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  • Publication . Other literature type . 2021
    Open Access
    Authors: 
    LAZHAR BENALLAL;
    Publisher: Zenodo

    Between reality and fiction, the unexpected appearance of SARS-COV2 on a global scale raises several questions about its true origin and what perspective on its long-term evolution.

  • Publication . Other literature type . Article . 2021
    Open Access English

    Someone who is unable or unwilling to return to their country of origin owing to a well-founded fear of being persecuted for reasons of race, religion, nationality, membership of a particular social group, or political opinion is known as Refugee. And an asylum seeker is someone whose request for sanctuary has yet to be processed. In Today's world, the rights of Rohingya refugees are very debatable. Our topic is The Educational rights of Rohingya Refugees Children in Bangladesh (an analysis). There are some social, cultural, and language barriers to providing education rights to Rohingya children and Bangladesh is not also under an obligation to do so as Bangladesh hasn’t signed the 1951 convention of refugees. So basically the research is based on how to ensure the right of Rohingya children otherwise in its absence. We also tried to understand the problems, the gaps, the Bangladesh situation, and international instruments. A big question is Bangladesh has been under the duty to secure the interest of refugee education and the explanation on that by which law and convention are labile or not for refugee children's education. Bangladesh has not signed the Refugee Convention. So that, Bangladesh is not legally bound to ensure that right and no law regulates and for the administration of refugee affairs in Bangladesh or guarantees the rights of refugees. There are a lot of Refugees in Bangladesh but because Bangladesh is not a signatory state of the 1951 convention, that's why they are known as Asylum Seekers. Though Education is a very important and basic entitlement for humans still there is some debate. Being born as human refugees are entitled to have some rights and education is one of them. But now there is a lot of debate on that ground. {"references": ["Alif Ovi D, and Mridha T, 'Education Rights Of Rohingya Refugees Children In Bangladesh: An Analysis' (2021) 2 Jus Corpus Law Journal ", "Alif Ovi, D., & Mridha, T. (2021). Education Rights of Rohingya Refugees Children in Bangladesh: An Analysis. Jus Corpus Law Journal, 2(2), 26-47. from https://jgateplus.com/.", "Alif Ovi, D. and Mridha, T., 2021. Education Rights of Rohingya Refugees Children in Bangladesh: An Analysis. Jus Corpus Law Journal, [online] 2(2), pp.26-47. Available at: "]}

  • Open Access English
    Authors: 
    Frank Lehrbass;
    Publisher: Zenodo

    The European Markets Infrastructure Regulation (EMIR) allows burdening a clearing obligation on non-financial corporations, which formerly did not necessarily clear their business. We give 10 recommendations on how to cope with this obligation. These are motivated by a case study for which we consider a stylized German power producer. For this entity, we derive optimal levels of planned production and forward sales of power using microeconomic theory. Since this results in a significant short position in the German power forward market, we investigate the resulting variation margin call dynamics with a special interest in the ability to forecast worst-case price up moves. We compare different models for the forward log-returns and their performance in 99% quantile forecasting. A GARCH model with Student-t distribution emerges as the most suitable model. This is used in the case study, which is inspired by data published by the power producer E.ON. Using recent material from the Basel Committee on Banking Supervision we distill the reliable liquidity buffer from an allegedly rich liquidity position and show how suddenly it can be eroded. We point to feedback loops, which make the challenges—posed by the clearing obligation—even more severe. We also spend some thoughts on how to cope with the crisis caused by Corona.

