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description Publicationkeyboard_double_arrow_right Article , Other ORP type , Preprint 2022 France, ItalyPublisher:American Chemical Society (ACS) Funded by:EC | CaLecLig, ANR | CBH-EUR-GS, EC | HPC-EUROPA3EC| CaLecLig ,ANR| CBH-EUR-GS ,EC| HPC-EUROPA3Vanessa Porkolab; Martin Lepšík; Stefania Ordanini; Alexander St John; Aline Le Roy; Michel Thépaut; Emanuele Paci; Christine Ebel; Anna Bernardi; Franck Fieschi;The C-type lectin receptor DC-SIGN has been highlighted as co-receptor for the spike protein of the SARS-CoV-2 virus. A multivalent glycomimetic ligand, Polyman26, has been found to inhibit DCSIGN- dependent trans-infection of SARS-CoV-2. The molecular details underlying avidity generation in such systems remain poorly characterized. In an effort to dissect the contribution of the known multivalent effects - chelation, clustering and statistical rebinding – we studied a series of dendrimer constructs related to Polyman26 with a rod core rationally designed to engage simultaneously two binding sites of the tetrameric DC-SIGN. Binding properties of these compounds have been studied with a range of biophysical techniques, including recently developed Surface Plasmon Resonance oriented-surface methodology. Using molecular modelling we addressed, for the first time, the impact of the carbohydrate recognition domains’ flexibility of the DC-SIGN tetramer on the compounds’ avidity. We were able to gain deeper insight into the role of different binding modes, which in combination produce a construct with a nM affinity despite a limited valency. This multi-faceted experimental-theoretical approach provides detailed understanding of multivalent ligand/multimeric protein interactions which can lead to future predictions. This work opens the way to the development of new virus attachment blockers adapted to different C-type lectin receptors of viruses.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.26434/chemrxiv-2022-4n79q&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other ORP type , Other literature type 2021 France, Italy, Spain, United Kingdom, FrancePublisher:AIP Publishing Funded by:EC | CROSS, NSF | UCLA CUORE Neutrino Physi..., EC | FELLINI +1 projectsEC| CROSS ,NSF| UCLA CUORE Neutrino Physics Research Program ,EC| FELLINI ,NSF| RUI: A Program of Undergraduate Participation in the Search for Rare Events with CUOREC. Accorsi; P. Agnes; E. Alessi; Pierre-Andre Amaudruz; Alberto Annovi; F. Ardellier Desages; S. Back; C. Badia; J. Bagger; V. Basile; G. Batignani; A. Bayo; B. Bell; M. Beschi; D. Biagini; G. Bianchi; S. Bicelli; D. Bishop; T. Boccali; Andrea Bombarda; Silvia Bonfanti; W. Bonivento; M. Bouchard; M. Breviario; R. Brown; J. M. Calvo-Mozota; L. Camozzi; M. Camozzi; A. Capra; M. Caravati; M. Carlini; A. Ceccanti; B. Celano; J. M. Cela Ruiz; C. Charette; G. Cogliati; M. Constable; Gabriele Croci; C. E. Dahl; A. Dal Molin; M. Daley; C. Di Guardo; O. Davignon; M. Del Tutto; J. De Ruiter; A. Devoto; P. Diaz Gomez Maqueo; F. Di Francesco; M. Dossi; E. Druszkiewicz; C. Duma; E. Elliott; D. Farina; C. Fernandes; F. Ferroni; G. Finocchiaro; G. Fiorillo; G. Foti; R. D. Fournier; D. Franco; C. Fricbergs; F. Gabriele; Cristiano Galbiati; P. Garcia Abia; Angelo Gargantini; L. Giacomelli; F. Giacomini; L. S. Giarratana; S. Gillespie; T. Girma; R. Gobui; D. Goeldi; F. Golf; P. Gorel; Giuseppe Gorini; E. Gramellini; Giovanni Grosso; F. Guescini; E. Guetre; T. Hadden; W. Hawkins; K. Hayashi; A. Heavey; G. Hersak; Nigel Hessey; G. Hockin; K. Hudson; An. Ianni; C. Ienzi; Valerio Ippolito; C. C. James; C. Jillings; S. Khan; E. Kim; M. King; S. King; A. Kittmer; R. Krücken; M.H. Kushoro; S. Kuula; M. Laclaustra; L. Lee; A. Lennarz; M. Leyton; X. Li; P. Liimatainen; C. Lim; T. Lindner; T. Lomonaco; P. Lu; G. A. Lukhanin; G. Luzón; M. MacDonald; G. Magni; R. Maharaj; S. Manni; C. Mapelli; P. Margetak; L. Martin; S. Martin; M. I. Martínez; N. Massacret; P. McClurg; A. B. McDonald; R. Migalla; T. A. Mohayai; L. M. Tosatti; G. Monzani; Claudio