- home
- Advanced Search
Filters
Clear All- COVID-19
- Open Access
- Publications
- Other research products
- IE
- Hyper Article en Ligne
- COVID-19
- Open Access
- Publications
- Other research products
- IE
- Hyper Article en Ligne
Loading
description Publicationkeyboard_double_arrow_right Article 2022 Ireland, Belgium EnglishPublisher:Senate Hall Academic Publishing Authors: Coulombe, Simon; Dejardin, Marcus; Luc, Sylvain;Coulombe, Simon; Dejardin, Marcus; Luc, Sylvain;handle: 2078/264788 , 2262/102664
International audience; Triggering events can be associated with entrepreneurial intentions. Using data from a survey on the mental health of Canadian workers carried out in the context of the COVID-19 pandemic crisis, we specifically test the association between entrepreneurial intentions and psychological distress, along with other individual demographic and personal-level measurements such as risk-aversion, and financial concern. Our results substantiate a positive relationship between entrepreneurial intention and individual psychological distress, as well as financial deterioration measured at the household level. Taken as a whole, our contribution helps to feed a discussion on the links between mental health and entrepreneurship in a process of personal resilience and, more generally, on well-being as a motivational factor in the entrepreneurial process.
Hyper Article en Lig... arrow_drop_down Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Article . 2022Repository of the University of NamurArticle . 2022Data sources: Repository of the University of NamurTrinity's Access to Research ArchiveArticle . 2022Data sources: Trinity's Access to Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2078/264788&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Hyper Article en Lig... arrow_drop_down Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Article . 2022Repository of the University of NamurArticle . 2022Data sources: Repository of the University of NamurTrinity's Access to Research ArchiveArticle . 2022Data sources: Trinity's Access to Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2078/264788&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Other literature type 2021 FrancePublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:EC | MultiSeroSurv, WT | Wellcome – Health Researc..., EC | SynarchiC +1 projectsEC| MultiSeroSurv ,WT| Wellcome – Health Research Board Irish Clinical Academic Training Programme ,EC| SynarchiC ,SFI| How immunology can help to address the COVID-19 epidemic in IrelandPelleau, Stéphane; Woudenberg, Tom; Rosado, Jason; Donnadieu, Françoise; Garcia, Laura; Obadia, Thomas; Gardais, Soazic; Elgharbawy, Yasmine; Velay, Aurelie; Gonzalez, Maria; Nizou, Jacques; Khelil, Nizar; Zannis, Konstantinos; Cockram, Charlotte; Merkling, Sarah; Meola, Annalisa; Kerneis, Solen; Terrier, Benjamin; de Seze, Jerome; Planas, Delphine; Schwartz, Olivier; Déjardin, François; Pêtres, Stéphane; von Platen, Cassandre; Arowas, Laurence; Facci, Louise Perrin De; Duffy, Darragh; Ni Cheallaigh, Cliona; Conlon, Niall; Townsend, Liam; Auerswald, Heidi; Backovic, Marija; Hoen, Bruno; Fontanet, Arnaud; Mueller, Ivo; Fafi-Kremer, Samira; Bruel, Timothée; White, Michael;AbstractInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time. Waning antibody levels lead to reduced sensitivity of serological diagnostic tests over time. This undermines the utility of serological surveillance as the SARS-CoV-2 pandemic progresses into its second year. Here we develop a multiplex serological test for measuring antibodies of three isotypes (IgG, IgM, IgA) to five SARS-CoV-2 antigens (Spike (S), receptor binding domain (RBD), Nucleocapsid (N), Spike subunit 2, Membrane-Envelope fusion) and the Spike proteins of four seasonal coronaviruses. We measure antibody responses in several cohorts of French and Irish hospitalized patients and healthcare workers followed for up to eleven months after symptom onset. The data are analysed with a mathematical model of antibody kinetics to quantify the duration of antibody responses accounting for inter-individual variation. One year after symptoms, we estimate that 36% (95% range: 11%, 94%) of anti-S IgG remains, 31% (9%, 89%) anti-RBD IgG remains, and 7% (1%, 31%) anti-N IgG remains. Antibodies of the IgM isotype waned more rapidly, with 9% (2%, 32%) anti-RBD IgM remaining after one year. Antibodies of the IgA isotype also waned rapidly, with 10% (3%, 38%) anti-RBD IgA remaining after one year. Quantitative measurements of antibody responses were used to train machine learning algorithms for classification of previous infection and estimation of time since infection. The resulting diagnostic test classified previous infections with 99% specificity and 98% (95% confidence interval: 94%, 99%) sensitivity, with no evidence for declining sensitivity over the time scale considered. The diagnostic test also provided accurate classification of time since infection into intervals of 0 – 3 months, 3 – 6 months, and 6 – 12 months. Finally, we present a computational method for serological reconstruction of past SARS-CoV-2 transmission using the data from this test when applied to samples from a single cross-sectional sero-prevalence survey.