  • German
    Authors: 
    Bala, Mehmet Murat; Bala, Keziban Aslı; Hancı, Fatma; Bayraktar, Zehra; Kabakuş, Nimet;
    Publisher: Unpublished
  • English
    Authors: 
    Edmond, Jennifer; Basaraba, Nicole; Doran, Michelle; Garnett, Vicky; Grile, Courtney Helen; Papaki, Eliza; Tóth-Czifra, Erzsébet;
    Publisher: HAL CCSD
    Country: France
  • Open Access
    Authors: 
    BALA, Mehmet Murat; BALA, Keziban Aslı;
    Publisher: Wroclaw Medical University

    BACKGROUND Osteogenesis imperfecta (OI) is a genetic disorder that causes skeletal fragility, multiple fractures and several extraskeletal disorders. Most cases of OI are caused by mutations in COL1A1/A2. Osteogenesis imperfecta type VIII typically causes a severe and fatal phenotype that presents at birth with severe osteopenia, congenital fractures and other clinical manifestations. OBJECTIVES We describe the cases of an 11-year-old female and a 9-year-old male with homozygous truncating mutations in P3H1. Both cases were born with intrauterine fractures and suffered multiple fractures shortly after birth, requiring multiple operations to correct both fractures and severe scoliosis. The patients have been treated with pamidronate since the age of 2. MATERIAL AND METHODS Whole exome sequencing (WES) was performed by Gene by Gene using Twist Bioscience technology. Initially, ~36.5 Mb of consensus coding sequences (targeting >98% of RefSeq and Gencode v. 28 regions obtained from the human genome) was replicated from fragmented genomic DNA using the Twist Human Core Exome Plus kit. The subsequent library was sequenced on the Illumina Novaseq Next Generation Sequencing platform to achieve at least ×20 reading depth for >98% of the targeted bases. Variant annotations and filtering was performed using Ingenuity Variant Analysis software. RESULTS We identified a homozygous mutation in the 3rd exon of P3H1 (c.628C>T/p.Arg210 Ter). Our cases broaden the phenotypic spectrum of OI type VIII as, to the best of our knowledge, these are the first postnatal cases with P3H1 (c.628C>T/p.Arg210 Ter) mutations published in the literature. CONCLUSIONS We present the first recorded postnatal cases from unrelated families of OI type VIII, broadening our understanding of the severe, but nonfatal spectrum of clinical phenotype of this recessive form of OI.

  • Closed Access
    Authors: 
    Durukan, Yasin; Bala, Mehmet Murat; Şahin, Abdullah Alper; Fırat, Tülin; Buğdaycı, Güler; Özturan, Kutay Engin;
    Publisher: Elsevier BV

    Abstract Background We aimed to compare biochemical and histopathological findings of astaxanthin's potential effects on oxidative stress in ischemia/reperfusion damage (I/R). Methods Thirty-two rats were randomly divided into four groups: control group; I/R group; I/R + treatment group; drug group. Astaxanthin was orally administered to groups C and D for 14 days. In groups B and C, the femoral artery was clamped for 2 h to form ischemia. The clamp was opened, and reperfusion was performed for 1 h. In all groups, 4 ml of blood sample through intracardiac puncture and gastrocnemius muscle tissue samples were collected. Serum and tissue samples were analyzed by measuring malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and total oxidative level (TOL). Necrosis, inflammation, and caspase-3 in muscle tissue collected for histopathological examination were evaluated. Results Tissue MDA, SOD and TOL values significantly differed between groups. Serum MDA, SOD, TOL and TAC values significantly differed between groups. On necrosis examination, there was a significant difference between groups B and C. Although signs of inflammation significantly differed between groups, there was no significant difference between groups A and C and groups A and D. Although there was a significant difference in caspase-3 results between groups, there was no significant difference between groups A and C. Conclusions The use of astaxanthin before and after surgery showed preventive or therapeutic effects against I/R damage.

  • Open Access English
    Authors: 
    Mehmet Akif Boz; Husamettin Cakici; M. Pakdil; Abdullah Alper Şahin; Selma Erdogan Duzcu; Mehmet Murat Bala; Metin Celik;
    Publisher: Turkish Joint Diseases Foundation
    Country: Turkey

