funded by:CIHR, ARC | ARC Centres of Excellence..., WT | Malawi-Liverpool-Wellcome... +7 projectsCIHR ,ARC| ARC Centres of Excellence - Grant ID: CE170100009 ,WT| Malawi-Liverpool-Wellcome Trust COVID-19 Epidemic Preparedness ,NIH| CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) study ,EC| RECoVER ,WT| Understanding cross-reactive immunity to Japanese encephalitis virus ,EC| ECRAID-Base ,UKRI| ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) ,WT| The ISARIC data platform: Optimizing data-driven pandemic preparedness and response ,WT| ISARICSung-Min Cho; Nicole White; Lavienraj Premraj; Denise Battaglini; Jonathon Fanning; Jacky Suen; Gianluigi Li Bassi; John Fraser; Chiara Robba; Matthew Griffee; Bhagteshwar Singh; ;?>Barbara Wanjiru Citarella; Laura Merson; Tom Solomon; David Thomson; Ali Abbas; Nurul Najmee Abdulkadir; Ryuzo Abe; Laurent Abel; Lara Absil; Subhash Acharya; Andrew Acker; Diana Adrião; Saleh Al Ageel; Shakeel Ahmed; Kate Ainscough; Tharwat Aisa; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Razi Alalqam; Tala Al-dabbous; Senthilkumar Alegesan; Cynthia Alegre; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Huda Alfoudri; Imran Ali; Naseem Ali Shah; Kazali Enagnon Alidjnou; Jeffrey Aliudin; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; Aneela Altaf; João Alves; Rita Alves; João Melo Alves; Maria Amaral; Nur Amira; Phoebe Ampaw; Roberto Andini; Claire Andrejak; Andrea Angheben; François Angoulvant; Séverine Ansart; Sivanesen Anthonidass; Massimo Antonelli; Carlos Alexandre Antunes de Brito; Ardiyan Apriyana; Irene Aragao; Francisco Arancibia; Carolline Araujo; Antonio Arcadipane; Patrick Archambault; Lukas Arenz; Jean-Benoît Arlet; Christel Arnold-Day; Lovkesh Arora; Rakesh Arora; Elise Artaud-Macari; Diptesh Aryal; Angel Asensio; Muhammad Ashraf; Namra Asif; Mohammad Asim; Jean Baptiste Assie; Amirul Asyraf; Anika Atique; AM Udara Lakshan Attanyake; Johann Auchabie; Hugues Aumaitre; Adrien Auvet; Laurène Azemar; Cecile Azoulay; Benjamin Bach; Delphine Bachelet; Claudine Badr; Nadia Baig; J Kenneth Baillie; Erica Bak; Agamemnon Bakakos; Nazreen Abu Bakar; Andriy Bal; Mohanaprasanth Balakrishnan; Valeria Balan; Firouzé Bani-Sadr; Renata Barbalho; Wendy S Barclay; Saef Umar Barnett; Michaela Barnikel; Audrey Barrelet; Cleide Barrigoto; Marie Bartoli; Joaquín Baruch; Romain Basmaci; Muhammad Fadhli Hassin Basri; Denise Battaglini; Jules Bauer; Diego Fernando Bautista Rincon; Abigail Beane; Alexandra Bedossa; Ker Hong Bee; Husna Begum; Sylvie Behilill; Albertus Beishuizen; Aleksandr Beljantsev; David Bellemare; Anna Beltrame; Marine Beluze; Nicolas Benech; Lionel Eric Benjiman; Dehbia Benkerrou; Suzanne Bennett; Luís Bento; Jan-Erik Berdal; Delphine Bergeaud; Hazel Bergin; José Luis Bernal Sobrino; Giulia Bertoli; Lorenzo Bertolino; Simon Bessis; Sybille Bevilcaqua; Karine Bezulier; Amar Bhatt; Krishna Bhavsar; Claudia Bianco; Farah Nadiah Bidin; Moirangthem Bikram Singh; Mohd Nazlin Bin Kamarudin; François Bissuel; Laurent Bitker; Jonathan Bitton; Pablo Blanco-Schweizer; Catherine Blier; Frank Bloos; Mathieu Blot; Filomena Boccia; Laetitia Bodenes; Alice Bogaarts; Debby Bogaert; Anne-Hélène Boivin; Pierre-Adrien Bolze; François Bompart; Diogo Borges; Raphaël Borie; Hans Martin Bosse; Elisabeth Botelho-Nevers; Lila Bouadma; Olivier Bouchaud; Sabelline Bouchez; Dounia Bouhmani; Damien Bouhour; Kévin Bouiller; Laurence Bouillet; Camile Bouisse; Anne-Sophie Boureau; John Bourke; Maude Bouscambert; Aurore Bousquet; Jason Bouziotis; Bianca Boxma; Marielle Boyer-Besseyre; Maria Boylan; Fernando Augusto Bozza; Axelle Braconnier; Cynthia Braga; Timo Brandenburger; Filipa Brás Monteiro; Luca Brazzi; Patrick Breen; Dorothy Breen; Patrick Breen; Kathy Brickell; Shaunagh Browne; Nicolas Brozzi; Marjolein Brusse-Keizer; Nina Buchtele; Christian Buesaquillo; Marielle Buisson; Erlina Burhan; Aidan Burrell; Ingrid G Bustos; André Cabie; Susana Cabral; Eder Caceres; Cyril Cadoz; Jose Andres Calvache; Yih-Sharng Chen; Sebastiano Maria