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description Publicationkeyboard_double_arrow_right Article 2021 FrancePublisher:Elsevier BV Dubey, Rameshwar; Bryde, David J; Blome, Constantin; Roubaud, David; Giannakis, Mihalis;The COVID-19 pandemic has disrupted global supply chains and exposed weak links in the chains far beyond what most people have witnessed in their living memory. The scale of disruption affects every nation and industry, and the sudden and dramatic changes in demand and supply that have occurred during the pandemic crisis clearly differentiate its impact from other crises. Using the dynamic capabilities view, we studied alliance management capability (AMC) and artificial intelligence (AI) driven supply chain analytics capability (AI-SCAC) as dynamic capabilities, under the moderating effect of environmental dynamism. We tested our four research hypotheses using survey data collected from the Indian auto components manufacturing industry. For data analysis we used Warp PLS 7.0 (a variance-based structural equation modelling tool). We found that alliance management capability under the mediating effect of artificial intelligence-powered supply chain analytics capability enhances the operational and financial performance of the organization. Moreover, we also observed that the alliance management capability has a significant effect on artificial intelligence-powered supply chain analytics capability under the moderating effect of environmental dynamism. The results of our study provide a nuanced understanding of the dynamic capabilities and the relational view of organization. Finally, we noted the limitations of our study and provide numerous research directions that may help answer some of the questions that arise from our study.
CORE (RIOXX-UK Aggre... arrow_drop_down Industrial Marketing ManagementArticle . 2021 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.indmarman.2021.05.003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu89 citations 89 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 54visibility views 54 download downloads 16 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Industrial Marketing ManagementArticle . 2021 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.indmarman.2021.05.003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2020 United Kingdom, France, United KingdomPublisher:Cold Spring Harbor Laboratory Funded by:NIH | MIDAS Center for Communic...NIH| MIDAS Center for Communicable Disease DynamicsMoritz U. G. Kraemer; Chia-Hung Yang; Bernardo Gutierrez; Chieh-Hsi Wu; Brennan Klein; David M. Pigott; Louis du Plessis; Nuno R. Faria; Ruoran Li; William P. Hanage; John S. Brownstein; Maylis Layan; Alessandro Vespignani; Huaiyu Tian; Christopher Dye; Oliver G. Pybus; Samuel V. Scarpino;pmc: PMC7239080 , PMC7146642
The ongoing COVID-19 outbreak has expanded rapidly throughout China. Major behavioral, clinical, and state interventions are underway currently to mitigate the epidemic and prevent the persistence of the virus in human populations in China and worldwide. It remains unclear how these unprecedented interventions, including travel restrictions, have affected COVID-19 spread in China. We use real-time mobility data from Wuhan and detailed case data including travel history to elucidate the role of case importation on transmission in cities across China and ascertain the impact of control measures. Early on, the spatial distribution of COVID-19 cases in China was well explained by human mobility data. Following the implementation of control measures, this correlation dropped and growth rates became negative in most locations, although shifts in the demographics of reported cases are still indicative of local chains of transmission outside Wuhan. This study shows that the drastic control measures implemented in China have substantially mitigated the spread of COVID-19. One sentence summary: The spread of COVID-19 in China was driven by human mobility early on and mitigated substantially by drastic control measures implemented since the end of January.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7239080Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7146642Data sources: PubMed CentralmedRxivPreprint . 2020Oxford University Research Archive; ScienceOther literature type . Article . 2020 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.03.02.20026708&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 2K citations 2,103 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!visibility 25visibility views 25 download downloads 45 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7239080Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7146642Data sources: PubMed CentralmedRxivPreprint . 2020Oxford University Research Archive; ScienceOther literature type . Article . 2020 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.03.02.20026708&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FrancePublisher:Oxford University Press (OUP) Arnot, Megan; Brandl, Eva; Campbell, O L K; Chen, Yuan; Du, Juan; Dyble, Mark; Emmott, Emily H; Ge, Erhao; Kretschmer, Luke D W; Mace, Ruth; Micheletti, Alberto J C; Nila, Sarah; Peacey, Sarah; Salali, Gul Deniz; Zhang, Hanzhi;AbstractThe COVID-19 pandemic has brought science into the public eye and to the attention of governments more than ever before. Much of this attention is on work in epidemiology, virology and public health, with most behavioural advice in public health focusing squarely on ‘proximate’ determinants of behaviour. While epidemiological models are powerful tools to predict the spread of disease when human behaviour is stable, most do not incorporate behavioural change. The evolutionary basis of our preferences and the cultural evolutionary dynamics of our beliefs drive behavioural change, so understanding these evolutionary processes can help inform individual and government decision-making in the face of a pandemic.Lay summary: The COVID-19 pandemic has brought behavioural sciences into the public eye: Without vaccinations, stopping the spread of the virus must rely on behaviour change by limiting contact between people. On the face of it, “stop seeing people” sounds simple. In practice, this is hard. Here we outline how an evolutionary perspective on behaviour change can provide additional insights. Evolutionary theory postulates that our psychology and behaviour did not evolve to maximize our health or that of others. Instead, individuals are expected to act to maximise their inclusive fitness (i.e, spreading our genes) – which can lead to a conflict between behaviours that are in the best interests for the individual, and behaviours that stop the spread of the virus. By examining the ultimate explanations of behaviour related to pandemic-management (such as behavioural compliance and social distancing), we conclude that “good of the group” arguments and “one size fits all” policies are unlikely to encourage behaviour change over the long-term. Sustained behaviour change to keep pandemics at bay is much more likely to emerge from environmental change, so governments and policy makers may need to facilitate significant social change – such as improving life experiences for disadvantaged groups.