HAL-Pasteur; HAL-Ins... arrow_drop_down HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Preprint . 2021HAL-Inserm; Hal-DiderotPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.03.04.21252532&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert HAL-Pasteur; HAL-Ins... arrow_drop_down HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Preprint . 2021HAL-Inserm; Hal-DiderotPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.03.04.21252532&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2000 FrancePublisher:American Society for Microbiology Publicly fundedFunded by:FCT | D4, WTFCT| D4 ,WTEléouët, Jean-François; Slee, E.A.; Saurini, F.; Castagné, N.; Poncet, Didier; Garrido, Carmen; Solary, E.; Martin, S.J.;ABSTRACT The transmissible gastroenteritis coronavirus (TGEV), like many other viruses, exerts much of its cytopathic effect through the induction of apoptosis of its host cell. Apoptosis is coordinated by a family of cysteine proteases, called caspases, that are activated during apoptosis and participate in dismantling the cell by cleaving key structural and regulatory proteins. We have explored the caspase activation events that are initiated upon infection of the human rectal tumor cell line HRT18 with TGEV. We show that TGEV infection results in the activation of caspase-3, -6, -7, -8, and -9 and cleavage of the caspase substrates eIF4GI, gelsolin, and α-fodrin. Surprisingly, the TGEV nucleoprotein (N) underwent proteolysis in parallel with the activation of caspases within the host cell. Cleavage of the N protein was inhibited by cell-permeative caspase inhibitors, suggesting that this viral structural protein is a target for host cell caspases. We show that the TGEV nucleoprotein is a substrate for both caspase-6 and -7, and using site-directed mutagenesis, we have mapped the cleavage site to VVPD 359 ↓. These data demonstrate that viral proteins can be targeted for destruction by the host cell death machinery.
Europe PubMed Centra... arrow_drop_down Journal of VirologyArticle . 2000 . Peer-reviewedLicense: ASM Journals Non-Commercial TDMData sources: CrossrefHyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotOther literature type . Article . 2000add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1128/jvi.74.9.3975-3983.2000&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 81 citations 81 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Journal of VirologyArticle . 2000 . Peer-reviewedLicense: ASM Journals Non-Commercial TDMData sources: CrossrefHyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotOther literature type . Article . 2000add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1128/jvi.74.9.3975-3983.2000&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
Loading
description Publicationkeyboard_double_arrow_right Article 2022 Ireland, Belgium EnglishPublisher:Senate Hall Academic Publishing Authors: Coulombe, Simon; Dejardin, Marcus; Luc, Sylvain;Coulombe, Simon; Dejardin, Marcus; Luc, Sylvain;handle: 2078/264788 , 2262/102664
International audience; Triggering events can be associated with entrepreneurial intentions. Using data from a survey on the mental health of Canadian workers carried out in the context of the COVID-19 pandemic crisis, we specifically test the association between entrepreneurial intentions and psychological distress, along with other individual demographic and personal-level measurements such as risk-aversion, and financial concern. Our results substantiate a positive relationship between entrepreneurial intention and individual psychological distress, as well as financial deterioration measured at the household level. Taken as a whole, our contribution helps to feed a discussion on the links between mental health and entrepreneurship in a process of personal resilience and, more generally, on well-being as a motivational factor in the entrepreneurial process.
