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9,673 Data sources

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  • mirDNMR is a database for the collection of gene-centered background DNMRs obtained from different methods and population variation data. The database has the following functions: (i) browse and search the background DNMRs of each gene predicted by four different methods, including GC content (DNMR-GC), sequence context (DNMR-SC), multiple factors (DNMR-MF) and local DNA methylation level (DNMR-DM); (ii) search variant frequencies in publicly available databases, including ExAC, ESP6500, UK10K, 1000G and dbSNP and (iii) investigate the DNM burden to prioritize candidate genes based on the four background DNMRs using three statistical methods (TADA, Binomial and Poisson test). In conclusion, mirDNMR can be widely used to identify the genetic basis of sporadic genetic diseases.

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  • Through the generous support of The Polonsky Foundation, this project made 1.5 million digitized pages freely available. Portions of the Biblioteca Apostolica Vaticana (Vatican Library) and the Bodleian Libraries’ collections of Hebrew manuscripts, Greek manuscripts, and incunabula were selected for digitization by a team of scholars and curators from around the world. The selection process was informed by a balance of scholarly and practical concerns; conservation staff at the Bodleian and Vatican Libraries worked with curators to assess not only the significance of the content, but the physical condition of the items, prioritizing items that are robust enough to withstand being transported to the imaging studio and handled by the photographers. In order to preserve the integrity and completeness of the manuscript collections, the libraries also agreed to digitize whole collections where appropriate. While the Vatican and the Bodleian had been creating digital images from our collections for a number of years, this project provided an opportunity for both libraries to increase the scale of their digitization services. In both cases, this meant significant investments in the equipment, infrastructure and people that make digitization possible. Over the course of this project, both libraries also revealed information about their digitization techniques and methods.

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  • EcoliWiki is a community-based resource for the annotation of all non-pathogenic E. coli, its phages, plasmids, and mobile genetic elements. Users can contribute data to this wiki-style repository.

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  • The NINDS Human Cell and Data Repository (NHCDR) provides access to fibroblast and/or induced pluripotent stem cell (iPSC) lines for a number neurological disorders within the NINDS mission as well as healthy controls. NHCDR also supports access to unique iPSC collections from NeuroLINCS, PDBP, LEFFTDS and Target ALS with associated metadata. A GMP-grade iPSC line and corresponding research grade iPSC line are also available through the NHCDR.

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9,673 Data sources
  • more_vert
  • mirDNMR is a database for the collection of gene-centered background DNMRs obtained from different methods and population variation data. The database has the following functions: (i) browse and search the background DNMRs of each gene predicted by four different methods, including GC content (DNMR-GC), sequence context (DNMR-SC), multiple factors (DNMR-MF) and local DNA methylation level (DNMR-DM); (ii) search variant frequencies in publicly available databases, including ExAC, ESP6500, UK10K, 1000G and dbSNP and (iii) investigate the DNM burden to prioritize candidate genes based on the four background DNMRs using three statistical methods (TADA, Binomial and Poisson test). In conclusion, mirDNMR can be widely used to identify the genetic basis of sporadic genetic diseases.

    more_vert
  • more_vert
  • more_vert
  • more_vert
  • Through the generous support of The Polonsky Foundation, this project made 1.5 million digitized pages freely available. Portions of the Biblioteca Apostolica Vaticana (Vatican Library) and the Bodleian Libraries’ collections of Hebrew manuscripts, Greek manuscripts, and incunabula were selected for digitization by a team of scholars and curators from around the world. The selection process was informed by a balance of scholarly and practical concerns; conservation staff at the Bodleian and Vatican Libraries worked with curators to assess not only the significance of the content, but the physical condition of the items, prioritizing items that are robust enough to withstand being transported to the imaging studio and handled by the photographers. In order to preserve the integrity and completeness of the manuscript collections, the libraries also agreed to digitize whole collections where appropriate. While the Vatican and the Bodleian had been creating digital images from our collections for a number of years, this project provided an opportunity for both libraries to increase the scale of their digitization services. In both cases, this meant significant investments in the equipment, infrastructure and people that make digitization possible. Over the course of this project, both libraries also revealed information about their digitization techniques and methods.

    more_vert
  • more_vert
  • EcoliWiki is a community-based resource for the annotation of all non-pathogenic E. coli, its phages, plasmids, and mobile genetic elements. Users can contribute data to this wiki-style repository.

    more_vert
  • The NINDS Human Cell and Data Repository (NHCDR) provides access to fibroblast and/or induced pluripotent stem cell (iPSC) lines for a number neurological disorders within the NINDS mission as well as healthy controls. NHCDR also supports access to unique iPSC collections from NeuroLINCS, PDBP, LEFFTDS and Target ALS with associated metadata. A GMP-grade iPSC line and corresponding research grade iPSC line are also available through the NHCDR.

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