Moretti; B. Morrison; M. Mountaniol; A. Muraro; P. Napoli; Federico Nati; C. R. Natzke; A. J. Noble; A. Norrick; A. Ortiz de Solórzano; F. Padula; Marco Pallavicini; I. Palumbo; E. Panontin; N. Papini; S. Parmeggiano; K. Patel; A. Patel; M. Paterno; C. Pellegrino; P. Pelliccione; V. Pesudo; A. Pocar; A. Pope; S. Pordes; F. Prelz; O. Putignano; J. L. Raaf; C. Ratti; M. Razeti; D. Reed; J. Refsgaard; T. Reilly; F. Retriere; Elvinia Riccobene; D. Rigamonti; A. Rizzi; J. Rode; J. Romualdez; L. Russel; D. Sablone; S. Sala; D. Salomoni; P. Salvo; E. Sansoucy; R. Santorelli; C. Savarese; Eugenio Scapparone; M. Settimo; B. Shaw; S. Shawyer; A. Sher; A. Shi; P. Skensved; A. S. Slutsky; B. Smith; N. J. T. Smith; A. Stenzler; C. Straubel; P. Stringari; M. Suchenek; Bhaskar Sur; S. Tacchino; L. Takeuchi; R. Tartaglia; E. Thomas; D. Trask; J. Tseng; L. VanPagee; V. Vedia; B. Velghe; S. Viel; A. Visioli; L. Viviani; D. Vonica; M. Wada; D. Walter; H. Wang; M. H. L. S. Wang; S. Westerdale; D. Wood; D. Yates; S. Yue; V. Zambrano;doi: 10.1063/5.0044445
pmc: PMC8060010
pmid: 33897243
handle: 11311/1205777 , 11588/852737 , 11567/1061033 , 11379/550011 , 2434/919815
doi: 10.1063/5.0044445
pmc: PMC8060010
pmid: 33897243
handle: 11311/1205777 , 11588/852737 , 11567/1061033 , 11379/550011 , 2434/919815
International audience; This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world
Archivio istituziona... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8060010Data sources: PubMed CentralOxford University Research ArchiveOther literature type . 2021Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2021License: CC BYArchivio Istituzionale Università di BergamoArticle . 2021Data sources: Archivio Istituzionale Università di BergamoArchivio della Ricerca - Università di PisaArticle . 2021Data sources: Archivio della Ricerca - Università di PisaBOA - Bicocca Open Archive; Physics of FluidsArticle . 2021 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1063/5.0044445&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 30 citations 30 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 2visibility views 2 download downloads 15 Powered bymore_vert Archivio istituziona... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8060010Data sources: PubMed CentralOxford University Research ArchiveOther literature type . 2021Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2021License: CC BYArchivio Istituzionale Università di BergamoArticle . 2021Data sources: Archivio Istituzionale Università di BergamoArchivio della Ricerca - Università di PisaArticle . 2021Data sources: Archivio della Ricerca - Università di PisaBOA - Bicocca Open Archive; Physics of FluidsArticle . 2021 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1063/5.0044445&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other ORP type , Other literature type 2021 France FrenchPublisher:HAL CCSD Authors: Gagnayre, Rémi;Gagnayre, Rémi;E-book : recueils des travaux de recherche du LEPS sur la pandémie Covid-19; Pendant la période de crise sanitaire liée à la COVID-19, les chercheurs du LEPS et des Chaires RI et EPU2S ont conduit des études dans le domaine des soins et des éducations en santé, concernant tout autant les patients et les professionnels. Il s’agit de contribuer à résoudre des problèmes que posent cette situation inédite et de proposer des solutions par rapport à ce qu’elle révèle des pratiques et du système de santé. Ce e-book rassemble l’ensemble des recherches sur la pandémie en relation avec les problématiques du LEPS et des chaires que le laboratoire héberge ainsi que les références des textes que ces mêmes chercheurs ont publié dans différents médias (les conférences bien que nombreuses n'ont pas été prises en compte dans ce document).