Evolution, Medicine ... arrow_drop_down Evolution, Medicine and Public HealthArticle . 2020Full-Text: http://europepmc.org/articles/PMC7665496Data sources: PubMed CentralFachrepositorium LebenswissenschaftenArticle . 2020Data sources: Fachrepositorium LebenswissenschaftenHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2020License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/emph/eoaa038&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 32 citations 32 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Evolution, Medicine ... arrow_drop_down Evolution, Medicine and Public HealthArticle . 2020Full-Text: http://europepmc.org/articles/PMC7665496Data sources: PubMed CentralFachrepositorium LebenswissenschaftenArticle . 2020Data sources: Fachrepositorium LebenswissenschaftenHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2020License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/emph/eoaa038&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 FrancePublisher:Wiley Funded by:ANR | ISBlueANR| ISBlueAuthors: Kavousi, Javid; Goudarzi, Forough; Izadi, Mohammad; Gardner, Charlie J.;Kavousi, Javid; Goudarzi, Forough; Izadi, Mohammad; Gardner, Charlie J.;doi: 10.1111/gcb.15197
pmid: 32479657
International audience; The conservation of biodiversity-and the vital ecosystem services it generates-is one of the greatest challenges humanity faces, yet the field faces drastic funding cuts as society realigns its priorities in the face of the COVID-19 pandemic. Here, we argue that diverting attention from conservation would, however, increase the risk of further global health crises because the emergence of novel infectious diseases is partially driven by global environmental change. As the discrepancy between conservation needs and society's willingness to pay for them grows, conservation will have to evolve to stay relevant in the age global change-induced human infectious disease.
Global Change Biolog... arrow_drop_down ArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of Ifremeradd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/gcb.15197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 1visibility views 1 download downloads 9 Powered bymore_vert Global Change Biolog... arrow_drop_down ArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of Ifremeradd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/gcb.15197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020 FrancePublisher:Cold Spring Harbor Laboratory AMMAR, ACHRAF; Brach, Michael; Trabelsi, Khaled; Chtourou, Hamdi; Boukhris, Omar; Masmoudi, Liwa; Bouaziz, Bassem; Bentlage, Ellen; How, Daniella; Ahmed, Mona; Mueller, Patrick; Mueller, Notger; Aloui, Asma; Hammouda, Omar; Paineiras-Domingos, Laisa Liane; Braakman-jansen, Annemarie; Wrede, Christian; Bastoni, Sophia; Pernambuco, Carlos Soares; Mataruna, Leonardo; Taheri, Morteza; Irandoust, Khadijeh; Khacharem, Aimen; Bragazzi, Nicola; Chamari, Karim; Glenn, Jordan M; Bott, Nicholas T; Gargouri, Faiez; Chaari, Lotfi; Batatia, Hadj; Ali, Gamal Mohamed; Abdelkarim, Osama; Jarraya, Mohamed; El Abed, Kais; Souissi, Nizar; Van Gemert-Pijnen, Lisette; Riemann, Bryan L; Riemann, Laurel; Moalla, Wassim; Gomez-Raja, Jonathan; Epstein, Monique; Sanderman, Robbert; Schulz, Sebastian; Jerg, Achim; Al-Horani, Ramzi; Mansi, Taysir; Jmail, Mohamed; Barbosa, Fernando; Santos, Fernando; Simunic, Bostjan; Pisot, Rado; Cowan, Donald; Gaggioli, Andrea; Bailey, Stephen J; Steinacker, Jurgen; Driss, Tarak; Hoekelmann, Anita;AbstractBackgroundPublic health recommendations and governmental measures during the COVID-19 pandemic have enforced numerous restrictions on daily living including social distancing, isolation and home confinement. While these measures are imperative to abate the spreading of COVID-19, the impact of these restrictions on health behaviours and lifestyle at home is undefined. Therefore, an international online survey was launched in April 2020 in seven languages to elucidate the behavioral and lifestyle consequences of COVID-19 restrictions. This report presents the preliminary results from the first thousand responders on physical activity (PA) and nutrition behaviours.MethodsThirty-five research organisations from Europe, North-Africa, Western Asia and the Americas promoted the survey through their networks to the general society, in English, German, French, Arabic, Spanish, Portugese, and Slovenian languages. Questions were presented in a differential format with questions related to responses “before” and “during” confinement conditions.Results1047 replies (54% women) from Asia (36%), Africa (40%), Europe (21%) and other (3%) were included into a general analysis. The COVID-19 home confinement had a negative effect on all intensities of PA (vigorous, moderate, walking and overall). Conversely, daily sitting time increased from 5 to 8 hours per day. Additionally, food consumption and meal patterns (the type of food, eating out of control, snacks between meals, number of meals) were more unhealthy during confinement with only alcohol binge drink decreasing significantly.ConclusionWhile isolation is a necessary measure to protect public health, our results indicate that it alters physical activity and eating behaviours in a direction that would compromise health. A more detailed analysis of survey data will allow for a segregation of these responses in different age groups, countries and other subgroups which will help develop bespoke interventions to mitigate the negative lifestyle behaviors manifest during the COVID-19 confinement.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.05.04.20072447&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu32 citations 32 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.05.04.20072447&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 France, United Kingdom, United StatesPublisher:Springer Science and Business Media LLC Funded by:UKRI | Mechanistic understanding...UKRI| Mechanistic understanding of virus pathogenesis and resistancePriscilla F. Gerber; Chao-Ting Xiao; Kelly M. Lager; Kimberly Crawford; Vikas Kulshreshtha; Dianjun Cao; Xiang-Jin Meng; Tanja Opriessnig;pmc: PMC5118895
pmid: 27871312
International audience; AbstractPorcine epidemic diarrhea virus (PEDV) causes enteric disease in pigs and spreads rapidly after entering naïve pig populations. The objectives were to (1) compare the disease course following inoculation with PEDV isolate US/Colorado/2013 in naïve 10 day and 8 week-old pigs, and (2) contrast the naïve response to homologous challenge in 8 week-old pigs. Pigs were randomly assigned into group 1 (n = 40, no PEDV exposure), group 2 (n = 43, PEDV inoculation at 10 days of age) and group 3 (n = 48, PEDV inoculation at 8 weeks of age). Thirty-three group 2 pigs received a homologous challenge at 8 weeks of age. Following primary or secondary inoculation, 3–10 pigs were euthanized at days post-inoculation (dpi) 1, 2, 3, 7 or 14. Clinical signs were more pronounced in 10 day-old pigs compared to 8 week-old pigs at dpi 2 and 3, a higher number of 10 day-old pigs shed PEDV RNA in feces compared to 8 week-old pigs. Typical severe atrophic enteritis of PEDV infection was observed at dpi 3 in both age groups, and at dpi 4 and 14 fecal shedding patterns were also similar. While both age groups had seroconverted to PEDV by dpi 14, IgG levels were higher in 8 week-old pigs. PEDV IgA antibodies were detected in feces of approximately 50% of the pigs at dpi 44. In homologous challenged pigs, no clinical signs or lesions were found, and PEDV fecal shedding was restricted to less than 10% of the pigs indicating the existence of homologous protection 44 days after initial PEDV exposure.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5118895Data sources: PubMed CentralMémoires en Sciences de l'Information et de la CommunicationArticle . 2016Full-Text: https://hal.science/hal-01479400/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13567-016-0402-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5118895Data sources: PubMed CentralMémoires en Sciences de l'Information et de la CommunicationArticle . 2016Full-Text: https://hal.science/hal-01479400/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13567-016-0402-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United Kingdom, FrancePublisher:SAGE Publications Funded by:SSHRC, CIHRSSHRC ,CIHRAuthors: Gordon Pennycook; Jonathon McPhetres; Bence Bago; David G. Rand;Gordon Pennycook; Jonathon McPhetres; Bence Bago; David G. Rand;What are the psychological consequences of the increasingly politicized nature of the COVID-19 pandemic in the United States relative to similar Western countries? In a two-wave study completed early (March) and later (December) in the pandemic, we found that polarization was greater in the United States ( N = 1,339) than in Canada ( N = 644) and the United Kingdom. ( N = 1,283). Political conservatism in the United States was strongly associated with engaging in weaker mitigation behaviors, lower COVID-19 risk perceptions, greater misperceptions, and stronger vaccination hesitancy. Although there was some evidence that cognitive sophistication was associated with increased polarization in the United States in December (but not March), cognitive sophistication was nonetheless consistently negatively correlated with misperceptions and vaccination hesitancy across time, countries, and party lines. Furthermore, COVID-19 skepticism in the United States was strongly correlated with distrust in liberal-leaning mainstream news outlets and trust in conservative-leaning news outlets, suggesting that polarization may be driven by differences in information environments.