Colombo; Amanda Corley; Dominique Deplanque; Susanne Dudman; Christopher A Green; Ewen M Harrison; Leanne Hays; Nina Jamieson; Ravi Kant; Kalynn Kennon; Anders Benjamin Kildal; Demetrios Kutsogiannis; John G Laffey; Eka Yudha Lantang; Antonio Loforte; Kenneth A McLean; Mary Mone; Srinivas Murthy; Alistair Nichol; Jamel Ortoleva; Patricia Patricio; Scott Pharand; Sergio Poli; Jolanta Popielska; Pedro Povoa; Cornelius Rau; Luis Felipe Reyes; Jordi Riera; Oana Sandulescu; Justin Schaffer; Tjard Schermer; Malcolm G Semple; Filipa Sequeira; Pablo Serrano Balazote; Hoi Ping Shum; Adrian Streinu-Cercel; Jaques Sztajnbok; Olivier Terrier; Nicolas Terzi; Emma C Thomson; Anders Tveita; Sara Ventura;pmid: 36087305
pmc: PMC9494397
AbstractDifferent neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models.Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001).Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke. All in-hospital neurological complications were associated with increased odds of death. The likelihood of death rose with increasing age, especially after 25 years of age.In conclusion, adults and children have different neurological manifestations and in-hospital complications associated with COVID-19. Stroke risk increased with increasing age, while CNS infection and seizure risk decreased with age.
Archivio Istituziona... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2022License: CC BY NCData sources: Spiral - Imperial College Digital RepositoryOxford University Research ArchiveOther literature type . 2022License: CC BY NCData sources: Oxford University Research ArchiveBrain; Archivio istituzionale della ricerca - Università di Genova; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"Article . 2023 . 2022 . Peer-reviewedLicense: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/brain/awac332&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2022License: CC BY NCData sources: Spiral - Imperial College Digital RepositoryOxford University Research ArchiveOther literature type . 2022License: CC BY NCData sources: Oxford University Research ArchiveBrain; Archivio istituzionale della ricerca - Università di Genova; Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"Article . 2023 . 2022 . Peer-reviewedLicense: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/brain/awac332&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, GermanyPublisher:Elsevier BV Funded by:EC | iNEXT-Discovery, EC | EUbOPEN, EC | SEE-DRUGEC| iNEXT-Discovery ,EC| EUbOPEN ,EC| SEE-DRUGAuthors: Tsika, Aikaterini C; Gallo, Angelo; Fourkiotis, Nikolaos K; Argyriou, Aikaterini I; +13 AuthorsTsika, Aikaterini C; Gallo, Angelo; Fourkiotis, Nikolaos K; Argyriou, Aikaterini I; Sreeramulu, Sridhar; Löhr, Frank; Rogov, Vladimir V; Richter, Christian; Linhard, Verena; Gande, Santosh L; Altincekic, Nadide; Krishnathas, Robin; Elamri, Isam; Schwalbe, Harald; Wollenhaupt, Jan; Weiss, Manfred S; Spyroulias, Georgios A;Viral infection in cells triggers a cascade of molecular defense mechanisms to maintain host-cell homoeostasis. One of these mechanisms is ADP-ribosylation, a fundamental post-translational modification (PTM) characterized by the addition of ADP-ribose (ADPr) on substrates. Poly(ADP-ribose) polymerases (PARPs) are implicated in this process and they perform ADP-ribosylation on host and pathogen proteins. Some viral families contain structural motifs that can reverse this PTM. These motifs known as macro domains (MDs) are evolutionarily conserved protein domains found in all kingdoms of life. They are divided in different classes with the viral belonging to Macro-D-type class because of their properties to recognize and revert the ADP-ribosylation. Viral MDs are potential pharmaceutical targets, capable to counteract host immune response. Sequence and structural homology between viral and human MDs are an impediment for the development of new active compounds against their function. Remdesivir, is a drug administrated in viral infections inhibiting viral replication