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______1398::5945ae991d8823fdde0580bc63433304&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______1398::5945ae991d8823fdde0580bc63433304&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 Italy, FrancePublisher:Springer Science and Business Media LLC Funded by:EC | COSY-BIOEC| COSY-BIOFabio Della Rossa; Davide Salzano; Anna Di Meglio; Francesco De Lellis; Marco Coraggio; Carmela Calabrese; Agostino Guarino; Ricardo Cardona-Rivera; Pietro De Lellis; Davide Liuzza; Francesco Lo Iudice; Giovanni Russo; Mario di Bernardo;The COVID-19 epidemic hit Italy particularly hard, yielding the implementation of strict national lockdown rules. Previous modelling studies at the national level overlooked the fact that Italy is divided into administrative regions which can independently oversee their own share of the Italian National Health Service. Here, we show that heterogeneity between regions is essential to understand the spread of the epidemic and to design effective strategies to control the disease. We model Italy as a network of regions and parameterize the model of each region on real data spanning over two months from the initial outbreak. We confirm the effectiveness at the regional level of the national lockdown strategy and propose coordinated regional interventions to prevent future national lockdowns, while avoiding saturation of the regional health systems and mitigating impact on costs. Our study and methodology can be easily extended to other levels of granularity to support policy- and decision-makers. An ongoing global debate concerns effective and sustainable lockdown release strategies in the current pandemic. Here, the authors implement a network model at healthcare-relevant spatial scale to show that coordinated local strategies can be effective in containing further resurgence of the disease.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC7547104Data sources: PubMed CentralZENODO; ENEA Open Archive; Archivio della ricerca - Università degli studi di Napoli Federico II; Nature Communications; RE.PUBLIC@POLIMI Research Publications at Politecnico di MilanoOther literature type . Article . Other ORP type . 2020 . Peer-reviewedLicense: CC BYArchivio della Ricerca - Università di SalernoArticle . 2020Data sources: Archivio della Ricerca - Università di SalernoMémoires en Sciences de l'Information et de la Communication; HAL AMUArticle . 2023License: CC BYFull-Text: https://hal.science/hal-03598263/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-020-18827-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 124 citations 124 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 17visibility views 17 download downloads 23 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC7547104Data sources: PubMed CentralZENODO; ENEA Open Archive; Archivio della ricerca - Università degli studi di Napoli Federico II; Nature Communications; RE.PUBLIC@POLIMI Research Publications at Politecnico di MilanoOther literature type . Article . Other ORP type . 2020 . Peer-reviewedLicense: CC BYArchivio della Ricerca - Università di SalernoArticle . 2020Data sources: Archivio della Ricerca - Università di SalernoMémoires en Sciences de l'Information et de la Communication; HAL AMUArticle . 2023License: CC BYFull-Text: https://hal.science/hal-03598263/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-020-18827-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 France, ItalyPublisher:Cold Spring Harbor Laboratory Funded by:EC | VIRUSCANEC| VIRUSCANMichel Thépaut; Joanna Luczkowiak; Corinne Vivès; Nuria Labiod; Isabelle Bally; Fátima Lasala; Yasmina Grimoire; Daphna Fenel; Sara Sattin; Nicole M. Thielens; Guy Schoehn; Anna Bernardi; Rafael L. Delgado; Franck Fieschi;Author summary For their infectious effectiveness, viruses often use host attachment factors to improve their adhesion to the cell surface. This will mainly increase viruses concentration at cell surfaces, potentiating access and final engagement with their real entry receptors. This mechanism enhances viral infection of target cells or even allow viruses to be captured by non-permissive cells for secondary presentation to permissive cells by a process called trans-infection. While, the entry mechanism of SARS-CoV-2 using the ACE2 entry receptor, is well defined, little is known about