Durham Research Onli... arrow_drop_down Durham Research OnlineArticle . 2022 . Peer-reviewedFull-Text: http://dro.dur.ac.uk/35143/1/35143.pdfData sources: Durham Research OnlinePersonality and Social Psychology BulletinArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/01461672211023652&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 111 citations 111 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Durham Research Onli... arrow_drop_down Durham Research OnlineArticle . 2022 . Peer-reviewedFull-Text: http://dro.dur.ac.uk/35143/1/35143.pdfData sources: Durham Research OnlinePersonality and Social Psychology BulletinArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/01461672211023652&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2018 FrancePublisher:Elsevier BV Cyril Fersing; Clotilde Boudot; Julien Pedron; Sébastien Hutter; Nicolas Primas; Caroline Castera-Ducros; Sandra Bourgeade-Delmas; Alix Sournia-Saquet; Alain Moreau; Anita Cohen; Jean-Luc Stigliani; Geneviève Pratviel; Maxime D. Crozet; Susan Wyllie; Alan H. Fairlamb; Alexis Valentin; Pascal Rathelot; Nadine Azas; Bertrand Courtioux; Pierre Verhaeghe; Patrice Vanelle;International audience; Based on a previously identified antileishmanial 6,8-dibromo-3-nitroimidazo[1,2-a]pyridine derivative, a Suzuki-Miyaura coupling reaction at position 8 of the scaffold was studied and optimized from a 8-bromo-6-chloro-3-nitroimidazo[1,2-a]pyridine substrate. Twenty-one original derivatives were prepared, screened in vitro for activity against L. infantum axenic amastigotes and T. brucei brucei trypomastigotes and evaluated for their cytotoxicity on the HepG2 human cell line. Thus, 7 antileishmanial hit compounds were identified, displaying IC50 values in the 1.1-3 μM range. Compounds 13 and 23, the 2 most selective molecules (SI = >18 or >17) were additionally tested on both the promastigote and intramacrophage amastigote stages of L. donovani. The two molecules presented a good activity (IC50 = 1.2-1.3 μM) on the promastigote stage but only molecule 23, bearing a 4-pyridinyl substituent at position 8, was active on the intracellular amastigote stage, with a good IC50 value (2.3 μM), slightly lower than the one of miltefosine (IC50 = 4.3 μM). The antiparasitic screening also revealed 8 antitrypanosomal hit compounds, including 14 and 20, 2 very active (IC50 = 0.04-0.16 μM) and selective (SI = >313 to 550) molecules toward T. brucei brucei, in comparison with drug-candidate fexinidazole (IC50 = 0.6 & SI > 333) or reference drugs suramin and eflornithine (respective IC50 = 0.03 and 13.3 μM). Introducing an aryl moiety at position 8 of the scaffold quite significantly increased the antitrypanosomal activity of the pharmacophore. Antikinetoplastid molecules 13, 14, 20 and 23 were assessed for bioactivation by parasitic nitroreductases (either in L. donovani or in T. brucei brucei), using genetically modified parasite strains that over-express NTRs: all these molecules are substrates of type 1 nitroreductases (NTR1), such as those that are responsible for the bioactivation of fexinidazole. Reduction potentials measured for these 4 hit compounds were higher than that of fexinidazole (-0.83 V), ranging from -0.70 to -0.64 V.
Horizon / Pleins tex... arrow_drop_down European Journal of Medicinal ChemistryArticle . 2018 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Horizon / Pleins tex... arrow_drop_down European Journal of Medicinal ChemistryArticle . 2018 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France Funded by:UKRI | WatchChainR, EC | EduliaUKRI| WatchChainR ,EC| EduliaAuthors: Philippe, Kaat; Chabanet, Claire; Issanchou, Sylvie; Monnery-Patris, Sandrine;Philippe, Kaat; Chabanet, Claire; Issanchou, Sylvie; Monnery-Patris, Sandrine;pmid: 33493611
pmc: PMC7825985
International audience; The COVID-19 pandemic caused France to impose a strict lockdown, affecting families’ habits in many domains. This study evaluated possible changes in child eating behaviors, parental feeding practices, and parental motivations when buying food during the lockdown, compared to the period before the lockdown. Parents of 498 children aged 3–12 years (238 boys; M = 7.32; SD = 2.27) completed an online survey with items from validated questionnaires (e.g., CEDQ, CEBQ, HomeSTEAD). They reported on their (child’s) current situation during the lockdown, and retrospectively on the period before the lockdown. Many parents reported changes in child eating behaviors, feeding practices, and food shopping motivations. When changes occurred, child appetite, food enjoyment, food responsiveness and emotional overeating significantly increased during the lockdown. Increased child boredom significantly predicted increased food responsiveness, emotional overeating and snack frequency in between meals. When parents changed their practices, they generally became more permissive: less rules, more soothing with food, more child autonomy. They bought pleasurable and sustainable foods more frequently, prepared more home-cooked meals and cooked more with the child. Level of education and increased stress level predicted changes in parental practices and motivations. This study provides insights in factors that can induce positive and negative changes in families’ eating, feeding and cooking behaviors. This can stimulate future studies and interventions.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7825985Data sources: PubMed CentralAppetiteArticle . 2021License: Elsevier TDMData sources: WHO Global literature on coronavirus diseaseMémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCFull-Text: https://hal.inrae.fr/hal-03144233/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 38 citations 38 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7825985Data sources: PubMed CentralAppetiteArticle . 2021License: Elsevier TDMData sources: WHO Global literature on coronavirus diseaseMémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCFull-Text: https://hal.inrae.fr/hal-03144233/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC7825985&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FrancePublisher:Elsevier BV Yongxian Hu; Elaine Tan Su Yin; Yingying Yang; Hengwei Wu; Guoqing Wei; Junwei Su; Qu Cui; Aiyun Jin; Li Yang; Shan Fu; Jianfeng Zhou; Lugui Qiu; Xi Zhang; Aibin Liang; Hongmei Jing; Yuhua Li; Didier Blaise; Mohamad Mohty; Arnon Nagler; He Huang;The pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly across the world. Currently, the COVID-19 pandemic is affecting the continuity of essential routine healthcare services and procedures, including chimeric antigen receptor T-cell (CAR-T) therapy, a life-saving option for patients with relapsed/refractory (R/R) hematologic malignancies. Due to the rapid disease progression of hematological malignancies, there is an urgent need to manufacture and utilize CAR T-cells. However, CAR-T treatment has become extraordinarily challenging during this COVID-19 pandemic. Thus, many medical and technical factors must now be taken into consideration before, during, and after CAR-T therapy. The purpose of this review is to provide brief suggestions for rational decision-making strategies in evaluating and selecting CAR T-cell treatment and appropriate CAR T-cell products, and protective strategies for medical staff and patients to prevent infection in the midst of the current COVID-19 pandemic.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7321051Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 34 citations 34 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7321051Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2021 FrancePublisher:Elsevier BV Dubey, Rameshwar; Bryde, David J; Blome, Constantin; Roubaud, David; Giannakis, Mihalis;The COVID-19 pandemic has disrupted global supply chains and exposed weak links in the chains far beyond what most people have witnessed in their living memory. The scale of disruption affects every nation and industry, and the sudden and dramatic changes in demand and supply that have occurred during the pandemic crisis clearly differentiate its impact from other crises. Using the dynamic capabilities view, we studied alliance management capability (AMC) and artificial intelligence (AI) driven supply chain analytics capability (AI-SCAC) as dynamic capabilities, under the moderating effect of environmental dynamism. We tested our four research hypotheses using survey data collected from the Indian auto components manufacturing industry. For data analysis we used Warp PLS 7.0 (a variance-based structural equation modelling tool). We found that alliance management capability under the mediating effect of artificial intelligence-powered supply chain analytics capability enhances the operational and financial performance of the organization. Moreover, we also observed that the alliance management capability has a significant effect on artificial intelligence-powered supply chain analytics capability under the moderating effect of environmental dynamism. The results of our study provide a nuanced understanding of the dynamic capabilities and the relational view of organization. Finally, we noted the limitations of our study and provide numerous research directions that may help answer some of the questions that arise from our study.
CORE (RIOXX-UK Aggre... arrow_drop_down Industrial Marketing ManagementArticle . 2021 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu89 citations 89 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 54visibility views 54 download downloads 16 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Industrial Marketing ManagementArticle . 2021 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2020 United Kingdom, France, United KingdomPublisher:Cold Spring Harbor Laboratory Funded by:NIH | MIDAS Center for Communic...NIH| MIDAS Center for Communicable Disease DynamicsMoritz U. G. Kraemer; Chia-Hung Yang; Bernardo Gutierrez; Chieh-Hsi Wu; Brennan Klein; David M. Pigott; Louis du Plessis; Nuno R. Faria; Ruoran Li; William P. Hanage; John S. Brownstein; Maylis Layan; Alessandro Vespignani; Huaiyu Tian; Christopher Dye; Oliver G. Pybus; Samuel V. Scarpino;pmc: PMC7239080 , PMC7146642
The ongoing COVID-19 outbreak has expanded rapidly throughout China. Major behavioral, clinical, and state interventions are underway currently to mitigate the epidemic and prevent the persistence of the virus in human populations in China and worldwide. It remains unclear how these unprecedented interventions, including travel restrictions, have affected COVID-19 spread in China. We use real-time mobility data from Wuhan and detailed case data including travel history to elucidate the role of case importation on transmission in cities across China and ascertain the impact of control measures. Early on, the spatial distribution of COVID-19 cases in China was well explained by human mobility data. Following the implementation of control measures, this correlation dropped and growth rates became negative in most locations, although shifts in the demographics of reported cases are still indicative of local chains of transmission outside Wuhan. This study shows that the drastic control measures implemented in China have substantially mitigated the spread of COVID-19. One sentence summary: The spread of COVID-19 in China was driven by human mobility early on and mitigated substantially by drastic control measures implemented since the end of January.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7239080Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7146642Data sources: PubMed CentralmedRxivPreprint . 2020Oxford University Research Archive; ScienceOther literature type . Article . 2020 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 2K citations 2,103 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!visibility 25visibility views 25 download downloads 45 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7239080Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7146642Data sources: PubMed CentralmedRxivPreprint . 2020Oxford University Research Archive; ScienceOther literature type . Article . 2020 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.03.02.20026708&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FrancePublisher:Oxford University Press (OUP) Arnot, Megan; Brandl, Eva; Campbell, O L K; Chen, Yuan; Du, Juan; Dyble, Mark; Emmott, Emily H; Ge, Erhao; Kretschmer, Luke D W; Mace, Ruth; Micheletti, Alberto J C; Nila, Sarah; Peacey, Sarah; Salali, Gul Deniz; Zhang, Hanzhi;AbstractThe COVID-19 pandemic has brought science into the public eye and to the attention of governments more than ever before. Much of this attention is on work in epidemiology, virology and public health, with most behavioural advice in public health focusing squarely on ‘proximate’ determinants of behaviour. While epidemiological models are powerful tools to predict the spread of disease when human behaviour is stable, most do not incorporate behavioural change. The evolutionary basis of our preferences and the cultural evolutionary dynamics of our beliefs drive behavioural change, so understanding these evolutionary processes can help inform individual and government decision-making in the face of a pandemic.Lay summary: The COVID-19 pandemic has brought behavioural sciences into the public eye: Without vaccinations, stopping the spread of the virus must rely on behaviour change by limiting contact between people. On the face of it, “stop seeing people” sounds simple. In practice, this is hard. Here we outline how an evolutionary perspective on behaviour change can provide additional insights. Evolutionary theory postulates that our psychology and behaviour did not evolve to maximize our health or that of others. Instead, individuals are expected to act to maximise their inclusive fitness (i.e, spreading our genes) – which can lead to a conflict between behaviours that are in the best interests for the individual, and behaviours that stop the spread of the virus. By examining the ultimate explanations of behaviour related to pandemic-management (such as behavioural compliance and social distancing), we conclude that “good of the group” arguments and “one size fits all” policies are unlikely to encourage behaviour change over the long-term. Sustained behaviour change to keep pandemics at bay is much more likely to emerge from environmental change, so governments and policy makers may need to facilitate significant social change – such as improving life experiences for disadvantaged groups.
