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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Rodrigo, Javier; Flecha, Ainhoa; Kasprowicz, Dominika; Hess, Karolina; +4 Authors

    Storytelling tools aim to leverage the technological restraints of creating and sharing digital narratives, allowing non-expert users to deploy projects and populate them with custom-made content. In other words, storytelling tools aim at giving space for diverse narratives to emerge and spread in the digital sphere. As facilitators of imagining and communicating ideas, they may also be considered incubators of rethinking societal challenges. The three storytelling tools developed in the framework of the HORIZON2020 SO-CLOSE project allow users to create and publish multimedia, multilingual and accessible digital cultural heritage projects. In this demonstration, we present the three tools: the interactive story map, the immersive web doc and the participatory virtual exhibition. We showcase the publishing interfaces (front-end), the authoring and content management system (back-end) and a use-case application (project). The present prototypes will be publicly released by the end of the project (December 2022). SO-CLOSE is a three-year project that aims at enhancing social cohesion through sharing the cultural heritage of forced migrations. Based on theories of cultural heritage-making, the project works towards exposing the commonalities of past and present experiences with the mediation of innovative digital tools and collaborative approaches. The act of storytelling becomes a premise for the potential of a better understanding between local communities and newcomers. In this context, the three tools are conceived and developed to empower cultural institutions and communities in building and publishing their digital stories. To achieve this, end-users were intensively involved in the design process, through participatory methodologies. Starting from a state-of-the-art tools analysis, the project collaborated with cultural institutions, NGOs, refugees and asylum seekers, local communities, researchers and policy makers in the requirements elicitation process (interviews and focus groups), co-design workshops and validation surveys. Overall, the users of the storytelling tools can create projects based on journeys, chapters or exhibitions, use modules that can be selected, shuffled and repeated, populate them with their own content – including 360 videos and images and 3D models – and carry out crowdsourcing calls. The projects are published online, with integrated features for accessibility, interactivity and data interoperability with other repositories. The use-case that will illustrate the tools application will be a pilot project of Greek Forum of Refugees, co-created together with three different refugee communities living in Greece and the Contemporary Social History Archives. posters & demos: 142

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Conference object . 2022
    License: CC BY
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    Other literature type . Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Other literature type . Article . 2022
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Petzold, Andreas; Bundke, Ulrich; Hienola, Anca; Laj, Paolo; +10 Authors

    Abstract. Acquiring and distributing essential information for understanding global biogeochemical interactions between the atmosphere and ecosystems, and how climate-ecosystem feedback loops may change atmospheric composition in the future is a fundamental pre-requisite for societal resilience in view of climate change. Particularly, the detection of trends and periodicity in the presence of greenhouse gases and short-lived climate-active atmospheric constituents is an important aspect of climate science. Thus, the availability of an easy and fast access to reliable, long-term, and high-quality environmental data is recognized as fundamental for research and for developing environmental prediction and assessment services. In our Opinion Article, we develop the role environmental research infrastructures in Europe (ENVRI RIs) and particularly the atmosphere-centred research infrastructures ACTRIS, IAGOS and ICOS can assume with their capacities for standardised acquisition and reporting of long-term and high-quality observational data, complemented by rich metadata, for the provision of data by open access, and for data interoperability across different research fields including all fields of environmental sciences and beyond. Resulting from these capacities in data collection and provision, we elaborate on the novel research opportunities in atmospheric sciences which evolve from the combination of open-access and interoperable observational data, tools and technologies offered by data-intensive science, and the emerging service ecosystem of the collaboration platform ENVRI-Hub, hosted by the European Open Science Cloud.