Hyper Article en Lig... arrow_drop_down Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Article . 2022Repository of the University of NamurArticle . 2022Data sources: Repository of the University of NamurTrinity's Access to Research ArchiveArticle . 2022Data sources: Trinity's Access to Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2078/264788&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Hyper Article en Lig... arrow_drop_down Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Article . 2022Repository of the University of NamurArticle . 2022Data sources: Repository of the University of NamurTrinity's Access to Research ArchiveArticle . 2022Data sources: Trinity's Access to Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=2078/264788&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Other literature type 2021 FrancePublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:EC | MultiSeroSurv, WT | Wellcome – Health Researc..., EC | SynarchiC +1 projectsEC| MultiSeroSurv ,WT| Wellcome – Health Research Board Irish Clinical Academic Training Programme ,EC| SynarchiC ,SFI| How immunology can help to address the COVID-19 epidemic in IrelandPelleau, Stéphane; Woudenberg, Tom; Rosado, Jason; Donnadieu, Françoise; Garcia, Laura; Obadia, Thomas; Gardais, Soazic; Elgharbawy, Yasmine; Velay, Aurelie; Gonzalez, Maria; Nizou, Jacques; Khelil, Nizar; Zannis, Konstantinos; Cockram, Charlotte; Merkling, Sarah; Meola, Annalisa; Kerneis, Solen; Terrier, Benjamin; de Seze, Jerome; Planas, Delphine; Schwartz, Olivier; Déjardin, François; Pêtres, Stéphane; von Platen, Cassandre; Arowas, Laurence; Facci, Louise Perrin De; Duffy, Darragh; Ni Cheallaigh, Cliona; Conlon, Niall; Townsend, Liam; Auerswald, Heidi; Backovic, Marija; Hoen, Bruno; Fontanet, Arnaud; Mueller, Ivo; Fafi-Kremer, Samira; Bruel, Timothée; White, Michael;AbstractInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time. Waning antibody levels lead to reduced sensitivity of serological diagnostic tests over time. This undermines the utility of serological surveillance as the SARS-CoV-2 pandemic progresses into its second year. Here we develop a multiplex serological test for measuring antibodies of three isotypes (IgG, IgM, IgA) to five SARS-CoV-2 antigens (Spike (S), receptor binding domain (RBD), Nucleocapsid (N), Spike subunit 2, Membrane-Envelope fusion) and the Spike proteins of four seasonal coronaviruses. We measure antibody responses in several cohorts of French and Irish hospitalized patients and healthcare workers followed for up to eleven months after symptom onset. The data are analysed with a mathematical model of antibody kinetics to quantify the duration of antibody responses accounting for inter-individual variation. One year after symptoms, we estimate that 36% (95% range: 11%, 94%) of anti-S IgG remains, 31% (9%, 89%) anti-RBD IgG remains, and 7% (1%, 31%) anti-N IgG remains. Antibodies of the IgM isotype waned more rapidly, with 9% (2%, 32%) anti-RBD IgM remaining after one year. Antibodies of the IgA isotype also waned rapidly, with 10% (3%, 38%) anti-RBD IgA remaining after one year. Quantitative measurements of antibody responses were used to train machine learning algorithms for classification of previous infection and estimation of time since infection. The resulting diagnostic test classified previous infections with 99% specificity and 98% (95% confidence interval: 94%, 99%) sensitivity, with no evidence for declining sensitivity over the time scale considered. The diagnostic test also provided accurate classification of time since infection into intervals of 0 – 3 months, 3 – 6 months, and 6 – 12 months. Finally, we present a computational method for serological reconstruction of past SARS-CoV-2 transmission using the data from this test when applied to samples from a single cross-sectional sero-prevalence survey.
HAL-Pasteur; HAL-Ins... arrow_drop_down HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Preprint . 2021HAL-Inserm; Hal-DiderotPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.03.04.21252532&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert HAL-Pasteur; HAL-Ins... arrow_drop_down HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Preprint . 2021HAL-Inserm; Hal-DiderotPreprint . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.03.04.21252532&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2000 FrancePublisher:American Society for Microbiology Publicly fundedFunded by:FCT | D4, WTFCT| D4 ,WTEléouët, Jean-François; Slee, E.A.; Saurini, F.; Castagné, N.; Poncet, Didier; Garrido, Carmen; Solary, E.; Martin, S.J.;ABSTRACT The transmissible gastroenteritis coronavirus (TGEV), like many other viruses, exerts much of its cytopathic effect through the induction of apoptosis of its host cell. Apoptosis is coordinated by a family of cysteine proteases, called caspases, that are activated during apoptosis and participate in dismantling the cell by cleaving key structural and regulatory proteins. We have explored the caspase activation events that are initiated upon infection of the human rectal tumor cell line HRT18 with TGEV. We show that TGEV infection results in the activation of caspase-3, -6, -7, -8, and -9 and cleavage of the caspase substrates eIF4GI, gelsolin, and α-fodrin. Surprisingly, the TGEV nucleoprotein (N) underwent proteolysis in parallel with the activation of caspases within the host cell. Cleavage of the N protein was inhibited by cell-permeative caspase inhibitors, suggesting that this viral structural protein is a target for host cell caspases. We show that the TGEV nucleoprotein is a substrate for both caspase-6 and -7, and using site-directed mutagenesis, we have mapped the cleavage site to VVPD 359 ↓. These data demonstrate that viral proteins can be targeted for destruction by the host cell death machinery.
Europe PubMed Centra... arrow_drop_down Journal of VirologyArticle . 2000 . Peer-reviewedLicense: ASM Journals Non-Commercial TDMData sources: CrossrefHyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotOther literature type . Article . 2000add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1128/jvi.74.9.3975-3983.2000&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 81 citations 81 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Journal of VirologyArticle . 2000 . Peer-reviewedLicense: ASM Journals Non-Commercial TDMData sources: CrossrefHyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotOther literature type . Article . 2000add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1128/jvi.74.9.3975-3983.2000&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu