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  • COVID-19
  • 2017-2021
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Pedro M Machado; Saskia Lawson-Tovey; Anja Strangfeld; Elsa F Mateus; +27 Authors

    ObjectivesTo describe the safety of vaccines against SARS-CoV-2 in people with inflammatory/autoimmune rheumatic and musculoskeletal disease (I-RMD).MethodsPhysician-reported registry of I-RMD and non-inflammatory RMD (NI-RMDs) patients vaccinated against SARS-CoV-2. From 5 February 2021 to 27 July 2021, we collected data on demographics, vaccination, RMD diagnosis, disease activity, immunomodulatory/immunosuppressive treatments, flares, adverse events (AEs) and SARS-CoV-2 breakthrough infections. Data were analysed descriptively.ResultsThe study included 5121 participants from 30 countries, 90% with I-RMDs (n=4604, 68% female, mean age 60.5 years) and 10% with NI-RMDs (n=517, 77% female, mean age 71.4). Inflammatory joint diseases (58%), connective tissue diseases (18%) and vasculitis (12%) were the most frequent diagnostic groups; 54% received conventional synthetic disease-modifying antirheumatic drugs (DMARDs), 42% biological DMARDs and 35% immunosuppressants. Most patients received the Pfizer/BioNTech vaccine (70%), 17% AstraZeneca/Oxford and 8% Moderna. In fully vaccinated cases, breakthrough infections were reported in 0.7% of I-RMD patients and 1.1% of NI-RMD patients. I-RMD flares were reported in 4.4% of cases (0.6% severe), 1.5% resulting in medication changes. AEs were reported in 37% of cases (37% I-RMD, 40% NI-RMD), serious AEs in 0.5% (0.4% I-RMD, 1.9% NI-RMD).ConclusionThe safety profiles of SARS-CoV-2 vaccines in patients with I-RMD was reassuring and comparable with patients with NI-RMDs. The majority of patients tolerated their vaccination well with rare reports of I-RMD flare and very rare reports of serious AEs. These findings should provide reassurance to rheumatologists and vaccine recipients and promote confidence in SARS-CoV-2 vaccine safety in I-RMD patients.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ The University of Ma...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Annals of the Rheumatic Diseases
    Article . 2021 . Peer-reviewed
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    Authors: Jacques Reis; Serefnur Ozturk; Zeliha Tulek; Peter Spencer;

    The coronavirus disease-2019 pandemic, one of many global threats to human health, provides an opportunity to analyze how to detect, minimize, and even prevent the spread of future viral zoonotic agents with pandemic potential. Such analysis can utilize existing risk assessment techniques that seek formally to define the hazard, assess the health risk, characterize the health threat, and estimate the probability of occurrence.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Türk Nöroloji Dergis...arrow_drop_down
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    Article . 2021
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Article . 2021 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Türk Nöroloji Dergis...arrow_drop_down
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      Article . 2021 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Kathleen McColl; Marion Debin; Cecile Souty; Caroline Guerrisi; +12 Authors

    International audience; Unrealistic optimism, the underestimation of one’s risk of experiencing harm, has been investigated extensively to understand better and predict behavioural responses to health threats. Prior to the COVID-19 pandemic, a relative dearth of research existed in this domain regarding epidemics, which is surprising considering that this optimistic bias has been associated with a lack of engagement in protective behaviours critical in fighting twenty-first-century, emergent, infectious diseases. The current study addresses this gap in the literature by investigating whether people demonstrated optimism bias during the first wave of the COVID-19 pandemic in Europe, how this changed over time, and whether unrealistic optimism was negatively associated with protective measures. Taking advantage of a pre-existing international participative influenza surveillance network (n = 12,378), absolute and comparative unrealistic optimism were measured at three epidemic stages (pre-, early, peak), and across four countries—France, Italy, Switzerland and the United Kingdom. Despite differences in culture and health response, similar patterns were observed across all four countries. The prevalence of unrealistic optimism appears to be influenced by the particular epidemic context. Paradoxically, whereas absolute unrealistic optimism decreased over time, comparative unrealistic optimism increased, suggesting that whilst people became increasingly accurate in assessing their personal risk, they nonetheless overestimated that for others. Comparative unrealistic optimism was negatively associated with the adoption of protective behaviours, which is worrying, given that these preventive measures are critical in tackling the spread and health burden of COVID-19. It is hoped these findings will inspire further research into sociocognitive mechanisms involved in risk appraisal.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Javier Urmeneta-Ulloa; José A. Cabrera; Ana Álvarez-Vázquez; Esther Merino-Lanza; +1 Authors

    Varon de 56 anos con enfisema pulmonar y episodios previos de neumotorax espontaneos secundarios a bullas subpleurales. Acude a nuestro centro por clinica de fiebre 38.5 °C, disnea de reposo y tos seca.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Archivos de Cardiolo...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Archivos de Cardiología de México
    Article . 2021 . Peer-reviewed
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Archivos de Cardiología de México
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Archivos de Cardiolo...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Archivos de Cardiología de México
      Article . 2021 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Archivos de Cardiología de México
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Katerina Kavalidou; Konstantinos Kotsis; Dimitra Laimou; Dionysia Panagidou; +1 Authors

    Background: Individuals with physical or mental health conditions represent a vulnerable population, especially during the COVID-19 pandemic. However, limited information is available concerning posttraumatic growth and common mental health symptoms of this vulnerable health group during COVID-19. Methods: An online cross-sectional study (STRONG study; psychological changes and effects after COVID-19 quarantine in Greece) was conducted from 28 September 2020 (no lockdown restrictions) to 2 November 2020, just before the second lockdown in Greece. Main outcomes were depressive and anxiety symptoms as well as posttraumatic growth. Results: A total of 860 adults participated in the study. A high proportion of participants did not report any pre-existing health condition (61%), while 334 individuals reported one or more physical or mental health conditions. Overall, 20.2% of the participants reported significant depressive symptoms, and 27.9% reported moderate to high posttraumatic growth. The presence of physical and mental health conditions, either as single diagnosis or as a multimorbidity, was significantly associated with the development of depressive symptomatology (either physical or mental health conditions: OR = 1.12; 95% CI, 1.07–1.17, p < 0.001; both physical and mental health conditions: OR = 1.23; 95% CI, 1.14–1.33, p < 0.001). Posttraumatic growth did not differ between those with or without any pre-existing health issue. Conclusions: Although having a physical or/and a mental health condition predicted the development of depressive symptomatology in a post-lockdown period, the presence of pre-existing conditions was not associated with posttraumatic growth development. Clinicians should be aware of depressive symptoms among their multimorbid patients, even after exiting lockdown.

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    Psychiatry International
    Other literature type . Article . 2021 . Peer-reviewed
    License: CC BY
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    Psychiatry International
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Psychiatry Internati...arrow_drop_down
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      Psychiatry International
      Other literature type . Article . 2021 . Peer-reviewed
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  • Authors: Vialle, Manon; Linconstant, Léa;

    International audience; In France, as in many other countries, the activities of assisted reproductive technology (ART) centers were interrupted with the occurrence of the COVID-19 health crisis in March 2020. Various national institutions governing these medical activities, such as the Biomedicine agency in France, have recommended that ART centers stop all services. Following the slow restart of their activities in May 2020, the delays for treatment were prolonged, and it was difficult for the professionals to respond to all the requests within a short timeframe. While some people were able to resume their ART course safely at the end of the first lockdown, others had their medical appointments scheduled and then deprogrammed several times without ever being able to start their ART procedure. Some of those interviewed were still waiting almost a year after the start of the health crisis. While the procreative paths of these couples are already tinged with uncertainty due to their infertility, the parental horizons of the people interviewed have become darker during the health crisis. The latter has resulted in increased uncertainty and a prolongation of the ART process, undermining the temporality of the parental project. The analysis of the interviews shows how, within the framework of these disrupted temporalities, the perception of risk evolves and leads to a hierarchy of priorities: from the pandemic risk to the risk of not being able to procreate, from the health priority to the parental project priority.; En Francia, los centros de reproducción médicamente asistida (RMA) debieron interrumpir su atención debido a la crisis sanitaria vinculada al Covid-19, en marzo del 2020, según las recomendaciones de varias autoridades nacionales. Tras la lenta reanudación de sus actividades en mayo del mismo año, los tiempos se alargaron y para los profesionales fue difícil acceder a todas las solicitudes en un corto período de tiempo. Si algunas personas pudieron retomar su recorrido de RMA sin incidentes al cabo del primer confinamiento, otras vieron sus citas médicas programadas y luego canceladas varias veces, sin poder iniciar nunca su tratamiento. Entre los entrevistados, algunos seguían esperando casi un año después del inicio de la crisis sanitaria. Aunque el camino procreativo de estas parejas ya está teñido de incertidumbre por su infertilidad, el horizonte parental se ha oscurecido aún más durante la crisis sanitaria, con mayores incertidumbres y demoras, lo cual pone en peligro el calendario del proyecto parental. El análisis de las entrevistas muestra cómo, en el contexto de estas temporalidades trastocadas, la percepción del riesgo evoluciona y conduce a una jerarquización de prioridades: del riesgo de pandemia al riesgo de no poder procrear, de la prioridad sanitaria a la prioridad del proyecto parental.; En France, la crise sanitaire liée au Covid-19 a conduit, en mars 2020, les centres d’assistance médicale à la procréation (AMP) à interrompre leurs prises en charge, suite aux recommandations de différentes instances nationales. Suite à la lente reprise de leurs activités en mai 2020, les délais de prise en charge ont été allongés et il a été difficile pour les professionnel·les d’accéder à l’ensemble des demandes dans un laps de temps court. Si certaines personnes ont pu reprendre sans encombre leur parcours à la fin du premier confinement, d’autres ont vu leurs rendez-vous médicaux programmés puis déprogrammés à plusieurs reprises, sans jamais pouvoir commencer leur tentative d’AMP. Parmi les personnes interrogées, certaines étaient toujours dans l’attente près d’un an après le début de la crise sanitaire. Alors que les parcours procréatifs de ces couples sont déjà teintés d’incertitude du fait de leur infertilité, l’horizon parental des personnes interrogées s’est obscurci pendant la crise sanitaire. Cette dernière a pour conséquence un renforcement des incertitudes ainsi qu’un allongement des parcours d’AMP et met ainsi à mal le calendrier du projet parental. L’analyse des entretiens montre comment, dans le cadre de ces temporalités bouleversées, la perception du risque évolue et conduit à une hiérarchisation des priorités : du risque pandémique au risque de ne pouvoir procréer, de la priorité sanitaire à la priorité du projet parental.

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    Authors: Baudoin, Lesya; Glanard, Anne; Maddi, Abdelghani; Mescheba, Wilfriedo; +1 Authors

    Research on infectious diseases constitutes a transversal scientific field. A specific corpus is designed by combining a controlled language (Medline MeSH thesaurus) and the categorization of journals (Web of Science). From this global corpus, the article characterizes the publications from the top 20 countries publishing in the field and evolutions between 2000 and 2020. Topic maps show the research themes within the field of infectious diseases both in the world and in France. The explosion of publications on Covid-19 in 2020 has a quite visible impact on the topic map in infectious diseases and changes the position of some countries in this field of research. The conclusion points to issues for further research as more complete data will become available on the Covid-19 period. Comment: in French. Histoire de la recherche contemporaine : la revue du Comit{\'e} pour l'histoire du CNRS , CNRS {\'E}ditions, 2021

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    OpenEdition
    Article . 2022
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    https://doi.org/10.4000/hrc.66...
    Article . 2021 . Peer-reviewed
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    Authors: Luchian, Maria-Luiza; Motoc, Andreea Iulia; Lochy, Stijn; Magne, Julien; +15 Authors

    Background: Coronavirus disease 2019 (COVID-19) emerged as a worldwide health crisis, overwhelming healthcare systems. Elevated cardiac troponin T (cTn T) at admission was associated with increased in-hospital mortality. However, data addressing the role of cTn T in major adverse cardiovascular events (MACE) in COVID-19 are scarce. Therefore, we assessed the role of baseline cTn T and cTn T kinetics for MACE and in-hospital mortality prediction in COVID-19. Methods: Three hundred and ten patients were included prospectively . One hundred and eight patients were excluded due to incomplete records. Patients were divided into three groups according to cTn T kinetics: ascending, descending, and constant. The cTn T slope was defined as the ratio of the cTn T change over time. The primary and secondary endpoints were MACE and in-hospital mortality. Results: Two hundred and two patients were included in the analysis (mean age 64.4 ± 16.7 years, 119 [58.9%] males). Mean duration of hospitalization was 14.0 ± 12.3 days. Sixty (29.7%) patients had MACE, and 40 (19.8%) patients died. Baseline cTn T predicted both endpoints ( p = 0.047, hazard ratio [HR] 1.805, 95% confidence interval [CI] 1.009 – 3.231 ; p = 0.009, HR 2.322, 95% CI 1.234 – 4.369) . Increased cTn T slope predicted mortality (p = 0.041, HR 1.006, 95% CI 1.000–1.011). Constant cTn T was associated with lower MACE and mortality (p = 0.000, HR 3.080, 95% CI 1.914–4.954, p = 0.000, HR 2.851, 95% CI 1.828–4.447). Conclusions: The present study emphasizes the additional role of cTn T testing in COVID-19 patients for risk stratification and improved diagnostic pathway and management.

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    Cardiology Journal
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      Cardiology Journal
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    Authors: Wronowski, M.; Wozniak, W.; Wanke-Rytt, M.; Jazdzewski, K.; +3 Authors

    International audience; The symptoms of SARS-CoV-2 infection and COVID-19 provoked by this virus are poorly described in children. Here we analyse a case of orchiepididymitis associated with COVID-19 in a 14-year-old boy. We discuss the possibility of SARS-CoV-2-associated testicular inflammation. This report strengthens the necessity for more in-depth study of the clinical presentation of paediatric COVID-19 and the potential association with non-respiratory symptoms.

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    South African Journal of Child Health
    Article . 2021 . Peer-reviewed
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    South African Journal of Child Health
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      South African Journal of Child Health
      Article . 2021 . Peer-reviewed
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      South African Journal of Child Health
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    Authors: Olivier Terrier; Mustapha Si-Tahar; Mariette Ducatez; Christophe Chevalier; +5 Authors

    International audience; The development of safe and effective vaccines in a record time after the emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a remarkable achievement, partly based on the experience gained from multiple viral outbreaks in the past decades. However, the Coronavirus Disease 2019 (COVID-19) crisis also revealed weaknesses in the global pandemic response and large gaps that remain in our knowledge of the biology of coronaviruses (CoVs) and influenza viruses, the 2 major respiratory viruses with pandemic potential. Here, we review current knowns and unknowns of influenza viruses and CoVs, and we highlight common research challenges they pose in 3 areas: the mechanisms of viral emergence and adaptation to humans, the physiological and molecular determinants of disease severity, and the development of control strategies. We outline multidisciplinary approaches and technological innovations that need to be harnessed in order to improve preparedeness to the next pandemic.

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    PLoS Pathogens
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    PLoS Pathogens
    Article . 2021 . Peer-reviewed
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    Hal-Diderot
    Article . 2021
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      PLoS Pathogens
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      PLoS Pathogens
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      Hal-Diderot
      Article . 2021
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Pedro M Machado; Saskia Lawson-Tovey; Anja Strangfeld; Elsa F Mateus; +27 Authors

    ObjectivesTo describe the safety of vaccines against SARS-CoV-2 in people with inflammatory/autoimmune rheumatic and musculoskeletal disease (I-RMD).MethodsPhysician-reported registry of I-RMD and non-inflammatory RMD (NI-RMDs) patients vaccinated against SARS-CoV-2. From 5 February 2021 to 27 July 2021, we collected data on demographics, vaccination, RMD diagnosis, disease activity, immunomodulatory/immunosuppressive treatments, flares, adverse events (AEs) and SARS-CoV-2 breakthrough infections. Data were analysed descriptively.ResultsThe study included 5121 participants from 30 countries, 90% with I-RMDs (n=4604, 68% female, mean age 60.5 years) and 10% with NI-RMDs (n=517, 77% female, mean age 71.4). Inflammatory joint diseases (58%), connective tissue diseases (18%) and vasculitis (12%) were the most frequent diagnostic groups; 54% received conventional synthetic disease-modifying antirheumatic drugs (DMARDs), 42% biological DMARDs and 35% immunosuppressants. Most patients received the Pfizer/BioNTech vaccine (70%), 17% AstraZeneca/Oxford and 8% Moderna. In fully vaccinated cases, breakthrough infections were reported in 0.7% of I-RMD patients and 1.1% of NI-RMD patients. I-RMD flares were reported in 4.4% of cases (0.6% severe), 1.5% resulting in medication changes. AEs were reported in 37% of cases (37% I-RMD, 40% NI-RMD), serious AEs in 0.5% (0.4% I-RMD, 1.9% NI-RMD).ConclusionThe safety profiles of SARS-CoV-2 vaccines in patients with I-RMD was reassuring and comparable with patients with NI-RMDs. The majority of patients tolerated their vaccination well with rare reports of I-RMD flare and very rare reports of serious AEs. These findings should provide reassurance to rheumatologists and vaccine recipients and promote confidence in SARS-CoV-2 vaccine safety in I-RMD patients.

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    Annals of the Rheumatic Diseases
    Article . 2021 . Peer-reviewed
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    Authors: Jacques Reis; Serefnur Ozturk; Zeliha Tulek; Peter Spencer;

    The coronavirus disease-2019 pandemic, one of many global threats to human health, provides an opportunity to analyze how to detect, minimize, and even prevent the spread of future viral zoonotic agents with pandemic potential. Such analysis can utilize existing risk assessment techniques that seek formally to define the hazard, assess the health risk, characterize the health threat, and estimate the probability of occurrence.

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    Article . 2021
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    Article . 2021 . Peer-reviewed
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    Article . 2021
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Kathleen McColl; Marion Debin; Cecile Souty; Caroline Guerrisi; +12 Authors

    International audience; Unrealistic optimism, the underestimation of one’s risk of experiencing harm, has been investigated extensively to understand better and predict behavioural responses to health threats. Prior to the COVID-19 pandemic, a relative dearth of research existed in this domain regarding epidemics, which is surprising considering that this optimistic bias has been associated with a lack of engagement in protective behaviours critical in fighting twenty-first-century, emergent, infectious diseases. The current study addresses this gap in the literature by investigating whether people demonstrated optimism bias during the first wave of the COVID-19 pandemic in Europe, how this changed over time, and whether unrealistic optimism was negatively associated with protective measures. Taking advantage of a pre-existing international participative influenza surveillance network (n = 12,378), absolute and comparative unrealistic optimism were measured at three epidemic stages (pre-, early, peak), and across four countries—France, Italy, Switzerland and the United Kingdom. Despite differences in culture and health response, similar patterns were observed across all four countries. The prevalence of unrealistic optimism appears to be influenced by the particular epidemic context. Paradoxically, whereas absolute unrealistic optimism decreased over time, comparative unrealistic optimism increased, suggesting that whilst people became increasingly accurate in assessing their personal risk, they nonetheless overestimated that for others. Comparative unrealistic optimism was negatively associated with the adoption of protective behaviours, which is worrying, given that these preventive measures are critical in tackling the spread and health burden of COVID-19. It is hoped these findings will inspire further research into sociocognitive mechanisms involved in risk appraisal.

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    Authors: Javier Urmeneta-Ulloa; José A. Cabrera; Ana Álvarez-Vázquez; Esther Merino-Lanza; +1 Authors

    Varon de 56 anos con enfisema pulmonar y episodios previos de neumotorax espontaneos secundarios a bullas subpleurales. Acude a nuestro centro por clinica de fiebre 38.5 °C, disnea de reposo y tos seca.

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    Archivos de Cardiología de México
    Article . 2021 . Peer-reviewed
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    Archivos de Cardiología de México
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      Archivos de Cardiología de México
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      Archivos de Cardiología de México
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    Authors: Katerina Kavalidou; Konstantinos Kotsis; Dimitra Laimou; Dionysia Panagidou; +1 Authors

    Background: Individuals with physical or mental health conditions represent a vulnerable population, especially during the COVID-19 pandemic. However, limited information is available concerning posttraumatic growth and common mental health symptoms of this vulnerable health group during COVID-19. Methods: An online cross-sectional study (STRONG study; psychological changes and effects after COVID-19 quarantine in Greece) was conducted from 28 September 2020 (no lockdown restrictions) to 2 November 2020, just before the second lockdown in Greece. Main outcomes were depressive and anxiety symptoms as well as posttraumatic growth. Results: A total of 860 adults participated in the study. A high proportion of participants did not report any pre-existing health condition (61%), while 334 individuals reported one or more physical or mental health conditions. Overall, 20.2% of the participants reported significant depressive symptoms, and 27.9% reported moderate to high posttraumatic growth. The presence of physical and mental health conditions, either as single diagnosis or as a multimorbidity, was significantly associated with the development of depressive symptomatology (either physical or mental health conditions: OR = 1.12; 95% CI, 1.07–1.17, p < 0.001; both physical and mental health conditions: OR = 1.23; 95% CI, 1.14–1.33, p < 0.001). Posttraumatic growth did not differ between those with or without any pre-existing health issue. Conclusions: Although having a physical or/and a mental health condition predicted the development of depressive symptomatology in a post-lockdown period, the presence of pre-existing conditions was not associated with posttraumatic growth development. Clinicians should be aware of depressive symptoms among their multimorbid patients, even after exiting lockdown.

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    Psychiatry International
    Other literature type . Article . 2021 . Peer-reviewed
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    Psychiatry International
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      Psychiatry International
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      Psychiatry International
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  • Authors: Vialle, Manon; Linconstant, Léa;

    International audience; In France, as in many other countries, the activities of assisted reproductive technology (ART) centers were interrupted with the occurrence of the COVID-19 health crisis in March 2020. Various national institutions governing these medical activities, such as the Biomedicine agency in France, have recommended that ART centers stop all services. Following the slow restart of their activities in May 2020, the delays for treatment were prolonged, and it was difficult for the professionals to respond to all the requests within a short timeframe. While some people were able to resume their ART course safely at the end of the first lockdown, others had their medical appointments scheduled and then deprogrammed several times without ever being able to start their ART procedure. Some of those interviewed were still waiting almost a year after the start of the health crisis. While the procreative paths of these couples are already tinged with uncertainty due to their infertility, the parental horizons of the people interviewed have become darker during the health crisis. The latter has resulted in increased uncertainty and a prolongation of the ART process, undermining the temporality of the parental project. The analysis of the interviews shows how, within the framework of these disrupted temporalities, the perception of risk evolves and leads to a hierarchy of priorities: from the pandemic risk to the risk of not being able to procreate, from the health priority to the parental project priority.; En Francia, los centros de reproducción médicamente asistida (RMA) debieron interrumpir su atención debido a la crisis sanitaria vinculada al Covid-19, en marzo del 2020, según las recomendaciones de varias autoridades nacionales. Tras la lenta reanudación de sus actividades en mayo del mismo año, los tiempos se alargaron y para los profesionales fue difícil acceder a todas las solicitudes en un corto período de tiempo. Si algunas personas pudieron retomar su recorrido de RMA sin incidentes al cabo del primer confinamiento, otras vieron sus citas médicas programadas y luego canceladas varias veces, sin poder iniciar nunca su tratamiento. Entre los entrevistados, algunos seguían esperando casi un año después del inicio de la crisis sanitaria. Aunque el camino procreativo de estas parejas ya está teñido de incertidumbre por su infertilidad, el horizonte parental se ha oscurecido aún más durante la crisis sanitaria, con mayores incertidumbres y demoras, lo cual pone en peligro el calendario del proyecto parental. El análisis de las entrevistas muestra cómo, en el contexto de estas temporalidades trastocadas, la percepción del riesgo evoluciona y conduce a una jerarquización de prioridades: del riesgo de pandemia al riesgo de no poder procrear, de la prioridad sanitaria a la prioridad del proyecto parental.; En France, la crise sanitaire liée au Covid-19 a conduit, en mars 2020, les centres d’assistance médicale à la procréation (AMP) à interrompre leurs prises en charge, suite aux recommandations de différentes instances nationales. Suite à la lente reprise de leurs activités en mai 2020, les délais de prise en charge ont été allongés et il a été difficile pour les professionnel·les d’accéder à l’ensemble des demandes dans un laps de temps court. Si certaines personnes ont pu reprendre sans encombre leur parcours à la fin du premier confinement, d’autres ont vu leurs rendez-vous médicaux programmés puis déprogrammés à plusieurs reprises, sans jamais pouvoir commencer leur tentative d’AMP. Parmi les personnes interrogées, certaines étaient toujours dans l’attente près d’un an après le début de la crise sanitaire. Alors que les parcours procréatifs de ces couples sont déjà teintés d’incertitude du fait de leur infertilité, l’horizon parental des personnes interrogées s’est obscurci pendant la crise sanitaire. Cette dernière a pour conséquence un renforcement des incertitudes ainsi qu’un allongement des parcours d’AMP et met ainsi à mal le calendrier du projet parental. L’analyse des entretiens montre comment, dans le cadre de ces temporalités bouleversées, la perception du risque évolue et conduit à une hiérarchisation des priorités : du risque pandémique au risque de ne pouvoir procréer, de la priorité sanitaire à la priorité du projet parental.

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    Authors: Baudoin, Lesya; Glanard, Anne; Maddi, Abdelghani; Mescheba, Wilfriedo; +1 Authors

    Research on infectious diseases constitutes a transversal scientific field. A specific corpus is designed by combining a controlled language (Medline MeSH thesaurus) and the categorization of journals (Web of Science). From this global corpus, the article characterizes the publications from the top 20 countries publishing in the field and evolutions between 2000 and 2020. Topic maps show the research themes within the field of infectious diseases both in the world and in France. The explosion of publications on Covid-19 in 2020 has a quite visible impact on the topic map in infectious diseases and changes the position of some countries in this field of research. The conclusion points to issues for further research as more complete data will become available on the Covid-19 period. Comment: in French. Histoire de la recherche contemporaine : la revue du Comit{\'e} pour l'histoire du CNRS , CNRS {\'E}ditions, 2021

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    OpenEdition
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    https://doi.org/10.4000/hrc.66...
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    Authors: Luchian, Maria-Luiza; Motoc, Andreea Iulia; Lochy, Stijn; Magne, Julien; +15 Authors

    Background: Coronavirus disease 2019 (COVID-19) emerged as a worldwide health crisis, overwhelming healthcare systems. Elevated cardiac troponin T (cTn T) at admission was associated with increased in-hospital mortality. However, data addressing the role of cTn T in major adverse cardiovascular events (MACE) in COVID-19 are scarce. Therefore, we assessed the role of baseline cTn T and cTn T kinetics for MACE and in-hospital mortality prediction in COVID-19. Methods: Three hundred and ten patients were included prospectively . One hundred and eight patients were excluded due to incomplete records. Patients were divided into three groups according to cTn T kinetics: ascending, descending, and constant. The cTn T slope was defined as the ratio of the cTn T change over time. The primary and secondary endpoints were MACE and in-hospital mortality. Results: Two hundred and two patients were included in the analysis (mean age 64.4 ± 16.7 years, 119 [58.9%] males). Mean duration of hospitalization was 14.0 ± 12.3 days. Sixty (29.7%) patients had MACE, and 40 (19.8%) patients died. Baseline cTn T predicted both endpoints ( p = 0.047, hazard ratio [HR] 1.805, 95% confidence interval [CI] 1.009 – 3.231 ; p = 0.009, HR 2.322, 95% CI 1.234 – 4.369) . Increased cTn T slope predicted mortality (p = 0.041, HR 1.006, 95% CI 1.000–1.011). Constant cTn T was associated with lower MACE and mortality (p = 0.000, HR 3.080, 95% CI 1.914–4.954, p = 0.000, HR 2.851, 95% CI 1.828–4.447). Conclusions: The present study emphasizes the additional role of cTn T testing in COVID-19 patients for risk stratification and improved diagnostic pathway and management.

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    Cardiology Journal
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    Authors: Wronowski, M.; Wozniak, W.; Wanke-Rytt, M.; Jazdzewski, K.; +3 Authors

    International audience; The symptoms of SARS-CoV-2 infection and COVID-19 provoked by this virus are poorly described in children. Here we analyse a case of orchiepididymitis associated with COVID-19 in a 14-year-old boy. We discuss the possibility of SARS-CoV-2-associated testicular inflammation. This report strengthens the necessity for more in-depth study of the clinical presentation of paediatric COVID-19 and the potential association with non-respiratory symptoms.

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    South African Journal of Child Health
    Article . 2021 . Peer-reviewed
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    South African Journal of Child Health
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      South African Journal of Child Health
      Article . 2021 . Peer-reviewed
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      South African Journal of Child Health
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    Authors: Olivier Terrier; Mustapha Si-Tahar; Mariette Ducatez; Christophe Chevalier; +5 Authors

    International audience; The development of safe and effective vaccines in a record time after the emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a remarkable achievement, partly based on the experience gained from multiple viral outbreaks in the past decades. However, the Coronavirus Disease 2019 (COVID-19) crisis also revealed weaknesses in the global pandemic response and large gaps that remain in our knowledge of the biology of coronaviruses (CoVs) and influenza viruses, the 2 major respiratory viruses with pandemic potential. Here, we review current knowns and unknowns of influenza viruses and CoVs, and we highlight common research challenges they pose in 3 areas: the mechanisms of viral emergence and adaptation to humans, the physiological and molecular determinants of disease severity, and the development of control strategies. We outline multidisciplinary approaches and technological innovations that need to be harnessed in order to improve preparedeness to the next pandemic.

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    PLoS Pathogens
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    PLoS Pathogens
    Article . 2021 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
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    Article . 2021
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      PLoS Pathogens
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      PLoS Pathogens
      Article . 2021 . Peer-reviewed
      License: CC BY
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      Hal-Diderot
      Article . 2021
      Data sources: Hal-Diderot
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