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    https://doi.org/10.5194/egusph...
    Preprint . 2023 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
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    Copernicus Publications
    Other literature type . 2023
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      https://doi.org/10.5194/egusph...
      Preprint . 2023 . Peer-reviewed
      License: CC BY
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      Copernicus Publications
      Other literature type . 2023
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    Authors: Marin, Monica; Glăvan, Eugen; Chiș, Alin; Corad, Bogdan;

    Abstract This study analyses the spatial differences in EU funds absorption among Romanian rural municipalities through the 2014–2020 programming period. The absorption capacity for EU funds is measured by the volume of spent EU funds by inhabitant, for each Romanian rural municipality. The results of the analysis highlight the importance of the territorial dimension when studying the distribution of EU funds among the rural municipalities of Romania. Affiliation with a specific development region (NUTS 2), county (NUTS 3) or a functional urban area (FUA) is used to differentiate the volume of absorbed EU funds. In Romania, rural municipalities with higher levels of absorbed EU funding are, to a statistically higher extent, located in development regions in the Centre, North-West, South-West and West of the country; in communes with no change, or even an increase, in population between 2014 and 2021; in the highest quartile of fiscal capacity and in communes with experience with EU funding from the preceding programming period. This article adds to the growing body of territorial evidence and can be used as a policy instrument to more closely examine the intervention tools embedded in EU funding policy.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ figsharearrow_drop_down
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    Moravian Geographical Reports
    Article . 2023 . Peer-reviewed
    License: CC BY NC ND
    Data sources: Crossref
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      Moravian Geographical Reports
      Article . 2023 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Maryl, Maciej; Błaszczyńska, Marta; Szulińska, Agnieszka; Rams, Paweł;

    John Unsworth (2000) proposed a tentative list of scholarly primitives, and although he made a reservation that it was not meant to be exhaustive, one omission is striking, namely the exclusion of communicating. It is even more visible once one realises that all the examples he provides in the paper of comparison IBabble), linking (Blake Archive), or sampling (VRML visualisation of Dante’s Inferno) have the indispensable communication component attached to them. The aim of this presentation is two-fold. First of all, we will reclaim the role of communication as one of the fundamental functional primitives, crucial in all stages of the research workflow. To use Unsworth’s nomenclature, communication takes advantage of the additive characteristics of scholarly primitives and enters into combinations with all other scholarly primitives. Secondly, right after reestablishing the communication as a scholarly primitive we will swiftly proceed to problematise the notion of its universality for all disciplines through exploration of the specificity of scholarly communication in the humanities. We will achieve that using New Panorama of Polish Literature (NPLP.pl) as a case-study, outlining the relevant digital infrastructure for the humanities. It has long been suggested that communication should be seen as a fundamental element of the research workflow, rather than an activity running somewhat separate to the research practice (Latour and Woolgar 1986; Garvey 1979; Galison and Galison 1997; Nielsen 2011). Recently this idea wass reinforced by Hillyer et al. (2017) who describe open science as “opening of the entire research cycle” and include communication as one of its key elements. It means that dissemination is no longer perceived as the final stage of a research process but becomes an integral part of all scholarly activities. New digital methods and tools (Dallas et al. 2017), including electronic communication and social media (Kjellberg 2010), facilitate this process. allowing scholars to communicate and collaborate with each other and the wider audience quickly and efficiently at all stages of their work. This also includes intermediary results of the work, including raw and secondary data (Castelli, Manghi, and Thanos 2013). The incorporation of communication into all stages of the research workflow also means that choosing a certain communication strategy is obviously influenced by the perceived goal, but also the goal influences other phases of the research process. This feedback loop more precisely on the example of NPLP, a research infrastructure for literary scholars enabling the creation of extended, multimedia monographs and presenting scholarly arguments through linking text with image, visualisation, map and video content. Yet, Creating a new digital collection forces researchers to rethink how their work is presented, categorised and displayed . For instance in "Postmodern Sienkiewicz" collection (http://nplp.pl/en/kolekcja/postmodern-sienkiewicz/) authors divided their articles into shorter fragments with additional iconography allowing for non-linear reading and access through image-interface. These activities required additional work on the stage of data collection, analysis and interpretation. In conclusion we will tackle upon the question remains to what extent such communication practices are universal for all sciences and what could be treated as reserved for the humanities in the spirit of Diltheyan disctinction between explaining (in sciences) and understanding (in the humanities). {"references": ["Castelli, D., P. Manghi, and C. Thanos. 2013. 'A Vision towards Scientific Communication Infrastructures: On Bridging the Realms of Research Digital Libraries and Scientific Data Centers'. International Journal on Digital Libraries 13 (3\u20134): 155\u201369. https://doi.org/10.1007/s00799-013-0106-7.", "Dallas, Costis, Nephelie Chatzidiakou, Agiatis Benardou, Michael Bender, Aur\u00e9lien Berra, Claire Clivaz, John Cunningham, et al. 2017. 'European Survey on Scholarly Practices and Digital Needs in the Arts and Humanities - Highlights Report'. Zenodo. https://doi.org/10.5281/zenodo.260101.", "Galison, Peter, and Joseph Pellegrino University Professor Peter Galison. 1997. Image and Logic: A Material Culture of Microphysics. University of Chicago Press.", "Garvey, WILLIAM D. 1979. 'CHAPTER 1 - The Role of Scientific Communication in the Conduct of Research and the Creation of Scientific Knowledge'. In Communication: The Essence of Science, edited by WILLIAM D. Garvey, 1\u201339. Pergamon. https://doi.org/10.1016/B978-0-08-023344-4.50006-4.", "Hillyer, Rebecca, Alejandro Posada, Denisse Albornoz, Leslie Chan, and Angela Okune. 2017. 'Framing a Situated and Inclusive Open Science: Emerging Lessons from the Open and Collaborative Science in Development Network'. 2017.", "Kjellberg, Sara. 2010. 'I Am a Blogging Researcher: Motivations for Blogging in a Scholarly Context'. First Monday 15 (8). https://doi.org/10.5210/fm.v15i8.2962.", "Latour, Bruno, and Steve Woolgar. 1986. Laboratory Life: The Construction of Scientific Facts. Princeton University Press.", "Nielsen, Michael A. 2011. Reinventing Discovery\u202f: The New Era of Networked Science. Princeton, N.J.: Princeton University Press. http://press.princeton.edu/titles/9517.html.", "Unsworth, John. 2000. 'Scholarly Primitives: What Methods Do Humanities Researchers Have in Common, and How Might Our Tools Reflect This?' In . King's College London. http://people.brandeis.edu/~unsworth/Kings.5-00/primitives.html."]}