through RNA-dependent RNA polymerase (RdRp). Herein, GS-441524, the active metabolite of the remdesivir, is tested as a hydrolase inhibitor for several viral MDs and for its binding to human homologs found in PARPs. This study presents biochemical and biophysical studies, which indicate that GS-441524 selectively modifies SARS-CoV-2 MD de-MARylation activity, while it does not interact with hPARP14 MD2 and hPARP15 MD2. The structural investigation of MD•GS-441524 complexes, using solution NMR and X-ray crystallography, discloses the impact of certain amino acids in ADPr binding cavity suggesting that F360 and its adjacent residues tune the selective binding of the inhibitor to SARS-CoV-2 MD.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Molecular BiologyOther literature type . Article . 2022 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jmb.2022.167720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Molecular BiologyOther literature type . Article . 2022 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jmb.2022.167720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Switzerland, Italy, Italy, Italy, ItalyPublisher:Elsevier BV Funded by:EC | MARVELEC| MARVELBurrello, Jacopo; Caporali, Elena; Gauthier, Lorenzo Grazioli; Pianezzi, Enea; Balbi, Carolina; Rigamonti, Elia; Bolis, Sara; Lazzarini, Edoardo; Biemmi, Vanessa; Burrello, Alessio; Frigerio, Roberto; Martinetti, Gladys; Fusi-Schmidhauser, Tanja; Vassalli, Giuseppe; Ferrari, Enrico; Moccetti, Tiziano; Gori, Alessandro; Cretich, Marina; Melli, Giorgia; Monticone, Silvia; Barile, Lucio;Inflammatory response following SARS-CoV-2 infection results in substantial increase of amounts of intravascular pro-coagulant extracellular vesicles (EVs) expressing tissue factor (CD142) on their surface. CD142-EV turned out to be useful as diagnostic biomarker in COVID-19 patients. Here we aimed at studying the prognostic capacity of CD142-EV in SARS-CoV-2 infection. Expression of CD142-EV was evaluated in 261 subjects admitted to hospital for pneumonia and with a positive molecular test for SARS-CoV-2. The study population consisted of a discovery cohort of selected patients (n = 60) and an independent validation cohort including unselected consecutive enrolled patients (n = 201). CD142-EV levels were correlated with post-hospitalization course of the disease and compared to the clinically available 4C Mortality Score as referral. CD142-EV showed a reliable performance to predict patient prognosis in the discovery cohort (AUC = 0.906) with an accuracy of 81.7%, that was confirmed in the validation cohort (AUC = 0.736). Kaplan-Meier curves highlighted a high discrimination power in unselected subjects with CD142-EV being able to stratify the majority of patients according to their prognosis. We obtained a comparable accuracy, being not inferior in terms of prediction of patients' prognosis and risk of mortality, with 4C Mortality Score. The expression of surface vesicular CD142 and its reliability as prognostic marker was technically validated using different immunocapture strategies and assays. The detection of CD142 on EV surface gains considerable interest as risk stratification tool to support clinical decision making in COVID-19.
ZENODO; Vascular Pha... arrow_drop_down ZENODO; Vascular Pharmacology; Publications Open Repository TOrinoArticle . 2022 . Peer-reviewedLicense: Elsevier TDMZurich Open Repository and ArchiveOther literature type . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.vph.2022.106999&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 10visibility views 10 download downloads 32 Powered bymore_vert ZENODO; Vascular Pha... arrow_drop_down ZENODO; Vascular Pharmacology; Publications Open Repository TOrinoArticle . 2022 . Peer-reviewedLicense: Elsevier TDMZurich Open Repository and ArchiveOther literature type . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.vph.2022.106999&type=result"></script>'); --> </script>
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