Evolution, Medicine ... arrow_drop_down Evolution, Medicine and Public HealthArticle . 2020Full-Text: http://europepmc.org/articles/PMC7665496Data sources: PubMed CentralFachrepositorium LebenswissenschaftenArticle . 2020Data sources: Fachrepositorium LebenswissenschaftenHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2020License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 32 citations 32 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Evolution, Medicine ... arrow_drop_down Evolution, Medicine and Public HealthArticle . 2020Full-Text: http://europepmc.org/articles/PMC7665496Data sources: PubMed CentralFachrepositorium LebenswissenschaftenArticle . 2020Data sources: Fachrepositorium LebenswissenschaftenHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotArticle . 2020License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 FrancePublisher:Wiley Funded by:ANR | ISBlueANR| ISBlueAuthors: Kavousi, Javid; Goudarzi, Forough; Izadi, Mohammad; Gardner, Charlie J.;Kavousi, Javid; Goudarzi, Forough; Izadi, Mohammad; Gardner, Charlie J.;doi: 10.1111/gcb.15197
pmid: 32479657
International audience; The conservation of biodiversity-and the vital ecosystem services it generates-is one of the greatest challenges humanity faces, yet the field faces drastic funding cuts as society realigns its priorities in the face of the COVID-19 pandemic. Here, we argue that diverting attention from conservation would, however, increase the risk of further global health crises because the emergence of novel infectious diseases is partially driven by global environmental change. As the discrepancy between conservation needs and society's willingness to pay for them grows, conservation will have to evolve to stay relevant in the age global change-induced human infectious disease.
Global Change Biolog... arrow_drop_down ArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of Ifremeradd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/gcb.15197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 1visibility views 1 download downloads 9 Powered bymore_vert Global Change Biolog... arrow_drop_down ArchiMer - Institutional Archive of IfremerOther literature type . 2020Data sources: ArchiMer - Institutional Archive of Ifremeradd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/gcb.15197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020 FrancePublisher:Cold Spring Harbor Laboratory AMMAR, ACHRAF; Brach, Michael; Trabelsi, Khaled; Chtourou, Hamdi; Boukhris, Omar; Masmoudi, Liwa; Bouaziz, Bassem; Bentlage, Ellen; How, Daniella; Ahmed, Mona; Mueller, Patrick; Mueller, Notger; Aloui, Asma; Hammouda, Omar; Paineiras-Domingos, Laisa Liane; Braakman-jansen, Annemarie; Wrede, Christian; Bastoni, Sophia; Pernambuco, Carlos Soares; Mataruna, Leonardo; Taheri, Morteza; Irandoust, Khadijeh; Khacharem, Aimen; Bragazzi, Nicola; Chamari, Karim; Glenn, Jordan M; Bott, Nicholas T; Gargouri, Faiez; Chaari, Lotfi; Batatia, Hadj; Ali, Gamal Mohamed; Abdelkarim, Osama; Jarraya, Mohamed; El Abed, Kais; Souissi, Nizar; Van Gemert-Pijnen, Lisette; Riemann, Bryan L; Riemann, Laurel; Moalla, Wassim; Gomez-Raja, Jonathan; Epstein, Monique; Sanderman, Robbert; Schulz, Sebastian; Jerg, Achim; Al-Horani, Ramzi; Mansi, Taysir; Jmail, Mohamed; Barbosa, Fernando; Santos, Fernando; Simunic, Bostjan; Pisot, Rado; Cowan, Donald; Gaggioli, Andrea; Bailey, Stephen J; Steinacker, Jurgen; Driss, Tarak; Hoekelmann, Anita;AbstractBackgroundPublic health recommendations and governmental measures during the COVID-19 pandemic have enforced numerous restrictions on daily living including social distancing, isolation and home confinement. While these measures are imperative to abate the spreading of COVID-19, the impact of these restrictions on health behaviours and lifestyle at home is undefined. Therefore, an international online survey was launched in April 2020 in seven languages to elucidate the behavioral and lifestyle consequences of COVID-19 restrictions. This report presents the preliminary results from the first thousand responders on physical activity (PA) and nutrition behaviours.MethodsThirty-five research organisations from Europe, North-Africa, Western Asia and the Americas promoted the survey through their networks to the general society, in English, German, French, Arabic, Spanish, Portugese, and Slovenian languages. Questions were presented in a differential format with questions related to responses “before” and “during” confinement conditions.Results1047 replies (54% women) from Asia (36%), Africa (40%), Europe (21%) and other (3%) were included into a general analysis. The COVID-19 home confinement had a negative effect on all intensities of PA (vigorous, moderate, walking and overall). Conversely, daily sitting time increased from 5 to 8 hours per day. Additionally, food consumption and meal patterns (the type of food, eating out of control, snacks between meals, number of meals) were more unhealthy during confinement with only alcohol binge drink decreasing significantly.ConclusionWhile isolation is a necessary measure to protect public health, our results indicate that it alters physical activity and eating behaviours in a direction that would compromise health. A more detailed analysis of survey data will allow for a segregation of these responses in different age groups, countries and other subgroups which will help develop bespoke interventions to mitigate the negative lifestyle behaviors manifest during the COVID-19 confinement.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu32 citations 32 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.05.04.20072447&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 France, United Kingdom, United StatesPublisher:Springer Science and Business Media LLC Funded by:UKRI | Mechanistic understanding...UKRI| Mechanistic understanding of virus pathogenesis and resistancePriscilla F. Gerber; Chao-Ting Xiao; Kelly M. Lager; Kimberly Crawford; Vikas Kulshreshtha; Dianjun Cao; Xiang-Jin Meng; Tanja Opriessnig;pmc: PMC5118895
pmid: 27871312
International audience; AbstractPorcine epidemic diarrhea virus (PEDV) causes enteric disease in pigs and spreads rapidly after entering naïve pig populations. The objectives were to (1) compare the disease course following inoculation with PEDV isolate US/Colorado/2013 in naïve 10 day and 8 week-old pigs, and (2) contrast the naïve response to homologous challenge in 8 week-old pigs. Pigs were randomly assigned into group 1 (n = 40, no PEDV exposure), group 2 (n = 43, PEDV inoculation at 10 days of age) and group 3 (n = 48, PEDV inoculation at 8 weeks of age). Thirty-three group 2 pigs received a homologous challenge at 8 weeks of age. Following primary or secondary inoculation, 3–10 pigs were euthanized at days post-inoculation (dpi) 1, 2, 3, 7 or 14. Clinical signs were more pronounced in 10 day-old pigs compared to 8 week-old pigs at dpi 2 and 3, a higher number of 10 day-old pigs shed PEDV RNA in feces compared to 8 week-old pigs. Typical severe atrophic enteritis of PEDV infection was observed at dpi 3 in both age groups, and at dpi 4 and 14 fecal shedding patterns were also similar. While both age groups had seroconverted to PEDV by dpi 14, IgG levels were higher in 8 week-old pigs. PEDV IgA antibodies were detected in feces of approximately 50% of the pigs at dpi 44. In homologous challenged pigs, no clinical signs or lesions were found, and PEDV fecal shedding was restricted to less than 10% of the pigs indicating the existence of homologous protection 44 days after initial PEDV exposure.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5118895Data sources: PubMed CentralMémoires en Sciences de l'Information et de la CommunicationArticle . 2016Full-Text: https://hal.science/hal-01479400/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5118895Data sources: PubMed CentralMémoires en Sciences de l'Information et de la CommunicationArticle . 2016Full-Text: https://hal.science/hal-01479400/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United Kingdom, FrancePublisher:SAGE Publications Funded by:SSHRC, CIHRSSHRC ,CIHRAuthors: Gordon Pennycook; Jonathon McPhetres; Bence Bago; David G. Rand;Gordon Pennycook; Jonathon McPhetres; Bence Bago; David G. Rand;What are the psychological consequences of the increasingly politicized nature of the COVID-19 pandemic in the United States relative to similar Western countries? In a two-wave study completed early (March) and later (December) in the pandemic, we found that polarization was greater in the United States ( N = 1,339) than in Canada ( N = 644) and the United Kingdom. ( N = 1,283). Political conservatism in the United States was strongly associated with engaging in weaker mitigation behaviors, lower COVID-19 risk perceptions, greater misperceptions, and stronger vaccination hesitancy. Although there was some evidence that cognitive sophistication was associated with increased polarization in the United States in December (but not March), cognitive sophistication was nonetheless consistently negatively correlated with misperceptions and vaccination hesitancy across time, countries, and party lines. Furthermore, COVID-19 skepticism in the United States was strongly correlated with distrust in liberal-leaning mainstream news outlets and trust in conservative-leaning news outlets, suggesting that polarization may be driven by differences in information environments.
Durham Research Onli... arrow_drop_down Durham Research OnlineArticle . 2022 . Peer-reviewedFull-Text: http://dro.dur.ac.uk/35143/1/35143.pdfData sources: Durham Research OnlinePersonality and Social Psychology BulletinArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/01461672211023652&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 111 citations 111 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Durham Research Onli... arrow_drop_down Durham Research OnlineArticle . 2022 . Peer-reviewedFull-Text: http://dro.dur.ac.uk/35143/1/35143.pdfData sources: Durham Research OnlinePersonality and Social Psychology BulletinArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/01461672211023652&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2018 FrancePublisher:Elsevier BV Cyril Fersing; Clotilde Boudot; Julien Pedron; Sébastien Hutter; Nicolas Primas; Caroline Castera-Ducros; Sandra Bourgeade-Delmas; Alix Sournia-Saquet; Alain Moreau; Anita Cohen; Jean-Luc Stigliani; Geneviève Pratviel; Maxime D. Crozet; Susan Wyllie; Alan H. Fairlamb; Alexis Valentin; Pascal Rathelot; Nadine Azas; Bertrand Courtioux; Pierre Verhaeghe; Patrice Vanelle;International audience; Based on a previously identified antileishmanial 6,8-dibromo-3-nitroimidazo[1,2-a]pyridine derivative, a Suzuki-Miyaura coupling reaction at position 8 of the scaffold was studied and optimized from a 8-bromo-6-chloro-3-nitroimidazo[1,2-a]pyridine substrate. Twenty-one original derivatives were prepared, screened in vitro for activity against L. infantum axenic amastigotes and T. brucei brucei trypomastigotes and evaluated for their cytotoxicity on the HepG2 human cell line. Thus, 7 antileishmanial hit compounds were identified, displaying IC50 values in the 1.1-3 μM range. Compounds 13 and 23, the 2 most selective molecules (SI = >18 or >17) were additionally tested on both the promastigote and intramacrophage amastigote stages of L. donovani. The two molecules presented a good activity (IC50 = 1.2-1.3 μM) on the promastigote stage but only molecule 23, bearing a 4-pyridinyl substituent at position 8, was active on the intracellular amastigote stage, with a good IC50 value (2.3 μM), slightly lower than the one of miltefosine (IC50 = 4.3 μM). The antiparasitic screening also revealed 8 antitrypanosomal hit compounds, including 14 and 20, 2 very active (IC50 = 0.04-0.16 μM) and selective (SI = >313 to 550) molecules toward T. brucei brucei, in comparison with drug-candidate fexinidazole (IC50 = 0.6 & SI > 333) or reference drugs suramin and eflornithine (respective IC50 = 0.03 and 13.3 μM). Introducing an aryl moiety at position 8 of the scaffold quite significantly increased the antitrypanosomal activity of the pharmacophore. Antikinetoplastid molecules 13, 14, 20 and 23 were assessed for bioactivation by parasitic nitroreductases (either in L. donovani or in T. brucei brucei), using genetically modified parasite strains that over-express NTRs: all these molecules are substrates of type 1 nitroreductases (NTR1), such as those that are responsible for the bioactivation of fexinidazole. Reduction potentials measured for these 4 hit compounds were higher than that of fexinidazole (-0.83 V), ranging from -0.70 to -0.64 V.
Horizon / Pleins tex... arrow_drop_down European Journal of Medicinal ChemistryArticle . 2018 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Horizon / Pleins tex... arrow_drop_down European Journal of Medicinal ChemistryArticle . 2018 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ejmech.2018.07.064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France Funded by:UKRI | WatchChainR, EC | EduliaUKRI| WatchChainR ,EC| EduliaAuthors: Philippe, Kaat; Chabanet, Claire; Issanchou, Sylvie; Monnery-Patris, Sandrine;Philippe, Kaat; Chabanet, Claire; Issanchou, Sylvie; Monnery-Patris, Sandrine;pmid: 33493611
pmc: PMC7825985
International audience; The COVID-19 pandemic caused France to impose a strict lockdown, affecting families’ habits in many domains. This study evaluated possible changes in child eating behaviors, parental feeding practices, and parental motivations when buying food during the lockdown, compared to the period before the lockdown. Parents of 498 children aged 3–12 years (238 boys; M = 7.32; SD = 2.27) completed an online survey with items from validated questionnaires (e.g., CEDQ, CEBQ, HomeSTEAD). They reported on their (child’s) current situation during the lockdown, and retrospectively on the period before the lockdown. Many parents reported changes in child eating behaviors, feeding practices, and food shopping motivations. When changes occurred, child appetite, food enjoyment, food responsiveness and emotional overeating significantly increased during the lockdown. Increased child boredom significantly predicted increased food responsiveness, emotional overeating and snack frequency in between meals. When parents changed their practices, they generally became more permissive: less rules, more soothing with food, more child autonomy. They bought pleasurable and sustainable foods more frequently, prepared more home-cooked meals and cooked more with the child. Level of education and increased stress level predicted changes in parental practices and motivations. This study provides insights in factors that can induce positive and negative changes in families’ eating, feeding and cooking behaviors. This can stimulate future studies and interventions.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7825985Data sources: PubMed CentralAppetiteArticle . 2021License: Elsevier TDMData sources: WHO Global literature on coronavirus diseaseMémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCFull-Text: https://hal.inrae.fr/hal-03144233/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC7825985&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 38 citations 38 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7825985Data sources: PubMed CentralAppetiteArticle . 2021License: Elsevier TDMData sources: WHO Global literature on coronavirus diseaseMémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCFull-Text: https://hal.inrae.fr/hal-03144233/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC7825985&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 FrancePublisher:Elsevier BV Yongxian Hu; Elaine Tan Su Yin; Yingying Yang; Hengwei Wu; Guoqing Wei; Junwei Su; Qu Cui; Aiyun Jin; Li Yang; Shan Fu; Jianfeng Zhou; Lugui Qiu; Xi Zhang; Aibin Liang; Hongmei Jing; Yuhua Li; Didier Blaise; Mohamad Mohty; Arnon Nagler; He Huang;The pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly across the world. Currently, the COVID-19 pandemic is affecting the continuity of essential routine healthcare services and procedures, including chimeric antigen receptor T-cell (CAR-T) therapy, a life-saving option for patients with relapsed/refractory (R/R) hematologic malignancies. Due to the rapid disease progression of hematological malignancies, there is an urgent need to manufacture and utilize CAR T-cells. However, CAR-T treatment has become extraordinarily challenging during this COVID-19 pandemic. Thus, many medical and technical factors must now be taken into consideration before, during, and after CAR-T therapy. The purpose of this review is to provide brief suggestions for rational decision-making strategies in evaluating and selecting CAR T-cell treatment and appropriate CAR T-cell products, and protective strategies for medical staff and patients to prevent infection in the midst of the current COVID-19 pandemic.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7321051Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 34 citations 34 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7321051Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.retram.2020.06.003&type=result"></script>'); --> </script>
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