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    Authors: Callingham, J. R.; Shimwell, T. W.; Vedantham, H. K.; Bassa, C. G.; +43 Authors

    The LOFAR data in this manuscript were processed by the LOFAR Two-Metre Sky Survey (LoTSS) team. This team made use of the LOFAR direction-independent calibration pipeline (https://github.com/lofar-astron/prefactor), which was deployed by the LOFAR e-infragroup on the Dutch National Grid infrastructure with support of the SURF Co-operative through grants e-infra 160022 e-infra 160152 (Mechev et al. 2017). The LoTSS direction dependent calibration and imaging pipeline (http://github.com/mhardcastle/ddf-pipeline/) was run on compute clusters at Leiden Observatory and the University of Hertfordshire, which are supported by a European Research Council (ERC) Advanced Grant [NEWCLUSTERS-321271] and the UK Science and Technology Funding Council (STFC) [ST/P000096/1]. The Jülich LOFAR Long Term Archive and the German LOFAR network are both coordinated and operated by the Jülich Supercomputing Centre (JSC), and computing resources on the supercomputer JUWELS at JSC were provided by the Gauss Centre for Supercomputing e.V. (grant CHTB00) through the John von Neumann Institute for Computing (NIC). J.R.C. thanks the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) for support via the Talent Programme Veni grant. H.K. and S.B. acknowledge funding from the NWO for the project e-MAPS (project number Vi.Vidi.203.093) under the NWO talent scheme VIDI. T.W.H.Y. acknowledges funding from EOSC Future (Grant Agreement no. 101017536) projects funded by the European Union’s Horizon 2020 research and innovation programme. P.N.B. is grateful for support from the UK STFC via grant ST/V000594/1. M.J.H. acknowledges support from the UK STFC [ST/V000624/1]. M.H. acknowledges funding from the ERC under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 772663). R.J.v.W. and R.T. acknowledge support from the ERC Starting Grant ClusterWeb 804208. G.J.W. gratefully acknowledges the support of an Emeritus Fellowship from The Leverhulme Trust. D.J.B. acknowledges funding from the German Science Foundation DFG, via the Collaborative Research Center SFB1491 “Cosmic Interacting Matters – From Source to Signal”. A. Bonafede, A. Botteon, D.N.H., and C.J.R. acknowledge support from ERC Stg DRA-NOEL n. 714245 and MIUR FARE grant “SMS”. A.D. acknowledges support by the BMBF Verbundforschung under the grant 05A20STA. K.L.E. is a Jan-sky Fellow of the National Radio Astronomy Observatory. M. Haj and K.C.H. acknowledge the MSHE for granting funds for the Polish contribution to the International LOFAR Telescope (MSHE decision no. DIR/WK/2016/2017/05-1) and for maintenance of the LOFAR PL-612 Baldy (MSHE decision no. 59/E-383/SPUB/SP/2019.1), and LOFAR PL-611 Lazy (MSHE decision no. 46/E-338/SPUB/SP/2019). M.K. acknowledges support from the German Science Foundation DFG, via the Research Unit FOR 5195 “Relativistic Jets in Active Galaxies”. M.K.B. acknowledges support from the National Science Centre, Poland under grant no. 2017/26/E/ST9/00216. B.M. acknowledges support from the UK STFC under grants ST/R00109X/1, ST/R000794/1, and ST/T000295/1. L.K.M. is grateful for support from the UKRI Future Leaders Fellowship (grant MR/T042842/1). D.G.N. acknowledges funding from Conicyt through Fondecyt Postdoctorado (project code 3220195). M.P.T. acknowledges financial support from the Spanish Ministerio de Ciencia e Innovación (MCIN), the Agencia Estatal de Investigación (AEI) through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709) and through grant PID2020-117404GB-C21 funded by MCIN/AEI/10.13039/501100011033. T.P.R. acknowledges support from the ERC Grant No. 743029 (EASY). A.R. acknowledges funding from the NWO Aspasia grant (number: 015.016.033). M.V. acknowledges financial support from the Inter-University Institute for Data Intensive Astronomy (IDIA), a partnership of the University of Cape Town, the University of Pretoria, the University of the Western Cape and the South African Radio Astronomy Observatory, and from the South African Department of Science and Innovation’s National Research Foundation under the ISARP RADIOSKY2020 Joint Research Scheme (DSI-NRF Grant Number 113121) and the CSUR HIPPO Project (DSI-NRF Grant Number 121291). This research has made use of the SIMBAD database, operated at CDS, Strasbourg, France, and NASA’s Astrophysics Data System. This work has also made use of TOPCAT (Taylor 2005); the IPYTHON package (Pérez & Granger 2007); SciPy (Jones et al. 2001); MATPLOTLIB, a PYTHON library for publication quality graphics (Hunter 2007); ASTROPY, a community-developed core PYTHON package for astronomy (Astropy Collaboration 2013); and NUMPY (Van Der Walt et al. 2011). We present the detection of 68 sources from the most sensitive radio survey in circular polarisation conducted to date. We used the second data release of the 144 MHz LOFAR Two-metre Sky Survey to produce circularly polarised maps with a median noise of 140 µJy beam−1 and resolution of 20″ for ≈27% of the northern sky (5634 deg2). The leakage of total intensity into circular polarisation is measured to be ≈0.06%, and our survey is complete at flux densities ≥1 mJy. A detection is considered reliable when the circularly polarised fraction exceeds 1%. We find the population of circularly polarised sources is composed of four distinct classes: stellar systems, pulsars, active galactic nuclei, and sources unidentified in the literature. The stellar systems can be further separated into chromospherically active stars, M dwarfs, and brown dwarfs. Based on the circularly polarised fraction and lack of an optical counterpart, we show it is possible to infer whether the unidentified sources are likely unknown pulsars or brown dwarfs. By the completion of this survey of the northern sky, we expect to detect 300±100 circularly polarised sources. © The Authors 2023. Full list of authors: Callingham, J. R.; Shimwell, T. W.; Vedantham, H. K.; Bassa, C. G.; O'Sullivan, S. P.; Yiu, T. W. H.; Bloot, S.; Best, P. N.; Hardcastle, M. J.; Haverkorn, M.; Kavanagh, R. D.; Lamy, L.; Pope, B. J. S.; Rottgering, H. J. A.; Schwarz, D. J.; Tasse, C.; van Weeren, R. J.; White, G. J.; Zarka, P.; Bomans, D. J.; Bonafede, A.; Bonato, M.; Botteon, A.; Bruggen, M.; Chyzy, K. T.; Drabent, A.; Emig, K. L.; Gloudemans, A. J.; Guerkan, G.; Hajduk, M.; Hoang, D. N.; Hoeft, M.; Iacobelli, M.; Kadler, M.; Kunert-Bajraszewska, M.; Mingo, B.; Morabito, L. K.; Nair, D. G.; Perez-Torres, M.; Ray, T. P.; Riseley, C. J.; Rowlinson, A.; Shulevski, A.; Sweijen, F.; Timmerman, R.; Vaccari, M.; Zheng, J.-- This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S). Peer reviewed