    WOS:000545984600012 PubMed: 32584721 Objectives: This study aims to biomechanically and histopathologically investigate the effects of methylene blue (MB) on preventing postoperative adhesion in chickens undergoing full - thickness flexor tendon incision. Materials and methods: This study was performed between June 2017 and June 2018 on Hubbard JA 57 type chickens (age, 6 months; weight, 2.2?0.3 kg). Sixty-four tendons were studied in 32 chickens, including 16 in the control group and 16 in the experimental group. The second and third finger flexor digitorum profundus tendons of the left foot of each chicken were repaired primarily after a full -thickness incision approximately 1 cm proximal to the distal adhesion area. In the control (n=32) and experimental groups (n=32), 0.25 mL of normal saline and 0.25 mL of 1% MB solutions were applied locally to the surgical site, respectively. The operated limb was immobilized using a circular cast. 16 chickens were randomly selected in each group and examined at the fourth week, and the remaining 16 chickens were examined at the sixth week. Thirty-two of these tendons were evaluated using the Tang histopathological adhesion classification system, and the other 32 were evaluated with a biomechanical pull system. Results: Adhesion was found to be less in the experimental group compared to the control group at the end of the fourth and sixth weeks both histopathologically and biomechanically. Furthermore, adhesion was significantly less in the experimental group at the end of the sixth week compared to the fourth week both histopathologically and biomechanically. Conclusion: Histopathological and biomechanical results show that MB, which has anti-inflammatory, antiseptic, antimicrobial and antioxidant effects, reduces adhesion during the healing process after tendon repair. We think that local MB application, particularly in surgeries performed after this type of injury, will be beneficial on early rehabilitation and functional results.

  • Open Access
    Authors: 
    Mehmet Murat Bala; Abdullah Alper Şahin; Mehmet Akif Boz; Yasin Durukan; Tulin Firat; M. Pakdil; Kutay Engin Ozturan;
    Publisher: International Scientific Information, Inc.

    BACKGROUND In this study, we aimed to investigate the effects of N-butyl-2-cyanoacrylate (cyanoacrylate) on the biomechanical and histopathological aspects of tendon healing in a rabbit model of Achilles tendon injury. MATERIAL AND METHODS In total, 36 rabbits were randomized to experimental (cyanoacrylate) and control groups (n=36 tendons in each group). A simple suture was used in the control group and a simple suture plus cyanoacrylate was used in the experimental group. Nine rabbits from each group were euthanized at week 4 and week 6 after surgery for histopathological and biomechanical testing. RESULTS Granulation tissue formation was significantly greater in the experimental group in week 4 and week 6 than in the control group. Foreign body giant cell formation was significantly higher in the experimental group in week 4 and week 6. The maximum rupture force was significantly higher in the experimental group in week 4 and week 6 than in the control group. Elasticity and stiffness were comparable between groups in week 4; however, stiffness, but not elasticity, was significantly higher in the experimental group in week 6. CONCLUSIONS In the short term, cyanoacrylate enhanced tendon endurance in both a histopathological and biomechanical manner. We conclude that the early initiation of rehabilitation in patients may be safe in cases of cyanoacrylate use for surgical repair of tendon injury.

  • Open Access English
    Authors: 
    Khan, Fahad; Romary, Laurent; Salgado, Ana; Bowers, Jack; Khemakhem, Mohamed; Tasovac, Toma;
    Publisher: Zenodo
    Country: France
    Project: EC | ELEXIS (731015), EC | ELEXIS (731015)

    Due to COVID19 pandemic, the 12th edition is cancelled. The LREC 2020 Proceedings are available at http://www.lrec-conf.org/proceedings/lrec2020/index.html; International audience; In this article, we will introduce two of the new parts of the new multi-part version of the Lexical Markup Framework (LMF) ISO standard, namely Part 3 of the standard (ISO 24613-3), which deals with etymological and diachronic data, and Part 4 (ISO 24613-4), which consists of a TEI serialisation of all of the prior parts of the model. We will demonstrate the use of both standards by describing the LMF encoding of a small number of examples taken from a sample conversion of the reference Portuguese dictionary Grande Dicionário Houaiss da Língua Portuguesa, part of a broader experiment comprising the analysis of different, heterogeneously encoded, Portuguese lexical resources. We present the examples in the Unified Modelling Language (UML) and also in a couple of cases in TEI.