additional factors explaining the high transmission rate of this virus. The level of glycosylations on the SARS-CoV-2 Spike protein prompted us to assess whether CLRs of immune cells, regularly diverted by pathogens, could play a role in the spread of SARS-CoV-2. Here, we show that these receptors are able to recognize Spike envelope protein of SARS-CoV-2 and two receptors among the four tested, DC-SIGN and L-SIGN, are able to promote virus trans-infection. This work identifies a new family of alternative SARS-CoV-2 cell receptors involved in uncharacterized dissemination mechanism. Moreover, considering the role of CLRs in immunomodulation, their early involvement opens avenues for understanding the imbalanced innate immune response observed in COVID-19 pathogenesis. The efficient spread of SARS-CoV-2 resulted in a unique pandemic in modern history. Despite early identification of ACE2 as the receptor for viral spike protein, much remains to be understood about the molecular events behind viral dissemination. We evaluated the contribution of C-type lectin receptors (CLRS) of antigen-presenting cells, widely present in respiratory mucosa and lung tissue. DC-SIGN, L-SIGN, Langerin and MGL bind to diverse glycans of the spike using multiple interaction areas. Using pseudovirus and cells derived from monocytes or T-lymphocytes, we demonstrate that while virus capture by the CLRs examined does not allow direct cell infection, DC/L-SIGN, among these receptors, promote virus transfer to permissive ACE2+ Vero E6 cells. A glycomimetic compound designed against DC-SIGN, enable inhibition of this process. These data have been then confirmed using authentic SARS-CoV-2 virus and human respiratory cell lines. Thus, we described a mechanism potentiating viral spreading of infection.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8136665Data sources: PubMed CentralArchivio Istituzionale della Ricerca dell'Università degli Studi di MilanoPreprint . Other ORP type . 2020PLoS Pathogens; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoArticle . 2021 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.08.09.242917&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 139 citations 139 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8136665Data sources: PubMed CentralArchivio Istituzionale della Ricerca dell'Università degli Studi di MilanoPreprint . Other ORP type . 2020PLoS Pathogens; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoArticle . 2021 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.08.09.242917&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Other ORP type , Preprint 2022 France, ItalyPublisher:American Chemical Society (ACS) Funded by:EC | CaLecLig, ANR | CBH-EUR-GS, EC | HPC-EUROPA3EC| CaLecLig ,ANR| CBH-EUR-GS ,EC| HPC-EUROPA3Vanessa Porkolab; Martin Lepšík; Stefania Ordanini; Alexander St John; Aline Le Roy; Michel Thépaut; Emanuele Paci; Christine Ebel; Anna Bernardi; Franck Fieschi;The C-type lectin receptor DC-SIGN has been highlighted as co-receptor for the spike protein of the SARS-CoV-2 virus. A multivalent glycomimetic ligand, Polyman26, has been found to inhibit DCSIGN- dependent trans-infection of SARS-CoV-2. The molecular details underlying avidity generation in such systems remain poorly characterized. In an effort to dissect the contribution of the known multivalent effects - chelation, clustering and statistical rebinding – we studied a series of dendrimer constructs related to Polyman26 with a rod core rationally designed to engage simultaneously two binding sites of the tetrameric DC-SIGN. Binding properties of these compounds have been studied with a range of biophysical techniques, including recently developed Surface Plasmon Resonance oriented-surface methodology. Using molecular modelling we addressed, for the first time, the impact of the carbohydrate recognition domains’ flexibility of the DC-SIGN tetramer on the compounds’ avidity. We were able to gain deeper insight into the role of different binding modes, which in combination produce a construct with a nM affinity despite a limited valency. This multi-faceted experimental-theoretical approach provides detailed understanding of multivalent ligand/multimeric protein interactions which can lead to future predictions. This work opens the way to the development of new virus attachment blockers adapted to different C-type lectin receptors of viruses.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.26434/chemrxiv-2022-4n79q&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.26434/chemrxiv-2022-4n79q&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other ORP type , Other literature type 2021 France, Italy, Spain, United Kingdom, FrancePublisher:AIP Publishing Funded by:EC | CROSS, NSF | UCLA CUORE Neutrino Physi..., EC | FELLINI +1 projectsEC| CROSS ,NSF| UCLA CUORE Neutrino Physics Research Program ,EC| FELLINI ,NSF| RUI: A Program of Undergraduate Participation in the Search for Rare Events with CUOREC. Accorsi; P. Agnes; E. Alessi; Pierre-Andre Amaudruz; Alberto Annovi; F. Ardellier Desages; S. Back; C. Badia; J. Bagger; V. Basile; G. Batignani; A. Bayo; B. Bell; M. Beschi; D. Biagini; G. Bianchi; S. Bicelli; D. Bishop; T. Boccali; Andrea Bombarda; Silvia Bonfanti; W. Bonivento; M. Bouchard; M. Breviario; R. Brown; J. M. Calvo-Mozota; L. Camozzi; M. Camozzi; A. Capra; M. Caravati; M. Carlini; A. Ceccanti; B. Celano; J. M. Cela Ruiz; C. Charette; G. Cogliati; M. Constable; Gabriele Croci; C. E. Dahl; A. Dal Molin; M. Daley; C. Di Guardo; O. Davignon; M. Del Tutto; J. De Ruiter; A. Devoto; P. Diaz Gomez Maqueo; F. Di Francesco; M. Dossi; E. Druszkiewicz; C. Duma; E. Elliott; D. Farina; C. Fernandes; F. Ferroni; G. Finocchiaro; G. Fiorillo; G. Foti; R. D. Fournier; D. Franco; C. Fricbergs; F. Gabriele; Cristiano Galbiati; P. Garcia Abia; Angelo Gargantini; L. Giacomelli; F. Giacomini; L. S. Giarratana; S. Gillespie; T. Girma; R. Gobui; D. Goeldi; F. Golf; P. Gorel; Giuseppe Gorini; E. Gramellini; Giovanni Grosso; F. Guescini; E. Guetre; T. Hadden; W. Hawkins; K. Hayashi; A. Heavey; G. Hersak; Nigel Hessey; G. Hockin; K. Hudson; An. Ianni; C. Ienzi; Valerio Ippolito; C. C. James; C. Jillings; S. Khan; E. Kim; M. King; S. King; A. Kittmer; R. Krücken; M.H. Kushoro; S. Kuula; M. Laclaustra; L. Lee; A. Lennarz; M. Leyton; X. Li; P. Liimatainen; C. Lim; T. Lindner; T. Lomonaco; P. Lu; G. A. Lukhanin; G. Luzón; M. MacDonald; G. Magni; R. Maharaj; S. Manni; C. Mapelli; P. Margetak; L. Martin; S. Martin; M. I. Martínez; N. Massacret; P. McClurg; A. B. McDonald; R. Migalla; T. A. Mohayai; L. M. Tosatti; G. Monzani; Claudio Moretti; B. Morrison; M. Mountaniol; A. Muraro; P. Napoli; Federico Nati; C. R. Natzke; A. J. Noble; A. Norrick; A. Ortiz de Solórzano; F. Padula; Marco Pallavicini; I. Palumbo; E. Panontin; N. Papini; S. Parmeggiano; K. Patel; A. Patel; M. Paterno; C. Pellegrino; P. Pelliccione; V. Pesudo; A. Pocar; A. Pope; S. Pordes; F. Prelz; O. Putignano; J. L. Raaf; C. Ratti; M. Razeti; D. Reed; J. Refsgaard; T. Reilly; F. Retriere; Elvinia Riccobene; D. Rigamonti; A. Rizzi; J. Rode; J. Romualdez; L. Russel; D. Sablone; S. Sala; D. Salomoni; P. Salvo; E. Sansoucy; R. Santorelli; C. Savarese; Eugenio Scapparone; M. Settimo; B. Shaw; S. Shawyer; A. Sher; A. Shi; P. Skensved; A. S. Slutsky; B. Smith; N. J. T. Smith; A. Stenzler; C. Straubel; P. Stringari; M. Suchenek; Bhaskar Sur; S. Tacchino; L. Takeuchi; R. Tartaglia; E. Thomas; D. Trask; J. Tseng; L. VanPagee; V. Vedia; B. Velghe; S. Viel; A. Visioli; L. Viviani; D. Vonica; M. Wada; D. Walter; H. Wang; M. H. L. S. Wang; S. Westerdale; D. Wood; D. Yates; S. Yue; V. Zambrano;doi: 10.1063/5.0044445
pmc: PMC8060010
pmid: 33897243
handle: 11311/1205777 , 11588/852737 , 11567/1061033 , 11379/550011 , 2434/919815
doi: 10.1063/5.0044445
pmc: PMC8060010
pmid: 33897243
handle: 11311/1205777 , 11588/852737 , 11567/1061033 , 11379/550011 , 2434/919815
International audience; This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world
Archivio istituziona... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8060010Data sources: PubMed CentralOxford University Research ArchiveOther literature type . 2021Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2021License: CC BYArchivio Istituzionale Università di BergamoArticle . 2021Data sources: Archivio Istituzionale Università di BergamoArchivio della Ricerca - Università di PisaArticle . 2021Data sources: Archivio della Ricerca - Università di PisaBOA - Bicocca Open Archive; Physics of FluidsArticle . 2021 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1063/5.0044445&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 30 citations 30 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 2visibility views 2 download downloads 15 Powered bymore_vert Archivio istituziona... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8060010Data sources: PubMed CentralOxford University Research ArchiveOther literature type . 2021Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; Digital Repository of University of ZaragozaArticle . 2021License: CC BYArchivio Istituzionale Università di BergamoArticle . 2021Data sources: Archivio Istituzionale Università di BergamoArchivio della Ricerca - Università di PisaArticle . 2021Data sources: Archivio della Ricerca - Università di PisaBOA - Bicocca Open Archive; Physics of FluidsArticle . 2021 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1063/5.0044445&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other ORP type , Other literature type 2021 France FrenchPublisher:HAL CCSD Authors: Gagnayre, Rémi;Gagnayre, Rémi;E-book : recueils des travaux de recherche du LEPS sur la pandémie Covid-19; Pendant la période de crise sanitaire liée à la COVID-19, les chercheurs du LEPS et des Chaires RI et EPU2S ont conduit des études dans le domaine des soins et des éducations en santé, concernant tout autant les patients et les professionnels. Il s’agit de contribuer à résoudre des problèmes que posent cette situation inédite et de proposer des solutions par rapport à ce qu’elle révèle des pratiques et du système de santé. Ce e-book rassemble l’ensemble des recherches sur la pandémie en relation avec les problématiques du LEPS et des chaires que le laboratoire héberge ainsi que les références des textes que ces mêmes chercheurs ont publié dans différents médias (les conférences bien que nombreuses n'ont pas été prises en compte dans ce document).
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______1398::5945ae991d8823fdde0580bc63433304&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______1398::5945ae991d8823fdde0580bc63433304&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 Italy, FrancePublisher:Springer Science and Business Media LLC Funded by:EC | COSY-BIOEC| COSY-BIOFabio Della Rossa; Davide Salzano; Anna Di Meglio; Francesco De Lellis; Marco Coraggio; Carmela Calabrese; Agostino Guarino; Ricardo Cardona-Rivera; Pietro De Lellis; Davide Liuzza; Francesco Lo Iudice; Giovanni Russo; Mario di Bernardo;The COVID-19 epidemic hit Italy particularly hard, yielding the implementation of strict national lockdown rules. Previous modelling studies at the national level overlooked the fact that Italy is divided into administrative regions which can independently oversee their own share of the Italian National Health Service. Here, we show that heterogeneity between regions is essential to understand the spread of the epidemic and to design effective strategies to control the disease. We model Italy as a network of regions and parameterize the model of each region on real data spanning over two months from the initial outbreak. We confirm the effectiveness at the regional level of the national lockdown strategy and propose coordinated regional interventions to prevent future national lockdowns, while avoiding saturation of the regional health systems and mitigating impact on costs. Our study and methodology can be easily extended to other levels of granularity to support policy- and decision-makers. An ongoing global debate concerns effective and sustainable lockdown release strategies in the current pandemic. Here, the authors implement a network model at healthcare-relevant spatial scale to show that coordinated local strategies can be effective in containing further resurgence of the disease.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC7547104Data sources: PubMed CentralZENODO; ENEA Open Archive; Archivio della ricerca - Università degli studi di Napoli Federico II; Nature Communications; RE.PUBLIC@POLIMI Research Publications at Politecnico di MilanoOther literature type . Article . Other ORP type . 2020 . Peer-reviewedLicense: CC BYArchivio della Ricerca - Università di SalernoArticle . 2020Data sources: Archivio della Ricerca - Università di SalernoMémoires en Sciences de l'Information et de la Communication; HAL AMUArticle . 2023License: CC BYFull-Text: https://hal.science/hal-03598263/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-020-18827-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 124 citations 124 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 17visibility views 17 download downloads 23 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC7547104Data sources: PubMed CentralZENODO; ENEA Open Archive; Archivio della ricerca - Università degli studi di Napoli Federico II; Nature Communications; RE.PUBLIC@POLIMI Research Publications at Politecnico di MilanoOther literature type . Article . Other ORP type . 2020 . Peer-reviewedLicense: CC BYArchivio della Ricerca - Università di SalernoArticle . 2020Data sources: Archivio della Ricerca - Università di SalernoMémoires en Sciences de l'Information et de la Communication; HAL AMUArticle . 2023License: CC BYFull-Text: https://hal.science/hal-03598263/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-020-18827-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 France, ItalyPublisher:Cold Spring Harbor Laboratory Funded by:EC | VIRUSCANEC| VIRUSCANMichel Thépaut; Joanna Luczkowiak; Corinne Vivès; Nuria Labiod; Isabelle Bally; Fátima Lasala; Yasmina Grimoire; Daphna Fenel; Sara Sattin; Nicole M. Thielens; Guy Schoehn; Anna Bernardi; Rafael L. Delgado; Franck Fieschi;Author summary For their infectious effectiveness, viruses often use host attachment factors to improve their adhesion to the cell surface. This will mainly increase viruses concentration at cell surfaces, potentiating access and final engagement with their real entry receptors. This mechanism enhances viral infection of target cells or even allow viruses to be captured by non-permissive cells for secondary presentation to permissive cells by a process called trans-infection. While, the entry mechanism of SARS-CoV-2 using the ACE2 entry receptor, is well defined, little is known about additional factors explaining the high transmission rate of this virus. The level of glycosylations on the SARS-CoV-2 Spike protein prompted us to assess whether CLRs of immune cells, regularly diverted by pathogens, could play a role in the spread of SARS-CoV-2. Here, we show that these receptors are able to recognize Spike envelope protein of SARS-CoV-2 and two receptors among the four tested, DC-SIGN and L-SIGN, are able to promote virus trans-infection. This work identifies a new family of alternative SARS-CoV-2 cell receptors involved in uncharacterized dissemination mechanism. Moreover, considering the role of CLRs in immunomodulation, their early involvement opens avenues for understanding the imbalanced innate immune response observed in COVID-19 pathogenesis. The efficient spread of SARS-CoV-2 resulted in a unique pandemic in modern history. Despite early identification of ACE2 as the receptor for viral spike protein, much remains to be understood about the molecular events behind viral dissemination. We evaluated the contribution of C-type lectin receptors (CLRS) of antigen-presenting cells, widely present in respiratory mucosa and lung tissue. DC-SIGN, L-SIGN, Langerin and MGL bind to diverse glycans of the spike using multiple interaction areas. Using pseudovirus and cells derived from monocytes or T-lymphocytes, we demonstrate that while virus capture by the CLRs examined does not allow direct cell infection, DC/L-SIGN, among these receptors, promote virus transfer to permissive ACE2+ Vero E6 cells. A glycomimetic compound designed against DC-SIGN, enable inhibition of this process. These data have been then confirmed using authentic SARS-CoV-2 virus and human respiratory cell lines. Thus, we described a mechanism potentiating viral spreading of infection.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8136665Data sources: PubMed CentralArchivio Istituzionale della Ricerca dell'Università degli Studi di MilanoPreprint . Other ORP type . 2020PLoS Pathogens; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoArticle . 2021 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.08.09.242917&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 139 citations 139 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8136665Data sources: PubMed CentralArchivio Istituzionale della Ricerca dell'Università degli Studi di MilanoPreprint . Other ORP type . 2020PLoS Pathogens; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoArticle . 2021 . Peer-reviewedLicense: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.08.09.242917&type=result"></script>'); --> </script>
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