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      https://doi.org/10.48550/arxiv...
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    Authors: Berg, Hannes; Wirtz Martin, Maria A.; Altincekic, Nadide; Alshamleh, Islam; +20 Authors

    SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti-virals. Within the international Covid19-NMR consortium, we have identified binders targeting the RNA genome of SCoV2. We established protocols for the production and NMR characterization of more than 80 % of all SCoV2 proteins. Here, we performed an NMR screening using a fragment library for binding to 25 SCoV2 proteins and identified hits also against previously unexplored SCoV2 proteins. Computational mapping was used to predict binding sites and identify functional moieties (chemotypes) of the ligands occupying these pockets. Striking consensus was observed between NMR-detected binding sites of the main protease and the computational procedure. Our investigation provides novel structural and chemical space for structure-based drug design against the SCoV2 proteome. Angewandte Chemie. International Edition, 61 (46) ISSN:0570-0833 ISSN:1433-7851 ISSN:1521-3773

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    Authors: Müller, Eike; Carenza, Pierluca; Eckner, Christopher; Goobar, Ariel;

    The Fermi-LAT observations of SN 2023ixf, a Type II supernova in the nearby Pinwheel Galaxy, Messier 101 (M101), presents us with an excellent opportunity to constrain MeV-scale Axion-Like Particles (ALPs). By examining the photon decay signature from heavy ALPs that could be produced in the explosion, the existing constraints on the ALP-photon coupling can be improved, under optimistic assumptions, by up to a factor of $ \sim 2 $ for masses $ m_a \lesssim 3 $ MeV. Under very conservative assumptions, we find a bound that is slightly weaker than the existing ones for $ m_a \lesssim 0.5$ MeV. The exact reach of these searches depends mostly on properties of the SN progenitor. This study demonstrates the relevance of core-collapse supernovae, also beyond the Magellanic Clouds, as probes of fundamental physics. Comment: 10 pages, 2 figures. Matching version accepted in PRD

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    Authors: Hannes Berg; Maria A. Wirtz Martin; Nadide Altincekic; Islam Alshamleh; +79 Authors

    Work at BMRZ is supported by the state of Hesse. Work in Covid19-NMR was supported by the Goethe Corona Funds, by the IWBEFRE-program 20007375 of state of Hesse, the DFG through CRC902: “Molecular Principles of RNA-based regulation.” and through infrastructure funds (project numbers: 277478796, 277479031, 392682309, 452632086, 70653611) and by European Union’s Horizon 2020 research and innovation program iNEXT-discovery under grant agreement No 871037. BY-COVID receives funding from the European Union’s Horizon Europe Research and Innovation Programme under grant agreement number 101046203. “INSPIRED” (MIS 5002550) project, implemented under the Action “Reinforcement of the Research and Innovation Infrastructure,” funded by the Operational Program “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014–2020) and co-financed by Greece and the EU (European Regional Development Fund) and the FP7 REGPOT CT-2011-285950—“SEE-DRUG” project (purchase of UPAT’s 700 MHz NMR equipment). The support of the CERM/CIRMMP center of Instruct-ERIC is gratefully acknowledged. This work has been funded in part by a grant of the Italian Ministry of University and Research (FISR2020IP_02112, ID-COVID) and by Fondazione CR Firenze. A.S. is supported by the Deutsche Forschungsgemeinschaft [SFB902/B16, SCHL2062/2-1] and the Johanna Quandt Young Academy at Goethe [2019/AS01]. M.H. and C.F. thank SFB902 and the Stiftung Polytechnische Gesellschaft for the Scholarship. L.L. work was supported by the French National Research Agency (ANR, NMR-SCoV2-ORF8), the Fondation de la Recherche Médicale (FRM, NMR-SCoV2-ORF8), FINOVI and the IR-RMN-THC Fr3050 CNRS. Work at UConn Health was supported by grants from the US National Institutes of Health (R01 GM135592 to B.H., P41 GM111135 and R01 GM123249 to J.C.H.) and the US National Science Foundation (DBI 2030601 to J.C.H.). Latvian Council of Science Grant No. VPP-COVID-2020/1-0014. National Science Foundation EAGER MCB-2031269. This work was supported by the grant Krebsliga KFS-4903-08-2019 and SNF-311030_192646 to J.O. P.G. (ITMP) The EOSC Future project is co-funded by the European Union Horizon Programme call INFRAEOSC-03-2020—Grant Agreement Number 101017536. Open Access funding enabled and organized by Projekt DEAL SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti-virals. Within the international Covid19-NMR consortium, we have identified binders targeting the RNA genome of SCoV2. We established protocols for the production and NMR characterization of more than 80 % of all SCoV2 proteins. Here, we performed an NMR screening using a fragment library for binding to 25 SCoV2 proteins and identified hits also against previously unexplored SCoV2 proteins. Computational mapping was used to predict binding sites and identify functional moieties (chemotypes) of the ligands occupying these pockets. Striking consensus was observed between NMR-detected binding sites of the main protease and the computational procedure. Our investigation provides novel structural and chemical space for structure-based drug design against the SCoV2 proteome. 12 pags., 4 figs., 3 tabs. Peer reviewed

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    Angewandte Chemie International Edition
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    Fraunhofer-ePrints
    Other literature type . 2022
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Angewandte Chemie
    Article . 2022 . Peer-reviewed
    License: CC BY
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://doi.org/10.26083/tupri...
    Article . 2024
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Angewandte Chemie In...arrow_drop_down
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      Angewandte Chemie International Edition
      Other literature type . Article . 2022 . Peer-reviewed
      License: CC BY
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      tuprints
      Article . 2024
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Fraunhofer-ePrints
      Other literature type . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Angewandte Chemie
      Article . 2022 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      https://doi.org/10.26083/tupri...
      Article . 2024
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Kemmer, Isabel; Keppler, Antje; Serrano-Solano, Beatriz; Rybina, Arina; +5 Authors

    AbstractBioimaging has now entered the era of big data with faster-than-ever development of complex microscopy technologies leading to increasingly complex datasets. This enormous increase in data size and informational complexity within those datasets has brought with it several difficulties in terms of common and harmonized data handling, analysis, and management practices, which are currently hampering the full potential of image data being realized. Here, we outline a wide range of efforts and solutions currently being developed by the microscopy community to address these challenges on the path towards FAIR bioimaging data. We also highlight how different actors in the microscopy ecosystem are working together, creating synergies that develop new approaches, and how research infrastructures, such as Euro-BioImaging, are fostering these interactions to shape the field.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Histochemistry and C...arrow_drop_down
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    Histochemistry and Cell Biology
    Article . 2023 . Peer-reviewed
    License: CC BY
    Data sources: Sygma; Crossref
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    ZENODO
    Preprint . 2023
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    ZENODO
    Preprint . 2023
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    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Histochemistry and C...arrow_drop_down
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      Histochemistry and Cell Biology
      Article . 2023 . Peer-reviewed
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      Data sources: Sygma; Crossref
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      ZENODO
      Preprint . 2023
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Preprint . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    OPERAS Innovation Lab provides targeted guidance for scholars seeking to disseminate their outputs in an innovative way. This poster presents three case studies of workflows for innovative scholarly communication: 1) toolkit/anthology; 2) interdisciplinary online journal; 3) software services. The workflows will serve as blueprints for SSH scholars.

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    ZENODO
    Article . 2023
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    Data sources: Datacite
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    ZENODO
    Conference object . 2023
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    ZENODO
    Other literature type . 2023
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    ZENODO
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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      Article . 2023
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      Other literature type . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Rodrigo, Javier; Flecha, Ainhoa; Kasprowicz, Dominika; Hess, Karolina; +4 Authors

    Storytelling tools aim to leverage the technological restraints of creating and sharing digital narratives, allowing non-expert users to deploy projects and populate them with custom-made content. In other words, storytelling tools aim at giving space for diverse narratives to emerge and spread in the digital sphere. As facilitators of imagining and communicating ideas, they may also be considered incubators of rethinking societal challenges. The three storytelling tools developed in the framework of the HORIZON2020 SO-CLOSE project allow users to create and publish multimedia, multilingual and accessible digital cultural heritage projects. In this demonstration, we present the three tools: the interactive story map, the immersive web doc and the participatory virtual exhibition. We showcase the publishing interfaces (front-end), the authoring and content management system (back-end) and a use-case application (project). The present prototypes will be publicly released by the end of the project (December 2022). SO-CLOSE is a three-year project that aims at enhancing social cohesion through sharing the cultural heritage of forced migrations. Based on theories of cultural heritage-making, the project works towards exposing the commonalities of past and present experiences with the mediation of innovative digital tools and collaborative approaches. The act of storytelling becomes a premise for the potential of a better understanding between local communities and newcomers. In this context, the three tools are conceived and developed to empower cultural institutions and communities in building and publishing their digital stories. To achieve this, end-users were intensively involved in the design process, through participatory methodologies. Starting from a state-of-the-art tools analysis, the project collaborated with cultural institutions, NGOs, refugees and asylum seekers, local communities, researchers and policy makers in the requirements elicitation process (interviews and focus groups), co-design workshops and validation surveys. Overall, the users of the storytelling tools can create projects based on journeys, chapters or exhibitions, use modules that can be selected, shuffled and repeated, populate them with their own content – including 360 videos and images and 3D models – and carry out crowdsourcing calls. The projects are published online, with integrated features for accessibility, interactivity and data interoperability with other repositories. The use-case that will illustrate the tools application will be a pilot project of Greek Forum of Refugees, co-created together with three different refugee communities living in Greece and the Contemporary Social History Archives. posters & demos: 142

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Conference object . 2022
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    Data sources: Datacite
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Other literature type . Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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      Conference object . 2022
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      Other literature type . Article . 2022
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